Go to ground.news/Labcoatz to see how any news story is being framed by news outlets around the world and across the political spectrum. Use my link to get 50% off unlimited access with the Vantage Subscription.
Mate congrats on the 100k subs! Your little self-aware text remarks had rolling. The troll face on the drug lab test results was *chefs kiss* very enjoyable watching your borderline legal videos
Make pseudoephedrine next to tell DEA (and FDA) it's dumb to restrict it. EDIT: Nice that google's first autocomplete result is propylhexedrine abuse...
@@norbert.kiszka it *has the potential* to be converted into MDMA or meth. But so do the rest of the chemical elements in meth. Our DEA likes to make chemicals illegal without trying to help the people struggling with addiction. So yeah they just keep making more and more basic level chemicals illegal.
@@norbert.kiszka It's legal here too, can buy it at any pharmacy. You're just limited in the amount you can buy per month and you have to give your ID, which gets run through a centralized database to make sure you're not just running from pharmacy to buy more than you're supposed to
It's a fully scheduled drug in my state, meaning you need a doctor's prescription for it no matter what and can't get it OTC or from the pharmacist. And yet, meth is still a huge problem here and has actually gotten worse since the pseudo-ban (pun intended). Shocker 🙄
If you ever get around to doing an Amalgam reduction again, I'd love to see you do a Galinstan/Al alloy one. There's a post on science madness about it, it seems to work great and it's non toxic.
I believe the biggest issue was the impurities produced via the Henry reaction (it is well-known to be one of the dirtiest synthetic pathways, with enough unique impurities carrying through to the final product to allow for forensic fingerprinting), as well as the side-products formed from the uncontrolled LiAlH4 reduction. As an alternative route, you should really try doing a Grignand reaction with acetonitrile and the (bromomethyl)cyclohexane, which would allow you to directly reduce the formed imine to the primary amine in one pot. If you manage to exclude water, oxygen and CO2 (which excess Grignard reagent will also help to scavenge down to PPM levels if you seal the apparatus with something like a balloon), then this pathway will produce much a cleaner and easily crystallizeable primary amine: After the Grignand reaction is finished, cool down the resultant ether solution to around 0°C in an ice bath. Then, while still minimizing exposure to the atmosphere, you just need to slowly add some LiAlH4 or borohydride, with stirring and cooling.
Lol. There were two statements in here that will take this video down in a flash *when u say then that refuses or converts to anfetamine [purposefully spelled that wrong] Great video!
I remember when ChemPlayer got banned for making _precursors._ I know that drug chem (and energetics) gets the views, but I really hate seeing quality chem channel after quality chem channel go the way of the dodo.
True, but ChemPlayer was also dabbling with more extreme precursors, like phenylacetone. UA-cam chemistry is always a bit of a gamble, but as long as things stay legal (and far enough away from illegal drugs), things tend to go alright!
Only primary amines like norpropylhexedrine can form the necessary imine intermediate that is reduced to propylhexedrine. It's not impossible for n-methylpropylhexedrine to form, but it is very unlikely.
you could try crystallizing out the amine salt using oxalic or fumaric acid. fumaric being the better choice for human consumption tho. dont ask how i know. (dissolve product freebase in ether, and drip in fumaric acid dissolved in MeOH, or oxalic dissolved in acetone)
Avoid Al/Hg. Make an Al melt and make some pirate Raney nickel. It's not near as flammable as you might believe. I usually add some Zn as a promoter. Get a crucible and propane furnace and melt some beer cans. Thank me later.
I do not want to donate on multiple patreons, that is expensive and difficult. It's better if you were on Nebula, that way I could easily support you and other creators I love. Please I beg you.
Nitropropenes are kinda sensitive to pH, so it could've messed things up. I doubt cyclohexylamine caused the precipitation problem...when making P2NP for real amphetamine, it is often used as the catalyst in the same way!
@LabCoatz_Science yeahhh, I forgot about the alkene, was picturing a nitroalkane. AcOH buffer with an amine should be ~7, though, so I'd guess you'd at least get purer material using the acetate salt as the catalyst. Nice video, btw!
UA-cam is such a pain, they HATE chemistry yt, like you. Yeah they go back on their own policies a lot, even to the point of reviewing their policies case by case to never be wrong. They love pointing the finger but hate looking in the mirror. Well here we are, yt. Your mirror.
