Why focus on "connective tissue synthesis" when most people use collagen for their skin? Please do a video on the effect of collagen on skin health or lack thereof.
It’s likely the high amount of glycine in collagen that’s giving people skin benefits. I just use a glycine powder. A lot less expensive and I know its proven benefits.
Glycine powder isn't exactly cheap,if you're using 15 to 20 grams a day then you're paying a lot for glycine and you're paying almost as much as you'd pay for collagen The cheapest way to do this is to buy bulk gelatin powder which is about 40 dollars per 4 pounds.... use that either by adding it to your protein powder or making jello or custard with it and adding one tablespoon of glycine to your gelatin dose and that way you save money on both glycine and gelatin...
Here’s the thing. Young people produce loads of collagen naturally. So you may be filling an already full cup. How about the studies in people over 60 because that is when it matters and may make a genuine difference
Collagen is a fancy word for specific amino acids that make up structural tissues of the body (cartilage, ligaments, bone, skin, etc) If you’re consuming adequate protein in your diet, you are already getting these amino acids in. Collagen is a sham.
Yeah, cuz ppl over 60 already learned how to digest whole proteins and peptides without breaking them down to individual amino acids. Makes total fucking sense.
Also, I really do not understand why they keep using young male research subjects. They are going to be fine no matter of what! I think these studies should be really focusing on aging population. I cannot imaging they would not find subjects for a study like this. Any university has staff and professors and I am sure they are all aging too....
cuz young males are your most anabolic population. If you make untrained young male train, you also should see increase in anabolic response in connective tissue. This study shows, that collagen shows no increase in connective tissue growth against placebo even in most growth-prone population. Good luck trying to repair joints that are already degrading with that.
In case someone is wondering: In this study also hydroxyproline concentrations increased following collagen peptide supplementation (p < 0.05). This might matter as apparently the receptors that activate the collagen build-up in connective tissue (and skin cells) respond specifically to hydroxyproline or it's peptides. (from collagen) Previous to the discussed study results it was hypothesized by some that hydroxyproline supplementation might increase collagen in connective tissues. It does not seem to. Perhaps in some situations an effect could be shown, like in burn victims or otherwise injured, but likely not in healthy individuals.
Here, for the Algorythm, and to say THANK YOU as some of your knowledge sharing here (along two other youtube science based channels) has helped me taking good decisions during the last year to repair my body, losing weight and training hard with more inspiration in my now 50 years young body. Blessings in all your doings, Layne!
You said the study only lasted a week, isn’t connective tissue turnover around 3-4 weeks though, so if the study was 6 weeks it may show collagen in the new connective tissues, also weight lifting is not the best practice for connective tissue gains, but rather jumping and sprinting high impact exercises would be superior for bone and connective tissue Adaptation.
Pretty much what I was thinking. 1 week just doesn't sound long enough to draw any real conclusions, unless maybe the company is claiming it can be effective in that short a time.
These collagen studies could be another example of a product that has shown to not hurt, but also not be much help. It would be interesting to see what future studies show as far as any possible benefits that are still not known.
It does hurt the wallet, to be fair. Gelatin is a lot cheaper per gram and has not been shown to differ in effect in non-industry funded/sponsored human trails. It might even be that even cheaper proteins have just as much effect on connective tissue and skin as (overpriced) collagen supplements.
Would love to have more research on the older community (weird to think of myself in that manner). I've noticed much more joint pain as I age, especially getting back to working out, and also my skin elasticity lessening. Figure at worst collagen is just a little waste of $. Few months into use I've noticed increased nail/hair growth but not sure anything more. Will keep it up longer and see.
@@ac27934 I've heard about this, but the findings on these studies on humans(!) are mixed. Maybe @biolayne can give us an update? Personally I feel fine when I take 1500 mg in the morning.
Hi there! Currently studying for my license exam to become a dietitian! And I really enjoy watching your videos as review and to re-enforce my learning 🤓
Personal observation that I realize could be subjective- My hair growth is next level since I started taking collagen, also seems more shiny and luscious 😊
While it doesn’t seem to do much of anything for connective tissue, there is some decent scientific evidence showing that it can improve skin health and the appearance or wrinkles/fine lines.
Yes ive also seen these, would be great if layne could over these instead. Especially when hes trying to answer if collagen supplements are overall effective. Which they seem to be in some areas.
