Helional to enamine intermediate then oxidative cleavage to yield Mdp2p. Then MDP2P reductive animation to MDMA. This reaction doesn't seem to be well known. Surprising because all it's reagents are readily available and the yields are quantitative. Maybe I know a secret that others don't but now the world knows
at 7:20 you said "the more you screw it, the more snug it gets" but in my experience, the more you screw it, the looser it gets. Just throwing it out there.
John, you can buy teflon overhead stir bars as well as a 24/xx adapter they fit in for about $25 total, please don't try making such a contraption with glass rods lol. I've had success driving such stirrers with a corded drill as you describe, you'd be better served building a wooden mount for such a heavy motor but 3 clamps on the reaction flask pole will do the job with enough tweaking. Also, have you ever synthesized nitroethane? I've tried a few routes but wasn't satisfied with any of them. It condenses very nicely with furfural, which is good because I wouldn't ever want to possess EtNO2 and benzaldehyde (or piperonal, or anisaldehyde...) at the same time.
@@martinterhaar3287 That's precisely my point. Anethole and anisaldehyde are intrinsically linked to the clandestine manufacture of MDxx and can themselves be worked up into questionably legal """""""analogues""""""" of MDxx. So if you like exploring the chemistry of rings with tails it's wise to forgo phenyl rings altogether whenever possible, in the event that the blue boyz kick in your door to just make sure you're not having TOO much fun with your chemistry set.
Alex .......I will have to look into the teflon overhead stir bars like you said. Does sound alot better. No never made nitroethane yet but i am drying out some silver nitrite i made and as soon as i get off my lazy a$$ i will make some nitroethane. I am using silver nitrite / diethyl ether / and ethylbromide in a metathesis type reaction. Did you try that route yet (victor meyer reaction)??? I been planning on making some furfural for like forever. I even bought some xylose like 3 years ago.
@@johnblacksuperchemist2556 Victor Meyer is probably the best route on a prep scale, I had success with it but my percent yield was worse than ChemPlayer despite running it twice as big. Antoncho's sodium ethylsulfate method worked as well, but if I ever try that again I'm gonna make a giant buchner funnel because the procedure involves filtering literal gallons of calcium slop. My next attempt will be ethyl bromide and sodium nitrite dissolved in ethylene glycol.
Alex..........let me know how good it works with ethylene glycol as the solvent. I was thinking of trying 1,4 dioxane but first i am going to do it like chem player and just use diethyl ether
i came across this method its similar but uses no methanol will this work?: Phenyl-2-nitropropene (10 g, 61 mmol) was dissolved in 75 ml HOAc and slowly dripped into a refluxing slurry of Fe powder (32 g, 0.57 mol) in 140 ml HOAc. The mixture turned brownish and foamy, and the mixture was refluxed on low heat for 1.5 h. The reaction mixture was poured into 2000ml water, and was extracted with 3x100 ml CH2Cl2. The combined extracts was washed with 2x150 ml H2O and dried over MgSO4. The solvent was distilled off, and the residue distilled under vacuum to give phenyl-2-propanone in 75% yield.
Ricardo...........Seriously i do not even know if the method i mentioned in the video works. MY GUESS..........I do not think the methanol is REQUIRED. But using a weak acid like acetic acid might not work to good. What i would do first is take some acetic acid and and throw some iron into the acetic acid. If it bubbles a lot from making hydrogen then i would say it might work. If it barely bubbles from making hydrogen then i would say your method probably wont work. But this is all just guesses. Usually if i do a video with NO experiment ...like the video above......that means i have not personally done the experiment.
Fuck your the man my bro l wish you lived in New Zealand what an absolute legend you are. love your content. Could listen to you talk about cool chemistry stuff all day 😂
Trent............Thanks buddy. I made 2 other videos like this one. Showing different ways to make p2p with exact instructions. One was a friedel crafts alkylation. And the other was a Mn(III) coupling reaction of acetone and benzene. Check them out
Hey budd, how’s it going, i have a question please , may i use nitroethane instead of nitroalkene ? If not , what kind of chemical products i can use instead of nitroalkene that is available in the market ? Thank you
Mohamad...........You can use a phenyl nitro alkene OR phenyl nitro alkane OR phenyl oxime to directly make P2P. None are readily available in the market. You have to make the precursors
@@mohamadwehbe9246 ..............Go to this video and start watching at 8:30 ua-cam.com/video/rpoUe6aIR54/v-deo.html There i am talking about the henry reaction (nitroaldol reaction). Next go to this video where chem player does the henry reaction (nitroaldol reaction) www.bitchute.com/video/zUh0ZIhHc52F/ Now if you want to make p2np then do what chem player did in the video EXCEPT replace the vanillin aldehyde with benzaldehyde and replace the nitromethane with nitroethane and you will make p2np. If you can master his method then i can tell you how to do it a better way and get a better yield using a dean stark apparatus. If you have p2np then you can make p2p in one step by the instructions i give at 4:00 in the video above. Or you can make amphetamine from p2np in one step by either electrolysis or hydrogenation............Let me know if you have any more questions buddy. And your very welcome............Do you have a dean stark apparatus or can you build one?
