Hey Chad, Just wanna say Ive watched all of your o chem and gen chem vids and you have been my main source of studying for 3 semesters. Thank you so much and god bless you
Hi Chad! I have been following your videos since gen chem and they have been really helping me, my next chemistry course is biochemistry, are you planning on making videos on the subject? If yes that would be truly helpful!
😂😂😂 I had to go back and watch the video to understand your comment...I really thought you were implying something else. You put a smile on my face! Happy Studying!
First, thank you so much for your videos. Second, how did you find the chair conformation at 17:05? I've been struggling with those, do you have a video that explains them better?
Hey! Wouldn't a build-up of a negative charge on the beta carbon repulse the oxygen that's trying to bind to it? I'm unsure if I understand the reasoning behind the E2 w/bad leaving group's mechanics.
does anyone know if these are the same videos that are included in his 'premium' on the website? want to sign up, but if these are the same vids I'm going with the standard $90 vs the $180. Thanks
Maybe I missed it, but why did you show the chair configurations when explaining out the example with the cyclohexane? I didn't understand the connection.
The beta hydrogen and the leaving group have to be antiperiplanar (~180 degrees apart) for the E2 mechanism to be possible. For cyclohexane, this is only possible when the beta hydrogen and the leaving group are trans-diaxial. We show the chair conformation to demonstrate that the E2 reaction is only possible for one of the chair conformations, and we show that it is only a trans-beta hydrogen that can be antiperiplanar to the leaving group. Hope this helps!
For the last problem (with fluorine as a bad leaving group), will you still form the Zaitsev product with a double bond between the secondary and alpha carbons? I get confused when determining how many products will be formed.
With fluorine being a bad leaving group you will still get both the Zaitsev (more substituted) and Hofmann (less substituted) products, it's just that the Hofmann will be the major and the Zaitsev the minor. Hope this helps!
My teacher taught me that a bulky base is a must for E2 reactions, so seeing you use NaOH in the first example was confusing. Couldn't that reaction also be SN2? or is it not because of the fact that the H is shown?
He never mentioned that bulky bases sometimes go for the (anti zait) carbon and result in the Hofmann product. To be fair he never mentioned Hofmann product at all.
Jus read up on some differences between SN2 and E2. It seems to me that the presence of the antiperiplanar H causes the E2 reaction to dominate. A response would be still be appreciated. Thank you for the videos btw!
Hello TopperGames! First, make sure to go with exactly how your teacher presents this material. SN2 and E2 reactions are almost always a little more complicated than any textbook or professor makes them out to be. But we typically like giving students nice steadfast rules. The problem is they're really more like trends and there are commonly exceptions to the trends, but how do you teach that to students in a way that you can expect them to know for the exam? It's difficult and as a teacher there are some options about how simplified a view of reality to present. I try to go pretty far down this rabbit hole so that it is useful for just about any student, but it sounds like your teacher is going with a little simpler view which is common. So don't think your teacher is teaching it wrong, he or she is actually doing you a favor! If you look at lesson 7.7 I really try to spell out how you distinguish between SN1, SN2, E1, E2 reactions. And while I include a fair amount of detail even I simplify it some. But the truth is that you don't 'need' a bulky base to make sure E2 happens over SN2, but it is a way to accomplish exactly that. However, for a tertiary halide it wouldn't be necessary as SN2 is not even possible. And it turns out that SN2 is typically pretty slow for most secondary halides too and even with a strong base that is not bulky, E2 is often preferred (E2 major, SN2 minor). But for primary halides SN2 is usually preferred (SN2 major, E2 minor) and for methyl halides only SN2 is possible. I don't believe I cover it (possibly a quick mention but maybe not) but the solvent can have an impact as well. For small nucleophiles (atoms from period 2) like oxygen they will be more likely to act as a base than a nucleophile if a polar protic solvent is used which thus favors E2 over SN2 also. This is much more likely to be left out of the discussion in most textbooks and classes which is why I opted to not address it either. Definitely take a look at lesson 7.7, but at the end of the day go with the rules presented by the one administering your test!👍
My apologies Garett! I cover E/Z in lesson *8.0 Naming Alkenes* just a few lessons later in the playlist. I got a little ahead of myself. But yes it is an alternative way identifying cis/trans isomers, especially when cis and trans are ambiguous which is quite often the case. Happy Studying!
