Tinnitus and NHPN-1010, A Fascinating Drug Treatment!
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- Опубліковано 4 жов 2024
- ➡️ Unlock Lasting Relief From Tinnitus! Schedule a FREE Consultation with Treble Health Today: treble.health/...
In this episode of Sound Science, Dr. Ben Thompson and Dr. Michelle Neidleman-Kennedy delve into the latest developments around NHPN 1010, an emerging drug candidate targeting noise-induced tinnitus, created by researchers at the Hough Ear Institute and supported by AOIc Pharmaceutics. Join us as we unpack the science behind this drug and its journey through clinical trials.
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THE 3 WAYS TO FIND RELIEF FROM TINNITUS WITH TREBLE HEALTH:
1️⃣ Call Us at (855) 714-0921. On mobile? Click here: treble.health/...
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3️⃣ Take the Tinnitus Quiz: tinnitusquiz.c...
💜 Message From Dr. Ben & Treble Health:
Thank you for watching my UA-cam channel. I hope you find the information you need to help with your hearing or tinnitus conditions. If you'd like more personalized support, I encourage you to work with Treble Health, a company that I founded. Treble Health is recognized as the nation's leading telehealth service helping adults improve tinnitus and hearing loss. Our nationwide team of expert audiologists are available and excited to help you. To learn more about our tinnitus treatment program, please go to TrebleHealth.com/.
Make sure to subscribe to our UA-cam channel, where I make new videos every week. Subscribe now: / @treblehealth
Thanks for stopping by and if you have any tinnitus- or hearing-related questions or want me to cover a specific topic, just let me know in the comments section below.
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Disclaimer: The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional.
➡ This pill is not yet available, but you can still get help for tinnitus. Book a free consultation with a specialist from Treble Health: treble.health/schedule106
Comuniquese con luis miguel y cris martin que ellos son los mas interesados en ello
@@treblehealth it astounds me that you talk about a pill that is unavailable, give us false hope then you have audacity to mention help is available by contacting you and your team for therapy free of charge of course for first consultation. My point is you are preying on us who are suffering to make a few dollars. If pill not available why even talk about it????
This is what I read on reddit about it.
"It has passed FDA phase 1 trials. It is stuck in the trial process because they cannot find a company with enough money to move it through phase II and III. "
I hope one day the Gov. can fund something to improve way of life and get these things rolling.
Tinnitus is so common that I hope some pharmaceutical company sees the potential market for this.
I'm from Australia 🇦🇺 They need to get onto to this quickly so people like all of us here can get the relief that we need !
Yes, very quickly. I'm from Australia as well. I have suffered from this 3 long tormenting years. Something needs to be done. Cheers!
Sorry to say this will not cure tinnitus, maybe help a little for some and for protection from acoustic damage. Science has no idea how to cure tinnitus.
As a former police officer who has suffered for 30+ years with tinnitus, this sounds promising.
I FEEL YOUR PAIN 😢❤ GOD BLESS US AND HELP US PLEASE! 🙏🏼
The only pill that reallly works is carbamazepine ......it redusess the sound with about 50%
What does your Tinnitus sound like?
We hope so
@@Hew.Jarsol A high pitch tone in both ears, slightly different pitch between left and right.
This new pill gives hope to us tinnitus and hyperacusis sufferers! I hope they can get the funding they need. This is very important research, for sure!
As a competitive shooter, I’ve dealt with tinnitus for years now, even though I ensure I’m using significant protection, the years of shooting in the sport I love does have the side effect of tinnitus over time. Something like this would be life changing for so many people, whether its job related, hobby related, or any audible trauma. Tinnitus is quite frustrating and annoying. Big hopes for this. Please keep us updated if you hear more.
This is very promising. Hope the FDA can approve it some day. Long road ahead, but we can all make others know about it and move it forward.
Dr Michelle Neidleman-Kennedy thank you this is hopeful. I wish I could be on a trial after 5 years straight of this hell aka tinnitus
Please get it fast approval from FDA and release it out for all peoples suffering this dreadful suffering. Do it fast.
I don't have hearing impairment.except with some frequencies actually. But I have problems with insomnia. I hope that this medicine will bring a cure for humanity.
White noise can help a lot pal. I use Zen Tinnitus app.
Get this on the market asap please
Years of waiting for approvals which may or may not happen. Meanwhile, minute by minute … day by day … month after month … we continue to experience the torture of high pitched whistling and hissing. Give us more than ‘studies’ and faint hope. Please.
How many of you are from "Tinnitus Sufferers" Group on Facebook? One step closer ❤
Too many doomed stories. I had to leave the group.
50 years of tinnitus I’ll try anything 😢😢😢😢😢😢😢😢😢😢😢
Really? Shittt
@@pitstopman Loud Combustion engines will do you in even with ear protection. The vibration of the inner ear bones with ear protection can and will cause damage. I was on the Flight-line with Fighter Jets and wore ear protection and my audiologist explained the inner ear bones and vibration from noise. 20 yrs later and still deal with tinnitus. Guns, Loud Music, Loud Motorcycles ; I stay clear of ....
Laser Light Therapie?
