The Future of Insulin: Innovations Now & Where it’s Headed
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- Опубліковано 30 чер 2024
- 🎧 Listen on Spotify, Apple Podcasts & more: www.diabetech.info
T1D Exchange Registry: bit.ly/t1dregistry
From inhaled insulin to an oral smart insulin pill the future of insulin innovation is bright! David Ahn and I discuss the history of insulin, why it is slower than insulin produced from the pancreas and the standings of insulin research in the works, such as once-a-week long-acting insulin injections.
▶️ Future of Diabetes Tech - • Future Diabetes Tech -...
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DISCLAIMER: This podcast is not medical advice. Always consult with your doctor before making changes to your health care.
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Chapters:
Intro: 00:00
History of Insulin: 02:38
Insulin Effectiveness: 08:01
Inhaled Insulin & Afrezza: 12:33
Ultra Rapid Insulin: 25:09
Long-Acting Insulin: 38:08
Smart Insulin Targeting Glucose: 43:55
Oral Insulin Pill: 46:34
Insulin Affordability: 49:44
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#t1d #diabetes #insulin #insulinpump
This was FANTASTIC.
As NYC nurse of a school medical room, I treat, educate, and assist children with Type-1 Diabetes every day. You my friend, are SO right- 'Diabetes is like a daily science project'. Infact, it was my Diabetic patients that made me fall-in-love with nursing on a deeper level- realizing that I was actually changing the trajectory of children's lives! Such a fascinating topic, and you are such a good interviewer. Well done!
Aww thank you so much. Such a wonderful comment 💕
This is such a great video about the latest treatment. I am fortunately to live near Dr. Ahn and just called to get an appointment. I am so excited to get on his program. BTW, when he talked about putting your T-Slim in sleep mode for 24 hours, that is what I have been doing for the past year. It forces the basal rate to vary and because I constant monitor I make adjustments frequently. Thanks for the content!!!
Yassss happy to hear it!
16:03 I like the "tool kit" approach. We NEED the ability to have tool kit options in our treatment plans. Insurance needs to support this.
I actually use fiasp in my medtronic 720g pump. It works fine, i just needed to adjust certain settings. The fiasp does crystalize in the tube, but its fine for 3 to 4 days even. And it does sometimes stings when i get insulin into my body through the infusion set. But it mostly occurs only after the first bolus i get after swapping the infusion set, which actually tells me the infusion is working.
This was a wonderful video. David is so clear in his explanations and I feel like he is talking at a level that almost anyone who understands Diabetes can grasp. Thank you so much for sharing! Education is key and you are definitely helping all Diabetics with your videos! The “toolkit” analogy is spot on!
Thanks for the wonderful feedback 🥰
Brilliant podcast I found by accident.
I'm a 1957er that's been T1D for 25 years. I'm not doing to badly but this video made me feel a bit out of date.
Thanks for the motivation to expand my knowledge.
Thanks Justin and David.
So happy to hear you stumbled onto the pod and channel. Hope you continue to find the content helpful!
I can't say enough how grateful I am for your content. Thank you, Justin. This is exactly what the T1D demographic needs; a modernly executed, up to date consistent coverage on this disease. Great work
the problem with getting the newest meds is insurance co. wont pay for it
I love it. Excited for what the future holds for us!
Ditto!
This video is sooooooo good and useful. Thanks. David explained everything so clearly and Justin, you asked GREAT questions to have the conversations go smoothly and meaningfully. I learnt a lot from this video. I can't thank you enough.
WOW. My head is spinning after this amazing video. So much information in one interview. My sincere thanks to you and this amazing doctor for shedding new light on the promising direction that diabetes care is going.
Thanks for listening! 😃😄
Great video, thanks for bringing us all this info
Our pleasure!
This episode is a great knowledge enhancing one. Would like to explore into the side effects of inhaled insulin and the relevance of insulin pumps in the future.
Great episode, really interesting thank you!
Definitely the least sucky time yet to be t1d.
💯💯💯
That episode was epic, thank you so much.
