I studied a lot Chemistry during high school and Biochemistry at med school, but still feel enlightened by Prof Imperiali's lecture. Thank you so much, and thanks MIT for publishing this for us.
Hey there. Do you know other resources online for layman (non med scholl trained) person to understand more about their body. I started with James Hamblin books, If Our Bodies Coudl Talk and Clean and then found The Song of Cell. And I find it infintely interesting.
My God! I've literally never seen anyone explaining better than this professor. I've searched a lot of videos that provide basic protein structure information and none of them could satisfy me until I came across this 51 mins long masterpiece. Thank you so much MIT ❤❤❤
In a polypeptide many of the bonds show free rotation, however the amide(peptide bond) is unique upon the fact that there is restricted rotation in that bond, like spaghetti with little bits that haven't been cooked
you did not meet my biochemistry, one Dr Julian Coleman, far better than this lecturer. Recently I have listened to Professor Dasgupta of Indian who did a splendid job on this subject.
Very interesting. My background is in solid state electronics so I am familiar with solid state atomic structures and valences etc. It struck me that this topic is what I would call liquid state life enabling structures. Solid state electronics is about electron flow in solid crystals whereas this topic is about self forming molecular structures in water where non-covalent bonding is critical to structure formation. A very good instructor.
Great lecture. I am listening to the whole series and relearning things I forgot 20+yrs after receiving a biochemistry degree. I do take exception with her lack of comprehension of the humor embedded in the cartoon. What makes it funny is the cartoonist is clearly (it is illustrated!) referring to folding a physical map, like the kind we had to buy prior to ubiquitous GPS. And, to me, it is also implied that the cartoonist is fully aware that ‘genomes’ don’t fold, and proteins do, thus making it funny on a few levels. Context and expectation is what separates a humor cartoonist from a textbook illustrator, professor.
Thank you for your time and effort in posting these videos... note that if you keep the bath for the amino acids in a light and airy vibe so to speak nonlocal communication can occur...
@@MrNiOGAMING Yes -- this was roughly a week after I made this comment. I remember hearing the news of AlphaFold and thinking "oh i just made a yt comment on comp bio" haha
20:49 Why does she say the primary sequence does not determine function except by determining shape? The function of triosephosphate isomerase, for example, depends on the exact locations of the charged amino acids that serve as temporary donors and acceptors of protons. Saying only "shape" matters implies that charges don't. But a different protein with the same shape but a different charged/uncharged amino acid sequence would not have the same function. I am not a biologist or a chemist, but I believe it's possible to have two different proteins with the same shape (e.g. alpha helix or beta sheet) but a different charged/uncharged amino acid sequence.
33:40 Are these illustrations correct? It looks like some of the carbon atoms have been drawn in the wrong order, in both the alpha helix and in the beta sheet. We should have nitrogen and then the alpha carbon connected to the side chain (not shown) and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the nitrogen of the next amino acid. But the pictures show nitrogen and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the alpha carbon and then the nitrogen of the next amino acid. Also, in the beta sheet, the first carboxyl group has a single bond, instead of a double bond. Finally, the lower strand in the beta sheet shows a nitrogen connected to an oxygen, instead of carbon. Whoever made these pictures must have been on ethanol.
Wouldn't it be cool if you could measure the amount of water molecules produced from a condensation reaction, and from that figure out how many peptide bonds and therefore exactly how many amino acids were in a protein? They've probably already done this but i will pretend i've invented it.
Is a polymer protein strand, recreated as a viral cancer gene in G_nome RNA carboxylic ameno chain, is it possible to replace the viral strand, your body recreated from your Chromosome stick recount for autonomous Operation production, as a G_nome viral protein stand with a Organic Chemistry Chain Reaction Formula and recreate the original polymer protein syrand with peptide bonded ameno's carrying the original genetic sequence, and set in place during uptake recount.???
hey im med student but i dont know where are the community surfing on internet (forums, websites etc.) please give me some advice about how can i follow the community.
