A Higher Kynurenine/Tryptophan Ratio Is Associated With Lower Muscle Mass
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- Опубліковано 1 чер 2024
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Papers referenced in the video:
Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging
pubmed.ncbi.nlm.nih.gov/34117...
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality The Hordaland Health Study pubmed.ncbi.nlm.nih.gov/26823...
The mediating role of kynurenine pathway metabolites on the relationship
between inflammation and muscle mass in oldest-old men
pubmed.ncbi.nlm.nih.gov/38761... - Наука та технологія
You're mapping one of the pathways of NAD dysfunction.
Aryl hydrocarbon receptor and ace2 receptor dysfunction due to certain infections or chemical exposures like benzopyrene dysregulates these pathways.
Prevents Kynurenine becoming NAD+
The inflammatory Kynurenine builds up and doesn't convert.
How is this fixed?
@@alexxxO_O Ace2 receptors, I do not know. Aryl Hydrocarbon receptor?
I found that a chemical called Theabrownin stimulates bile acid synthesis and seems to jump start it. Either via a chemical in bile acid or probiotic bacteria that live in it.
Hopefully, this comment doesn't get shadow banned again. I just realized my first response was deleted.
@@alexxxO_O Every time I answer it gets deleted. Shadow bans are out of control
Always enjoy your videos! Thank you!!
Thanks @Hail2MasterChief!
So how do effect it? More tryptophan?
I wouldn't go with more tryptophan which was bad in my case. Reducing systemic inflammation, as less tryptophan would be degraded is a top priority. For more insight, I calculate correlations after every test (story at 4:30), but nothing was significant following this test.
@@conqueragingordietrying1797thanks for your detail as always. What are your top 2 levers that you pull regarding lowering inflammation?
I'm currently experimenting with lowering inflammation w/ cold exposure (45° - 65° ice baths) 4 hours prior to melatonin production window to lower Kynurenine for better tryptophan to (5htp >> serotonin) melatonin production.
Interesting, Cal-please post your results when you have them!
There’s research showing this metric was improved with tart cherry juice
Please post the paper?
TCJ Everyday 👍🏽
It works well for me for serotonin and people I know, but it might be a little histamine producing over time and has some subjective counter effects.
Btw I think this pathway is responsible for a lot of diseases, it’s a really important topic
What dosage?
Mike, how do you improve this ratio?
Hi Ed, nothing was significant for my 8 tests, but when considering that inflammation induces IDO expression, anything that reduces inflammation (weight loss, for ex), would be expected to reduce the KTR.
Thanks. Your study curve seem to show flattening around a ratio of 15 or lower although it was cutoff at around 10. My 2023 iollo was 29 nM/uM then 22 nM/uM. Not sure of difference in diet except possibly less alcohol. Anyhow was 69 yo for those test. The Iollo report showed a vertical axis indicating that a 62 yo value would be about 8 nM/uM. Havn't asked them about this but it seems to be at odds with your data which suggests there's no continuous drop. Does your Iollo report show you as optimum per their reference data or do you just ignore that ? They show < 47 as optimal but it appears to be age specific. I will inquire as I'm really interested in what's optimum for a male human, not what appears optimum based on typical data for my age group.
Hi Peter, I'm most interested in the raw data-I ignore their proposed "optimal ranges" in most cases, instead focusing on ACM and aging-related trends, which are not generally background info for their recommended ranges.
Even if what's optimal is debatable (venipuncture vs interstitial), the KTR increases during aging, so avoiding that is a top priority for me.
@@conqueragingordietrying1797 Agree. Thanks.
Any number one food u recommend?
No correlations with diet are currently significant at p< 0.05 (covered at 4:30), so it's tough to say, for now
@@conqueragingordietrying1797 oof...
This is very interesting! Once again it seems as though highest muscle mass per body weight is beneficial! Inflammation is also known as excess heat inside the body. I’m wondering if something simple such as cold shower less than 2 min a day will have any effect on this ratio? Cold showers have been shown to help produce brown adipose tissue from white adipose fat.
The only way to know if cold showers impact the KTR is to do the experiment...