When to prescribe Medications for Obesity ?

The role of Pharmacotherapy in Obesity management in 2024
00:13 🩺 Obesity is becoming increasingly prevalent in women's health, impacting conditions like PCOS and metabolic syndrome, necessitating early intervention.
00:54 🧬 Genetic factors and intrauterine environment play significant roles in predisposing individuals to obesity.
03:27 🩸 Puberty presents challenges in obesity management due to hormonal changes and increased insulin resistance.
04:08 🛌 Environmental factors such as improper sleep, lack of exercise, and obstructive sleep apnea contribute to chronic weight gain.
05:20 🩺 Endocrinological disorders such as hypothyroidism, PCOS, and Cushing's syndrome must be considered in obesity management.
06:44 🧠 The brain, gut, and endocrine system play crucial roles in obesity, with the brain's control over homeostatic, hedonic, and executive functions being particularly significant.
08:12 🍽️ Distinguishing between stomach hunger and head hunger is essential to understand the psychological aspect of overeating.
10:01 🍔 Hormones like ghrelin and peptides YY regulate hunger and satiety, while dopamine and opioid pathways drive pleasure in eating.
12:19 🧠 Executive function plays a vital role in self-regulation of eating habits, although it's challenging to control.
14:25 ⚖️ Weight loss is not linear; it requires a gradual, stepwise approach to adaptation and maintenance to prevent metabolic handicap.
16:18 💊 Pharmacotherapy for weight loss is indicated for individuals with BMI over 30 or over 25 with complications, showing effectiveness comparable to bariatric surgery.
17:55 💊 Pharmacotherapy for obesity management is increasingly effective and evolving over time.
18:10 🌱 In India, pharmacotherapy for weight loss has lower weight indication thresholds compared to Western guidelines.
18:52 💊 Only two drugs are approved for weight loss in India: orlistat and semaglutide.
19:35 🔄 Injectable semaglutide 2.4 mg isn't available in India yet, but oral semaglutide can be used off-label for weight loss.
20:19 🧠 Serendipity led to the discovery of GLP-1 receptor agonists for weight loss, originally developed for diabetes management.
21:43 🍽️ GLP-1 receptor agonists like semaglutide reduce food-seeking behavior and cravings, leading to weight loss.
23:04 📊 Clinical trials demonstrate significant weight loss with GLP-1 receptor agonists, especially in women and in conditions like PCOS.
25:04 💉 Semaglutide is available in oral, injectable for diabetes and injectable for weight loss (Vovi) forms, with only oral available in India currently.

[@deepthikondagari9813]

Excellent presentation

[@EndocrinologyIndia]

Thank you

[@kamalkiran4644]

Excellent Presentation Sir. You are much ahead of your time and in the long term you will build a legacy. Combination of AI Technology with your Medical Knowledge will be a boon for our country. This Vdo should be made in different languages & reach the bottom. You have done a thorough research and this will help to tackle the obesity tsunami that is foreseen. Most sad thing is there are lakhs patients like me who dont even know what is going on in their body & even medical fraternity in our country has low knowledge on it. .

[@EndocrinologyIndia]

Thank you so much

[@EndocrinologyIndia]

🎯 Key Takeaways for quick navigation:
00:13 *🩺 Obesity is becoming increasingly prevalent in women's health, impacting conditions like PCOS and metabolic syndrome, necessitating early intervention.*
00:54 *🧬 Genetic factors and intrauterine environment play significant roles in predisposing individuals to obesity.*
03:27 *🩸 Puberty presents challenges in obesity management due to hormonal changes and increased insulin resistance.*
04:08 *🛌 Environmental factors such as improper sleep, lack of exercise, and obstructive sleep apnea contribute to chronic weight gain.*
05:20 *🩺 Endocrinological disorders such as hypothyroidism, PCOS, and Cushing's syndrome must be considered in obesity management.*
06:44 *🧠 The brain, gut, and endocrine system play crucial roles in obesity, with the brain's control over homeostatic, hedonic, and executive functions being particularly significant.*
08:12 *🍽️ Distinguishing between stomach hunger and head hunger is essential to understand the psychological aspect of overeating.*
10:01 *🍔 Hormones like ghrelin and peptides YY regulate hunger and satiety, while dopamine and opioid pathways drive pleasure in eating.*
12:19 *🧠 Executive function plays a vital role in self-regulation of eating habits, although it's challenging to control.*
14:25 *⚖️ Weight loss is not linear; it requires a gradual, stepwise approach to adaptation and maintenance to prevent metabolic handicap.*
16:18 *💊 Pharmacotherapy for weight loss is indicated for individuals with BMI over 30 or over 25 with complications, showing effectiveness comparable to bariatric surgery.*
17:55 *💊 Pharmacotherapy for obesity management is increasingly effective and evolving over time.*
18:10 *🌱 In India, pharmacotherapy for weight loss has lower weight indication thresholds compared to Western guidelines.*
18:52 *💊 Only two drugs are approved for weight loss in India: orlistat and semaglutide.*
19:35 *🔄 Injectable semaglutide 2.4 mg isn't available in India yet, but oral semaglutide can be used off-label for weight loss.*
20:19 *🧠 Serendipity led to the discovery of GLP-1 receptor agonists for weight loss, originally developed for diabetes management.*
21:43 *🍽️ GLP-1 receptor agonists like semaglutide reduce food seeking behavior and cravings, leading to weight loss.*
23:04 *📊 Clinical trials demonstrate significant weight loss with GLP-1 receptor agonists, especially in women and in conditions like PCOS.*
25:04 *💉 Semaglutide is available in oral (Rebels), injectable for diabetes (OIC), and injectable for weight loss (Vovi) forms, with only oral available in India currently.*
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