Glad you enjoyed it! I loved it too.
Great video. Thank You.
Isn't it amazing how big pharmacy is always looking for more, better, easier to use and more profitable medicine than finding the root cause and cure for disease.
I love your videos! It helps me make my decisions when it comes to my treatment plan
💕💕💕💕 glad you find it helpful!
T2 here, on basal injections and I occasionally get burnout from it. I'd be excited to do weekly injections instead, and it would go well with my monjauro injections weekly. What a fantastic time to have t2 - there's so much to do to treat it. :)
Justin,
Absolutely fantastic episode! I learned so much about all the different types of insulin that I previously just had my own idea how they worked.
Dr. Ahn is incredible in explaining how the different insulin work!
I'm inspired! 😊
Isn’t he great! Thanks for watching :)
I’ve had T1D for 56 yrs & have been using OmniPod 5 since June of 2023. I’ve had great success w/tubeless pump & the automation effect. I’m interested in seeing how the Afeszza inhaled insulin works w/Omnipod 5! Regards, JG
I have Keizer insurance with OPH, I’m tired of the games my dr plays. After taking insulin for 52 years I’m ready for a change
first time watching already enjoyig
Great info, from a type 2 diabetic and fellow youtuber
Very interesting episode. Thanks to both of you.
Glad you enjoyed it
I live in UK and my child has Td1 so this is great insight for the future
A oh my , I have been a diabetic for 52 years. I have routinely ask my doctor if they could put me on different medication. I am tired of being told that there’s not choice.
There is SO MUCH CHOICE. Now it’s your turn to choose another doctor 😂
Hi Justin, thanks for another great video👏 ! I would love if you can try Afrezza and let us know your thoughts.
I’d like to, at some point I will!
Justin, i want to thank you ao much for the nice loud volume of this video! I'm about to listen while taking a shower, and only 1% of UA-cam videos are loud enough for me to hear in the shower 👍👍👍👍 EXCELLENT LOUD VOLUME THANK YOU. And, excellent video, I've watched 30% and reallly loving this interview with Dr. Ahn!!!!!!🌟🌟🌟🌟🌟🌟
hahahaha yay glad I could provide good audio for you ;) Enjoy and thanks for watching!!
A good videos and very informative , Regards Perú South América...
Thanks!
THANK YOU!!! 💕
Great ep! I use Afrezza as a “tool in my toolkit”, while also being on the Omnipod 5. I’m a fan and would definitely recommend to others. Let me know if you have any questions.
Thanks for sharing! :)
I’ve been a diabetic for over 45yrs no major complications, I was told to go on the pump… afraid 😢. Im very glad I found this pod cast. Im subscribing because I truly find your videos very informative. Not sure which pump to get. I feel like most people, there should have been a cure a long time ago, sometimes I think they ( who ever they are) are holding back on a cure. Too much money to be had with diabetes. Right now eat right, exercise and find the right pump 😊
Thanks for watching and the sub :)
I use Afrezza along with my DIY Medtronic Loop system. Loop allows me to log my Afrezza dose so that Loop is aware of that external dose and it integrates Loop basal adjustments going forward.
I just saw this! So cool! May be one of the only there is that allows for it
sadly not only in us insulin prices r fkd up everywhere I'll say it on behalf of everyone they have enough to do research and development the main reason prices r so high is because of pure greed yes I know they have to make a profit for the shareholders but they did us dirty it's the same as tobacco companies except they r on the health field
Awesome
Hi what is the device on your commode for monitoring blood sugar ,where i can get one,thanks
Currently watching this after a site failure that’s causing me to spike like crazy, while I’m still amazed with my new rapid acting insulin, I’d stub a toe for some afrezza right about now 😂
Thanks again for your videos I'm always looking at improvements, especially since I just got on the iLet pump by Beta Bionics (it's my first pump ever). I've been having difficulties because once every 4-5 times I change the transfusion the needle doesn't go in my body so it basically just shoots insulin without knowing and I've had nights of around 350-400. Are you familiar with this and is there anything I can buy or is there an easier injection set associated? Are there better pumps?
