Antifungal Drugs Concepts of pharmacology for USMLE/NEET/FMGE/PLAB

Antifungal Drugs Concepts of pharmacology for USMLE/NEET/FMGE/PLAB
Learn about the concept of mechanism of action of antifungal drugs. In this lecture i would be discussing about the structure of a fungus and the different drugs targeting those structures.
1. Amphotericin B -
Old mechanism - Forms pores in the fungus by acting on the cell membrane.
New mechanism - I have discussed the old mechanism in the video but the mechanism was updated recently. Currently it is believed that amphotericin B sequesters ergosterol in cell membrane like a sponge due to which cell membrane breaks. It is combined with liposomes called as liposomal amphotericin B to decreases nephrotoxicity.
2. Azoles - This class has systemic drugs like fluconazole, ketoconazole, itraconazole, voriconazole (DOC for aspergillus), posaconazole etc and topical drugs like clotrimazole, miconazole, luliconazole etc. They act by inhibiting ergosterol synthesis by blocking an enzyme called as 14-alpha sterol demethylase.
3. Echinocandins - This class has drugs like caspofungin, micafungin and anidulafungin, which act by inhibiting cell wall synthesis by blocking an enzyme beta-glucan synthase.
4. Griseofulvin - It acts by blocking microtubules in fungus.
5. Terbinafine - It blocks cell wall synthesis by inhibiting an enzyme called as squalene epoxidase.
6. Tavaborole - It acts by blocking RNA synthase in the fungus
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Pharmacology for Medical Licensing Examinations

[@RanjanKumarPatel]

75 hours of online pharmacology video for NEET/USMLE/FMGE/PLAB by Dr.Ranjan Kumar Patel at
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[@paullesieur147]

Lovely video content! Sorry for chiming in, I would love your opinion. Have you ever tried - Millawdon Muscles Mountain Trick (just google it)? It is a great one of a kind product for discovering the secret to get rid of fungus minus the hard work. Ive heard some incredible things about it and my cousin at last got astronomical success with it.

[@jkings6602]

Nice Video clip! Forgive me for chiming in, I would appreciate your opinion. Have you thought about - Millawdon Muscles Mountain Trick (just google it)? It is a smashing one of a kind guide for discovering the secret to get rid of fungus without the normal expense. Ive heard some awesome things about it and my BF at very last got great results with it.

[@kentcernechez2392]

Thanks for the Video clip! Forgive me for the intrusion, I would love your opinion. Have you heard the talk about - Millawdon Muscles Mountain Trick (google it)? It is a good exclusive product for discovering the secret to get rid of fungus without the headache. Ive heard some incredible things about it and my work buddy after a lifetime of fighting got great results with it.

[@bestoffootballers465]

Thanks u so much Sir for the very informative lecture, sir as u mention in the synthesis of Ergostrol, Lanosterol and levonosterol are they the same?

[@KiranSharma-so7xp]

Sir is it correct that u have made the beta glucan synthase in the cell membrane ?

[@allenfernando4619]

Wow! Well explained. I have kerion in my scalp. Found this very informative. Got to know what the drugs my doctor prescribed actually do!

[@seenu_kchsreddy742]

Plz upload as many as ur videos sir..its most welcoming

[@abcde......5260]

Very conceptual video 👌👌👌

[@kundanrajbhar8810]

Best video interested sir keep it up

[@dr.nishantkania4511]

Salute to your marvellous work sir

[@eljinisca1425]

Very informative sir. You are brilliant. Making us also.

[@mianabidrahman8038]

Great Methodology, Appreciated..!

[@sonhalirickeelal7700]

this has helped me so much! thank you sir.

[@vasusridhar9401]

Useful sir! Thank you

[@tatrajuramchandra6909]

thank you sir... when i see your lecture then i understand why ..polyenes dig the membrane

[@vinithvikram2259]

Ranjan Sir , has a site PHARMLE, the whole of pharmacology is available. I purchased the 3 month subscription plan, couldn’t finish it due to personal reasons. I completed ANS on the site and it’s explained really well. I just watched 7 hours out of 75 and boy almost all of ANS concept is crystal clear. The highlight of Sir’s teaching is his clinical co relation and basic concept building. So to all my friends do check out his website , it will help us all in future too. Thank you.