I have a question to make. I have no chemistry/biology background. I have been watching the first 3 lectures and I am kind of lost with the jargon and the chemistry notation. Is it worth continuing or should I go back and review something before I continue?
Might be a few days too late. But they have a getting up to speed course, it's called "Getting up to Speed in Biology, Summer 2020". It's a great start and free on their YT channel. Good luck!
I went to MIT and have a chemistry degree. I highly recommend that if you do not understand something to take a pause and go backwards. This is a first semester freshman course and is slow compared to others so it is incredibly beneficial to you to get a solid and strong understanding of the foundations before continuing. You will not regret it! Like CIA said, there is a course for incoming freshman who are on the same page as you by a different professor that would be great for you! It is a short, prep course basically
The required textbook is: Sadava, D. E., D. M. Hillis, et al. Life: The Science of Biology. 11th ed. W. H. Freeman, 2016. ISBN: 9781319145446. See the course materials on MIT OpenCourseWare for more info at: ocw.mit.edu/7-016F18. Best wishes on your studies!
(On Sunday of January 29, 2023). Introductory Biology and the Structures of Amino Acids (Alpha Amino Acids because of the Human Emphasis), Peptides (Dipeptides and Polypeptides) and Proteins (Quaternary Structured Proteins Along the Lines Of Collagen, Hemoglobin, And A multitude of others), otherwise the Basics and Fundamentals Proteomics (More than Covalent and Non-Covalent Bonding). PhD Barbara Imperiali, Emperatrix Mea Gloriosa Est; Ego malo Fare Qui Vedere. Heil!
I am not hydrophobic, but now that I have learned this terminology, I am definitely going to insist that whenever people address me they use my preferred proteins.
I studied a lot Chemistry during high school and Biochemistry at med school, but still feel enlightened by Prof Imperiali's lecture. Thank you so much, and thanks MIT for publishing this for us.
Long Hoàng that was well saying. Very good.
Thấy fb a giới thiệu mà xem nè, hay quá ạ!
Hey there. Do you know other resources online for layman (non med scholl trained) person to understand more about their body. I started with James Hamblin books, If Our Bodies Coudl Talk and Clean and then found The Song of Cell. And I find it infintely interesting.
@@praveensanap there aren't any. You just need to keep trying until you understand. If you're not studying for school just take away big topics
Thank you for bringing back my enthusiasm and passion for learning. I am truly touched and eternally grateful for these lectures.
My God! I've literally never seen anyone explaining better than this professor. I've searched a lot of videos that provide basic protein structure information and none of them could satisfy me until I came across this 51 mins long masterpiece.
Thank you so much MIT ❤❤❤
Protein structure: spaghetti with lots of little bits that haven't been cooked. I'm not going to ever forget that. Thanks Prof Imperiali
In a polypeptide many of the bonds show free rotation, however the amide(peptide bond) is unique upon the fact that there is restricted rotation in that bond, like spaghetti with little bits that haven't been cooked
cool simile :D
I know the information for years but never felt how awesome it actually is.
the best explanation I have ever seen for "Structures of Amino Acids, Peptides, and Proteins"
you did not meet my biochemistry, one Dr Julian Coleman, far better than this lecturer. Recently I have listened to Professor Dasgupta of Indian who did a splendid job on this subject.
Very interesting. My background is in solid state electronics so I am familiar with solid state atomic structures and valences etc. It struck me that this topic is what I would call liquid state life enabling structures. Solid state electronics is about electron flow in solid crystals whereas this topic is about self forming molecular structures in water where non-covalent bonding is critical to structure formation. A very good instructor.
This is thoroughly satisfying. She made it look so simple and interesting. I have much better understanding now. Thank you for publishing this.
Great lecture. I am listening to the whole series and relearning things I forgot 20+yrs after receiving a biochemistry degree.
I do take exception with her lack of comprehension of the humor embedded in the cartoon. What makes it funny is the cartoonist is clearly (it is illustrated!) referring to folding a physical map, like the kind we had to buy prior to ubiquitous GPS. And, to me, it is also implied that the cartoonist is fully aware that ‘genomes’ don’t fold, and proteins do, thus making it funny on a few levels. Context and expectation is what separates a humor cartoonist from a textbook illustrator, professor.
