Wize wanted me to let you know that they have noticed that for some reason, some addresses are blocked. They recently changed warehouses so there’s a backend issue. If you don’t mind sending them an email at Info@drinkwize.com then Wize can help you out. They can definitely ship to most places in the US!
Do you think it would be possible to make a video on chemical structures and making sense of chemical equations for people who are getting into chemistry?
Hi That_Chemist I wanted to ask you about the recent Ohio train derailment. Apparently bad things are going to happen because the state of Ohio blew up the railcars full of vinyl chloride and created a chemical cloud of vinyl chloride over Ohio state. Could you tell us what you would have done if you were in charge of the cleanup? Is there some way to render vinyl chloride inert? Could you think of a better way to clean it up? What is your opinion about blowing up dangerous chemicals? I would love to see you make a video about this. Thank you!
Cycloheptatriene is super uncanny to me, it looks so familiar but, wrong somehow. Imagine a chemist with dementia on their deathbed, trying to remember what benzene looks like.
my concern is that in 20 years, the "I can't believe this is not toxic" list will become untrue - Iodopropynyl butylcarbamate is a good example of one which is very sus
@@That_Chemist maybe you phrase it as “I can’t believe this isn’t considered toxic” instead? I agree that it would be cool to see either a tier list or just a discussion video of chemicals that are considered safe by the wider community but you’re unsure of that assessment.
@@That_Chemist There's a more serious problem in that anything can be considered toxic in sufficient quantities, even things like water, table salt, and oxygen.
@Pegged Yourdad in another video of his, (I'm binge-ing) he explained that eating star fruit can kill you. Because it contains a neurotoxin in it. Which is terrifying and I want to k ow if there is a group I can join to test its toxicity.
I have an idea for the next tierlist. My highschool students always view chemistry as "the science that makes toxic stuff", and it's reflected in your tirelists (nerve agents, risky chemicals, drugs, pesticide ...). You could do a tierlist of compounds that are absolutely good and friendly for life or for humans. Organic ompounds with positive effects on the body, with no uncanny side effect ... etc.
A problem with this is that any compound can be harmful or hazardous in some settings, e.g. when there is too much of it. Even water or oxygen can kill a human
@@SuperAngelofglory good ol’ dick pills! Sertraline is also great, very safe antidepressant. Diphenhydramine is one of the best, powerful and safe antihistamine that works in a pinch even for emergencies.
English is not my first language. While I know what uncanny means but my mind still went to chemicals that wants to escape its container. Maybe that could be the next tier list. Chemicals that refuses to be contained.
Bromine, chromyl chloride, mercury... does fluoroantimonic acid count? There are very few substances you can use to make bottles or beakers containing the stuff.
I'm a high school student who's planning to to get a degree in chemistry (or science in general) and you have introduced me to a new lifestyle of science, there's not many youtubers talking about cursed chemicals, I thank you for your work
(edit i'm just gonna live-update my comment) Okay I haven't even watched the video yet, but the ad has me ROLLING with laughter just because of how abrupt the "I sure love the taste of mango" is, with the mid tier acting of an old cable TV commercial. fucking class act m8. i will now be looking into coffee tea because of you! 4:20 Yup the folinic acid doesn't look too bad from a bio perspective, you can lop off a huge chunk as nearly identical to folic acid, and the aldehyde group would be weird if not for the existence of other micronutrients like pyridoxine-5-phosphate being a common form of B6. But I can see how it carries the classic biochem "TOO CHUNKY" when it's really just a bunch of simple chunks connected. 7:20 would love a video on terpenes in all aspects (synthetic pathway, natural pathway, variety, utility, culture, &c), plus prenylation in other cells 11:20 "i know what you're thinking" what, are the rest of you also trying to grow a pair of tits while struggling with local laws? at least its safer than diethylstilbestrol lmao 16:20 vanadium bromoperoxidase vanadium bromoperoxidase vanadium bromoperoxidase vANADIUM BROMOPEROXIDASE VANADIUM BROMOPEROXIDASE joey i think you mentioned it in an old video about fungi but MAN vanadium and bromine have so much fun in marine life 17:20 lamotrigine is one of the best multiuse neuropsychiatric drugs developed, it's in my favorite little niche of "treats epilepsy and a half dozen depression-like odd diseases that don't get their own category like BPD, OCD, etc" and it's fantastic as an adjunct even to standard Major Depressive Disorder because it sorta stops your brain from spazzing out in the certain places that highlight a severe downswing (usually taken to prevent bipolar downswings in the way lithium prevents manic swings). NOTHING fucks harder than aripiprazole though, I think it makes my top 5 favorite psych drugs 18:20 oh no dont let the RC nuts get their hands on nitrated memantine
Keep watching you'll soak up information overtime. While you won't be educated as someone university educated you'll still know way more about chemistry than the average person
T. Chemist, ever think about doing a tier list for “most slippery chemicals,” or “strongest adhesives”? It’s like the least friction vs the most friction. That could be interesting content
you could do a tierlist on uncanny/cursed medication, molecules that when you look at them you would NOT want them in your body yet they are used as treatment for illness, for example nitroglycerin for angina... probably gonna contain alot of chemotherapeutics
Organo Mercury is the type of compound I would favor banning from Earth completely. Just staying at a 10 meter radius of one of those gets my hair rising
these videos are amazing. i think im gonna major in organic chemistry now because all these chemical structures are so fascinating. i barely even know much about chemistry lol
It is good to hear - I don't usually have a sense of the prevalence of these molecules in the world, so I appreciate it when people comment that it was special to them :)
Having bipolar, I take it every day. I wish I got on it sooner because it has improved the quality of my life immeasurably. Bipolar is weird. It's fucking amazing in manic creative stages sitting there coding for 14 hours straight but the crash sucks.