I think what you're saying is the insulin isn't going into your body because the infusion set isn't in you properly, right? To me, what you are describing isn't a pump issue, it is an infusion set issue. I would check with your doctor that you are applying that as advised, and maybe they have more information for you and a better way to go about it. I have not heard of this issue associated with the iLet. Aside from your issues, there are definitely other pumps available that have algorithms and customization that allow for better control of glucose levels. The iLet doesn't allow enough control to get better Time in Range (TIR) as other pumps do. Tandem's tslim, Omnipod 5 and Medtronic 780g all can achieve higher standards of TIR because of the settings they allow for programming.
Thank you so much for your support, its incredibly appreciated
35:00 I don't think that technically there is a reason to worry about pumps working with faster insulins. I know some things about regulation and it only confirms my experiences with faster insulins in my pumps (both Fiasp and Lyumjev): The faster, the better. Even for the same algorithms. Basically, when you reduce delay, you improve, stabilize, existing regulation, not make it worse. A delay makes the regulation worse, causes bigger overshoots and undershoots and eventually destabilizes the whole loop and makes it oscillate. Reducing it makes it the other way, more precise and stable. Make it faster. It could only start to become a problem, if it would act so fast, that mistakes in bolus could no longer be corrected well enough with food intake. This problem would appear much sooner, than any possible problems with basal regulation. At least in my view. No worries.
Luckily for Medicare patients FIASP is $35 per. Has saved a number of my clients who couldn’t afford their fast acting.
What are the adverse effects of the inhaled insulin?
not gonna lie, but i spent way too much time watching your blood sugar in the background rise from 112 to 124 and was wondering if you were going to bolus if you even noticed. great interview none the less.
I run a tandem tslim with the autosoft injection sites. A friend offered a couple vials of fiasp they were running in a Medtronic pump with quickset. I kept getting blockages detected on my tandem setup with fiasp. I called tandem and they claim there is a known viscosity issue with the fiasp when the temperature of the insulin changes. Tandem said their pump is not compatible with fiasp.
Please let me know if anyone has had luck with this? Also if anyone is using the ultra fast acting insulin with the beta bionic pump?? I have been looking into that setup as well.
Thanks!
umm whaaat??? "Insurances are not covering Ozemnpic for T1D".. what if someone is suffering from double diabetes? They should know that is a thing. Where you have type 1 but also have a family history of Type 2. So a type 1 can essentially ALSO become type 2 overtime due to genetic history of insulin resistance, and/or hormonal problems. Like women that may be type 1 and develop other metabolic issues that cause insulin resistance like PCOS that cause them to gain weight and have trouble loosing it. OR because of the added autoimmunity risk of having Hashimoto's that can cause hypothyroidism, thus metabolic disorder due to added weight gain and hard time loosing weight, therefore increasing insulin resistance especially for those that again have genetic predisposition to insulin resistance/type 2 diabetes. The different types of diabetes are not mutually exclusive. That's a ridiculous thing to do. Things like this often make me feel like BigPharma puts barriers up to prevent people from getting as healthy as they can get. So instead of just allowing someone with T1D who may also be suffering from a metabolic disorder for one reason or another causing them to have insulin resistance, you'd rather just have them keep pumping tons and tons more insulin (increasing fatty liver, worsening insulin resistance) instead of just giving something like Ozemipc that could help them loose weight and thus rectify their insulin resistance. Don't get me started on how minorities are often the ones that suffer more of genetic metabolic disorders. Its like telling a Hispanic/African American person that "Oh yes, everyone in your family has type 2 diabetes because their metabolism is designed to turn out that way after a certain period of time. But you have type 1, so even though your metabolism is designed to also develop type 2 because you came from that family, even if your type 1 is putting stress on your thyroid and you are doubling/tripling your insulin, and not loosing weight despite exercise and barely eating, its impossible for you to have type 2 because you already have type 1! So no metabolic help for you!🤗"
Most insulins cost about $5 a bottle and that includes the bottle and packaging. Years ago the editor of Diabetes Forecast interviewed an official with a blood glucose test strip manufacturing agency. She asked the rep how much it costs to manufacture a test strip. The answer? Five cents! To this the editor replied, "Isn't that a rather large markup? The rep smiled and said, "This is America where it isn't illegal to make a profit." As long as Americans put up with this idea of taking advantage of people with an illness the prices will remain high.