ANOTHER P2P SYNTHESIS.......MAYBE .........Manganese(III)acetate mediated coupling reactions via free radicals. A mixture of Manganese(III)acetate dihydrate (13.4g, 50 mmol), benzene (150ml), acetone (150ml) and glacial acetic acid (250ml) was refluxed under an inert atmosphere (argon, helium or nitrogen) until the dark brown color of manganese(III)acetate changed to the pale pink of manganese(II)acetate (about 90 min). The reaction mixture was partitioned between 400ml ether and 250ml water. The ether layer was separated and washed with 250ml water and with 2x250ml 5% Na2CO3 to remove any remaining acetic acid. The ether was then dried over anhydrous Na2SO4 (or MgSO4), the solvent evaporated and the residue fractionately distilled to recover unreacted benzene, and to give phenyl-2-propanone in 40% yield (1.34g) based on the reacted manganese(III)acetate, which is the limiting reagent in this reaction.
@@johnblacksuperchemist2556 Sorry John, I mean the Willgerodt rearrangement, there is also a few modifications of the original procedure, namely the Kindler modification. I think the ammonia version run under pressure would be quite interesting. A catalyst tube should take care of the resultant products.
@@willeveryday The condensation releases one mole of H2S and the hydrolysis yields a second, Willgerodt is a fascinating approach but very stinky and very dangerous.
@@alexredacted2123 The danger is almost part of the appeal but I think if performed in a very good gloved fume hood with exhaust gases being scrubbed, the smell and inherent danger involved should be minimised.
Hey i need a question i have c10 h15 NO and i need to transfet to c10 h15 N i need to remove oxigen by doing so calad birch but if i mih dietyl ethar c10 h15 NO which is sudo by the way and add nh3 with litium in it.Formyla of diethyl ethar is (C2H5)2O and im afraid that wil ruin the reaction beaucuse it have ohygen,i have mix ethar with litium and it react werry slovly i can see the little bubles afther some time but ethar was dried...What do you think...I will have by prodyct in metttttttttttttttttth....What do you think can i use some other solvent or?
markoni............I am not sure what you are saying. But if you want dry ether. AND KEEP IN MIND I HAVE TOLD YOU THIS A FEW TIMES NOW. You need to put it in a sep funnel with some saturated NaCl water. Then take the ether portion and put some anhydrous MgSO4 in it and stir for a while and then filter and distill and keep the portion that comes over at the boiling point of ether. THEN THERE IS ONE MORE STEP IF YOU WANT DRY ETHER!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! There is still trace amounts of water in the ether. TO DRY IT COMPLETELY you throw some small bits of sodium(or lithium) in to the ether. The Na(or Li) will react with any trace amounts of water that is in the ether and make NaOH(or LiOH) and hydrogen. The hydrogen will bubble out of the ether. Wait for it to stop bubbling and throw a little more Na(or Li) chunks in to the ether and wait. WHEN YOU THROW SOME SODIUM(OR LITHIUM) INTO THE ETHER AND THERE IS NO HYDROGEN BUBBLING OUT OF THE ETHER THEN YOU HAVE BONE DRY ETHER. Filter the Na/NaOH(or Li/LiOH) out of the ether and you can use the ether now for the experiment. DID YOU DO ALL THAT BEFORE YOU USED YOUR ETHER??????????????????YES OR NO??????????????????????
@@johnblacksuperchemist2556 Ok i will tell you wwhat happen,,,,i was a idiot and trow pseudoefedrine in nh3 and i was adding litium...It was in i cold dry ice bath.....im a idiot i ruined reaction pseudo did not disolve in nh3....and i was having problem with the smell nh3 was realy smely my uncle was pissed off.....I kNow what you tell me to dry dietyl ether but the formula contain oxygen at the end of the formula and i need to remove oxygen from pseudo....can i used toluen instead...and if i disolve pseude in tolune and addnh3 and add litium what is the by prodyct that will be in meth ....i need a pure product.
Perhaps this sad man was using iron filings instead of hydrogenated reduced iron powder. The more limited surface area inhibits complete reduction of the nitro group.