@@aethrya yeah bipolar is very very weird! Sadly I also have epilepsy which lamotrigine didn't help me with, and I needed other medication that didn't play nice with it. So in total I was depression free for 3 days. Now years later I'm still searching for a replacement.
I've grown borage before. Its a very beautiful flower. The seeds are high in omega 6 fatty acids and so borage seed oil is used as a supplement. The leaves are eaten cooked, the flowers are added to salads as a garnish. I didn't eat it because I had better things growing in my garden to eat. But the bees seriously loved eating this stuff. Saint john's wort isn't just an herbal medicine, its also a fabric dye. It needs a mordant to stick, but most natural dyes need that. I also have a recipe for saint john's wort infused oil. I haven't tried it yet.
I take lamotrigine, and I was so surprised when I first looked up the structure, bc it feels more like the structure of an explosive rather than a pharmaceutical drug. Ig the strange taste makes sense
calicheadmicin seems like the thing a bored chemist would doodle in a boring class, not a real molecule. Of course it’s halogenated with that random iodine as if everything else wasn’t enough already.
Even with highschool level of chemistry, I can feel there is something deeply unsettling about this chemicals :l Great video, as always :D very informative That aside, I'm really sorry for the lack of activity in the comments! Life has been busier than usual so I watching the uploads in a sporadic schedule haha, usually not leaving comments. I hope this is not a problem, TC. Please keep being an awesome person and channel
@@That_Chemist It's a treat seeing new videos in here, I really enjoy watching them! So...I do hope that you do not mind the lack of inactivity from my part 😅 That is not a problem, is it? Haha
@@That_Chemist Understood ^^ Thank you for taking the time to reply back! It's great to know that you are completely comprehensive in this matter :) However, I do hope this question/topic was not strange to hear from my part, but if in the future I say or ask something that makes you uncomfortable, please let me know. Best regards!
Any chance you could do a deep dive into different animal venoms? There's some really amusing chemistry to be found in there...lionfish (the entire scorpaenidae family, really) are especially neat.
I love the medicines that end up looking like explosives - beyond straight nitroglycerine for heart conditions. A bit of a fan of absurd nitrogen conglomerations and the worried reactions other chemists have to those things.
So recently I've accidentally broken my capsule with atomoxetine, and a bit of powder spilled out into my mouth. Now, I might not be a connoisseur of strong flavours, but I drank absinthe e.g., and may I tell you, that a bottle of absinthe wouldn't make you taste so bitter as some micrograms of this thing. Like, much MORE bitter than a Nintendo cartridge, and yes, I tasted them. So a quick google later I found it is indeed one of the most awful tasting compounds - maybe a video idea? Chemicals that taste like satan's butthole tierlist"
I would honestly love for you to do a video on terpenes and so on. If not rated then at least explained how maybe different terpenes cause different taste/smell in fruits and how they are linked to even changing the effects of cannabis.
I know people really want the entourage effect to be real, but in my experience there is no attributable difference in qualitative experience that can’t be explained by relative dose of THC
Scientists in the 1960s: -What else could we use as a medicine? -I know: an organomercury chemical! -Genius! P.S. Why do I have the feeling that making CH3CO2NO3 in the lab is a very bad idea?
Vulcanized rubber and thermoset polymer materials are crazy the first time you realize the whole item is one big molecule you can see with your naked eye.
