@@paramanandbalara3602 Thanks man for your information 😊... I've passed out but I'll keep it in mind for my current first year physiology lectures on NMJ and during tricky exams
The myosin motor domain is what's doing the ATP hydrolysis. Myosin with no ATP bound is locked to the actin filament. ATP binds the myosin head, causes conformational change in both the head and lever arm, releasing the head from the filament and swinging it forward. ATP is hydrolyzed into ADP + Pi, which causes another conformational change in the head, increasing its affinity for actin, causing it to bind to the actin filament again, this time forward from where it was at the beginning. Pi is released, which causes the lever arm to return to its original position, pulling on the actin filament as it does so. ADP is then released, and another ATP binds the myosin head to release it and start the cycle over.
Can someone explain this to Me If we strap our hand to a machine which helps us move our hand move in and out and we let loose of it then how is it moving because we aren't sending neuro signals meaning the sites of bonding are still closed how is the muscle still contracting then??????
I feel your pain, but did you know that you can make the video play more slowly? If you click on the gear shaped icon under the video, it will give you a choice of speeds to play at. You can also turn on closed captions, and turn the voice off if you wish.
@@ahadzx8875 I think you are correct, and multiple sarcomeres are then stacked and connected one after another within the myofibrils, as far as I know so far.
Ca 2+ not Ca +. Acetylcholine = uh see - tul or uh-see-tl. Named after the acetyl groups in Chemistry. Not ass-e-til. Excellent illustrations + a few corrections in the voiceover = perfect.
There at the end..my muscles are not able to relax back. It's hell. On any activity when I finally get loose (usually in water floating and stretching) it takes only a few minutes and i get super tight again. I had t9t10 damage in spinal. Got one leg paralyzed but I was, am able to get that leg working after 3.5 years. My muscles in legs an glute are so tight, but I get them loose with hours of work and water..yet to feel them get so tight I can't walk after 100 yards. My Drs are clueless and really don't give a dam..
2hr lecture in 2minutes! Thank you💞
How did it go ?
@@offthemapss lmfaoooo
So much info condensed in a digestible formulation! Thanks
That's call crystal clear explanation 🔥🔥
Keep in mind that acetylcholine do not enter in the sarcomere , it remains at neuromuscular junction or motor end plate.
SOURCE - NCERT
@@paramanandbalara3602 Thanks man for your information 😊... I've passed out but I'll keep it in mind for my current first year physiology lectures on NMJ and during tricky exams
@@paramanandbalara3602Yes
@@paramanandbalara3602 Ca++ karta hai sarcoplasmic reticulum me
Explained very well thank you very much now my concepts are clear
Glad it helped
Thank you for this video
Very, very helpful
I literally watched this video to prep for the upcoming Biology test tomorrow...
Same...
Same here
@@langrisvaude9298 Hiiii jungkook 😁
How are you?
Mine is in 45 minutes :)
Extremely well explained and illustrated. Is there a complementary video for eccentric contraction?
Just helped me out for my exam . Amazing explanation 👍
Toughest concept made easy 😊 thank you 😇
So easy and well explained
I know right
Brilliant. Nature is brilliant. Wiser than whole humanity combined will ever be.
Very helpful...
My assignment is done🙏
Thank you very much to make a video on this vary topic..It was indeed very helpful ❤️
Really really helpful. Clear cut visualization. Thanks alot. Stay blesséd💕
Actin is basically crowd-surfing on myosin. Thank you for explaining! I could not understand my professor's lecture at all.
Shes really not Trynna catch her breath going hella fast🤦🏽♂️
Slow the video down
you can change playback speed
I'm viewing with 0.75x
0.75 speed is perfect
How does the myosin head pull the actin inwards? Is there some conformational change in a protein leading to shortening or something?
The myosin motor domain is what's doing the ATP hydrolysis. Myosin with no ATP bound is locked to the actin filament. ATP binds the myosin head, causes conformational change in both the head and lever arm, releasing the head from the filament and swinging it forward. ATP is hydrolyzed into ADP + Pi, which causes another conformational change in the head, increasing its affinity for actin, causing it to bind to the actin filament again, this time forward from where it was at the beginning. Pi is released, which causes the lever arm to return to its original position, pulling on the actin filament as it does so. ADP is then released, and another ATP binds the myosin head to release it and start the cycle over.
Smooth explaination.
satisfied😊
Veryy clearly explained..good✌️
R u a medical student?
I swear by god this thing helped me more than anything else.