If i wolud be you i would have lost hope
Hi my name is Ms REHMAN I have suffering from tinnitus for over15 years but for the past six months by buzzing is 24/7
I live in London UK have been following your videos for over a year
Glad to hear this news and hope it helps all the tinnitus suffers
How do we get help
With our NHS... we're doomed.
What I do find helpful is try and track down any triggers. Second, I do my best to just ignore it. Evenings are worse for some reason.
@@ruger6049our lifestyles slow down at night, as does the general day to day white noise. Cars on the roads, daytime activity. “Silent night”. The quieter our surroundings, the louder the silence. Tinnitus loves silence
Please keep the updates on this and other treatments coming. Thank you.
Hope this works and gets on the market. I’ve played in bands since the 80’s. We played ridiculously loud in the 80’s and 90’s, no doubt the cause of my tinnitus. We had fun though! Paying for it now.
Wow, this would be amazing. I have taken Nortriptyline for a few years to help sleep and calm my brain from my high frequency tinnitus. Something like this would be amazing.
I have taken 75 mg of Nortriptyline for 4 yrs now. For no use. I have tinnitus for 30 years now.
Please please I am praying they get the funding and this pill gets developed!!!
This is exciting!
I'm sure volunteers will be lined up to try the pill. I can imagine the result's after taking the pill will be based on the length of time the pill will be administered...hopefully.
But what about the vast amount of older people who have had tinnitus for years.
Thank you
I'm surprised it's been so challenging to find funding. This seems like it would be a blockbuster drug! I'm wondering if a crowd funding site can be set up and that would help with the financials.
Please DON'T give us false hope. This thing is suicidal. It has destroyed my mind, soul, body, life. Stop talking and do. Find the funds and help us.
I agree with you 100%. It has destroyed my life.
@@stevemargolies1187 HORRIBLE! No life. IT the DEMON took everything away from me. 2024 and NOTHING yet we communicate like this. Go bloody figure. All about fucking money.
@@stevemargolies1187 truly has taken everything away from me. Horrible. I'm merely existing now. 2024 and nothing yet we communicate like this. Go bloody figure. Makes you wonder. It must be all about fucking money.
I wonder if regular NAC pills could also help reduce tinnitus.
It doesn’t with mine. I even get nac IVs bimonthly
I TAKE, BUT WITHOUT RESULTS. GABAPENTIN HELPS ME 30-40% REDUCE TINNITUS BUT NOT THE PAIN AND HYPERACUSIS.
not really
$500 million for phase 2 and 3? that's insane...this project is already dead.
Please tell us where can we get this pill ?
When will we see this miracle?
Please please let us have it very very soon 🙏
Tinnitus pill when???
I think it depends on what type of tinnitus you have, is it from a illness?? tinnitus is a symptom not a disease.
This is Great news!
How do you measure tinnitus on a rat ?
damn good question! Rats can't exactly fill out a form like humans?
Will they get the money? How many years until it launches, 10 or 20 years?
Hello, there is a date when this pill will come out?
Typically, if a phase 1 trial shows success AND if follow-on studies are successful (without serious side effects), you're looking at an additional 6 years until market introduction.
2031/32. 8 years ago HEI say‘s in 2025/26, but in the middle of preparing NHPN-1010 for a Phase II trial this pharmaceutical partner shifted their focus away from developing therapeutics for hearing loss and decided to shift their focus towards developing therapeutics for cancer.😢
I've been experiencing tinnitus for the past 10 days, and it's been incredibly difficult. The loud buzzing sound is like a siren, and it's driving me crazy. I'm also suffering from migraine pain.
I want to express my utmost respect for those who have been dealing with this for 20, 30, or more years. It must be incredibly tough.
I'm curious to know how you're managing to cope with it. Any advice you can share would be greatly appreciated.
And I hope and pray that everyone who is suffering from this condition finds relief and heals quickly.
30+ years last two years loud.
@@louisminderhoud6010
it's crazy how there's no cure for it
they don't even consider it as a disease for them it's a damage that can't be repaired
What happened to you? 1 month with tinittus here, no hearing loss so I’m still trying to find why
7.1 surround music player app caused damage to my left ear. I thought the music sounded great through it. I deleted the app and all the music I had, and threw away my headphones. Now I hate everything.
@@ramo1824I took neomycin because I thought I had a stomach infection, stools were liquid during almost 3 weeks and had already taken everything available. Finished a whole bottle by taking the medicine like for 6 days straight. After one or two days of finishing it, it started in October 2022 and hasn’t stopped since. Actually last week began to increase (don’t know if because of another medicine I’m taking, stress, physical issues or what). First I was like you, I love surround sound and music and was very desperate for like 3 months, later I started reading about all of the people that suffer from it, even close friends shared their personal experiences when I shared mine with them, and my brain finally calmed down and then started getting used to it. Sometimes your mind doesn’t focus on it and all and you don’t even remember you hear it or have it. Give it some time, brain’s plasticity helps a lot learning by itself to mask it; it’s important not to get annoyed, frustrated or anxious and you will enjoy sounds and music again, just try not to focus too much on it. This channel and others with sounds that mask tinnitus noises with different frecuencies help A LOT mainly before going to sleep (that’s when it works for me the best). Keep calm, you got this. And thank you for sharing your experience too. We are not alone in this.