How about a video where you have to guess if something is a drug, toxin, pigment or non-existing compound. Some else has to make the selection and you see the results in the end
I've always heard lamotrigine pronounced lah-mo-tri(short I)-jean. At least, by the messages the pharmacy sends me. Also interesting that its unstable - the pills are chalky and bitter
From the enediyne, the trisulfide group, the hydroxylamine linkages, the cursed sugars, the thioester linkage, the hexasubstituted benzene all the way to that random single iodine atom, calicheamicins are some of my favorite structures ever discovered or synthesized
Folinic acid looks pretty boring. Nothing scary or spicy. Using an organomercury compound as a diuretic is extremely spooky. An episode on terpenes would be very interesting. That 10 member ring on calicheamicin is really strange.
My first thought upon seeing peroxyacetyl nitrate was not “wow that looks like a pretty bad air pollutant”, it was “wow, that looks extremely explosive”.
I use chemdraw - I have the darkmode and lightmode styles in the That Chemist Discord (#resources channel), and I export them as SVGs and then convert them to transparent PNGs in Adobe Illustrator
17:23 it’s conceivable that someone could prepare the dinitrophenyl pyrimidine analogue of lamotrigine and see if it still works, since the chloro and nitro are both ewgs. that might make it *actually* explosive.
After spending two months shadowing anesthesiologists in a hospital, I have developed the skill to determine from name and structure whether a chemical is a drug or a toxin (in chemistry it seems like it’s always one or the other)
I tried doing some TC logo concept designs based on them but the ppl in the discord said it looked like Jewish war memorials (where sometimes portions of the stars are weathered away) - no new logo this time :(
17:26 ayyee its the thing that keeps me sane. lol literally was just looking at a bottle of it when this came up lol. glad to know its as funky as i am
One of the side effects associated with Lamotrigine use is Steven-Johnson syndrome, which is a mild form of toxic epidermal necrolysis, which is exactly as pleasant as the name suggests
Nevirapine and loratidine also look a like carbamazepine and its oxidized derivative oxcarbazepine. Unsettling as hell that they’re NNRTI, antihistamine, and antiepileptics. Well chosen.
Dude 😂 i love this channel. I didnt know there were so many other chemists out there who is kinda obsessed with these fkn eldritch compounds like this. I dont understand how people think reality is so mundane when theres so much really strange stuff like the monacrotaline looks like the flower it comes from to me man. 😊
I'd have to put this video into S tier for all of the pharmacology involved but your pronunciation of lamotrigine was so uncanny this whole video is going to F tier. Still dropping the thumbs up though.
Whenever I see the words "mouth pipette" I an suddenly glad I'm not drinking anything as it makes me laugh to the point I would spit out anything in my mouth
memantine and nitromematine are neat. glutamatergic excitoxocity is part of the progression of damage after head trauma. nmda antagonists can attenuate the progression damage.
Bruh I hate how I work with reagents that are irritants in low concentration. Because there has been times where I’m cleaning my glassware and I somehow end up getting a drop on my lips or face and It won’t do anything because of low concentration but I get nervous and still wash my face and worry about it for hours
I guess you mean anisaldehyde, not anethole? Benzaldehyde, cinnamaldehyde and (to my nose) nonaldehyde (and other long alkyl chain aldehydes) are nice too. Butyraldehyde is not so nice, but a far cry from butyric acid. I cannot remember most of the others I worked with (I did lots of Horner-Wittig reactions, but benzaldehyde and butyraldehyde were my standard reagents). That reminds me that I should check out propionaldehyde, which I never used (at least it's not that toxic).
Please make a terpene video. I just decided to get a doctorate and my undergrad research is going to be on cannabis, and I want to do that research as a doctorate too. It would help me a lot and would be good to see other scientists know about it 😊
I‘m getting the feeling that studying medicinal chemistry and pharmaceutical biology really cranks up the tolerance for uncanny molecules. I‘m totally used to lot‘s of nitrogens and odd terpenoid/polyketide structures. Should you ever do another one of these you should definitely include Maitotoxin. It‘s a marine neurotoxine a 100.000 times more potent than VX. Additionally it‘s a non-peptide „small molecule“ with a molecular mass of ~ 3400 g/mol.
My PhD advisor was a steroid and terpene chemist, so I learned more about terpenes than I evert wanted to know. Just so you knoiws, I have a full set of Apsimin books on a bookshelf. (!)
My favorite/least favorite uncanny molecule has to be paclitaxel. It's got an oxetane and a bunch of weird-membered rings and totally failed to kill my mother's pancreatic cancer.
Do you think it would be possible to make a video on chemical structures and making sense of chemical equations for people who are getting into chemistry?
