Excess pancreatic elastase in diabetes / Cell Metab., June 19, 2023 (Vol. 35, Issue 7)

Giorgio Basile, Rohit Kulkarni, and colleagues have observed CELA3B genes to be upregulated in acinar cells linked to augmented CELA3B protein within the islet milieu of type 2 diabetes patients, resulting in reduced β cell homeostasis secondary to impairment of two signaling hubs: mechano-signaling and PAR2 pathways. PE inhibitors rescue β cell homeostasis and point to anti-PE therapies for diabetes.
Check out the paper at www.cell.com/cell-metabolism/f....
G. Basile, A. Vetere, J. Hu, O. Ijaduola, Y. Zhang, K.-C. Liu, A.M. Eltony, D.F. De Jesus, K. Fukuda, G. Doherty, et al. (2023). Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 35.
And read more great research at www.cell.com/cell-metabolism/home.

[@lingxiao673]

Thanks for posting this video, this is an extremely novel and promising topic. I really enjoyed leaning from your talk!!!

[@JoanSabadell]

This research should go viral, this is very provocative. Congratulations Dr. Basile

[@janineleblanc-straceski3181]

The scale analogy is backwards. A lower dish would indicate a heavier or increased amount.