Susan's brain: The science of addiction

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  • Опубліковано 21 січ 2018
  • Learn how opioid receptors regulate pain signals, how the body releases natural painkillers called endorphins, and how prescription opioid analgesics can lead to dependency and a cycle of addiction.
    From our free online course, “The Opioid Crisis in America”:
    www.edx.org/course/opioid-cri...
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КОМЕНТАРІ • 78

  • @HarvardOnline
    @HarvardOnline  5 років тому +5

    Learn more in our free online course, “The Opioid Crisis in America”: harvardx.link/9ybbs

  • @alwaysdisputin9930
    @alwaysdisputin9930 6 років тому +37

    i found this interesting:
    1:51 _"To keep dopamine neurons in check, inhibitory neurons keep the brakes on until something good comes along. Just like the pain neuron, these neurons are covered in opioid receptors. When Susan takes the painkiller prescribed by her doctor the opioid receptors turn off the inhibitory neurons & release the brake on the dopamine neurons."_

    • @NazriB
      @NazriB 4 години тому

      Lies again? Spank Bang USD SGD

  • @YananZhao0711
    @YananZhao0711 Рік тому +19

    This is the best video I've seen for drug and addiction. I'll show this to my patients in the future.

  • @omenknight1
    @omenknight1 Рік тому +22

    For people who are addicted coming to the realization that the brain is sick and it requires time to heal is what needs to be the emphasis. Without this self-actualized epiphany the probability of relapse is HIGH!
    In General Addictive behavior is predisposed in the brain people don’t know.
    Painkillers are just one medium to trigger that behavior, however there are a variety of things that can cause this disease to trigger.

    • @steinarjonsson_
      @steinarjonsson_ Рік тому +3

      Mental suffering is the most common denominator in terms of reasons why people abuse drugs (not just opioids). That's why detox fails so many people. Detox helps people overcome the physical withdrawal symptoms, but it doesn't treat the emotional trigger that incentivises the person to return back to abusing drugs (mental suffering being the person's emotional trigger).
      And one last thing some people tend to miss is that; not everyone who uses drugs abuses drugs, whether they are illicit or not.

    • @omenknight1
      @omenknight1 Рік тому +1

      @@steinarjonsson_ well said I agree.

    • @PGG98
      @PGG98 Рік тому +1

      I suffer from addiction am very aware and still struggle to break the cycle

  • @NathanHarrison7
    @NathanHarrison7 2 роки тому +3

    Excellent video. Thank you.

  • @Thomas-1023
    @Thomas-1023 3 місяці тому +1

    I'm hooked on every word. I read a book with similar content, and I'm completely hooked on every word. "Unlocking the Brain's Full Potential" by Alexander Sterling

  • @paolis2886
    @paolis2886 2 роки тому +4

    Una animación asombrosa acompañada de una asombrosa explicación.

  • @highfivebianca
    @highfivebianca 4 місяці тому

    this video is animation masterpiece! i thoroughly enjoyed watching the video. it is beneficial, educational, motivational, and beautiful!

  • @alwaysdisputin9930
    @alwaysdisputin9930 6 років тому +70

    goes back to riding bike without elbow pads.

  • @talkingmetastasis607
    @talkingmetastasis607 6 років тому +6

    great animation

  • @run1fall14
    @run1fall14 Рік тому +18

    3:10 It’s crazy how they downplaying The addictiveness of painkillers, and they just blame it on the individual

  • @ravigaware3383
    @ravigaware3383 4 роки тому +8

    Wow!!!!!! That's great explanation with great animation

  • @PiyushKumar-ie8pg
    @PiyushKumar-ie8pg 3 роки тому

    Thabks beautiful explaination

  • @Gemooora
    @Gemooora 4 роки тому +1

    Amazing!

  • @dipteeshukla7
    @dipteeshukla7 8 місяців тому +2

    Thank you for this wonderful video! I'm a teen and this video made me highly resistant to take opoids. :)

  • @tammcd
    @tammcd 4 роки тому +20

    The more interesting question --- merely hinted at --- concerns the genetic/environmental factors that predispose some individuals to developing addictions.

    • @Zayden.
      @Zayden. Рік тому +2

      I believe a sense of belonging, recognition, purpose, dignity and community, which all ultimately stem from material well-being, play a big part in the susceptibility to getting addicted. The system we live in is in decline and can't support basic material well-being of large amounts of people; this is causing high rates of drug addiction and suicide.

    • @tammcd
      @tammcd Рік тому

      @@Zayden. Actually, it's transpires that at the core of addiction lies the need for a dopamine fix --- in other words, genetic. The 25:50;25 incidence of alcoholic : take it or leave it : teetotal behavior in Vervets confirms the genetic predisposition.

    • @Zayden.
      @Zayden. Рік тому +1

      @@tammcd if its purely genetic disposition we wouldn't see such drastic changes in rates of addiction and suicide, since genes stay more or less constant.

    • @tammcd
      @tammcd Рік тому

      @@Zayden. Beware assuming universals --- I did NOT write "purely genetic".
      'genes stay more or less constant" Are you hinting at the impact of epigenetic markers?
      "drastic changes in rates of addiction and suicide" Are you assuming that behavior and affect are not impacted by environment?
      As with most brain-related manifestations, addiction is probably the result of the environment's interacting with genetic predisposition. In so far as almost-identical environments do not generate identical responses, the key factor appears to be genetic predisposition.