@@That_Chemist sorry if I seemed ignorant for the question though I’m just a 13 year old stuck at home due to medical issues that has a interest in your channel and chemistry!
I object to the pyrrolizidines being so high, but maybe its the fact that I spent a masters project looking at and making them, that makes them seem very normal to me
You find that some of those are big. Then, how about peptides ? And enzymes ? Calicheamicin... A 10 members ring with a 6 member ring budding out of it. A chain of 3 sulphurs. Not only uncanny, but also cursed.
Memantine itself is just a modified version of amantadine used to bypass patent expiry regulations. Also in my opinion the idea of marketing a drug similar to phencyclidine as a treatment for Alzheimer's patients is darkly comedic.
oh man bringing back memories with the jwh molecules. back in the day, in college, i made my own spice with jwh 018 and 073 that id sell or trade to athletes or people on probation necause theyd still piss clean and get high. there was one dude in particular, every wednesday id give him a like an 8th (i made it at a reasonable strength unlike the head shop shit) and hed hand me a few adderalls. youd think that was a productive semester, but id just go back to my apartment and play starcraft 2 for 10 hours thanks to addys. lol thanks for bringing that up in my mind :D
Wize wanted me to let you know that they have noticed that for some reason, some addresses are blocked. They recently changed warehouses so there’s a backend issue. If you don’t mind sending them an email at Info@drinkwize.com then Wize can help you out. They can definitely ship to most places in the US!
Thank.
Do you think it would be possible to make a video on chemical structures and making sense of chemical equations for people who are getting into chemistry?
Hi That_Chemist I wanted to ask you about the recent Ohio train derailment. Apparently bad things are going to happen because the state of Ohio blew up the railcars full of vinyl chloride and created a chemical cloud of vinyl chloride over Ohio state. Could you tell us what you would have done if you were in charge of the cleanup? Is there some way to render vinyl chloride inert? Could you think of a better way to clean it up? What is your opinion about blowing up dangerous chemicals? I would love to see you make a video about this. Thank you!
Cycloheptatriene is super uncanny to me, it looks so familiar but, wrong somehow. Imagine a chemist with dementia on their deathbed, trying to remember what benzene looks like.
AHAHAHAHAHA
Well, it forms stable carbocation, so it is even more cursed
E&F likes to have a word with you
@@swixpa212 Ikr it’s aromatic too.
@@swixpa212 are you kidding me
I'd love to see a "I can't believe this is not toxic" list. Or its inverse, "this looks benign but is gnarly AF"
my concern is that in 20 years, the "I can't believe this is not toxic" list will become untrue - Iodopropynyl butylcarbamate is a good example of one which is very sus
@@That_Chemist maybe you phrase it as “I can’t believe this isn’t considered toxic” instead? I agree that it would be cool to see either a tier list or just a discussion video of chemicals that are considered safe by the wider community but you’re unsure of that assessment.
@@That_Chemist There's a more serious problem in that anything can be considered toxic in sufficient quantities, even things like water, table salt, and oxygen.
@@That_Chemist Shit's sus (he is an analytical chemist)
@Pegged Yourdad in another video of his, (I'm binge-ing) he explained that eating star fruit can kill you. Because it contains a neurotoxin in it. Which is terrifying and I want to k ow if there is a group I can join to test its toxicity.
I have an idea for the next tierlist. My highschool students always view chemistry as "the science that makes toxic stuff", and it's reflected in your tirelists (nerve agents, risky chemicals, drugs, pesticide ...). You could do a tierlist of compounds that are absolutely good and friendly for life or for humans. Organic ompounds with positive effects on the body, with no uncanny side effect ... etc.
First that comes to mind: sildenafil citrate!
So, things like vitamins, sugars, hormones and such...
I think showing them nilered's videos where he turns random chemicals into edible chemicals would work well
A problem with this is that any compound can be harmful or hazardous in some settings, e.g. when there is too much of it. Even water or oxygen can kill a human
@@SuperAngelofglory good ol’ dick pills! Sertraline is also great, very safe antidepressant.
Diphenhydramine is one of the best, powerful and safe antihistamine that works in a pinch even for emergencies.
English is not my first language. While I know what uncanny means but my mind still went to chemicals that wants to escape its container.
Maybe that could be the next tier list. Chemicals that refuses to be contained.
Bromine, chromyl chloride, mercury... does fluoroantimonic acid count? There are very few substances you can use to make bottles or beakers containing the stuff.
lol that's a hilarious intepretation
@@cvspvr You can just store ClF3 in a normal steel drum tho.
He sure does love the taste of mango :D
Who doesn't?