@@cyclamen831Layne says in this video that those results were shown in this study. BUT he went on to say that mechanistically it doesn’t make sense why so he’s reluctant to recommend it. Just watch the video lol
@ also, a reason for this is the same reason he doenst go over more benefits of cold plunges. It’s not his speciality. Layne is not the type to cover something that he isn’t an expert in cause he could be wrong. If you want skin advice, find a good dermatologist to follow. Layne is a protein/nutrition expert. Which is why he mainly covers protein synthesis in this.
If you care about your skin appearance and or skin health, use a moisturizer with SPF first. Pretty much everything else is secondary to that. Also look into topical retinoids, maybe. There is more substantial evidence that it improves skin appearance (including collagen in skin, if I recall correctly)
I've read that glycine production slows after 30 and therefore supplementing with collagen could potentially stall connective tissue decline. I hope we get a study with older people
Collagen contains a unique amino acid called hydroxyproline, which is why collagen supplementation may be able to increase collagen synthesis (in theory). I'm not saying it does, but there is a plausible mechanistic basis for how it might
A 15g scoop a day is a miniscule amount. When I've supplemented with collagen and noticed benefits in injury recovery, I was taking several times that amount a couple of times a day.
In my late 40's I started taking collagen for knee and joint pain specifically. I do a lot of mountain biking and trail running. I'm not sure if it's placebo, but it really seems to help my knees. It would be interesting to study if there is any kind of difference in young vs old. The referenced study is 25 year olds. Seems like when you are young, you have the world by the balls and don't need to supplement anything. 🤣 I never felt the need to supplement when I was 25. I'm 51 and blood work has revealed the need to supplement several things like DHEA, B12, VitD, Testosterone, Thyroid, Folic Acid.
It also helped my knees when I started taking it at 27, and I didn't even have bad knees. Just sometimes they hurt from squatting or whatever. I don't think it's a placebo, I just think there are no long-term studies. Collagen synthesis takes a lot of time. They should do this over 2 years and then check.
My wife (60 year old) swear that in just two weeks collagen supplementation cleared her knee pain, that lasted more than a year. I was using collagen after surgery, and she tried it when I told her it might help her for wrinkles (it didn't seem to work for that, but I won't tell her this part).
I take it to prevent joint injury, I understand the studies are building up against that working, but aside from cost, I don't see any harm in it. I also am interested if these studies focused on older people.
I know it’s easy to clip the mic to your neck, but obviously that gets rustled and messes with the sound. What I have been doing recently Is just grabbing a heart rate monitor strap putting that on and then hooking the mic to that under my shirt, give that a shot, it makes the sound a lot less distorted. Love your stuff
I bought some of this because gut health quacks said it *might* help with IBS/bowel conditions. I never noticed it working, but it's a field of health where you'll try just about anything if it means you'll get an ounce of relief. Many, many quacks in that space though.
i do 2 scoops of vital proteins in my morning coffee. 2 cups 2 scoops. Seems like I have healthier skin, nails, hair. Might be the placebo effect. Costco usually has some really good Collagen powder on sale.
Thanks for including links to the studies! The second study showed higher average connective protein synthesis rates for whey and collagen vs. placebo, but it didn't rise to the level of statistical significance. There is also a section at the end with links to similar articles, including one titled "Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates" -- so maybe taking both is the answer? I put both in my coffee, and combined with light lifting, my bad knee is getting better -- slowly but steadily.
As others noted, it would be interesting to see more studies in different populations, e.g. older subjects and especially during recovery from injury. I'm generally quite skeptical about collagen supplements, especially in the context of a sufficiently high overall protein intake. That said, after my recent quad tendon autograft ACL reconstruction, I did take 10-15g of collagen and 3-5g of glycine per day for the first few months. I figured it was a reasonably cheap and low risk insurance policy (akin to a multivitamin) that might be useful in my specific situation. For that matter, a placebo effect that made recovery feel better and faster was also a useful outcome.
I'm just saying that since taking Collagen I stopped having knee pain (from squatting), and my skin health overall increased to a very high degree, to a point where everyone asks me what I'm doing... And I took Protein powder over that time, and it didn't have the same effect (despite having all the amino acids required to produce Collagen). So, for me it seems like there is something that we might have not discovered yet or looked at properly? In the end, it's not expensive, and it is natural (like you'd eat fish skin), so whatever. So, in the end, the worst thing it does is being a waste of money.
