DNA Replication at the replication fork

[@nobesuthundlovu7153]

Brilliant! 5 videos later this explains the process in the clearest format!

[@arpitakawale8052]

Brilliant video sir ... Thank you so much
For explaining this concept in the least simpler way✨✨✨

[@richrise6851]

Excellent video. This helped me a lot. Thank you so much! Liked.

[@nyawirawaithaka4993]

Great explanation. Thank you!

[@sondeshthenaughtylab5796]

Loved your explanation

[@dinamorozov8738]

This video is great except for the fact that DNA polymerase moves from 3 to 5 continuously on the leading strand not from 5 to 3

[@chickengirlslyrics]

this is perfect thank you!!

[@therealshandapanda8924]

Great video!

[@ananyajain7849]

Thank you. Helped alot. :)

[@Isumi03]

Thank you so much❤️

[@shezanrasoolsheikh4260]

amazing ...5 seconds on video ....and i subscribed .....☺☺☺☺☺☺☺

[@khatrinh3716]

Thank you!

[@demikoyen9340]

Thank you!!!

[@laiaplaiap1688]

Thank you so much

[@bandletv9237]

Well explained 🙌

[@mahsazb917]

Thank you so much sir

[@kainatsardar9069]

Thanks alot Sir 💕

[@hebahamood362]

Amazing!

[@Niovo]

thanks a lot understood now

[@AshishKumar-ls5es]

good job

[@angelasantoso7000]

Hi, thank you so much for this video! I just have a question that I can't seem to answer: why can't the lagging strand synthesise continuously toward the helicase on the left of the bubble?

[@Isumi03]

Because only 5" to 3" DNA polymerase synthesis new DNA strand.

[@Isumi03]

And dsDNA are antiparallel and when there is a 5"end in the strand in one place, the related other place on the other strand there is 3" end. This is the reason for synthesis of leading and lagging strand

[@madelynlewis8902]

primers???

[@fatalconclusion5651]

Can’t the leading strand become lagging the opposite way on the right

[@brianbradysyoutube3874]

Sure! The "origin of replication" is where the polymerase enzyme starts laying down new strand. It goes off in the 5'-3' direction to make the lagging strand, but *behind* the origin of replication, that's where the lagging strand gets laid down as the replication fork goes on unwinding the double helix. :-)

[@karolinawarzecha4789]

Thank you!