We love the taste of corporate money too
@@canonicaltom once again, who doesn't?
I'm a high school student who's planning to to get a degree in chemistry (or science in general) and you have introduced me to a new lifestyle of science, there's not many youtubers talking about cursed chemicals, I thank you for your work
Thank you :)
@@That_Chemist love from india
Hardest chemicals to synthesize tier list please!
(edit i'm just gonna live-update my comment) Okay I haven't even watched the video yet, but the ad has me ROLLING with laughter just because of how abrupt the "I sure love the taste of mango" is, with the mid tier acting of an old cable TV commercial. fucking class act m8. i will now be looking into coffee tea because of you!
4:20 Yup the folinic acid doesn't look too bad from a bio perspective, you can lop off a huge chunk as nearly identical to folic acid, and the aldehyde group would be weird if not for the existence of other micronutrients like pyridoxine-5-phosphate being a common form of B6. But I can see how it carries the classic biochem "TOO CHUNKY" when it's really just a bunch of simple chunks connected.
7:20 would love a video on terpenes in all aspects (synthetic pathway, natural pathway, variety, utility, culture, &c), plus prenylation in other cells
11:20 "i know what you're thinking" what, are the rest of you also trying to grow a pair of tits while struggling with local laws? at least its safer than diethylstilbestrol lmao
16:20 vanadium bromoperoxidase vanadium bromoperoxidase vanadium bromoperoxidase vANADIUM BROMOPEROXIDASE VANADIUM BROMOPEROXIDASE joey i think you mentioned it in an old video about fungi but MAN vanadium and bromine have so much fun in marine life
17:20 lamotrigine is one of the best multiuse neuropsychiatric drugs developed, it's in my favorite little niche of "treats epilepsy and a half dozen depression-like odd diseases that don't get their own category like BPD, OCD, etc" and it's fantastic as an adjunct even to standard Major Depressive Disorder because it sorta stops your brain from spazzing out in the certain places that highlight a severe downswing (usually taken to prevent bipolar downswings in the way lithium prevents manic swings). NOTHING fucks harder than aripiprazole though, I think it makes my top 5 favorite psych drugs
18:20 oh no dont let the RC nuts get their hands on nitrated memantine
THE "I sure love the taste of mango!" MADE ME LAUGH SO HARD
i love these, i really dont know much about chemistry but the diagrams of chemicals are really interesting
Me too
Keep watching you'll soak up information overtime. While you won't be educated as someone university educated you'll still know way more about chemistry than the average person
Spoken like a fellow true mouth pipetter
Sigma Aldrich shipping the chemical in a tuna can should have been points off for being uncanny
Hahahahahah groannnnn
T. Chemist, ever think about doing a tier list for “most slippery chemicals,” or “strongest adhesives”? It’s like the least friction vs the most friction. That could be interesting content
Type "silicon carbide electric motor" on YT search engine to see how such chemical perform as "lubricant" (coff!) for moving parts ;-D
I think the more basic the more slippery but there could be more to it great idea
you could do a tierlist on uncanny/cursed medication, molecules that when you look at them you would NOT want them in your body yet they are used as treatment for illness, for example nitroglycerin for angina... probably gonna contain alot of chemotherapeutics
After learning here that AVX-like chemical was used as a sedative for babies, I think that's a rather good idea.
Organo Mercury is the type of compound I would favor banning from Earth completely. Just staying at a 10 meter radius of one of those gets my hair rising
the uncannybinoid pun was insane
You are really improving video quality! Super interesting content.
Glad you think so!
plants make such bizarre stuff
they most certainly do
It's their only defense, aside from something like thorns.
I've always been intrigued by the diverse and unique compounds they produce, partly due to.. uhh, reasons.
Meralluride eh? It's got an "Hg" in it, so that screams at me, get away, get out of the lab, maybe leave the building. Don't walk away, RUN.
these videos are amazing. i think im gonna major in organic chemistry now because all these chemical structures are so fascinating. i barely even know much about chemistry lol
Thank you :) I wish you success in your studies!
Laughed so hard when I realised the first chem on the list is the notorious Cycloprop-2-ene carboxylic acid aka Tinky Winkenic Acid
Heh, cool to see lamotrigine. I had it once, always fun to see medication you take or have taken.
It is good to hear - I don't usually have a sense of the prevalence of these molecules in the world, so I appreciate it when people comment that it was special to them :)
I also took it! Super weird and cool.
Having bipolar, I take it every day. I wish I got on it sooner because it has improved the quality of my life immeasurably. Bipolar is weird. It's fucking amazing in manic creative stages sitting there coding for 14 hours straight but the crash sucks.