@britsticher8889 Silica supplementation, vitamin d, vitamin C are some of the cofactors that have been shown to increase collagen production. Also, polyphenols found in green tea prevent collagen breakdown
As someone with Ehlers Danlos Syndrome, I really wish there an ability to foster great collagen production. People with EDS are believed to have faulty production of collagen. ie we make it but it’s flawed, resulting in weak collagen. Producing more won’t directly help, but producing less as we age might why symptoms get worse in our 40s and beyond (at least they have for me)
this is IN MUSCLE. Muscle is few percent collagen obviously. And no one takes it to increase muscle collagen. It seems logical that we couldnt even measure slight changes in this little amount of collagen in muscle. And in such little amount there is also not a high demand for collagen... so why would it even do something.
All i know is this starting in my 30s i was getting bad knee pain to where i couldn't even do leg press or many other leg exercises and after i introduced collagen and that's the only change i made the pain was going away by 3-4 weeks and the one time i stopped taking it started to come back .. and im very skeptical of supplements but thsts one that made a noticeable difference for me. So i dont know how it works, or why, if its amino acids or whatnot but I'll take it forever, not for the protein i treat it as a joint supplement
Same. When I was 27 I had some minor knee issues when training. And that was 8 years ago. Since I took Collagen never again. Oh wait. Once, when I didn't take it for a month... And I immediately felt it again.. What a coincidence :D So, it clearly isn't placebo. Because I had so much to do that month that I just forgot about it.
I wonder about collagen protein derived from bone broth? I've been making my own and swear it has helped me recover and repair. I have 2-4 cups a day consistently. My family wants to choke me out for making it and smelling up the house. It better be good damnit.
Probably won't change anything - but as noted by others in these comments, studying connective tissue synthesis in young men between the ages of 22 and 28 seems intuitively pointless. Do young men even suffer connective tissue degeneration or anything that might stimulate a need for connective tissue synthesis for anything other than traumatic injury recovery? Not suggesting the results would be any different if tested on older adults, but simple logic seems to dictate older adults are the audience that most likely has actual age-related connective-tissue degradation and thus potential greatest benefit from collagen supplementation. Results might not be any different, but the point is - we don't know. As designed, this study seems almost pointless.
@MBT372 haha thanks but I am starting to need the claimed benefits of collagen peptides! I have been taking Vital for about 8 months now and my skin got a lot more tighter but it's hard to isolate and conclude it was due to this supplement. The reason is I also added a few different skin care routines too and I started eating healthy.
Hey Dr. Layne, I personally strength train for gymnastics, focusing on moves like the iron cross, Maltese, and planche. These exercises place a huge amount of pressure on the connective tissue, and I used to experience significant pain in my biceps tendons before I started taking collagen. Literally three hours after my first dose of collagen, my pain decreased significantly. Ever since, I’ve been taking collagen, and whenever I stop, the pain slowly comes back. What do you think?
Collagen supplementation is for hair, skin and nails. It's why i take it and anecdotally it works for me. I just don't count it towards my daily protein target for MPS.
I always advice that to everyone. I have some from the time I didn't take collagen but when I really exploded in terms of muscle mass and took Collagen nothing happened.
I'm not sure how they measure some these things for collagen or how the tests were done, but if one group was given whey then they could compare it to regular protein supplements. Maybe they have the same effect or more on skin etc. 🤷🏼♂️
Connective tissues like tendons and ligaments don’t have blood supplies so they would be very to respond. I wonder if there is an effect out 6 months to a year. But in any case, that may be slow enough that supplementation doesn’t matter because you don’t need a lot of substrates to keep up with the rate of replacement or growth. Based on this though, it makes sense, perhaps a good quality protein like whey is all you need.
