I do prescribe micronised progesterone to women with early pregnancy bleeding specially with recurrent miscarriages since a very long time. I am an OBG consultant in India. It has worked for these women with better outcomes- term livebirths. Thank you very much for your valuable research, Prof Arri. It is very helpful to me.🙏
After 3 miscarriages I had to go to india to get help as the uk wouldn't help and didnt seem to be bothered about miscarriages they prescribe me progestrone a gynecologist in India it worked the first time I took it I am now currently 6 months pregnant my miscarriages previous did not last longer than 5 weeks
Thanks a lot. How can I reach out to you please? I have experienced multiple losses and would like to get in touch with your clinic please for further testing and the use of progesterone.
Hello, our clinical trials only studied vaginal micronized progesterone. The evidence from our studies therefore only applies to this vaginal progesterone.
Is prophylactic micronized progesterone recommended in pcod pregnancies in pts with long period of infertility treatment (eg.6 yrs) with no symptoms of bleeding sir
Dear Basheera, no, in the context you have given, I would not generally use progesterone, but please note this is general guidance, and not specific to your care (for which you will need to seek a medical opinion). Thank you.
This Prism trial infuriates me because the data does NOT help those that need progesterone starting 3 days after ovulation! For half of those women in the PRISM trial it was too late to start the progesterone only starting when they have bleeding. There is data of this but why on earth do doctors not investigate this further?
Hello, I very much agree there is a need for a clinical trial to look at the value of luteal phase progesterone to prevent miscarriages. In the PRISM trial, we focused on the value of first trimester use of progesterone to prevent miscarriages.
Dear sir, This is interesting. I have few questions. 1. When suggesting a patient for vaginal progesterone, is there any possibility of increasing infections compared to oral progesterone? 2. As infections are a known cause of second-trimester miscarriage, do you recommend doing high vaginal swabs or bacterial vaginosis screening prior to starting vaginal progesterone? Thank you.
Dr I have bicurnate uterus and I had one preterm at 32weeks which is no more and stillbirth at 29weeks.what would be the medication for further pregnancy.pls suggest
I do prescribe micronised progesterone to women with early pregnancy bleeding specially with recurrent miscarriages since a very long time. I am an OBG consultant in India. It has worked for these women with better outcomes- term livebirths.
Thank you very much for your valuable research, Prof Arri. It is very helpful to me.🙏
After 3 miscarriages I had to go to india to get help as the uk wouldn't help and didnt seem to be bothered about miscarriages they prescribe me progestrone a gynecologist in India it worked the first time I took it I am now currently 6 months pregnant my miscarriages previous did not last longer than 5 weeks
Thank you, Caroline, for sharing your story with us. I hope all goes well with the pregnancy 🙏🏽
Experiencing exactly the same, Germany couldn't help, now I'm in Pakistan and get more help for my second pregnancy (1 miscarriage )
Hi Caroline, I got the same problem, I have never tried progesterone but I'll give it a try for sure
Great lecture, sir! Will be interesting to see what ACOG does with your work!
Thank you, Dr Sperling, for the kind comment. Yes, we are really keen to find out what ACOG will make of this evidence! Arri
Thanks a lot. How can I reach out to you please? I have experienced multiple losses and would like to get in touch with your clinic please for further testing and the use of progesterone.
Thanks alot
Dear Fadia, you are very welcome 🙏🏽
How much more effective are progesterone injections vs vaginal or oral pills?
Hello, our clinical trials only studied vaginal micronized progesterone. The evidence from our studies therefore only applies to this vaginal progesterone.
Has there been a new study for women with recurrent miscarriage with normal fetal karyotype that starts progesterone 3 days after ovulation?
Hello, such a study is needed, but to my knowledge, I have not seen a randomised controlled trial on this question.
Is prophylactic micronized progesterone recommended in pcod pregnancies in pts with long period of infertility treatment (eg.6 yrs) with no symptoms of bleeding sir
Dear Basheera, no, in the context you have given, I would not generally use progesterone, but please note this is general guidance, and not specific to your care (for which you will need to seek a medical opinion). Thank you.
@@Prof_Arri_MRCOG Thank you so much sir
This Prism trial infuriates me because the data does NOT help those that need progesterone starting 3 days after ovulation! For half of those women in the PRISM trial it was too late to start the progesterone only starting when they have bleeding. There is data of this but why on earth do doctors not investigate this further?
Hello, I very much agree there is a need for a clinical trial to look at the value of luteal phase progesterone to prevent miscarriages. In the PRISM trial, we focused on the value of first trimester use of progesterone to prevent miscarriages.
Can progestrone determine the gender of the baby?
Dear sir, This is interesting. I have few questions.
1. When suggesting a patient for vaginal progesterone, is there any possibility of increasing infections compared to oral progesterone?
2. As infections are a known cause of second-trimester miscarriage, do you recommend doing high vaginal swabs or bacterial vaginosis screening prior to starting vaginal progesterone?
Thank you.
I had progesterone pessary for 6 weeks as long as hands are washed before insert should be fine I had no infections with this method
Dear Yapa, we didn't find any increase in infection in our two large trials - so this is reassuring. Thank you 🙏🏽
Dr I have bicurnate uterus and I had one preterm at 32weeks which is no more and stillbirth at 29weeks.what would be the medication for further pregnancy.pls suggest
Dear Sarita, I am really sorry but I am not allowed to provide clinical advice for any specific individual - Thank you for your understanding.
It's ok dr.i was only asking for some opinion.since I was having hard times.
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