If you don't make drugs or energetics, they seem pretty chill with most things. But the moment you make things that go boom or things that are ostensibly intended for ingestion, that's where their harm reduction policies kick in. And it does make sense, the last thing you want to be doing is encouraging people to potentially harm themselves, others, or property.
Go to ground.news/Labcoatz to see how any news story is being framed by news outlets around the world and across the political spectrum. Use my link to get 50% off unlimited access with the Vantage Subscription.
Bro, can you do a course of oxytocin? And LSD,
6:30 As a fellow organic chemist.....
"So you decided on madness and then eventual suicide the long way around."
Careful, That Manchild might contact your family and their associates on you...
😂
we're so back (on the watchlist)
LabCoatz: “UA-cam, this is completely legal you have no recourse to age restrict or demonetize”
UA-cam: “and I took that personally”
It pays to remember that UA-cam is a global platform, and what is "technically legal" in one country can be very much an illegal analogue in others.
I would have just put a label on the specimen jar, peed in it, and added a drop haha.
THE GOVERNMENT HATES HIM FIND OUT THIS MAN STAYS AWAKE FOR 7 DAYS STRAIGHT
Mate congrats on the 100k subs! Your little self-aware text remarks had rolling. The troll face on the drug lab test results was *chefs kiss* very enjoyable watching your borderline legal videos
Oh boy we made it to the list now!
Make pseudoephedrine next to tell DEA (and FDA) it's dumb to restrict it.
EDIT: Nice that google's first autocomplete result is propylhexedrine abuse...
IDK how it's in USA, but in Poland pseudoephedrine is 100% legal and You can buy it everywhere.
@@norbert.kiszka it *has the potential* to be converted into MDMA or meth. But so do the rest of the chemical elements in meth. Our DEA likes to make chemicals illegal without trying to help the people struggling with addiction. So yeah they just keep making more and more basic level chemicals illegal.
@@norbert.kiszkaIts very restricted, due to people using to to make meth. You can get it OTC, but its a pain
@@norbert.kiszka It's legal here too, can buy it at any pharmacy. You're just limited in the amount you can buy per month and you have to give your ID, which gets run through a centralized database to make sure you're not just running from pharmacy to buy more than you're supposed to
It's a fully scheduled drug in my state, meaning you need a doctor's prescription for it no matter what and can't get it OTC or from the pharmacist. And yet, meth is still a huge problem here and has actually gotten worse since the pseudo-ban (pun intended). Shocker 🙄
12:12 "As with most of life's problems, this was readily overcome with a healthy dose of acid" lmfao
I rarely let ad reads play, but you’re on my cool people list.
If you ever get around to doing an Amalgam reduction again, I'd love to see you do a Galinstan/Al alloy one. There's a post on science madness about it, it seems to work great and it's non toxic.
I believe the biggest issue was the impurities produced via the Henry reaction (it is well-known to be one of the dirtiest synthetic pathways, with enough unique impurities carrying through to the final product to allow for forensic fingerprinting), as well as the side-products formed from the uncontrolled LiAlH4 reduction.
As an alternative route, you should really try doing a Grignand reaction with acetonitrile and the (bromomethyl)cyclohexane, which would allow you to directly reduce the formed imine to the primary amine in one pot.
If you manage to exclude water, oxygen and CO2 (which excess Grignard reagent will also help to scavenge down to PPM levels if you seal the apparatus with something like a balloon), then this pathway will produce much a cleaner and easily crystallizeable primary amine: After the Grignand reaction is finished, cool down the resultant ether solution to around 0°C in an ice bath. Then, while still minimizing exposure to the atmosphere, you just need to slowly add some LiAlH4 or borohydride, with stirring and cooling.
Congrats on 100k!
Propylhexedrine is a scheduled drug in Canada
That's why NileRed never made it
Watching this before it goes down 😂
I downloaded it just in case lmao
Dido lmao
Lol. There were two statements in here that will take this video down in a flash
*when u say then that refuses or converts to anfetamine [purposefully spelled that wrong]
Great video!
@@thengspjo4716same
Haha that is how these kind of synthesis usually go :D I completly feel your frustration.
