so every time MMA is high that means B12 deficiency? i mean high MMA = low B12? i think not. theres an enzyme that converts the MMA into succinylCoA, that could be deficient and that could be the reason for high MMA levels. I understand that the presentation is pointing entirely to megaloblastic anemic patient and thats why it should be understood that MMA has to be high because of low B12. But then pernicious anemia is the most common cause of b12 deficiency too. so just like pernicious anemia isn't "necessarily" the cause of b12 def anemia; high MMA doesn't "necessarily" mean b12 def anemia. On the other hand, pernicious anemia always = b12 def anemia while high MMA does not always = b12 anemia. NEVERTHELESS, b12 labs could show normal in these conditions? thats is GREART to know. i DID NOT know that. so Thank you, as always.
Ngl I was also thinking of concommitant autoimmune diseases because of AMS (“acting differently”), but that seems like more than a 4th order answer so I’d probably just pass on it Also as for not picking b12 or b9, MMA would rule in b12 and rule out b9 simultaneously
Disagree. Checking for B12 level *first makes more sense actually , if it’s down end of story (if equivocal then MMA is warranted ). Sparing your patient from *unnecessary work-ups*😊 6:26
In a nutshell : Vitamin B12 deficiency results in SECONDARY folate deficiency , on the contrary folate deficiency does NOT result in secondary vitamin B12 deficiency !
Yall, do not underestimate the power of these videos. Literally got this question on STEP 2.
Thank you for your videos Dirty 🤝🏽
Thanks man. This series has been super helpful in my exam prep. Watching them as they come out lol.
I m loving this series of high yield Q-Bank ... Thanks a ton...
Thank you so much. This series is one of your best. Please keep it up!!!
Does anyone know a reference likethis kind of clinical cases and answers? Appreciate your response
so every time MMA is high that means B12 deficiency? i mean high MMA = low B12? i think not. theres an enzyme that converts the MMA into succinylCoA, that could be deficient and that could be the reason for high MMA levels. I understand that the presentation is pointing entirely to megaloblastic anemic patient and thats why it should be understood that MMA has to be high because of low B12. But then pernicious anemia is the most common cause of b12 deficiency too. so just like pernicious anemia isn't "necessarily" the cause of b12 def anemia; high MMA doesn't "necessarily" mean b12 def anemia. On the other hand, pernicious anemia always = b12 def anemia while high MMA does not always = b12 anemia. NEVERTHELESS, b12 labs could show normal in these conditions? thats is GREART to know. i DID NOT know that. so Thank you, as always.
sounds like you understand the topic. but dont overthink this!
@@DirtyMedicine bro thats ALWAYS my problem. gets me in trouble so many times, not to mention the time it wastes.
@@FightBusiness1 my issue too :(
Is b12 normal bec you have a couple years worth of b12 stored in your liver?
Ngl I was also thinking of concommitant autoimmune diseases because of AMS (“acting differently”), but that seems like more than a 4th order answer so I’d probably just pass on it
Also as for not picking b12 or b9, MMA would rule in b12 and rule out b9 simultaneously
Good practice process about question Banks!
Thank you dirty will never forget this!
Get better soon!
Love this series !!!!
Research Methodology through Questioneare!😊
Disagree. Checking for B12 level *first makes more
sense actually , if it’s down end of story (if equivocal then MMA is warranted ). Sparing your patient from *unnecessary work-ups*😊 6:26
This series is great great great.
Can you please upload the ethics video back up? Exam in 2 days!
CBSE exams in 18 days for me. gl dude
FINALLY one that didn't make me feel stupid. Can this be my test plz
Great job thank you so much
❤
Thank you!
GOAT
Samad Rahman pneumonic?
@@doctorh5413 This dude is the Greatest Of All Time (GOAT).
Thank you
I learned a lot thanks a lot 🥀🥀🥀🌹💐
Thanks a ton
In a nutshell :
Vitamin B12 deficiency results in SECONDARY folate deficiency , on the contrary folate deficiency does NOT result in secondary vitamin B12 deficiency !
thank you so much
4 for 4! let's goo!
superb
Just love nothing else..
Isn't folate b6
md sohail no, cause mma is increased with neurological symptoms plus MCV>100. =b12 def.
In b6/biotin defi, propionyl Coa will be increased.
@@doctorh5413 thank you
B6 is pyridoxine, not biotin. Biotin is B7. The story about propionyl coA is correct.
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