When will this be available
The biggest challenge for neuroscientists has been to create a treatment for tinnitus that does not create another cognitive deficit aka side effect.
The best medicine I have personally taken as needed when my tinnitus is spiking is Clonazepam.
Clonazepam is a benzodiazepine medication that increases the inhibitory effects of GABAergic circuits. This translates to calming down the nervous system, leading to effects such as reduced anxiety, sedation, and muscle relaxation reducing tinnitus in many patients.
What dosage do you take and how often?
Benzo's are highly addictive.
@@JOEYader Yes, and why its best to take only as needed aka when tinnitus is spiking and feeling some level of desperation. No foul if taking Clonazepam episodically, as needed.
Bring it fucking out fast
I sense your pain. Yes, fucking fast.
Ther was also a brief mention in this report, that this might also help those with hearing damage and Tinnitus due to Ototoxic medications. Is that the case?
Hi there, I'm from the UK and I've been suffering with tennis's the last 2 years. 24 hours a day Non-Stop. Very hype. It sounds sometimes very starving and unsettling for me or anyone. Would this tablet be distributed in worldwide, especially to the UK? I hope this pulls off for use cuz I won't mind try this to get rid of this tinnitus. It's is so starving for me long time
Every new drug sounds promising. Years of waiting and waiting.
Provide something efficient finally.
We Had breakthrough with fx-322 and oto-313. None of them worked.
Mine isn’t caused by noise, but the Covid vaccine.
Hi there -- while Covid does not always result in tinnitus, a link between the 2 conditions has been documented. We have a blog article on the connection between the two, and you can check it out here: treblehealth.com/tinnitus-covid/. Regardless of the cause of tinnitus, there are treatment methods that can help to significantly reduce the perception of the ringing. If you would like to learn more about our program, we encourage you to schedule a free consultation with one of our experts treble.health/consultation. Our team has worked with numerous patients that have had tinnitus related to Covid, and we can help you find the same relief as them.
Companies want to go to Mars, innovates AI, spend billions in wars and still unavailable a pill for tinitus?
You right
Sounds promising. What about nicotine patches?
so this pill is 5 to 10 years away still?
If it doesn't have any hiccups along the way, YES. Of course this small company needs someone to shell out US$500m for the clinical trials (although, having worked in drug development, I think they could run them much more economically).
@@kwhatten that sucks big time
the hope!
(tylenol extended relief) has helped me for 2 years with pulsatile tinnitus from a covid infection! I dont know why but it wears off in 8 hrs then the hiss is front and center in my brain!
Can we buy it please
Are you talking about N-Acetyl-Cysteine?
A PILL REALLY!!
You know if they ever develop a proven treatment, the pill will be extortionate in price. $1000 a pill or smt. Always is when something works. 😢
I wouldn't be so cynical. Big pharma wants to make good money. Look at Propecia for hair loss. Has been a global hit for baldies The main brand works out at around £2.50 per day in the UK and the generic brands of Finasteride work out at 30 pence per pill.
I would tell them to... TAKE MY MONEY🎉
I have this ringing on my left ear since this year there was a noise coming from outside at night, and I decided to use ear plugs and the next day I have this noise couldn’t go away,my family Dr send me to see a specialist and I been told both ears are very good but I’m not sure what to think of it please help.
And what about if the cause might be stress?..is there any investigation about that..i know some people its caused by that..for myself it can be a cause.
Mine audiogram show a little dip on 2000hz 20a25 db..but they say its stress
What about otosclerosis - any pill for that? Or this one can also help?
Whats NAC?
N-Acetyl Cysteine. It's an amino acid. It's the gold standard drug for acetaminophen overdose which can lead to rapid liver failure. It's commonly prescribed to patients with lower respiratory disease (like bronchitis) because it inhibits the formation of phlegm. It's used in psychiatric medicine where it has been shown to reduce OCD episodes. And some studies show it may be beneficial in noise induced hearing loss.
@@kwhatten Ok I'm just so new to T well 6 months or so. Thinking of trying Taurine.
Out of interest, how do you test rats hearing... ? It's not as if you can talk to them...
I remember another video where a researcher explains how they measure tinnitus in rats. Something like they play a series of tones and they can observe twitches and movements in the rat's ear in reaction to the sounds, if there's a delayed reaction to a certain frquemcy then that means that's the tinnitus frequency of the rat
if pills work then i need it so bad my lefr awful teerible noise with new hearing aid i dont understand
Suprised this wasnt thought up sooner. Ppl desperate to get rid of a ringing in their ears will try anything especially a drive thru answer and given the placebo effect. Also how can you get money back if you think it kind of worked.
I have chronic tinitus. My eardrums are white instead of black due to scarring caused by constant infections. Nothing is going to stop the ringing in my ears. Its there its never going accept it and get on with your life. Its a bitter pill but its the truth pill
Old news
I've got two sounds. Hissing and eeeeee
I got 4 ..😊
🎉❤🎉
Another false hope