I want such kind of educators in India 😓…..i really impressed by the teaching style ❤️
They exist you just don't know where they are
You are an amazing teacher and know your subject so well. Inspired teachers are hard to find.
God bless these wonderful lecturers that make their explanations available ❤️
Substance defines form; form defines function. Sounds very much like an architectural mantra.
What a great teacher!!, I wish I had the opportunity to attend a class with such an incredible teacher when I was in collenge.
Thank you for your time and effort in posting these videos... note that if you keep the bath for the amino acids in a light and airy vibe so to speak nonlocal communication can occur...
tomorrow is my aa exam and this makes me feel so enthusiastic :DD thank you for sharing
Waow this is what I call good teacher and presentation and visual and speed....yez yez!
She is not just a excellent professor. She is a beautiful dancer, I believe :)
Amine group is at the alpha position to the carboxyl
She is an amazing professor!
Wow she's so good at teaching 🤣🤣 almost reminds me of like a harry potter movie where theyre at Hogwarts.
Very clear explanation. Brilliant.
Absolutely well done and definitely keep it up!!! 👍👍👍👍👍
धन्यवाद आपका ऐसे lacture देने के लिए। 🙏
Amazing lecture! I wonder if AI solutions would allow for the prediction of the folding of AA sequences.
Yes these applications exist. Very useful for drug discovery screening. Search for "computational biology"
Already done in 2018 and now 2020, a new record of prediction has been done !
@@MrNiOGAMING Yes -- this was roughly a week after I made this comment. I remember hearing the news of AlphaFold and thinking "oh i just made a yt comment on comp bio" haha
A-amino acid - amino acids that have been encoded in our proteins
Thank you Prof. Imperiali, great lecture! btw 30:32 that spells harvardharvardharvard LOL
When proteins are smaller and not able to adopt too much of a folded structure they are called peptides
Amazing! Thank you, professor ❤
The most abundant type of amino acids are with hydrophobic side chains
What a great teacher, heartiest regards
great lecture, interesting and pretty straight foward
What an amazing lecturer!
Very good Profesor, thanks 💖
20:49 Why does she say the primary sequence does not determine function except by determining shape? The function of triosephosphate isomerase, for example, depends on the exact locations of the charged amino acids that serve as temporary donors and acceptors of protons. Saying only "shape" matters implies that charges don't. But a different protein with the same shape but a different charged/uncharged amino acid sequence would not have the same function. I am not a biologist or a chemist, but I believe it's possible to have two different proteins with the same shape (e.g. alpha helix or beta sheet) but a different charged/uncharged amino acid sequence.
46:01 why are half of the protein types written in red and the other in blue?
Great lecture thank you
Thankyou so much
Thank you
Thank you so much for this informative lecture
Thanks 🤍❤️
33:40 Are these illustrations correct? It looks like some of the carbon atoms have been drawn in the wrong order, in both the alpha helix and in the beta sheet. We should have nitrogen and then the alpha carbon connected to the side chain (not shown) and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the nitrogen of the next amino acid. But the pictures show nitrogen and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the alpha carbon and then the nitrogen of the next amino acid.
Also, in the beta sheet, the first carboxyl group has a single bond, instead of a double bond.
Finally, the lower strand in the beta sheet shows a nitrogen connected to an oxygen, instead of carbon.
Whoever made these pictures must have been on ethanol.
superb lecture
Never thought biochemistry could be so funn
Mera toh dimag ghum gya 😵💫
This is helpful ❤️🤍
Thank you.
Can polymerization AA happen in primordial soup ?
Wouldn't it be cool if you could measure the amount of water molecules produced from a condensation reaction, and from that figure out how many peptide bonds and therefore exactly how many amino acids were in a protein? They've probably already done this but i will pretend i've invented it.