Martin ter Haar....... I think Alex makes a GREAT point. The metal needs activated. I am GUESSING he means to get some iron oxide powder and heat it in a tube while running hydrogen over it to reduce it to iron and activate it and give it more surface area. Just guessing again but maybe if you make the iron from a metathesis reaction by adding a more reactive metal into an aqueous solution of iron salt. This will make the more active metal go into solution and precipitate out VERY small particles of iron giving it more surface area and activating it more. Or maybe make the iron from electrolysis. This usually makes fine particles also. Just all guesses really. KEEP IN MIND I have never done the reaction before
@@alexredacted2123 .......How do you make hydrogenated reduced iron powder????? I am GUESSING you mean to get some iron oxide powder and heat it in a tube while running hydrogen over it to reduce it to iron and activate it and give it more surface area?????
@@johnblacksuperchemist2556 Yes it starts from iron oxide. I'm not sure what kind of pressure is needed. It's available online but that spoils the fun of making it yourself. Perhaps NurdRage's pyrophoric iron via the oxalate would work just as well.
Mohamad............Yes you can but it will NOT be worth it. And it will take forever to get any quantity and then another lifetime to purify it from distillation. The best way would be to buy some sodium benzoate on line or in a store that sells products to help you preserve food.. Since it is just a food preservative you can buy as much as want. Then take the sodium benzoate and do a soda lime decarboxylation. Here is a video where i talk about that reaction ua-cam.com/video/mbMsPPSxlT8/v-deo.html Here is a video of someone doing a soda lime decarboxylation of sodium benzoate to make benzene ua-cam.com/video/X10VZeQmFDo/v-deo.html
@@mohamadwehbe9246 ............There is only one benzene. Yes you could make p2p from benzene but it would take a few reactions to get there. OK if you want p2p you need a better starting material. Can you easily get any of these chemicals.....................toluene or benzaldehyde or benzyl chloride or benzyl alcohol or any benzyl ester or benzoyl chloride or phenyl acetic acid or 1_phenyl_2_propanol or allylbenzene??????????????????? Cause if you can not get any of the chemicals i just mentioned then you will need to make 1 or 2 from the list before you make the p2p.
JOHN BLACK SUPER CHEMIST ... yes i can easily get benzyl chloride, or benzaldehyde , the thing is i want to make p2p but with a short time , i saw reaction that can take 24 h to make p2p , i saw grignard reaction also , if you have a simple way to make p2p , i really appreciate it . Or if u can lead me to a simple way to do it. thank you very much
@@mohamadwehbe9246 .............With either starting material you could make p2p in 2 reactions. If you have benzyl chloride you could react it with acetaldehyde to make 1_phenyl_2_propanol. Then oxidize the 1_phenyl_2_propanol with either chromyl chloride or PCC or KCC or hypochlorous acid(bleach) to make p2p. So the hard to get chemical would be acetaldehyde. Now if you start with benzaldehyde you could react it with nitroethane and make p2np which is called 1_phenyl_2_nitropropene. Then use iron and HCl to reduce the p2np in to p2p. So the hard to get chemical would be nitroethane. I WOULD SUGGEST the benzaldehyde method because benzyl chloride is some NASTY stuff. Also chromyl chloride and PCC and acetaldehyde are nasty chemicals. If you really want to give it a try you would have to make some precursors. Pick which method you want to do and FIRST i will walk you threw each precursor to make. Then when you got all the precursors made i will help you with the 2 main reactions to make p2p if you want. Again i would SUGGEST method 2 using the benzaldehyde but it is up to you. WHich method do you want to try??????????????????
TheDoctor.........Must be some of the last of their toluene in stock. When i go to Ace hardware dot com they do not even sell it their anymore. I haven't seen it on their computer site for a couple years now
@@johnblacksuperchemist2556 I know you hate me for saying this but eBay you would not believe some of the stuff I as well as lasting connections on supplies from good old eBay
The shceme shows: p2np---> p2p p2p ----> amphetamine I don't understand. If the goal is amphetamine, just reduce the p2np with HgCl2. No need for the extra step. You'd go strait to amphetamine, in fact this is the easiest method. The only thing you do by converting the nitropropene into the ketone Is lower your total yeild of amine and waste precious Nitroethane. I'm not saying it won't work, but it's pointless. And no, iron chloride and nitropropene's don't ever yeild amine. That only works on aromatic nitrates. Even if it does work then it's very low yeilding. And an overhead stirrer? Too complex, magnetic stirring works just fine. And come on! 1.4g of product from 150ml of benzene is not a 40% yeild! Not by a long shot! Do you have any citations? That would make all of this much easier to believe.
