Is this amino acid acetylcysteine i.e. mucomyst? It's been given to people with kidney risk pre-angio for years, at least where I worked. It was usually oral though, but according to some other lit can also be IV
Out of curiosity (if anyone has read the study) what constitutes a "significant" reduction? As in what is the typical incidence of kidney injury, how significant was that injury and and how much was it reduced. Because if kidney injury only occurs 2% of the time and the procedure reduces the risk in that group by 2% it might be considered significant to a scientist but it could involve a lot of added stress to patients who have to go in three days early.
I believe in this context "significant" is shorthand for "statistically significant", aka the reduction is outside the margin of error for the test. I don't know the margin of error or the amount of reduction for this particular study though.
I wrote the article :) AKI occurred in 474 patients (26.9%) in the amino acid group and in 555 (31.7%) in the placebo group (relative risk, 0.85; 95% confidence interval [CI], 0.77 to 0.94; P=0.002). AKI3 occurred in 1.6% and 3.0%
@@giovannilandoni9381 Thank you for the response. A lot of these kind of articles get partially quoted and the results get distorted via the telephone game.
Why isn't this how all journals are structured? Tell me what it says in plain English and if this is relevant to me, so many abstracts are incomprehensible
thank you @NEJM and @DGlaucomflecken for this video on our #PROTECTIONtrial ! (low-dose short-term amino acids infusion is improving perioperative renal function) this is exactly what is happening in the majority of cardiac surgical theaters worldwide @SRAnesthesiaICU same faces same sentences @giovannilandoni
@@elielnham210 Yes, kidney. But my first thought skipped back 1,000 years to my High School Chemistry class and immediately thought "K = potassium". LOL!
I need this for every single paper ever
WAKE UP Dr. Glaucomflecken Journal club just dropped
LOVE THIS!!!
We need lady glaucoma to present some ob gyn stuff!!!
I've never before watched NEJM. Not even once. But now I can't wait to learn about another study! 😂
*Hiss hiss cardiology* 😆
I need this on a T-shirt
🤣🤣🤣🤣
The med student sounded a lot like Russell from Up reading from his Wilderness Explorer guidebook when he first meets the old guy.
Surprised nephrology didn't get murdered by scrub for walking in without surgical attire.
If only all researches were presented in Dr. Glaucomflecken format, I'd be educated as f*ck
Dr. G out here dropping knowledge & comedy.
Now I need a hiss hiss cardiology shirt
Absolutely!
Med student on standby with trial results😂😂
I love being educated in this manner. Thank you, Dr G!
ID just had a stroke because Staph doesnt care if the growth medium is salty or not, and the open patient is right there
The best way to convince Cardiology? Tell him he will have to deal with Nephrology less if he charts IV amino acids.
Wish i could have " liked" this nejm initiative much more than once
There is like for you😅
It’s almost like perioperative nutrition affects clinical outcomes!
- Acute care RD
So....this was purely educational? Ok. Well done.
I can't wait to see someone cite one of these for a student paper or something. :D
More of this please!
Is this the same intravenous amino acids we use for kidney protection during Radioactive Lutetium infusion for Nuclear Therapy?
Same question
no, this is something new! in this study we used a balanced mixture of 15 amino acids at a dose of 2 g per kilogram pubmed.ncbi.nlm.nih.gov/38865168/
Is this amino acid acetylcysteine i.e. mucomyst? It's been given to people with kidney risk pre-angio for years, at least where I worked. It was usually oral though, but according to some other lit can also be IV
in this study we used a balanced mixture of 15 amino acids at a dose of 2 g per kilogram pubmed.ncbi.nlm.nih.gov/38865168/
Out of curiosity (if anyone has read the study) what constitutes a "significant" reduction? As in what is the typical incidence of kidney injury, how significant was that injury and and how much was it reduced. Because if kidney injury only occurs 2% of the time and the procedure reduces the risk in that group by 2% it might be considered significant to a scientist but it could involve a lot of added stress to patients who have to go in three days early.
I believe in this context "significant" is shorthand for "statistically significant", aka the reduction is outside the margin of error for the test.
I don't know the margin of error or the amount of reduction for this particular study though.
I wrote the article :) AKI occurred in 474 patients (26.9%) in the amino acid group and in 555 (31.7%) in the placebo group (relative risk, 0.85; 95% confidence interval [CI], 0.77 to 0.94; P=0.002). AKI3 occurred in 1.6% and 3.0%
@@giovannilandoni9381 Thank you for the response. A lot of these kind of articles get partially quoted and the results get distorted via the telephone game.
Uhm who allowed the nephrologist and the med student to contaminate the OR by not changing into OR scrubs? 😂
If only med school was this fun
Next we will be collecting CMEs here! Yeah!
Is... is this what journal club looks like?
what kind of operating room is this lol
Why isn't this how all journals are structured? Tell me what it says in plain English and if this is relevant to me, so many abstracts are incomprehensible
Nephrology hates Cardiothoracic too? (They are not Cardiologists)
Pretty sure he hates anyone with cardio in the name. Full stop. lol
Is anybody else bothered that Nephrology didn't wear a bouffant cap in the operating room?
thank you @NEJM and @DGlaucomflecken for this video on our #PROTECTIONtrial ! (low-dose short-term amino acids infusion is improving perioperative renal function)
this is exactly what is happening in the majority of cardiac surgical theaters worldwide @SRAnesthesiaICU
same faces
same sentences
@giovannilandoni
bad surgeon. He didn't let Nephrology finish.
Has nephrology been directing his anger of cardiology toward his Morton container? Poor thing looks all beat up
k word 😂
I thought he meant POTASSIUM. Anyone else?
I thought it was kidney?
@@elielnham210 Yes, kidney. But my first thought skipped back 1,000 years to my High School Chemistry class and immediately thought "K = potassium". LOL!