These last few videos have explained SN1, SN2, and E2 so well! Watching them in order has been especially helpful. Thank you!
Glad to hear it - You're welcome!
Simple, Concise, Clear!! Thank you a million!!
A million You're Welcomes!
Sir, don't stop with the vids. I am indebted.
No worries Fritz, plenty more coming. Glad you're finding them helpful!
FACTS
Hey Chad, Just wanna say Ive watched all of your o chem and gen chem vids and you have been my main source of studying for 3 semesters. Thank you so much and god bless you
You're welcome and Thank You - All the best!
Appreciate you taking the time to help for real.
You're welcome.
Incredible series! Has helped me feel so much more confident for my O-Chem final :) You're amazing at explanations of these topics. Keep it up!
Thank you - Hope you do well on your final - Happy Studying!
Not this prof is literally amazing I don’t know how I could thank you for all this
You're welcome - glad you found the channel
I can't thank you enough. All your videos have been so so helpful!
Sir you're saving my life right now. Final coming up in a month please keep vids coming!!!
Aweseom E Hatipo! Glad you're finding them useful and we'll keep them coming!
Oh sweet papa Jesus why did I only find you now??? Holy balls 😭
Glad you found us and find the videos helpful.
Hi Chad! I have been following your videos since gen chem and they have been really helping me, my next chemistry course is biochemistry, are you planning on making videos on the subject? If yes that would be truly helpful!
my goat carrying me through organic chemistry now
Happy Studying!
Thanksgiving may be over but I'm still eating good. THX CHEF!!
This series is so helpful!!!!!
Glad you think so!
Thank you Chad, you the BEST!
Thank you, Adrianna!
20:36 me after i eat too much taco bell
😂😂😂 I had to go back and watch the video to understand your comment...I really thought you were implying something else. You put a smile on my face! Happy Studying!
So thankful for these videos!! Thank you!
You're welcome - glad to hear it!
Thank you so much, this has been so helpful
You're welcome - Glad to hear it!
Thanks this is amazing
You're welcome Fuad and I'm glad you've found it helpful!
First, thank you so much for your videos. Second, how did you find the chair conformation at 17:05? I've been struggling with those, do you have a video that explains them better?
Hey Courtney! Try this ua-cam.com/video/aV7kmU92Rdo/v-deo.html Happy Studying :)
For the example at 8:50, when ur rotating the substituents is the rotation always in a certain clockwise fashion?
Thanks your explanation is amazing!
Glad you think so, Oshin - thanks for commenting!
25:28 what do you mean by kinetic product? Its the fastest to form
thank you my king!!!!
You need a better king but you're welcome!
Great videos. Thank you so much for your help!!
You're very welcome, E Velez - Happy Studying!
I don't say this lightly- I love you.
Thanks for the love Ouarida. I hope this means you found this lesson most helpful. I wish you the best in your studies!🙂
dawg i love you
Glad the channel is helping you
Thank you
You're welcome
you are the best chad
Wow - thank you!
best teacher
Thank you
Thanks sir 👍👍🙏🏻😀 amazing video learned something new in this video 😀😀👍
Glad to hear, Sanyam!
Thanks Chad!
You're very welcome Joey!🙂
Well done sir
Thanks!
Thank u chad ur the best
You're welcome - thank you.
do you have meet and greets
Hey! Wouldn't a build-up of a negative charge on the beta carbon repulse the oxygen that's trying to bind to it? I'm unsure if I understand the reasoning behind the E2 w/bad leaving group's mechanics.
does anyone know if these are the same videos that are included in his 'premium' on the website? want to sign up, but if these are the same vids I'm going with the standard $90 vs the $180. Thanks
Maybe I missed it, but why did you show the chair configurations when explaining out the example with the cyclohexane? I didn't understand the connection.