Wasp..............First of all the goal is not amphetamine. The goal is learning chemistry. Secondly i did mention in the video that p2np could be turned directly into amphetamine. The example of how to do that was electrolysis. I really do not know how to use HgCl2 to react with a nitroalkene. BUT THANK YOU FOR THE TIP. I will look into it. Thirdly i have never done the experiment mentioned in the video and do not know any one has done it personally. So it is a guess somewhat. But i do believe it will work. And as for you saying that a nitroalkene can not be reduced to an amine is just crazy talk. I can show you a hundred papers that say you can reduce nitro groups and nitro alkene groups to a saturated amine. Go to this link and scroll down to "REDUCTION TO AMINES" and then look at the second paragraph labeled "α,β-Unsaturated nitro compounds can be reduced to saturated amines by" and read it en.wikipedia.org/wiki/Reduction_of_nitro_compounds And also you may be wrong about not needing an over head stirrer. I may be wrong but that is a lot of solids to stir.......meaning the metal iron. You must have a SUPER STRONG magnetic stirrer. KEEP IN MIND...........Using metal/acid on a nitro alkene will be reduced to an amine if there is NO methyl group on the one side of the nitro group. Now this next sentence is somewhat of a guess but...............If there is a methyl group then the nitro alkene is reduced to a saturated ketone. Now you say that a yield of 1.4 grams from using 150 mL of benzene is not a 40% yield. First of all i NEVER said that in this video. You are getting that from another video called "P2P SYNTHESIS via Mn(III) coupling. And in that video the LIMITING reagent is NOT benzene it is the Mn(III)triacetate. So when figuring out the yield you would start from the Mn(III) reagent and NOT the benzene reagent. And so YES THE YIELD IS 40%. In that video benzene was added in EXCESS to combat over alkylation and so it can NOT be used to figure out the yield. And finally your last comment/question. I have NO papers/citations/or college diploma. In high school i stopped going half way threw 11th grade and i did not go for 12th grade either but they gave me a diploma anyways. No kid left behind ......that slogan to most people means they will teach every kid and not let him fail. To me......it means if you fail they will just give you a diploma any ways. So i do have a high school diploma but i did not earn it. If you have any more questions please let me know
Wasp...........Here is my guess on the mechanism of a nitro group (alkyl or aryl) being reduced to an amine group. Tell me what you think of it. Do you think my guess is right or NOT??????? What is your guess?????? ua-cam.com/video/774gFSoJg9w/v-deo.html
part 1 www.bitchute.com/video/ONHBuflfcuqC/ part 2 www.bitchute.com/video/1Hjm356LwMjM/ part 3 www.bitchute.com/video/lU3TxHigJtId/ part 4 www.bitchute.com/video/tkj1qKGumzzG/ part 5 www.bitchute.com/video/HxShmngoE16z/ part 6 www.bitchute.com/video/rH9STXLt2ySS/ part 7 www.bitchute.com/video/S4iq9YPMHgNo/ part 8 www.bitchute.com/video/j4tVrqbuwp4J/ AND THEN THESE 3 VIDEOS part 1 www.bitchute.com/video/43YEUphAG5Mv/ part 2 www.bitchute.com/video/FBGDNJxWgltY/ part 3 www.bitchute.com/video/2WojhgIQSXTV/ AND IF YOU ARE CURIOUS ABOUT THE GREEN DEAL AND WHO IS REALLY CONTROLLING THAT THEN WATCH MY MOST RECENT 3 VIDEOS CALLED "IS GREEN REALLY BEING GREEN" THE REST OF THE VIDEOS ARE UNIMPORTANT
Helional to enamine intermediate then oxidative cleavage to yield Mdp2p. Then MDP2P reductive animation to MDMA. This reaction doesn't seem to be well known. Surprising because all it's reagents are readily available and the yields are quantitative. Maybe I know a secret that others don't but now the world knows
I’ve been curious about this route. What’s the best place to find information?
I've never heard of this, very interesting. Thanks for sharing!
@@BigMyz I have an answer, but YT isn't letting me post the link, or even the term to Google, lol.
I've done it
at 7:20 you said "the more you screw it, the more snug it gets" but in my experience, the more you screw it, the looser it gets. Just throwing it out there.
John, you can buy teflon overhead stir bars as well as a 24/xx adapter they fit in for about $25 total, please don't try making such a contraption with glass rods lol. I've had success driving such stirrers with a corded drill as you describe, you'd be better served building a wooden mount for such a heavy motor but 3 clamps on the reaction flask pole will do the job with enough tweaking.