[@ag-thebroken211]

What is cost of this lecture??

[@vinithvikram2259]

Love Your self at that time it was 3560 I guess

[@BabuBabu-hu3gi]

Excellent explanation sir.

[@funnymemer1132]

Brilliantly explained sir👌👌

[@sadiqullah2445]

Such a simple method thank alott Sir

[@doctorsdiary8741]

sir, your lecture us the best

[@snehavimal5772]

Nice teaching n best teacher

[@glisteningsky7251]

thanks your explanation was very clear

[@prashanthreddy4075]

Unique skill

[@angelabrotherston1258]

excellent. thank you.

[@shivalikatal5839]

Amazing sir 🌻

[@rehanaqamar2608]

Very informative.. thanks sir

[@allyangcos4262]

THANK U SM U ARE A BLESSING

[@arunpatel68]

I liked ur way of teaching

[@pharmacistkhan5969]

Tnk u sir for such an execellent vedios

[@ashwiniyara772]

It is very useful class sir pls upload more videos

[@uphckashibugga9553]

Thank you sir 🙏🏻

[@Ruralclinic]

Amazing

[@hafidhotulilmillah4139]

thank you sir, very helpful and clear, please upload more videos.. can i request about uterotonic sir?

[@salammahmood6037]

Thank you very much.

[@musafshorts]

Jazkallah
Allah app ko ajar day is ka ameen

[@ijazahamed3621]

Plz release ur individual app sir,waiting for your next edition pgmee book

[@MJ-ov6lb]

Sir , aap ka vdo mujhe khelne mei madat karta hei, aap ke vdo se padai jaldi ho jata hei fir khelne k liye waqt ki waqt hota hei..😁

[@user-gy3jo9mp8f]

Thank you Sir.

[@Drmuslimah2019]

Huge respect to you sir from kashmir

[@sunamsaha8985]

Sir pls upload the videos based on antihypertensive, diuretics, hypoglycemic,

[@manojsolankar3093]

Thank you Sir

[@rajwalamom7620]

Thankyou sir

[@azlanfa8286]

tq dr for a wonderful and simplified lecture
i have a question
in which class tolnaftate belongs?

[@doctorsdiary8741]

TQ sir keep on

[@naeemtasir8824]

Nice sir salute from Pakistan ❤️❤️

[@PharmacyLectures]

Good

[@himanshurana3558]

osm explanation

[@akashvashisth7085]

Thanks sir

[@praveenkumartavva4466]

is it lanosterol or levonosterol as per the text books..please, clarify the same.

[@laraibkhalid2635]

Sir from where squalene comes?

[@suryayadav6137]

sir please made videos on chemotherapy

[@Truth........]

The best antifungal tablets plz rply
I

[@monasaeed6710]

please upload more videos

[@7malayan]

Don’t tell like nothing but in your communication ...good lecture

[@kashifahteasham5705]

Please recommend a medicine for fungal infection because I am suffering from this disease for last 4 years. I have done many treatment for this and refers many doctor's about this. Please help me to cure my disease. Please help me 🙏🙏🙏

[@priyaanjimusic7806]

Sir plz upload more videos sir

[@sandeepkalsakar4748]

I have suffering form fungal infection sence 2 years ....pls guidness me what i do ..which medicine have better

[@Paulancar]

Did you try Clortrimazol.

[@user-ju3eo1pm7s]

What kind of infection?

[@voltatech7772]

Maybe NYSTATIN?

[@mindrises-satyamshukla4896]

Sir please full lecture daliye

[@arifullam9236]

Hi Sir it's very good to watch ur clip on Anti fungal,, but u have mentioned almost 8 Anti Fungal medicines, should we use all these 8 or How..

[@faroozbhat3992]

Antibiotics plzzz

[@skrashidul3737]

Can i get your individual app sir?....

[@RanjanKumarPatel]

SK RASHIDUL please log in to www.pharmle.com

[@statusmart6472]

it is not levonosterol it is lenosterol

[@mahendramishra2703]

Sir Hindi language me hame jankari chahiye plz

[@kamodthakur5186]

Sir hindi language vi use kijiye better rahega

[@zaheerahmad4102]

thank you Sir

[@dr.ranikumari3655]

Thank u Sir

[@pharmabeing6513]

Thank u sir