I have no explanation for why but my nails only grow when I take my collagen daily. When I forget it for a few days, a couple weeks later all my nails break. Maybe it’s the glycine? 🤷♀️
Hydroxyproline is a unique amino acid found only in collagen, which is needed for collagen synthesis. If collagen supplementation does help, that's probably why- it provides tons of a limiting amino acid that you don't get from other protein sources. That's why the "collagen doesn't work better than any other protein" argument for connective tissue doesn't make sense, because even though the whole collagen protein is torn apart in digestion, you still get intact hydroxyproline
I just stepped on the band wagon. Wish I'd watched this video sooner. I'm desperate to heal my chronic injuries. I'm getting new chronic injuries all the time and I too am super skeptical on the efficacy of collagen peptides for connective tissue and cartilage repair. I just started taking type 2 bovine collagen. I guess I'll check back in 2 months for an update. 🤷🏻♂️
Does this mean collagen is not good for bone density? If collagen is not good for bone density than I need to tell my osteoporosis support group that we are wasting our money buying collagen 😭
How would you respond to this video and it’s claims of the body processing the collagen protein as dipeptides and tripeptides as opposed to just single amino acids? ua-cam.com/video/w7rMq9olPow/v-deo.htmlsi=XF7khimE39onlWSu
Thank you Layne for this update. If young men taking collagen did not have any benefit, I cannot imagine older people or elderly having any effects either. But, by any chance, are there any specific RCT with this in mind? Perhaps there are mechanisms that may not affect young men but may be triggered in older population.
I recently read You Are Stronger Than You Think by borlest that goes deeper into this topic and offers practical ways to support testosterone naturally
Why focus on "connective tissue synthesis" when most people use collagen for their skin? Please do a video on the effect of collagen on skin health or lack thereof.
Agreed
It’s likely the high amount of glycine in collagen that’s giving people skin benefits. I just use a glycine powder. A lot less expensive and I know its proven benefits.
Layne is a powerlifter so he naturally focuses on becoming as strong as possible without injury.
Glycine powder isn't exactly cheap,if you're using 15 to 20 grams a day then you're paying a lot for glycine and you're paying almost as much as you'd pay for collagen
The cheapest way to do this is to buy bulk gelatin powder which is about 40 dollars per 4 pounds.... use that either by adding it to your protein powder or making jello or custard with it and adding one tablespoon of glycine to your gelatin dose and that way you save money on both glycine and gelatin...
Here’s the thing. Young people produce loads of collagen naturally. So you may be filling an already full cup. How about the studies in people over 60 because that is when it matters and may make a genuine difference
Collagen is a fancy word for specific amino acids that make up structural tissues of the body (cartilage, ligaments, bone, skin, etc)
If you’re consuming adequate protein in your diet, you are already getting these amino acids in.
Collagen is a sham.
Similar to when vitamin companies target fit and healthy people instead of the people that might actually be deficient in something.
A young person still needs raw materials and more of it to utilize.
Exactly
Yeah, cuz ppl over 60 already learned how to digest whole proteins and peptides without breaking them down to individual amino acids. Makes total fucking sense.
it's not the information we wanted, but it's the information we needed...
Also, I really do not understand why they keep using young male research subjects. They are going to be fine no matter of what! I think these studies should be really focusing on aging population. I cannot imaging they would not find subjects for a study like this. Any university has staff and professors and I am sure they are all aging too....
its far easier to get college students to do these studies
@@NeuronIronyeah they tend to need more the money and more keen to efforts and taking risks that elder people
Adults have lives and families and don't care to be a lab rat. Not hard to understand
cuz young males are your most anabolic population. If you make untrained young male train, you also should see increase in anabolic response in connective tissue. This study shows, that collagen shows no increase in connective tissue growth against placebo even in most growth-prone population. Good luck trying to repair joints that are already degrading with that.
@@NeuronIron I'm old, where do I sign up?! I will do it for free
In case someone is wondering:
In this study also hydroxyproline concentrations increased following collagen peptide supplementation (p < 0.05).
This might matter as apparently the receptors that activate the collagen build-up in connective tissue (and skin cells) respond specifically to hydroxyproline or it's peptides. (from collagen)
Previous to the discussed study results it was hypothesized by some that hydroxyproline supplementation might increase collagen in connective tissues. It does not seem to. Perhaps in some situations an effect could be shown, like in burn victims or otherwise injured, but likely not in healthy individuals.
Here, for the Algorythm, and to say THANK YOU as some of your knowledge sharing here (along two other youtube science based channels) has helped me taking good decisions during the last year to repair my body, losing weight and training hard with more inspiration in my now 50 years young body. Blessings in all your doings, Layne!