@@aethrya aye lamictal gang lets go
@@aethrya yeah bipolar is very very weird! Sadly I also have epilepsy which lamotrigine didn't help me with, and I needed other medication that didn't play nice with it. So in total I was depression free for 3 days. Now years later I'm still searching for a replacement.
Ichthyothereol looks like a fishing rod and was used to fish which is neat
Lmao it does look like a guy holding a fishing rod
Definitely would love a terpene video. It was a very curious class of molecules to me when I was starting out in biochemistry
I've grown borage before. Its a very beautiful flower. The seeds are high in omega 6 fatty acids and so borage seed oil is used as a supplement. The leaves are eaten cooked, the flowers are added to salads as a garnish. I didn't eat it because I had better things growing in my garden to eat. But the bees seriously loved eating this stuff.
Saint john's wort isn't just an herbal medicine, its also a fabric dye. It needs a mordant to stick, but most natural dyes need that. I also have a recipe for saint john's wort infused oil. I haven't tried it yet.
I take lamotrigine, and I was so surprised when I first looked up the structure, bc it feels more like the structure of an explosive rather than a pharmaceutical drug. Ig the strange taste makes sense
calicheadmicin seems like the thing a bored chemist would doodle in a boring class, not a real molecule. Of course it’s halogenated with that random iodine as if everything else wasn’t enough already.
absolutely
Even with highschool level of chemistry, I can feel there is something deeply unsettling about this chemicals :l Great video, as always :D very informative
That aside, I'm really sorry for the lack of activity in the comments! Life has been busier than usual so I watching the uploads in a sporadic schedule haha, usually not leaving comments. I hope this is not a problem, TC. Please keep being an awesome person and channel
Glad you enjoyed it!
@@That_Chemist It's a treat seeing new videos in here, I really enjoy watching them! So...I do hope that you do not mind the lack of inactivity from my part 😅 That is not a problem, is it? Haha
@@sacredyveltal4688 of course not - live your life :)
@@That_Chemist Understood ^^ Thank you for taking the time to reply back! It's great to know that you are completely comprehensive in this matter :)
However, I do hope this question/topic was not strange to hear from my part, but if in the future I say or ask something that makes you uncomfortable, please let me know.
Best regards!
Any chance you could do a deep dive into different animal venoms? There's some really amusing chemistry to be found in there...lionfish (the entire scorpaenidae family, really) are especially neat.
I expect that the one with all the buckyballs linked together is going to be developed into some kind of super-plastic.
This is genuinely one of the best UA-cam video essays I’ve ever seen. Amazing job.
I'm on lamotrigine. I had this video on in the background and suddenly snapped to attention when I heard it haha
Yes, I'll like to see a video on terpenoids!
3:40 I'm watching this while preparing for the biochem exam and this boi freaked me out
looking at meso-[5]triangulane, is there a star-of-davidane?
I love the medicines that end up looking like explosives - beyond straight nitroglycerine for heart conditions. A bit of a fan of absurd nitrogen conglomerations and the worried reactions other chemists have to those things.
So recently I've accidentally broken my capsule with atomoxetine, and a bit of powder spilled out into my mouth. Now, I might not be a connoisseur of strong flavours, but I drank absinthe e.g., and may I tell you, that a bottle of absinthe wouldn't make you taste so bitter as some micrograms of this thing. Like, much MORE bitter than a Nintendo cartridge, and yes, I tasted them.
So a quick google later I found it is indeed one of the most awful tasting compounds - maybe a video idea? Chemicals that taste like satan's butthole tierlist"
I love your videos, thank you for this amazing content
Glad you like them!
I would honestly love for you to do a video on terpenes and so on. If not rated then at least explained how maybe different terpenes cause different taste/smell in fruits and how they are linked to even changing the effects of cannabis.
I know people really want the entourage effect to be real, but in my experience there is no attributable difference in qualitative experience that can’t be explained by relative dose of THC
Scientists in the 1960s:
-What else could we use as a medicine?
-I know: an organomercury chemical!
-Genius!
P.S. Why do I have the feeling that making CH3CO2NO3 in the lab is a very bad idea?
Vulcanized rubber and thermoset polymer materials are crazy the first time you realize the whole item is one big molecule you can see with your naked eye.
How about a video where you have to guess if something is a drug, toxin, pigment or non-existing compound. Some else has to make the selection and you see the results in the end
I've always heard lamotrigine pronounced lah-mo-tri(short I)-jean. At least, by the messages the pharmacy sends me.
