Diabetic HbA1c - Everything You Need To Know - Dr. Nabil Ebraheim
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- Опубліковано 12 лис 2013
- Educational video describing diabetic HbA1c.
Red blood cells carry oxygen (O2) to the tissues through the blood flow of the circulatory system. Red blood cells contain hemoglobin and when the hemoglobin binds with glucose in the blood, it becomes “glycated”. When the hemoglobin binds to oxygen, the cells appear red.
The term HbA1c refers to glycated hemoglobin. The more glycated hemoglobin is made, the higher the percentage of HbA1c. a hemoglobin A1c (HbA1c) test is good for monitoring long-term glucose (sugar) control in people with diabetes. HbA1c is a percentage of the glycated hemoglobin relative to the total hemoglobin in the blood. The normal range of HbA1c is 4-6%. More than 7% is high. With more glucose present in the blood, the more likely that the glucose will interact with the hemoglobin and make more glycated hemoglobin. HbA1c is a better measurement used to track the progress of diabetes than a blood sugar test. The blood sugar test does not give the big picture.
Blood sugar in the body changes during the day depending on diet and level of activity, so the blood sugar test is not very accurate. The HbA1c is used to measure how much sugar a person has in their blood over a longer period of time, which is usually 3 months. The lifespan of red blood cells is about 120 days, while the life span of hemoglobin is on average only two months.
The HbA1c is usually done 2-4 times a year. The higher the HbA1c, the higher the risk of diabetic complications. a decrease of 1% in HbA1c decreases the risk of microvascular complications by 37%.
Diabetes is a serious disease that affects the eyes. Kidneys, heart and feet.
How does hemoglobin work? The red blood cells contain large quantities of proteins called hemoglobin which bind to oxygen loosely and reversibly. The hemoglobin molecules are composed of four subunits: each hemoglobin contains four heme molecules, one attached to each subunit and iron containing pigment that binds oxygen. Oxygen molecule bind at the center of each heme molecule. Heme makes it possible for the red blood cells to pick up oxygen for delivery to the cells of the body. Hemoglobin that is saturated with oxygen is called oxyhemoglobin and is bright red in color.
Glycated hemoglobin decreased the oxygen carrying capacity and limits the tissue oxygen delivery. Hemoglobin releases its oxygen when the red blood cells pass through capillaries where the oxygen then moves out of the capillaries and on to the cells where it is needed. In diabetes, glycated hemoglobin limits delivery of oxygen to the tissues. The physician should be alert of surgical wound complications in patients with a high hemoglobin A1c test.
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Great video, Dr Ebs! I like the fact that you touched on this subject. Diabetics need to understand they heal differently and as an orthopedic physician you show you understand every patient is different. I'm very happy to see these videos progress over the years. I kinda miss your narration though but that's probably just me. LOL
Thanks Dr. Ebraheim! We're covering various hemoglobin types and hemoglobinopathies in biochem, and this helped me understand the significance of HbA1c.
thanks
This is just superb, I been tryin to find out about "natural remedy to reduce blood sugar level" for a while now, and I think this has helped. Have you heard people talk about - Anebriel Foundational Ascendancy - (Have a quick look on google cant remember the place now ) ? It is an awesome one of a kind product for discovering how to reverse type 2 diabetes without the hard work. Ive heard some great things about it and my neighbour got great success with it.
Great video easy to understand
We look forward to educational presentations from neurosurgery and spinal surgery !
very helpful
As always great.Thank you doctor Nabil.
Thans a lot for these very informative videos can we have avideos for ortoprdic operations.
Mohamed Fakhry hi p
Previously, sugar was high and after three months, sugar fell to normal rang .Can a1c be lowered?
nice info
Thanks
Nice video, a doubt though ,the HbA1c measures glycated HbA..i.e alpha-2 beta-2, however if someone has thalassemia/ sickle cell disease the HbA will be low, so will HbA1c not be falsely low ???
Yeah, you are partly right.
In case of thalassemia, HbF level is increased, HbF and HbA1c move similarly in column chromatography, so a "non diabetic" thalassemia patient may be declared as diabetic.
And in sickle cell anemia, what you said is right.
HbA1 values are less due to defective beta chains. So HbA1c values are also less. So there is a possibility that a "diabetic" sickle cell anemia patient may be declared non diabetic.
In such cases fructosamine albumin / glycated albumin test is preferred.
This is given in Vasudevan textbook of Biochemistry for Medical Students 9th edition, chapter 9
Thanks :)
ty sir
nice
Do you know in what percentage of blood glucose, the glucose molecules will combine with hemoglobin to form the glycated hemoglobin. Thanks your reply.
i am guessing that it should be >200 mg/dl as post prandial and >126 random bloog glucose. 0.1 % i guess.
Thank you.
Sir it's a request if you explain videos in your own voice so it will be very beneficial. Thanks
Believe it or not, this is a hard concept to translate to the average patient. I have many diabetic patients who have had this testing for years, and they still don't understand it too well.
yeah it happens . they're not doctors but it's you. all they need is to have faith in you and stay positive and strong.
thanks
for more information regarding HbA1c visit:- www.hba1c-test.co.uk
GC😎😅.