You said the study only lasted a week, isn’t connective tissue turnover around 3-4 weeks though, so if the study was 6 weeks it may show collagen in the new connective tissues, also weight lifting is not the best practice for connective tissue gains, but rather jumping and sprinting high impact exercises would be superior for bone and connective tissue Adaptation.
Pretty much what I was thinking. 1 week just doesn't sound long enough to draw any real conclusions, unless maybe the company is claiming it can be effective in that short a time.
Why would you need full turnover to see the results?
Yeah the study should be 6 months at least. To see the collagen working.
@@davorzdralo8000because results?
@@dodgek5270 yes, results. You get those much sooner than the full turnover of tissue. So why would you need to wait that long?
These collagen studies could be another example of a product that has shown to not hurt, but also not be much help. It would be interesting to see what future studies show as far as any possible benefits that are still not known.
It does hurt the wallet, to be fair. Gelatin is a lot cheaper per gram and has not been shown to differ in effect in non-industry funded/sponsored human trails. It might even be that even cheaper proteins have just as much effect on connective tissue and skin as (overpriced) collagen supplements.
Would love to have more research on the older community (weird to think of myself in that manner). I've noticed much more joint pain as I age, especially getting back to working out, and also my skin elasticity lessening. Figure at worst collagen is just a little waste of $. Few months into use I've noticed increased nail/hair growth but not sure anything more. Will keep it up longer and see.
As for joint pain, have a look at glucosamine and chondroitin (and yes, you can find reseach on this).
@@the_notorious_basglucosamine could be problematic for insulin resistance. See Ben Bikman's video on this.
@@the_notorious_basglucosamine could be problematic for insulin resistance. See Ben Bikman's video on this.
@@ac27934 I've heard about this, but the findings on these studies on humans(!) are mixed. Maybe @biolayne can give us an update? Personally I feel fine when I take 1500 mg in the morning.
Hi there! Currently studying for my license exam to become a dietitian! And I really enjoy watching your videos as review and to re-enforce my learning 🤓
Appreciate the continuation on this topic. For the algorithm!!!!!!
Personal observation that I realize could be subjective- My hair growth is next level since I started taking collagen, also seems more shiny and luscious 😊
I feel like my very thin hair became marginelly more thick. And my nails a little less brittle.
While it doesn’t seem to do much of anything for connective tissue, there is some decent scientific evidence showing that it can improve skin health and the appearance or wrinkles/fine lines.
do you mind linking a few studies with regard skin appearance? Thanks!
Yes ive also seen these, would be great if layne could over these instead.
Especially when hes trying to answer if collagen supplements are overall effective. Which they seem to be in some areas.
@@cyclamen831Layne says in this video that those results were shown in this study. BUT he went on to say that mechanistically it doesn’t make sense why so he’s reluctant to recommend it. Just watch the video lol
@ also, a reason for this is the same reason he doenst go over more benefits of cold plunges. It’s not his speciality. Layne is not the type to cover something that he isn’t an expert in cause he could be wrong. If you want skin advice, find a good dermatologist to follow. Layne is a protein/nutrition expert. Which is why he mainly covers protein synthesis in this.
If you care about your skin appearance and or skin health, use a moisturizer with SPF first. Pretty much everything else is secondary to that.
Also look into topical retinoids, maybe. There is more substantial evidence that it improves skin appearance (including collagen in skin, if I recall correctly)
I will say collagen has helped the pain management of my arthritic shoulder. That’s why I am sticking with it…. I am 61
I've read that glycine production slows after 30 and therefore supplementing with collagen could potentially stall connective tissue decline. I hope we get a study with older people
Collagen contains a unique amino acid called hydroxyproline, which is why collagen supplementation may be able to increase collagen synthesis (in theory). I'm not saying it does, but there is a plausible mechanistic basis for how it might
A 15g scoop a day is a miniscule amount. When I've supplemented with collagen and noticed benefits in injury recovery, I was taking several times that amount a couple of times a day.
I think ultimately we need more glycine proline and hydroxyproline and typical protein sources don't have a ton of them
In my late 40's I started taking collagen for knee and joint pain specifically. I do a lot of mountain biking and trail running. I'm not sure if it's placebo, but it really seems to help my knees. It would be interesting to study if there is any kind of difference in young vs old. The referenced study is 25 year olds. Seems like when you are young, you have the world by the balls and don't need to supplement anything. 🤣 I never felt the need to supplement when I was 25. I'm 51 and blood work has revealed the need to supplement several things like DHEA, B12, VitD, Testosterone, Thyroid, Folic Acid.