The beta hydrogen and the leaving group have to be antiperiplanar (~180 degrees apart) for the E2 mechanism to be possible. For cyclohexane, this is only possible when the beta hydrogen and the leaving group are trans-diaxial. We show the chair conformation to demonstrate that the E2 reaction is only possible for one of the chair conformations, and we show that it is only a trans-beta hydrogen that can be antiperiplanar to the leaving group. Hope this helps!
16:10 I think u meant were not gonna use mr zaitsevs rule
Correct! :)
For the last problem (with fluorine as a bad leaving group), will you still form the Zaitsev product with a double bond between the secondary and alpha carbons? I get confused when determining how many products will be formed.
With fluorine being a bad leaving group you will still get both the Zaitsev (more substituted) and Hofmann (less substituted) products, it's just that the Hofmann will be the major and the Zaitsev the minor. Hope this helps!
thank you sir,where are u working?
You're welcome - the U.S. - and you?
@@ChadsPrep I live in Turkey sir
@@sameterden1161 Glad you found the channel!
My teacher taught me that a bulky base is a must for E2 reactions, so seeing you use NaOH in the first example was confusing. Couldn't that reaction also be SN2? or is it not because of the fact that the H is shown?
He never mentioned that bulky bases sometimes go for the (anti zait) carbon and result in the Hofmann product. To be fair he never mentioned Hofmann product at all.
Jus read up on some differences between SN2 and E2. It seems to me that the presence of the antiperiplanar H causes the E2 reaction to dominate. A response would be still be appreciated. Thank you for the videos btw!
Hello TopperGames! First, make sure to go with exactly how your teacher presents this material. SN2 and E2 reactions are almost always a little more complicated than any textbook or professor makes them out to be. But we typically like giving students nice steadfast rules. The problem is they're really more like trends and there are commonly exceptions to the trends, but how do you teach that to students in a way that you can expect them to know for the exam? It's difficult and as a teacher there are some options about how simplified a view of reality to present. I try to go pretty far down this rabbit hole so that it is useful for just about any student, but it sounds like your teacher is going with a little simpler view which is common. So don't think your teacher is teaching it wrong, he or she is actually doing you a favor!
If you look at lesson 7.7 I really try to spell out how you distinguish between SN1, SN2, E1, E2 reactions. And while I include a fair amount of detail even I simplify it some. But the truth is that you don't 'need' a bulky base to make sure E2 happens over SN2, but it is a way to accomplish exactly that. However, for a tertiary halide it wouldn't be necessary as SN2 is not even possible. And it turns out that SN2 is typically pretty slow for most secondary halides too and even with a strong base that is not bulky, E2 is often preferred (E2 major, SN2 minor). But for primary halides SN2 is usually preferred (SN2 major, E2 minor) and for methyl halides only SN2 is possible.
I don't believe I cover it (possibly a quick mention but maybe not) but the solvent can have an impact as well. For small nucleophiles (atoms from period 2) like oxygen they will be more likely to act as a base than a nucleophile if a polar protic solvent is used which thus favors E2 over SN2 also. This is much more likely to be left out of the discussion in most textbooks and classes which is why I opted to not address it either.
Definitely take a look at lesson 7.7, but at the end of the day go with the rules presented by the one administering your test!👍
@@ChadsPrep I will definitely check out the video. Thanks again!
What is the E and Z conformation. Is it a shorthand way of saying cis or trans?
My apologies Garett! I cover E/Z in lesson *8.0 Naming Alkenes* just a few lessons later in the playlist. I got a little ahead of myself. But yes it is an alternative way identifying cis/trans isomers, especially when cis and trans are ambiguous which is quite often the case. Happy Studying!
Thank you!
You need to leave 😂😂😂
😂