Say my name
Thy lab's...
your god dam right
now that's a... rewarding... synthesis ;)
I remember when ChemPlayer got banned for making _precursors._ I know that drug chem (and energetics) gets the views, but I really hate seeing quality chem channel after quality chem channel go the way of the dodo.
True, but ChemPlayer was also dabbling with more extreme precursors, like phenylacetone. UA-cam chemistry is always a bit of a gamble, but as long as things stay legal (and far enough away from illegal drugs), things tend to go alright!
Thanks you❤❤
So much relief when I saw you using a testing kit instead of taste testing it this time Lol
Super intresting.glad you put this video on.🙂
Doesn't regular table salt contain iodine. And is it in large enough quantities to even make a difference.
It won't make a difference. If anything, there might be a few milligrams of propylhexedrine hydroiodide with the hydrochloride.
If you have a less...expensive imine available, I would be curious if the reduction could be done with Al/Ga instead of Al/Hg.
I was thinking about that yesterday, lol
Next time use AcOH in the Henry, it really helps.
Also how can you be sure no dimethyl product formed due to the big excess?
Only primary amines like norpropylhexedrine can form the necessary imine intermediate that is reduced to propylhexedrine. It's not impossible for n-methylpropylhexedrine to form, but it is very unlikely.
you could try crystallizing out the amine salt using oxalic or fumaric acid. fumaric being the better choice for human consumption tho. dont ask how i know.
(dissolve product freebase in ether, and drip in fumaric acid dissolved in MeOH, or oxalic dissolved in acetone)
That was a great video I like to see the failures and successes.
I would try to do a TLC from product to see if another column could help further purifying it.
Avoid Al/Hg. Make an Al melt and make some pirate Raney nickel. It's not near as flammable as you might believe. I usually add some Zn as a promoter.
Get a crucible and propane furnace and melt some beer cans. Thank me later.
very nice video!
Eh, platinum dioxide's too difficult to keep wet.
lol I'd 100% be like "please do NOT credit me for the nitroethane"
It’s manufactured by reacting methamphetamine with palladium
I do not want to donate on multiple patreons, that is expensive and difficult. It's better if you were on Nebula, that way I could easily support you and other creators I love. Please I beg you.
Unfortunately, Nebula is an invite-only platform (AFAIK), so one couldn't just upload on it freely.
8:50 why not wash with aq acid? Can't imagine you'd get all the cyclohexylamine out under basic conditions? Could be why it didn't crystallize well?
Nitropropenes are kinda sensitive to pH, so it could've messed things up. I doubt cyclohexylamine caused the precipitation problem...when making P2NP for real amphetamine, it is often used as the catalyst in the same way!
@LabCoatz_Science yeahhh, I forgot about the alkene, was picturing a nitroalkane. AcOH buffer with an amine should be ~7, though, so I'd guess you'd at least get purer material using the acetate salt as the catalyst. Nice video, btw!
Much, much easier to make the other thing good old Birch reduction.
08:07 Normally huh? Okaaay
17:46 you might have forgotten to hydrogenate your phenyl-ring. Just fyi.
Just when you think you're ready to post...
Get assistance from Nile Red he can turn nothing into something and even manage to not piss off the government in general and the DEA specifically.
Legalize, regulate, and tax ALL DRUGS!!!
Cooking time
Please, I beg you, can I convince you and your fellow chemist youtubers tto start uploading on Nebula? Pretty please?
NileRed is on Nebula, but I think you have to be invited?
UA-cam is such a pain, they HATE chemistry yt, like you. Yeah they go back on their own policies a lot, even to the point of reviewing their policies case by case to never be wrong. They love pointing the finger but hate looking in the mirror. Well here we are, yt. Your mirror.
If you don't make drugs or energetics, they seem pretty chill with most things. But the moment you make things that go boom or things that are ostensibly intended for ingestion, that's where their harm reduction policies kick in. And it does make sense, the last thing you want to be doing is encouraging people to potentially harm themselves, others, or property.
Healthy dose of acid? Like, 3 maybe 4 hits😂
I sent you a DM on discord.
It is still illegal to manufacture propylhexedrine
Not the way I did it in the USA!
@@LabCoatz_Science If only the World Wide Web was not world wide, eh?