It also helped my knees when I started taking it at 27, and I didn't even have bad knees. Just sometimes they hurt from squatting or whatever. I don't think it's a placebo, I just think there are no long-term studies. Collagen synthesis takes a lot of time. They should do this over 2 years and then check.
My wife (60 year old) swear that in just two weeks collagen supplementation cleared her knee pain, that lasted more than a year.
I was using collagen after surgery, and she tried it when I told her it might help her for wrinkles (it didn't seem to work for that, but I won't tell her this part).
collagen changed my life. I literally grew 49 inches taller
Probably just coincidence
Damn bro, skill issue. I actually grew 56 inches wider. Checkmate.
I take it to prevent joint injury, I understand the studies are building up against that working, but aside from cost, I don't see any harm in it. I also am interested if these studies focused on older people.
I know it’s easy to clip the mic to your neck, but obviously that gets rustled and messes with the sound. What I have been doing recently Is just grabbing a heart rate monitor strap putting that on and then hooking the mic to that under my shirt, give that a shot, it makes the sound a lot less distorted. Love your stuff
I bought some of this because gut health quacks said it *might* help with IBS/bowel conditions.
I never noticed it working, but it's a field of health where you'll try just about anything if it means you'll get an ounce of relief. Many, many quacks in that space though.
Great video as always! Could you try to put your mic on center of your neck so it wouldn't maybe interact with your movement as much.
i do 2 scoops of vital proteins in my morning coffee. 2 cups 2 scoops. Seems like I have healthier skin, nails, hair. Might be the placebo effect. Costco usually has some really good Collagen powder on sale.
There is studies on skin. It's not placebo.
Thanks for including links to the studies! The second study showed higher average connective protein synthesis rates for whey and collagen vs. placebo, but it didn't rise to the level of statistical significance. There is also a section at the end with links to similar articles, including one titled "Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates" -- so maybe taking both is the answer?
I put both in my coffee, and combined with light lifting, my bad knee is getting better -- slowly but steadily.
Good to know !
As others noted, it would be interesting to see more studies in different populations, e.g. older subjects and especially during recovery from injury. I'm generally quite skeptical about collagen supplements, especially in the context of a sufficiently high overall protein intake. That said, after my recent quad tendon autograft ACL reconstruction, I did take 10-15g of collagen and 3-5g of glycine per day for the first few months. I figured it was a reasonably cheap and low risk insurance policy (akin to a multivitamin) that might be useful in my specific situation. For that matter, a placebo effect that made recovery feel better and faster was also a useful outcome.
I'm just saying that since taking Collagen I stopped having knee pain (from squatting), and my skin health overall increased to a very high degree, to a point where everyone asks me what I'm doing... And I took Protein powder over that time, and it didn't have the same effect (despite having all the amino acids required to produce Collagen). So, for me it seems like there is something that we might have not discovered yet or looked at properly? In the end, it's not expensive, and it is natural (like you'd eat fish skin), so whatever. So, in the end, the worst thing it does is being a waste of money.
Thanks for simplify that kind of info for us!!
Is there anything that has been shown to increase conective tissue synthesis?
Resistance training :)
Growth hormone
BPC-157 has shown to increase collagen
@britsticher8889 Silica supplementation, vitamin d, vitamin C are some of the cofactors that have been shown to increase collagen production. Also, polyphenols found in green tea prevent collagen breakdown
Does collagen supplementation help with tenton strengthening/integrity ????
As someone with Ehlers Danlos Syndrome, I really wish there an ability to foster great collagen production. People with EDS are believed to have faulty production of collagen. ie we make it but it’s flawed, resulting in weak collagen. Producing more won’t directly help, but producing less as we age might why symptoms get worse in our 40s and beyond (at least they have for me)
The concept of health in "The 23 Former Doctor Truths" book completely explains this. I wish I read it sooner.
Not many reviews on this book on Amazon.
Countless bots keep pushing this useless book with even more bots liking these comments
this is IN MUSCLE. Muscle is few percent collagen obviously. And no one takes it to increase muscle collagen. It seems logical that we couldnt even measure slight changes in this little amount of collagen in muscle. And in such little amount there is also not a high demand for collagen... so why would it even do something.