Also, have you ever synthesized nitroethane? I've tried a few routes but wasn't satisfied with any of them. It condenses very nicely with furfural, which is good because I wouldn't ever want to possess EtNO2 and benzaldehyde (or piperonal, or anisaldehyde...) at the same time.
anisaldehyde = 4-methoxy = Dr.Death
@@martinterhaar3287 That's precisely my point. Anethole and anisaldehyde are intrinsically linked to the clandestine manufacture of MDxx and can themselves be worked up into questionably legal """""""analogues""""""" of MDxx. So if you like exploring the chemistry of rings with tails it's wise to forgo phenyl rings altogether whenever possible, in the event that the blue boyz kick in your door to just make sure you're not having TOO much fun with your chemistry set.
Alex .......I will have to look into the teflon overhead stir bars like you said. Does sound alot better. No never made nitroethane yet but i am drying out some silver nitrite i made and as soon as i get off my lazy a$$ i will make some nitroethane. I am using silver nitrite / diethyl ether / and ethylbromide in a metathesis type reaction. Did you try that route yet (victor meyer reaction)??? I been planning on making some furfural for like forever. I even bought some xylose like 3 years ago.
@@johnblacksuperchemist2556 Victor Meyer is probably the best route on a prep scale, I had success with it but my percent yield was worse than ChemPlayer despite running it twice as big. Antoncho's sodium ethylsulfate method worked as well, but if I ever try that again I'm gonna make a giant buchner funnel because the procedure involves filtering literal gallons of calcium slop. My next attempt will be ethyl bromide and sodium nitrite dissolved in ethylene glycol.
Alex..........let me know how good it works with ethylene glycol as the solvent. I was thinking of trying 1,4 dioxane but first i am going to do it like chem player and just use diethyl ether
i came across this method its similar but uses no methanol will this work?: Phenyl-2-nitropropene (10 g, 61 mmol) was dissolved in 75 ml HOAc and slowly dripped into a refluxing slurry of Fe powder (32 g, 0.57 mol) in 140 ml HOAc. The mixture turned brownish and foamy, and the mixture was refluxed on low heat for 1.5 h. The reaction mixture was poured into 2000ml water, and was extracted with 3x100 ml CH2Cl2. The combined extracts was washed with 2x150 ml H2O and dried over MgSO4. The solvent was distilled off, and the residue distilled under vacuum to give phenyl-2-propanone in 75% yield.
Ricardo...........Seriously i do not even know if the method i mentioned in the video works. MY GUESS..........I do not think the methanol is REQUIRED. But using a weak acid like acetic acid might not work to good. What i would do first is take some acetic acid and and throw some iron into the acetic acid. If it bubbles a lot from making hydrogen then i would say it might work. If it barely bubbles from making hydrogen then i would say your method probably wont work. But this is all just guesses. Usually if i do a video with NO experiment ...like the video above......that means i have not personally done the experiment.
Fuck your the man my bro l wish you lived in New Zealand what an absolute legend you are. love your content. Could listen to you talk about cool chemistry stuff all day 😂
Trent............Thanks buddy. I made 2 other videos like this one. Showing different ways to make p2p with exact instructions. One was a friedel crafts alkylation. And the other was a Mn(III) coupling reaction of acetone and benzene. Check them out
Trent...........................NEW ZEALAND RULES !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Keep it up Brother
Hey budd, how’s it going, i have a question please , may i use nitroethane instead of nitroalkene ? If not , what kind of chemical products i can use instead of nitroalkene that is available in the market ? Thank you
Mohamad...........You can use a phenyl nitro alkene OR phenyl nitro alkane OR phenyl oxime to directly make P2P. None are readily available in the market. You have to make the precursors
JOHN BLACK SUPER CHEMIST .... oh , do you know the procedure to make them or any link that can help me make nitro alkene ? Thanks alot
@@mohamadwehbe9246 ..............Go to this video and start watching at 8:30 ua-cam.com/video/rpoUe6aIR54/v-deo.html There i am talking about the henry reaction (nitroaldol reaction). Next go to this video where chem player does the henry reaction (nitroaldol reaction) www.bitchute.com/video/zUh0ZIhHc52F/ Now if you want to make p2np then do what chem player did in the video EXCEPT replace the vanillin aldehyde with benzaldehyde and replace the nitromethane with nitroethane and you will make p2np. If you can master his method then i can tell you how to do it a better way and get a better yield using a dean stark apparatus. If you have p2np then you can make p2p in one step by the instructions i give at 4:00 in the video above. Or you can make amphetamine from p2np in one step by either electrolysis or hydrogenation............Let me know if you have any more questions buddy. And your very welcome............Do you have a dean stark apparatus or can you build one?