Also interesting that its unstable - the pills are chalky and bitter
17:55 the way the structure is drawn makes it look like a person, with the ethyl groups as the arms and the amino group as the head
I always love learning about cannabinoids, aka Canada Bois
"maybe it just looks like any other biomolecule"
there's a reason protiens are drawn as big squiggles
From the enediyne, the trisulfide group, the hydroxylamine linkages, the cursed sugars, the thioester linkage, the hexasubstituted benzene all the way to that random single iodine atom, calicheamicins are some of my favorite structures ever discovered or synthesized
Folinic acid looks pretty boring. Nothing scary or spicy.
Using an organomercury compound as a diuretic is extremely spooky.
An episode on terpenes would be very interesting.
That 10 member ring on calicheamicin is really strange.
Is it uncanny that my university doesn't require or provide ppe in labs?
6:00 Yeah all those varying types of oxygen-nitrogen bonds look very spicy.
2:00 You can tell the Israelis didn't synthesize those molecules, because if they did, they would have completed them.... ✡😉🙃
My first thought upon seeing peroxyacetyl nitrate was not “wow that looks like a pretty bad air pollutant”, it was “wow, that looks extremely explosive”.
13:55 not terrible untill some wack-o attaches a shit ton of flourines to it. 🙃
this molecule brings back memories.
Next video idea: most dangerous chemicals on plants
All of the rainbow agents, most notably Orange :-/
If you mean toxins from plants, abrin and whatever is on hogweed are brutal
Where do you get all your graphics for the chemicals from? They look really clean
I use chemdraw - I have the darkmode and lightmode styles in the That Chemist Discord (#resources channel), and I export them as SVGs and then convert them to transparent PNGs in Adobe Illustrator
@@That_Chemist Awesome, thanks! These videos are really making me fall in love with chemistry :)
17:23 it’s conceivable that someone could prepare the dinitrophenyl pyrimidine analogue of lamotrigine and see if it still works, since the chloro and nitro are both ewgs. that might make it *actually* explosive.
This TL was super fascinating
Thanks :)
Lamotrigine can also cause your skin to loosen, blister and peel, uncanny and unsettling!
After spending two months shadowing anesthesiologists in a hospital, I have developed the skill to determine from name and structure whether a chemical is a drug or a toxin (in chemistry it seems like it’s always one or the other)
I bet you should make a Terpene and terpenoid video and tierlist.
Salvinorin salvinorin salvinorin
14:16 "Uncannybinoid" 🤣
Triangulenes are neat af. Is there a 6 pointed star one? (Inb4 Kanye) A Sierpinski Triangle triangulene would be amazing lol
I tried doing some TC logo concept designs based on them but the ppl in the discord said it looked like Jewish war memorials (where sometimes portions of the stars are weathered away) - no new logo this time :(
Wake up babe "That Chemist" just posted
awe you commented
@Chemiolis showed me your channel
17:26 ayyee its the thing that keeps me sane. lol literally was just looking at a bottle of it when this came up lol. glad to know its as funky as i am
definitely do a video on terpines and similar plant structures.
One of the side effects associated with Lamotrigine use is Steven-Johnson syndrome, which is a mild form of toxic epidermal necrolysis, which is exactly as pleasant as the name suggests
That shit can get realllllly terrifying. As a bipolar patient who has been on it for years, it scared me to death at first
@@aethrya Yeah i imagine your providers have drilled it into you to be on the lookout for sudden skin changes! not to be messed around with fr
@ 7:15 a video about terpenes? Yes please!
I'd be interested into a Video about Terpenes, you said you would consider a Perfume Chemical Series, which I think Terpenes would go well in.
As one who has studied biochemistry, the ranks of some are totally off.
“Next we have peroxyacetyl nitrate”
*Me (an environmental engineering student)*: Wait I know this one 😮
Nevirapine and loratidine also look a like carbamazepine and its oxidized derivative oxcarbazepine. Unsettling as hell that they’re NNRTI, antihistamine, and antiepileptics. Well chosen.
Dude 😂 i love this channel.
I didnt know there were so many other chemists out there who is kinda obsessed with these fkn eldritch compounds like this.
I dont understand how people think reality is so mundane when theres so much really strange stuff like the monacrotaline looks like the flower it comes from to me man. 😊
I'd have to put this video into S tier for all of the pharmacology involved but your pronunciation of lamotrigine was so uncanny this whole video is going to F tier. Still dropping the thumbs up though.
honorary mentions: palytoxin (for its size) and diborane (what the hydrogen doin)
Whenever I see the words "mouth pipette" I an suddenly glad I'm not drinking anything as it makes me laugh to the point I would spit out anything in my mouth
Mr incredible becoming uncanny chemicals
memantine and nitromematine are neat. glutamatergic excitoxocity is part of the progression of damage after head trauma. nmda antagonists can attenuate the progression damage.