Hello, Here is a strange situation for you.
I went to a Diabetic convention in San Deigo. That is where I first learned about Afiasp. It takes 45 min. for insulin to react in my system.
So before I have dinner, I take my bolas 45 to 60 min. before I eat. Why would you put a powder insulin in your pump????
I can't understand the though process of this!
Hi Justin, thanks for another great video! I use G6+Dash+iAPS with Novolog insulin. I feel good and I never add carbohydrates. However, I would like to ask Dr Ahn if it is a good idea to replace the therapy with Afrezza+Icodec.
Thank you
Luigi
without knowing your specifics, I think what you're doing is the way to go. Icodec won't be available for a while. The only tweak I would suggest is possibly trying Fiasp or Lyumjev, and then maybe adding Afrezza on top for special situations.
@@DiabetesDoc
Thank you for the suggestion, I will integrate Fiasp.
Good day
Hi lui , so many manu questions want to ask you. How long did take you to build up the iAPS system ? Did you got any help from endo or anyone for buildup. How good is working for you ? And what is your average BG ? Do you have to he very expert in using the system or could be simple as omnipod 5 ?
Sorry for all the questions but I was looking for someone using this system .
Thanks
@@shahinmsh
HI,
Unfortunately I can't answer you here.
Better if you ask Justin
Thank you
Can anyone tell briefly what iAps is or direct me to where I can read about it?( My daughter is currently in Dexcom G6 +Omnipod 5 using Fiasp, but only started the Omnipod 5 recently. She has diabetic retinopathy, so I am also helping her due to visual impairment. Thank you.
" The American Helathcare system is broken ." .... understantment of the century!
I'm considering changing to fiasp myself 🙂
I love it
Aquacure AC50 is doing this for me...
Hi Justin , your blood auger looks amazing . Some update about iaps please , how well is working for you ?
Vids are coming ;)
Stuck with Humalog. Fiasp wont work with Tandem X2. I have Blockages. Some have had success but not me.
interesting...
Fiasp is included in the $ 35-a-month price.
Thanks! David clarified this in the episode. Happy to hear it.
I have horrible hba1c ie poorly controlled and I have tried to get afreeza but my insurance never approved it. I have fear towards needles so I am not really taking fast acting insulin. I would have loved afreeza but it was never covered by my insurance. I could not take lantus because it stung so bad and got levemir but my insurance created so many obstacles to get it. Now I no longer live in USA and afreeza is not available where I am.
ugh the struggles of t1d are real. Sorry to hear all this.
Where did you get that screen with the live chart on your BS in the background?
Link in the description of my video :) it’s called Tidbyt!
@@diabe_tech Thanks!
I live in the UK: this is sick. The price of insulin? WTF?
Yup....
What is a “rage bolus”?
A rage bolus is when someone uses a large amount of insulin to treat a high often resulting in a low. (Not advised!)
There isn’t any diabetic two or one insulin that’s going to bear any difference on the intake after a meal and the problem with that is that whether you type one or type two you bolus or you take your insulin as as as needed, and then you come out with a high blood sugar because you just finished eating and the medicines that attacked the food Before eating your food that’s my question
I felt that guy. ...hate oral insulin. As a pills ... so he is talk about not effective in absorb....not a clean guy
Basically, this video is just a commercial for another money-grabbing pharmaceutical company.
56:56 Hahahaha Justin, your face is exactly how I felt hearing that. That literally made me laugh out loud. Thanks for keeping it real out here for us. 🤣🦾🩵
Thanks!
Thank you so much!!! 🥰 your support means everything.
Thanks!
Thank YOU! 🥰