Crystal clear explanation 👏
Who else revising the day before 🙏 🔥🔥🔥
Can someone explain this to Me
If we strap our hand to a machine which helps us move our hand move in and out and we let loose of it then how is it moving because we aren't sending neuro signals meaning the sites of bonding are still closed how is the muscle still contracting then??????
This is my 2 hour clss in almost 2 min.
Very well understood....🙏🙏🙏
Thanks 😊 that lady is crystal clear 😊
This 2 minute video was a 3.5 hour lecture in the Army's ICU course.
A long lesson withing few minutes 😍 Thank you so much❤️
Can you please explain slowly. because of This is fast for beginers 🤗
I feel your pain, but did you know that you can make the video play more slowly? If you click on the gear shaped icon under the video, it will give you a choice of speeds to play at. You can also turn on closed captions, and turn the voice off if you wish.
So amazing my 2 hours lectures explain in 2 minute
Thanks you clear my confusion...
Which protein blocks the binding site on actin in a resting muscle?
Troponin c
Thank you so so so so much❤
I was always that ATP break before cross bridge formation or after crossbridge formation...now it's crystal clear..
Thank you😌😊
Mjhay sarcomere samjh n araha kya hai
@@Pricelesspeace-w5s area between two Z lines
@@SaraAli-cg3qj so technically sliding filament actually occurs in sacromere right?
@@ahadzx8875 I think you are correct, and multiple sarcomeres are then stacked and connected one after another within the myofibrils, as far as I know so far.
This video would be very good for revision
im going to nail this exam
Nice explanation but little bit it is fast . Please slow your speed of explanation.
Otherwise it is the best one ✅
Soooo clear!!
thank you so much ❤️
Interesting video
Thanks a lot for explanation.
Does magnesium have a role in this?
Great video, still super confused though im gonna have to watch a few times lol
0:58 wrong spelling, "acetylcholine", not "acetylecholine".
Perfectly condensed love it
Thank you! It was the toughest one I have done but worth the effort. Wish I had time to do many more.
Thank you
Thank you so much for this
Nice yrr maja aagaya 👍
Oscar winning legend ❤❤❤❤❤❤
धन्यवाद माऊली🙏
Mam from where atp molecule bind to myosin during relaxation of muscle mam
ATPase (where ATP binding site is present) that is present on myosin head
i now really understood thank you
Is it ca2 plus or only ca plus
Brilliant amazing spectacular 🥰
Very good explanation 🙂
thank you so much!
Thanks 👍
We talking about all types of muscle in the body or specific muscles, like heart muscle. Asking because Troponin is found in the muscles of the heart.
Thank you for this
0:53
Great Video
Bro.
This topic is fucked up LOL, by far the hardest 😅
Thank you!
Nice lecture
Well explain
Finally!! Peace ✌
Thank You! :)
loved it
2:00 Ca2+
Thank u sooo much 🥰🥰
Any personal training students here?😂🤣😂
😂
Yes 😂
Amazing
thank you sooo much
good job
Thanks
I never get the atp part
Amen.
Thanks
Better very little slowly......
Ty
Acetilcolina o calcio?
Sorry this vid was really slow; try 2x speed
Much better
Ca 2+ not Ca +. Acetylcholine = uh see - tul or uh-see-tl. Named after the acetyl groups in Chemistry. Not ass-e-til. Excellent illustrations + a few corrections in the voiceover = perfect.
The myosin looks so cute
There at the end..my muscles are not able to relax back. It's hell. On any activity when I finally get loose (usually in water floating and stretching) it takes only a few minutes and i get super tight again. I had t9t10 damage in spinal. Got one leg paralyzed but I was, am able to get that leg working after 3.5 years. My muscles in legs an glute are so tight, but I get them loose with hours of work and water..yet to feel them get so tight I can't walk after 100 yards. My Drs are clueless and really don't give a dam..
That sounds horrible Chas. Hopefully the Drs will figure out a solution for you soon. Wishing you all the best, stay strong.
It's ca+2
Thank you! I peeped that and scrolled to see if anyone corrected her in the comments...
I don't understand a little bit.
👌👌💛
Thnqq
Nice
Good
wait a minute why he stood there like that
with those grippers out
put those dogs away
woof woof
❤️
ACTUALLY i THINK you'll find it's Ca TWO PLUS, not Ca PLUS. i think lol
Kon kon meenakshi mam k batane prr aya h yha 🥰
من طرف استاذ احمد على 👍
What I was imagining seems to be completely wrong. 😂
best
Vdo shown in Aakash institute 😅
🤗
cap!
holy cow
Who all saw this video in 1.75 speed