Bruh I hate how I work with reagents that are irritants in low concentration. Because there has been times where I’m cleaning my glassware and I somehow end up getting a drop on my lips or face and It won’t do anything because of low concentration but I get nervous and still wash my face and worry about it for hours
Aldehydes tier list?
Like toxic and bad smelling ones as formaldehyde or acrolein and good smelling ones like vanillin, anethole or cyclamen aldehyde
I guess you mean anisaldehyde, not anethole?
Benzaldehyde, cinnamaldehyde and (to my nose) nonaldehyde (and other long alkyl chain aldehydes) are nice too. Butyraldehyde is not so nice, but a far cry from butyric acid.
I cannot remember most of the others I worked with (I did lots of Horner-Wittig reactions, but benzaldehyde and butyraldehyde were my standard reagents).
That reminds me that I should check out propionaldehyde, which I never used (at least it's not that toxic).
Ben Jordan recently made a video about the sketchyness of vinyl (or PVC) will you also make one about this?
Terpenes and terpenoids video would be great!
Please make a terpene video. I just decided to get a doctorate and my undergrad research is going to be on cannabis, and I want to do that research as a doctorate too. It would help me a lot and would be good to see other scientists know about it 😊
graphfullerite sure is ballin
Polyisoprene is also used in the manufacture of certain rubber based products like tires
I wonder what happens to the graphene-bucky ball thing under pressure, when the "3D" bonds are broken...
17:30 I've heard it most commonly pronounced "Lah-moe-trih-jin".
I‘m getting the feeling that studying medicinal chemistry and pharmaceutical biology really cranks up the tolerance for uncanny molecules.
I‘m totally used to lot‘s of nitrogens and odd terpenoid/polyketide structures.
Should you ever do another one of these you should definitely include Maitotoxin. It‘s a marine neurotoxine a 100.000 times more potent than VX. Additionally it‘s a non-peptide „small molecule“ with a molecular mass of ~ 3400 g/mol.
My PhD advisor was a steroid and terpene chemist, so I learned more about terpenes than I evert wanted to know. Just so you knoiws, I have a full set of Apsimin books on a bookshelf. (!)
17:50 ah i didn’t expect to see lamotrigine on this list. i reacted pretty badly to it so approve of calling it uncanny lol
Can we get a polymers tier list next?
There already is one! Which Polymers are the Most Useful?
ua-cam.com/video/SlsW7LwUCjg/v-deo.html
@@That_Chemist thanks man! You make great content, keep it up :)
My favorite/least favorite uncanny molecule has to be paclitaxel. It's got an oxetane and a bunch of weird-membered rings and totally failed to kill my mother's pancreatic cancer.
Do you think it would be possible to make a video on chemical structures and making sense of chemical equations for people who are getting into chemistry?
ua-cam.com/play/PL6OLqxmk7RtzLTsvdjQXsAO38aGuJj3e6.html guess what I made - a whole intro series
@@That_Chemist thank you!
@@That_Chemist sorry if I seemed ignorant for the question though I’m just a 13 year old stuck at home due to medical issues that has a interest in your channel and chemistry!
Some of the compounds in the list remind me of that old joke picture of "1,2-dimethyl chickenwire".
I object to the pyrrolizidines being so high, but maybe its the fact that I spent a masters project looking at and making them, that makes them seem very normal to me
You find that some of those are big. Then, how about peptides ? And enzymes ?
Calicheamicin... A 10 members ring with a 6 member ring budding out of it. A chain of 3 sulphurs. Not only uncanny, but also cursed.
Memantine itself is just a modified version of amantadine used to bypass patent expiry regulations. Also in my opinion the idea of marketing a drug similar to phencyclidine as a treatment for Alzheimer's patients is darkly comedic.
I feel kinda old after you mentioned agelongine...
Wait can ichthyothereol a gas? Can it be used to make acetylene
can you make hexacyclopropyl cyclopropane?
I really hope someone does - that would be amazing
oh man bringing back memories with the jwh molecules. back in the day, in college, i made my own spice with jwh 018 and 073 that id sell or trade to athletes or people on probation necause theyd still piss clean and get high. there was one dude in particular, every wednesday id give him a like an 8th (i made it at a reasonable strength unlike the head shop shit) and hed hand me a few adderalls. youd think that was a productive semester, but id just go back to my apartment and play starcraft 2 for 10 hours thanks to addys. lol thanks for bringing that up in my mind :D