2022.10.07 Columbia BME Faculty in Focus - Sanja Vickovic

Spatial Omics Technologies at Scale
Mucosal and barrier tissues such as the gut, lung, or skin, are composed of a complex network of cells and microbes forming a tight niche that prevents pathogen colonization and supports host-microbiome symbiosis. Characterizing these networks at high molecular and cellular resolution is crucial for our understanding of homeostasis and disease. Spatial transcriptomics has recently emerged as a key technique to capture and positionally barcode RNAs directly in tissues. Today, I will introduce two of the recent advances in the application of spatial transcriptomics at scale, by presenting Spatial Multi-Omics (SM-Omics); as a fully automated, high-throughput platform for combined and spatially resolved transcriptomics and antibody-based protein measurements, and Spatial Host-Microbiome sequencing (SHM-seq); an all-sequencing based approach that captures tissue histology, polyadenylated RNAs and bacterial 16S sequences directly from tissues on spatially barcoded glass surfaces.
ABOUT THE SPEAKER
Sanja Vicković, Ph.D., Assistant Professor of Biomedical Engineering at Columbia University
Dr. Vicković is a Core Faculty Member and the Director of the Technology Innovation Lab, at the New York Genome Center. She holds joint appointments as an Assistant Professor at the Fu Foundation School of Engineering and Applied Science and the Herbert and Florence Irving Institute for Cancer Dynamics at Columbia University, and as a Wallenberg Academy Fellow of the Royal Swedish Academy of Sciences and the Royal Swedish Academy of Engineering Sciences at Uppsala University. Dr. Vicković is an experienced and accomplished engineer and an inventor of the spatial transcriptomic technology called “Visium” and now commercialized by 10x Genomics.
ABOUT THE BME SEMINAR SERIES
The Department of Biomedical Engineering at Columbia University is proud to host an annual weekly seminar series on the latest developments and research in Biomedical Engineering. The weekly series takes place on Friday mornings at 11:00 AM Eastern and includes a variety of renowned academics from top universities to talk about their specific research and experience. This is a hybrid event.