John whats your p2p recipe
ANOTHER P2P SYNTHESIS.......MAYBE .........Manganese(III)acetate mediated coupling reactions via free radicals. A mixture of Manganese(III)acetate dihydrate (13.4g, 50 mmol), benzene (150ml), acetone (150ml) and glacial acetic acid (250ml) was refluxed under an inert atmosphere (argon, helium or nitrogen) until the dark brown color of manganese(III)acetate changed to the pale pink of manganese(II)acetate (about 90 min). The reaction mixture was partitioned between 400ml ether and 250ml water. The ether layer was separated and washed with 250ml water and with 2x250ml 5% Na2CO3 to remove any remaining acetic acid. The ether was then dried over anhydrous Na2SO4 (or MgSO4), the solvent evaporated and the residue fractionately distilled to recover unreacted benzene, and to give phenyl-2-propanone in 40% yield (1.34g) based on the reacted manganese(III)acetate, which is the limiting reagent in this reaction.
I wonder if the willgerodt on styrene will work
Will Everyday......... What does willgerodt mean?
@@johnblacksuperchemist2556 Sorry John, I mean the Willgerodt rearrangement, there is also a few modifications of the original procedure, namely the Kindler modification. I think the ammonia version run under pressure would be quite interesting. A catalyst tube should take care of the resultant products.
@@willeveryday The condensation releases one mole of H2S and the hydrolysis yields a second, Willgerodt is a fascinating approach but very stinky and very dangerous.
@@alexredacted2123 The danger is almost part of the appeal but I think if performed in a very good gloved fume hood with exhaust gases being scrubbed, the smell and inherent danger involved should be minimised.
@@willeveryday Ah yes, my old pastime, dreaming up the most dangerous preparations of controlled substances my intelligence can muster
Hey i need a question i have c10 h15 NO and i need to transfet to c10 h15 N i need to remove oxigen by doing so calad birch but if i mih dietyl ethar c10 h15 NO which is sudo by the way and add nh3 with litium in it.Formyla of diethyl ethar is (C2H5)2O and im afraid that wil ruin the reaction beaucuse it have ohygen,i have mix ethar with litium and it react werry slovly i can see the little bubles afther some time but ethar was dried...What do you think...I will have by prodyct in metttttttttttttttttth....What do you think can i use some other solvent or?
WHAT IS C10H15NO AND what is C10H15N? Also usually i can understand your post but this one is just to garbled. Can you ask your question again???
@@johnblacksuperchemist2556 C10H15NO is pseudoefedrine and C10H15N is methamphetamine.
markoni............I am not sure what you are saying. But if you want dry ether. AND KEEP IN MIND I HAVE TOLD YOU THIS A FEW TIMES NOW. You need to put it in a sep funnel with some saturated NaCl water. Then take the ether portion and put some anhydrous MgSO4 in it and stir for a while and then filter and distill and keep the portion that comes over at the boiling point of ether. THEN THERE IS ONE MORE STEP IF YOU WANT DRY ETHER!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! There is still trace amounts of water in the ether. TO DRY IT COMPLETELY you throw some small bits of sodium(or lithium) in to the ether. The Na(or Li) will react with any trace amounts of water that is in the ether and make NaOH(or LiOH) and hydrogen. The hydrogen will bubble out of the ether. Wait for it to stop bubbling and throw a little more Na(or Li) chunks in to the ether and wait. WHEN YOU THROW SOME SODIUM(OR LITHIUM) INTO THE ETHER AND THERE IS NO HYDROGEN BUBBLING OUT OF THE ETHER THEN YOU HAVE BONE DRY ETHER. Filter the Na/NaOH(or Li/LiOH) out of the ether and you can use the ether now for the experiment. DID YOU DO ALL THAT BEFORE YOU USED YOUR ETHER??????????????????YES OR NO??????????????????????
markoni........I can not really understand what you are saying when you say you need to get the oxygen out
@@johnblacksuperchemist2556 Ok i will tell you wwhat happen,,,,i was a idiot and trow pseudoefedrine in nh3 and i was adding litium...It was in i cold dry ice bath.....im a idiot i ruined reaction pseudo did not disolve in nh3....and i was having problem with the smell nh3 was realy smely my uncle was pissed off.....I kNow what you tell me to dry dietyl ether but the formula contain oxygen at the end of the formula and i need to remove oxygen from pseudo....can i used toluen instead...and if i disolve pseude in tolune and addnh3 and add litium what is the by prodyct that will be in meth ....i need a pure product.
I once dreamed about a sad man, he was complaining ALL THE TIME that the only thing he got was this oxime thing, wich was a solid en yellow as hell.