You convinced me. I will switch out my collagen for something with better evidence of effect.
All i know is this starting in my 30s i was getting bad knee pain to where i couldn't even do leg press or many other leg exercises and after i introduced collagen and that's the only change i made the pain was going away by 3-4 weeks and the one time i stopped taking it started to come back .. and im very skeptical of supplements but thsts one that made a noticeable difference for me. So i dont know how it works, or why, if its amino acids or whatnot but I'll take it forever, not for the protein i treat it as a joint supplement
Same. When I was 27 I had some minor knee issues when training. And that was 8 years ago. Since I took Collagen never again. Oh wait. Once, when I didn't take it for a month... And I immediately felt it again.. What a coincidence :D So, it clearly isn't placebo. Because I had so much to do that month that I just forgot about it.
I wonder about collagen protein derived from bone broth? I've been making my own and swear it has helped me recover and repair. I have 2-4 cups a day consistently. My family wants to choke me out for making it and smelling up the house. It better be good damnit.
Are there any high-quality studies looking into collagen's effect on the health of fibrous connective tissue?
Probably won't change anything - but as noted by others in these comments, studying connective tissue synthesis in young men between the ages of 22 and 28 seems intuitively pointless. Do young men even suffer connective tissue degeneration or anything that might stimulate a need for connective tissue synthesis for anything other than traumatic injury recovery? Not suggesting the results would be any different if tested on older adults, but simple logic seems to dictate older adults are the audience that most likely has actual age-related connective-tissue degradation and thus potential greatest benefit from collagen supplementation. Results might not be any different, but the point is - we don't know. As designed, this study seems almost pointless.
It's always fun when he goes science on us
I am so glad that commenters are smart! Test this for older people. Test me! I am 43.
You're young
@MBT372 haha thanks but I am starting to need the claimed benefits of collagen peptides! I have been taking Vital for about 8 months now and my skin got a lot more tighter but it's hard to isolate and conclude it was due to this supplement. The reason is I also added a few different skin care routines too and I started eating healthy.
Excellent as usual.
Hey Dr. Layne,
I personally strength train for gymnastics, focusing on moves like the iron cross, Maltese, and planche. These exercises place a huge amount of pressure on the connective tissue, and I used to experience significant pain in my biceps tendons before I started taking collagen. Literally three hours after my first dose of collagen, my pain decreased significantly.
Ever since, I’ve been taking collagen, and whenever I stop, the pain slowly comes back. What do you think?
Don't know about connective tissue synthesis, but it definitely helps me sleep. Doesn't take much, just a small spoonful. Probably around 5 grams.
I wasted 6 minutes and heard nothing
Collagen supplementation is for hair, skin and nails. It's why i take it and anecdotally it works for me. I just don't count it towards my daily protein target for MPS.
OK, it sounds convincing, but the question still remains: how to improve my connective tissues, ie. induce synthesis?
From my understanding I think most of it is done during puberty or earlier.
Exercising I would assume
Resistance training and enough rest 😂
I believe it is because of my collage supplementation, that I dont have strechmarks from muscle growth
I always advice that to everyone. I have some from the time I didn't take collagen but when I really exploded in terms of muscle mass and took Collagen nothing happened.
Thanks for the information
Any benefit if you have connective tissue tear or damage?
Are there any supplements that can improve connective tissue because I'm only 33 but my knees are killing me
Many NIH studies show benefits including brain benefits.
What about the data by Keith Barr using gelatine?
I had actually never heard of anyone younger taking this for connective tissue. My understanding was, it’s used by the older generations for skin.
What would you do for connective tissue repair? Any tips?
I'm not sure how they measure some these things for collagen or how the tests were done, but if one group was given whey then they could compare it to regular protein supplements. Maybe they have the same effect or more on skin etc. 🤷🏼♂️
Even if there was a slight improvement, it’s a cost benefit analysis just doesn’t hold up compared to basic whey.
What about vitamin C supplementation to help collagen production?
does it help with dry skin?
It is more condensed than whey concentrate,we use both cause we are cheap and need the protean ( food avoidance syndrome) source anyway.
The study was for connective tissue but not about hair/skin/nails. So the results of this study doesn’t cover that, right?
if collagen cannot be absorbed (i am not questioning that), how is creatine absorbed?
What about skin and hair?
