15 minutes about Brain Immune System

Johanna Kaindl
PhD student in Neuroscience
Did you know that our brain has its own immune system that protects it from damage? Changes in these immune cells can often lead to severe neurological diseases. But how can we study the brain immune cells in our labs? Let's make some brain organoids and find out!
The talk was a part of a special event organized in cooperation with the research consortium ForInter (www.bayfor.org/de/unsere-netz...)
, which studies the interaction of human brain cells.

[@SladkaPritomnost]

I personally think this is the key to neuroinflammation.
Tsimane indians of Bolivia with APOE4 have improved cognition when they have active parasitic worm infection.
Worms usually blocks rapid immune strikes via Treg cells production when the body is fighting off bacterial infection. The worms kinda cushioning immune strikes which is beneficial for neurons.

[@Harshitapandey0601]

Amazing vdeo❤

[@user-ts8bu1pe6c]

Wonderful

[@marianahecksheroliveira7017]

that was amazing!

[@15x4TalksEN]

thanks for supporting us!

[@tombridgebuilder1964]

Wow!

[@15x4TalksEN]

Thanks for watching!

[@Explainmerandom]

This is great, such interesting cutting edge research. This is jaw droppingly good. You are doing great work Johanna

[@15x4TalksEN]

Thanks for watching. Glad you enjoyed it!

[@fitcoachmarshall4310]

I have question! TBI’s in Veterans whom suffered damaged hypothalamus and development of mild epilepsy for only a few years, roughly 5 years… speech patterns, cognitive skills, neurological issues from the cervical through sacrum leading to fusion of L3 - sacrum, randomly once every few moths either on thighs and triceps are spots of numbness (not the limbs themselves, but more superficial), depth perception randomly sucks: mostly when heightened BP and heart rate, but every now and then while driving, and loss of words in the middle of a thought/speech and forgetting things just from the previous week to even few days prior. Can microglia be used to help heal or recreate new neurons before getting to a state of being “irreversible”? I have also been exposed to 12-15 anthrax vaccination/boosters within 2-2.5 years in early 2000 and exposed to liquid sarin on my hand when my glove ripped during a training event in 2004. Thanks for any info might be provided. If an answer is left, please explain qualifications the answers/ info is provided. I’m very careful where and from whom I get my knowledge from. THANK YOU!

[@VicenteMReyes-vs9nh]

Hi Johanna, Are there other immune cells in the brain (or CNS) besides microglia? Are there macrophages? The brain and the CNS share the same immune system, correct?

[@15x4TalksEN]

The most dominant immune cells in the brain are microglia, which comprise 80% of brain immune cells. Other immune cells identified in the brain include myeloid cells, monocytes/macrophages, dendritic cells, T cells, B cells and natural killer (NK) cells (Korin et al., 2017).