Glutamate Transmitter System Explained (NMDA, AMPA, Kainate, mGluR) | Clip

Welcome to Science With Tal!
In this video, we will cover the neurotransmitter: glutamate. More precisely, we will cover its synthesis pathway, its ionotropic receptors (NMDA, AMPA, Kainate) & metabotropic receptor (mGluR). Glutamate is the principal excitatory neurotransmitter in the CNS so it is important to understand its properties.
This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:
1- To watch the first part (Signal propagation in the Neuron), make sure to go to: • Signal Propagation In ...
2- To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to: • Neuromuscular Junction...
To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.
TIMESTAMPS
0:00 Introduction
0:15 Synthesis & reuptake
3:57 Ionotropic channels (NMDA, AMPA, Kainate)
12:39 Metabotropic channels (mGluR)
15:44 Conclusion
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (... )

[@peony286]

Glutamate molecular structure is wrongly written

[@sciencewithtal]

Wow, thank you for pointing that out! It should indeed have an OH group instead of the present NH2.

[@karlapatriciamunozbaldovin3703]

Great video, I had not found something explained as easy as this one, thank you!

[@sciencewithtal]

Thank you! I am glad it was helpful!

[@tyreseholder886]

Very well done video! It's a huge help while tackling neuroscience and I look forward to watching your other videos

[@sciencewithtal]

Thank you very much!

[@lorimav]

Overactivation of glutamate is a problem for certain autistic people like my daughter. Chris Masterjohn suggested glycine for sleep but some of the comments suggested that it could cause excitation which it definitely does with my daughter. Your presentation does mention glycine which was helpful for understanding this phenomenon.

[@sciencewithtal]

Hi, sorry to hear that your daughter has to go through this that must be very challenging! I am glad this video provided clarity for you!

[@user-bt9xy4il4v]

I wish I found your channel sooner. I am currently taking my course to be a pmhnp in a master's program. Your video is so helpful. Please continue to make more.

[@sciencewithtal]

Thank you for the support! Good luck with your studies!

[@user-so8dk1ex1z]

Very helpful. Thanks

[@sciencewithtal]

Thank you!

[@emilymears5208]

Thank you for making this! I need you to tutor me.

[@sciencewithtal]

Thank you for the support!

[@brendahaun5584]

Can you explain more about the effects of magnesium on glutamate transmission? Or is there a video for that?

[@sciencewithtal]

As far as this video explains, magnesium is involved with NMDA receptor transmission as it blocks the channel at rest. This property leads to the concept of coincidence detection described in the video. I do not know that magnesium has roles beyond this in glutamate transmission. Let me know if that clarifies your question!

[@user-no5bh2lq9x]

I cant find the acetylcholine video😢

[@sciencewithtal]

I did not cover acetylcholine alone but I did make videos that talk about all the relevant properties of acetylcholine and their receptors. Here they are:
1- Neuromuscular Junction Synapse Explained (nicotinic Acetylcholine Receptors) | Clip
ua-cam.com/video/memCXaPrkMQ/v-deo.html
2- Properties of Neurons In The Central Nervous System (Neurophysiology) | Full discussion (starting at 27:03)
ua-cam.com/video/bLhcKhYyxuw/v-deo.html
In video 1 I explain how acetylcholine is used at the periphery and their respective ionotropic receptors. In video 2, I discuss their metabotropic receptors. Hope this helps! Let me know if you need anything else!

[@user-no5bh2lq9x]

@@sciencewithtal thanks☺️