Is a polymer protein strand, recreated as a viral cancer gene in G_nome RNA carboxylic ameno chain, is it possible to replace the viral strand, your body recreated from your Chromosome stick recount for autonomous Operation production, as a G_nome viral protein stand with a Organic Chemistry Chain Reaction Formula and recreate the original polymer protein syrand with peptide bonded ameno's carrying the original genetic sequence, and set in place during uptake recount.???
This is much better than Gene Brown's 7.05. PreMeds ruined biochemistry back then.
Could someone please summarise all the bonds everywhere like in primary structure, secondary, etc etc.
Thank you!
hey im med student but i dont know where are the community surfing on internet (forums, websites etc.) please give me some advice about how can i follow the community.
Amino Acids part starts at 9:49
is it university vast lecture ?
Is this college content? I'm a high school student, so it feels a little difficult.
Yes it is.
This is Massachusetts Institute of Technology, aka MIT
is tyrosine hydrophobic and polar?
Amine peptide- not complete spaghetti, spaghetti with little bits that haven't been cooked
I could not find the 1st and 2nd vieo of this series, so are there anyone that provide me with a link pls?
UA-cam playlist: ua-cam.com/video/KlVHqq38KJU/v-deo.html&pp=gAQBiAQB
Best wishes on your studies!
Which is the software they're using in MacBook to present
I have a question to make. I have no chemistry/biology background. I have been watching the first 3 lectures and I am kind of lost with the jargon and the chemistry notation. Is it worth continuing or should I go back and review something before I continue?
Might be a few days too late. But they have a getting up to speed course, it's called "Getting up to Speed in Biology, Summer 2020". It's a great start and free on their YT channel. Good luck!
@@cia5791 not late at all, thank you very much, I will have a look at it :)
I went to MIT and have a chemistry degree. I highly recommend that if you do not understand something to take a pause and go backwards. This is a first semester freshman course and is slow compared to others so it is incredibly beneficial to you to get a solid and strong understanding of the foundations before continuing. You will not regret it! Like CIA said, there is a course for incoming freshman who are on the same page as you by a different professor that would be great for you! It is a short, prep course basically
What text they use? When we read "read 3.2 from the text" what text do they mean? Thank you!
The required textbook is: Sadava, D. E., D. M. Hillis, et al. Life: The Science of Biology. 11th ed. W. H. Freeman, 2016. ISBN: 9781319145446.
See the course materials on MIT OpenCourseWare for more info at: ocw.mit.edu/7-016F18. Best wishes on your studies!
@@mitocw thank you!
@@mitocw thx❤❤
Biochemistry made easy.
Ma'am good name?
Polymers of amino acids are heteropolymers, made up of a bunch of different monomers
Have a defined sequence
YA SE VOLVIERON LOKOS ALV JAJAJAJAJAJJAJA
(On Sunday of January 29, 2023). Introductory Biology and the Structures of Amino Acids (Alpha Amino Acids because of the Human Emphasis), Peptides (Dipeptides and Polypeptides) and Proteins (Quaternary Structured Proteins Along the Lines Of Collagen, Hemoglobin, And A multitude of others), otherwise the Basics and Fundamentals Proteomics (More than Covalent and Non-Covalent Bonding). PhD Barbara Imperiali, Emperatrix Mea Gloriosa Est; Ego malo Fare Qui Vedere. Heil!
9:48 to skip to title content
She says hydrogen bond but I always hear hydrogen bomb
How lucky Americans are? Just because I am born in India and also in a poor family, I am not able to study like this 😔. How unlucky I am.
15:00
21:30
harvardharvardharvardharvard
The stiff gearshift contrastingly print because control unquestionably change unlike a stimulating sister. expensive, comfortable armchair
jajajajajjajajajajajajaaj no mamen penados xD
Back when cis still meant something
What? Cis is and has been used in all sorts of senses. Cis-Alpina, Cis-Male etc, it simply means 'this side of'.
I am not hydrophobic, but now that I have learned this terminology, I am definitely going to insist that whenever people address me they use my preferred proteins.