Perhaps this sad man was using iron filings instead of hydrogenated reduced iron powder. The more limited surface area inhibits complete reduction of the nitro group.
Martin ter Haar....... I think Alex makes a GREAT point. The metal needs activated. I am GUESSING he means to get some iron oxide powder and heat it in a tube while running hydrogen over it to reduce it to iron and activate it and give it more surface area. Just guessing again but maybe if you make the iron from a metathesis reaction by adding a more reactive metal into an aqueous solution of iron salt. This will make the more active metal go into solution and precipitate out VERY small particles of iron giving it more surface area and activating it more. Or maybe make the iron from electrolysis. This usually makes fine particles also. Just all guesses really. KEEP IN MIND I have never done the reaction before
@@alexredacted2123 .......How do you make hydrogenated reduced iron powder????? I am GUESSING you mean to get some iron oxide powder and heat it in a tube while running hydrogen over it to reduce it to iron and activate it and give it more surface area?????
@@johnblacksuperchemist2556 Yes it starts from iron oxide. I'm not sure what kind of pressure is needed. It's available online but that spoils the fun of making it yourself. Perhaps NurdRage's pyrophoric iron via the oxalate would work just as well.
once I reed a vry interesting article about adream
Thank you for help 🏆🏆🏆 il let you know how that works out
David.............cool
And buddy , can i get benzene (C6H6) from the regular gasoline (example: car fuel 98 octane) through distillation or i can not ?
Mohamad............Yes you can but it will NOT be worth it. And it will take forever to get any quantity and then another lifetime to purify it from distillation. The best way would be to buy some sodium benzoate on line or in a store that sells products to help you preserve food.. Since it is just a food preservative you can buy as much as want. Then take the sodium benzoate and do a soda lime decarboxylation. Here is a video where i talk about that reaction ua-cam.com/video/mbMsPPSxlT8/v-deo.html Here is a video of someone doing a soda lime decarboxylation of sodium benzoate to make benzene ua-cam.com/video/X10VZeQmFDo/v-deo.html
JOHN BLACK SUPER CHEMIST .... and of course this type of benzene that i will get is used to make p2p right or its another type of benzene ?
@@mohamadwehbe9246 ............There is only one benzene. Yes you could make p2p from benzene but it would take a few reactions to get there. OK if you want p2p you need a better starting material. Can you easily get any of these chemicals.....................toluene or benzaldehyde or benzyl chloride or benzyl alcohol or any benzyl ester or benzoyl chloride or phenyl acetic acid or 1_phenyl_2_propanol or allylbenzene??????????????????? Cause if you can not get any of the chemicals i just mentioned then you will need to make 1 or 2 from the list before you make the p2p.
JOHN BLACK SUPER CHEMIST ... yes i can easily get benzyl chloride, or benzaldehyde , the thing is i want to make p2p but with a short time , i saw reaction that can take 24 h to make p2p , i saw grignard reaction also , if you have a simple way to make p2p , i really appreciate it . Or if u can lead me to a simple way to do it. thank you very much
@@mohamadwehbe9246 .............With either starting material you could make p2p in 2 reactions. If you have benzyl chloride you could react it with acetaldehyde to make 1_phenyl_2_propanol. Then oxidize the 1_phenyl_2_propanol with either chromyl chloride or PCC or KCC or hypochlorous acid(bleach) to make p2p. So the hard to get chemical would be acetaldehyde.
Now if you start with benzaldehyde you could react it with nitroethane and make p2np which is called 1_phenyl_2_nitropropene. Then use iron and HCl to reduce the p2np in to p2p. So the hard to get chemical would be nitroethane.
I WOULD SUGGEST the benzaldehyde method because benzyl chloride is some NASTY stuff. Also chromyl chloride and PCC and acetaldehyde are nasty chemicals.
If you really want to give it a try you would have to make some precursors. Pick which method you want to do and FIRST i will walk you threw each precursor to make. Then when you got all the precursors made i will help you with the 2 main reactions to make p2p if you want. Again i would SUGGEST method 2 using the benzaldehyde but it is up to you. WHich method do you want to try??????????????????
Does benzene (C6H6) can be used to make p2p ? Thanks alot 🙏
Mohamad............Yes benzene can be used to make p2p
What about Dimethylbenzene
Found toluene. Ace Hardware. 19 a gallon here.
TheDoctor....are you in the USA or Canada?????
@@johnblacksuperchemist2556 Texas.
TheDoctor.........Must be some of the last of their toluene in stock. When i go to Ace hardware dot com they do not even sell it their anymore. I haven't seen it on their computer site for a couple years now
Sears still has it on their site but i tried to order some like 4 years ago and they said they do not sell it any more.