And that’s why you have combine it with Glycin
Collagen gave me pain in my joints especially the knee. It took me 6 months to get better.
What about "tendon training" and using collagen?
Thanks Layne
Connective tissues like tendons and ligaments don’t have blood supplies so they would be very to respond. I wonder if there is an effect out 6 months to a year. But in any case, that may be slow enough that supplementation doesn’t matter because you don’t need a lot of substrates to keep up with the rate of replacement or growth. Based on this though, it makes sense, perhaps a good quality protein like whey is all you need.
Oh you do ? You sell a whey protein. I was looking to buy some. I'll buy yours because you have my trust
You don't deliver where I live. Nooooo !
Shhhh. I'm trying to trick myself into a placebo effect
Any hemp protein studies worth talking about?
I decided try some after reinjuring my rotator cuff. Most noticeable thing I saw was my body hair getting thicker 😭😭
There is a study that is on a 6 month study. Report on that.
Do they have studys of people eating hyperprocessed collagen vs people chewing gristle like a 1000 chews to get it down. Love chewing on gristle
The position of the mic doesn't help with the audio quality. Keep it in the middle.
I have no explanation for why but my nails only grow when I take my collagen daily. When I forget it for a few days, a couple weeks later all my nails break. Maybe it’s the glycine? 🤷♀️
Hydroxyproline is a unique amino acid found only in collagen, which is needed for collagen synthesis. If collagen supplementation does help, that's probably why- it provides tons of a limiting amino acid that you don't get from other protein sources. That's why the "collagen doesn't work better than any other protein" argument for connective tissue doesn't make sense, because even though the whole collagen protein is torn apart in digestion, you still get intact hydroxyproline
I was taught that you need extra glycine and vit C to ensure that the collagen is utilised.
If eating amino acids always break down to their base components for general use by the body then why does creatine work?
I just stepped on the band wagon. Wish I'd watched this video sooner.
I'm desperate to heal my chronic injuries. I'm getting new chronic injuries all the time and I too am super skeptical on the efficacy of collagen peptides for connective tissue and cartilage repair.
I just started taking type 2 bovine collagen. I guess I'll check back in 2 months for an update. 🤷🏻♂️
Hydrolyzed Collagen, Have joint pain ? do yourself a favor and take it . Better movement better gains.
Does it do anything for joints(knees)?
i still prefert to use growth hormone for connective tissue 😉😉
Idk why it makes my coffee tastes like cat's poop
Makes it really hard to take consistently since i dont make protein shake daily
I remember when you went on the huberman podcast the first time and said : I will never sell supplements to avoid any kind of conflict of interest ...
I had a split nail for decades until I took collagen.
im a 39 year old male, i dont supplement collagen for training benefits...
soooo wtf am i supposed to do for my tendons...
Layne norton
I'm on day 6 of taking 10g of collagen per day. I'm also on day 6 of explosive diarrhea.
I get terrible acne on the temples from beef collagen
My frogs are so cute and so shall rest be too
Does this mean collagen is not good for bone density?
If collagen is not good for bone density than I need to tell my osteoporosis support group that we are wasting our money buying collagen 😭
Canadian kinesiologist Keith Barr has some pretty compelling data on collagen/Ascorbic acid supplementation. Just sayin.
Algorithm!
Looks like I just saved £20 a month... Goodbye collagen
I add 3 grams of Glycine to my daily 26g whey protein drink.
How would you respond to this video and it’s claims of the body processing the collagen protein as dipeptides and tripeptides as opposed to just single amino acids?
ua-cam.com/video/w7rMq9olPow/v-deo.htmlsi=XF7khimE39onlWSu
Without even watching the video, I can already tell Lame is going to say no. My scientific rationale? He loves to piss in everybody's corn flakes.
'He loves to piss in everybody's corn flakes.' There's currently no scientific evidence that proves ...
Thank you Layne for this update. If young men taking collagen did not have any benefit, I cannot imagine older people or elderly having any effects either. But, by any chance, are there any specific RCT with this in mind? Perhaps there are mechanisms that may not affect young men but may be triggered in older population.
I recently read You Are Stronger Than You Think by borlest that goes deeper into this topic and offers practical ways to support testosterone naturally
I've always been skeptical of collagen. This is just like the ancients, who thought eating dried bull p*n*s would make them "bigger." 😂