    • @Zayden.
      @Zayden. Рік тому +2

      @@tammcd i'm saying that there's no evidence that genetic predisposition to addiction suddenly changed, and that's why we're seeing lots of addiction. Instead there's tons of evidence that there's socioeconomic decay taking place, so the environment changes are causing more suicide and addiction. Genes interacted in a certain way for a while, then have started interacting differently, due to the decaying socioeconomic environment.

  • @LegendGamer-cp7lm
    @LegendGamer-cp7lm 5 років тому +1

    Nice work ..looking forward to more videos

  • @multiyapples
    @multiyapples 5 років тому +1

    Interesting.

  • @JumpingJack6
    @JumpingJack6 Місяць тому

    I am happy for Susan, but what about those people who do not require opioids for pain, but rather try it recreationally just for fun? What happens to them? Do they get addicted to?

  • @TheMaskedRacoon1
    @TheMaskedRacoon1 Рік тому +3

    Prescription opioids, street Opioids, and benzodiazepines are highly addictive. Kratom is far less addictive. Kratom is an effective painkiller that's natural and doesn't have the side effects that opiates have. Kratom is only as addictive as coffee. Kratom gives mild to moderate mood lift, energy, relaxation, and pain killing effects without stopping your breathing. It's impossible to take too much Kratom because if you take too much, you will get nauseous and vomit.

  • @99.99
    @99.99 3 роки тому +3

    Uhhhhh, now I'm confused. With ephedrine, the science goes that long term use destroyed the shower heads on the neurons due to a high- non-stop of dopamine, which lead to a higher consumption after some time, not because the mechanism was trying to stop it. Shouldn't this be also the case for opioids?

  • @MicroWorld10
    @MicroWorld10 Рік тому +4

    The relapse is real and gonna happen why not mention this

  • @psyscar4996
    @psyscar4996 7 місяців тому +1

    "Susan then fell over and broke her pelvis after 2 minutes"
    to be continued...

    • @Flyingsquirrel3am
      @Flyingsquirrel3am 4 місяці тому

      she found a nice 'doctor' who prescribed her oxycontin.... and the cycle begins....

  • @parabrahmadas
    @parabrahmadas 3 місяці тому

    I feel like this video could have spent more time on what recovery can look like. Just briefly mentioning "setbacks" Is almost pigeonholing lots of collective trauma of being treated like a number. Clean houses are far worse recovery places for people than rehabilitation centers.

  • @SixTough
    @SixTough 5 років тому +6

    Some of these animations are very factual and some are kindergarten level. Inappropriate to present both as equally accurate

    • @Noname-rr5en
      @Noname-rr5en 9 місяців тому

      everybody know how people look like

  • @fuffi8550
    @fuffi8550 Рік тому +1

    can i addict myself into doing homework?

  • @gelechuchujaune
    @gelechuchujaune Рік тому +1

    The conclusion I understand:
    *You should not bike.*

  • @John-3692
    @John-3692 3 місяці тому

    This is exceptional. I had the privilege of reading something similar, and it was nothing short of exceptional. "Unlocking the Brain's Full Potential" by Alexander Sterling

  • @creampuff9934
    @creampuff9934 3 роки тому +4

    Why is Susan pink and shaped weirdly

  • @GoWithTheFro
    @GoWithTheFro 11 місяців тому +1

    So the medicine fucks her up, then she's given more medication to help her? Eh yeah, makes sense

  • @asifhossain2088
    @asifhossain2088 2 роки тому +1

    our Brain is still like a BlackHole

  • @cyclonemt
    @cyclonemt 4 роки тому +36

    It’s disempowering to call the symptoms “unbearable”. Instead we should call it “uncomfortable” or “painful”. We shouldn’t make people feel helpless as though they are “genetically” doomed without the help of medication. Yes, definitely a person who is addicted should seek help and therapy, and even medicine may help. But this is a negative way to look at addictions. We should instead empower people to conquer addictions with positivity.

    • @mr.teezee
      @mr.teezee 2 роки тому +34

      I found it to be validating, and therefore, helpful. Withdrawals do feel unbearable at times and many people stigmatize addiction as being easier to “just quit” or “just stop”. So it gives voice to the real pain many people struggle to express.

    • @lorraine70
      @lorraine70 Рік тому

      I agree

    • @letsreadtextbook1687
      @letsreadtextbook1687 Рік тому +4

      Uncomfortable is invalidating, but I agree with painful

    • @cyclonemt
      @cyclonemt Рік тому

      @@letsreadtextbook1687 I think that is fine, to call it pain if you prefer that. And you know better what you experienced. The point is not to invalidate a person's experience. But even if a person is a victim, for the person to continuously tell themselves the victim story is very disempowering because all that is there in that story is hopelessness. It doesn't lead to recovery or good outcomes. That's the danger of speaking about addictions as "unbearable". There should be a balance between empathizing with yourself so you don't over-shame or over-guilt yourself because that is also harmful, and taking responsibility. When we take more responsibility we start to regain control again. It's very important to tell someone who is addicted to something that every use of a drug or bad habit comes from their free will. Otherwise if they don't believe that, they will self victimize themselves into relapsing over and over

    • @myshoesarenowfullofwater
      @myshoesarenowfullofwater Рік тому

      @@cyclonemt Genuine question for you, are you speaking from experience?

  • @juanpedroperaltacota1990
    @juanpedroperaltacota1990 2 роки тому +3

    Genetics, bull shit!!!

  • @sixtorodriguez1902
    @sixtorodriguez1902 Рік тому

    a little too simplified..............