@@johnblacksuperchemist2556 I know you hate me for saying this but eBay you would not believe some of the stuff I as well as lasting connections on supplies from good old eBay
The shceme shows:
p2np---> p2p
p2p ----> amphetamine
I don't understand.
If the goal is amphetamine, just reduce the p2np with HgCl2. No need for the extra step. You'd go strait to amphetamine, in fact this is the easiest method. The only thing you do by converting the nitropropene into the ketone Is lower your total yeild of amine and waste precious Nitroethane.
I'm not saying it won't work, but it's pointless. And no, iron chloride and nitropropene's don't ever yeild amine. That only works on aromatic nitrates. Even if it does work then it's very low yeilding.
And an overhead stirrer? Too complex, magnetic stirring works just fine.
And come on! 1.4g of product from 150ml of benzene is not a 40% yeild!
Not by a long shot!
Do you have any citations? That would make all of this much easier to believe.
Wasp..............First of all the goal is not amphetamine. The goal is learning chemistry. Secondly i did mention in the video that p2np could be turned directly into amphetamine. The example of how to do that was electrolysis. I really do not know how to use HgCl2 to react with a nitroalkene. BUT THANK YOU FOR THE TIP. I will look into it. Thirdly i have never done the experiment mentioned in the video and do not know any one has done it personally. So it is a guess somewhat. But i do believe it will work. And as for you saying that a nitroalkene can not be reduced to an amine is just crazy talk. I can show you a hundred papers that say you can reduce nitro groups and nitro alkene groups to a saturated amine. Go to this link and scroll down to "REDUCTION TO AMINES" and then look at the second paragraph labeled "α,β-Unsaturated nitro compounds can be reduced to saturated amines by" and read it en.wikipedia.org/wiki/Reduction_of_nitro_compounds
And also you may be wrong about not needing an over head stirrer. I may be wrong but that is a lot of solids to stir.......meaning the metal iron. You must have a SUPER STRONG magnetic stirrer.
KEEP IN MIND...........Using metal/acid on a nitro alkene will be reduced to an amine if there is NO methyl group on the one side of the nitro group. Now this next sentence is somewhat of a guess but...............If there is a methyl group then the nitro alkene is reduced to a saturated ketone. Now you say that a yield of 1.4 grams from using 150 mL of benzene is not a 40% yield. First of all i NEVER said that in this video. You are getting that from another video called "P2P SYNTHESIS via Mn(III) coupling. And in that video the LIMITING reagent is NOT benzene it is the Mn(III)triacetate. So when figuring out the yield you would start from the Mn(III) reagent and NOT the benzene reagent. And so YES THE YIELD IS 40%. In that video benzene was added in EXCESS to combat over alkylation and so it can NOT be used to figure out the yield. And finally your last comment/question. I have NO papers/citations/or college diploma. In high school i stopped going half way threw 11th grade and i did not go for 12th grade either but they gave me a diploma anyways. No kid left behind ......that slogan to most people means they will teach every kid and not let him fail. To me......it means if you fail they will just give you a diploma any ways. So i do have a high school diploma but i did not earn it. If you have any more questions please let me know
Wasp...........Here is my guess on the mechanism of a nitro group (alkyl or aryl) being reduced to an amine group. Tell me what you think of it. Do you think my guess is right or NOT??????? What is your guess?????? ua-cam.com/video/774gFSoJg9w/v-deo.html
part 1 www.bitchute.com/video/ONHBuflfcuqC/
part 2 www.bitchute.com/video/1Hjm356LwMjM/
part 3 www.bitchute.com/video/lU3TxHigJtId/
part 4 www.bitchute.com/video/tkj1qKGumzzG/
part 5 www.bitchute.com/video/HxShmngoE16z/
part 6 www.bitchute.com/video/rH9STXLt2ySS/
part 7 www.bitchute.com/video/S4iq9YPMHgNo/
part 8 www.bitchute.com/video/j4tVrqbuwp4J/
AND THEN THESE 3 VIDEOS
part 1 www.bitchute.com/video/43YEUphAG5Mv/
part 2 www.bitchute.com/video/FBGDNJxWgltY/
part 3 www.bitchute.com/video/2WojhgIQSXTV/
AND IF YOU ARE CURIOUS ABOUT THE GREEN DEAL AND WHO IS REALLY CONTROLLING THAT THEN WATCH MY MOST RECENT 3 VIDEOS CALLED "IS GREEN REALLY BEING GREEN" THE REST OF THE VIDEOS ARE UNIMPORTANT