Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging
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- Опубліковано 8 тра 2024
- Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.
EPISODE LINKS:
Show notes and transcript: www.foundmyfitness.com/episod...
"The Telomere Effect" Book: amzn.to/2KHvaen
Dr. Elissa Epel on Twitter: / dr_epel
Aging, Metabolism, and Emotions center at UCSF: www.amecenter.ucsf.edu/
Seeking 30-to-60-year-old females in Northern California for a trial at UCSF:
www.stressresilience.net
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Chapters:
00:00:00 - Introduction
00:01:37 - Lifespan vs healthspan
00:04:29 - Factors of aging
00:05:47 - What are telomeres
00:10:57 - Telomerase activity and cancer
00:13:39 - Short telomeres accelerates aging
00:15:56 - Telomere length factors:
00:16:45 - Chemical and heavy-metal exposure
00:17:35 - Air pollution
00:18:30 - Diet
00:19:04 - Coffee
00:19:17 - Sugar
00:23:48 - Chronic stress
00:28:34 - Exercise
00:29:05 - Gender
00:33:48 - Pregnancy and pre-conception
00:42:01 - Education
00:43:38 - Cancer trade-off
00:44:53 - Omega-3 fatty acids EPA and DHA
00:45:44 - Vitamin D
00:45:58 - Weight loss
00:50:06 - Glucose management
00:53:07 - Psychological stress and meditation
01:00:36 - Consumer telomere length tests
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The educational quality is superb. This is the best use of technology for this. How generous for Patrick to do this; how lucky we are to be a receptive part of the audience.
x2
Dr Patrick did a great job interviewing as usual, but I also have to applaud the interviewee for answering questions so clearly and at an understandable level. Sometimes these interviews go over my head.
Dr. Rhonda Patrick is the best, and I love the way Dr. Epel articulates the dangers of a toxic lifestyle, yet speaks about eustress (positive stress).
Dr. Rhonda Patrick is one of the most knowledgable people on UA-cam and I love the very scientific talks and podcast of her!
I'm drinking my sulforaphane broccoli sprout smoothie while watching this, thanks to you Dr. Rhonda. So appreciate this information.
I simply cannot believe this priceless content is available at no cost. There's many, many serious problems in this world, but here we have 2 exceptionally well-informed researchers sharing the best science currently available so anyone with internet access can benefit. It's a great reason to be optimistic about the future of humanity. Thank you, to both Dr. Epel and Dr. Patrick.
I look forward to this one Dr Rhonda!! Thanks for all of the great info you continue to put out!!😀👊🔥
It's so refreshing to hear genuinely intelligent interviews like this, thanks for continuing to do and to post them.
than you Rhonda!! was so happy to se a new video! great content as always
Dr. Rhonda Patrick, you are the best as always. Always glad to see all your videos, much respect to you and thank you for setting this up. 😊 ✊🏿
THAN YOU ! Dr. Rhonda ...
for yet an other amazingly interesting interview !
I usually don’t watch long videos like this, but for Ronda I’m always willing to make an exception. Her videos are always full of knowledge that we finish it wanting more. Thank you!
Me too! She is the best. I want to be on her level with my channel eventually. Thank you Dr. Rhonda Patrick.
Thank you so much for always posting the most interesting interviews. I haven't watched this one all the way through yet, but I am going to. This is going to be awesome information to tell my nutrition clients and to have on my UA-cam channel eventually! Thank you!
Rhonda, you are fantastic. Congratulations for the amazing and really inspiring work you do.
One of the best interview and very informative at different dimentions.
I love your show it's given me so much insight on cellular function and research!
Best video of yours I've watched so far... Thanks for your great work!! It really motivated me to be healthier 💚
Always a pleasure
Dr Rhonda Rhocks!
Always a pleasure to see and hear from you!
Missed your wisdom, interviews and knowledge like crazy!
Thank you!
Thanks for the great information, fascinating interview!
Thank you so much Rhonda for this podcast!! I graduated with a degree in Biochemistry and listening to your podcast reminds me why I fell in love with the subject! You are seriously someone I aspire to be like!
Please keep doing these videos.. the information on here and you're website are none other✊✊
Awesome program as always
a phenomenal eye opener, informative and educational
Thank you for sharing this information!
Im in love i love all of Dr Rhonda Patricks podcasts but im extra grateful for knowing the graceful elegant sharp intellect called Dr Elissa Epels
GREAT discussion, making healthy choices is the best UA-cam topic ever. We need to take control of our health, you can't trust corporations.
Hello rhonda thank you for sharing such nice information
Thanks for so much information; but especially for the way it is presented; all those texts and graphs; Now screen shots in my gallery; to be read rather slowly. Obviously!
Terrific! Thank You 🙏💙
Love your podcasts very interesting
Recorded in October, published in June , but thank you very much for the video
This is excellent information.
Wonderful video, please do more!
Another interesting podcast thank you!
RHONDA YOUR HAIR IN A PONYTAIL IS SO AMAZING
great episode. thank you.
🌟Love all your podcasts Rhonda! I’ve received my DNA report and currently reviewing it. It’s a great look into possible future health. 😁🌟
Love Rhonda's work and Found My Fitness! Great work, keep it up :)
Delighted to login and see another high-level, informative interview via DRP! Thanks so much!!!
Interesting culmination of life health markers; thanks for sharing
Hi Rhonda, love your podcasts, I am listening to all of them and changing my habits. Thanks! Would you maybe one day do one about menopause and hot flashes?
thank you for this amazing upload! so much nosebleed for me understanding but the amount of information are so critical and enlightening. we need to share Dr. Rhonda's thoughts/practice to a lot of medical fields esp. here in asia where u can't pick apart a doctor & police in their dumbness :)
wow the production quality is very high for all her videos, that must cost a lot, thank you Dr Rhonda P
I am having a tough time listening to this one. I’m in my 50’s and did all the wrong things. Your interview is great, but i kept hearing what I should have done, and while spot on, feeling a bit defeated. We have good genes in our family and in great health, but with high functioning ASD and ADHD, it’s super easy to let things get to me. Anyhow, I’ll pick back up on it later, just thought I’d give a bit of real world human feedback. Thanks Rhonda and enjoy your work.
very valid points... look into PreKure dot com there is a 21 day lifestyle challenge PreKureMe, coming up in September taking registrations now.
Don't be hard on yourself. We can all linger on what ifs and what not. I'm currently obese and at one point had a bmi of 46. I also smoked 10 years. I may be 30, but I also have regrets.
No doubt when I'm in my 50's I will have some regrets.
Let's do what we can now with the this new knowledge. Average life expectancy is around 80 and assuming your are adopting the newest advice into your philosophy you will live much longer.
Rhonda, how come you didn't talk about the fact that curcumin, berberine, quercetin, resveratrol all inhibit the telomerase in human cells, and so most likely shorten telomeres? And also prolong fasting (more than a day) shortens telomeres too.
So should we consume curcumin ? And isn't longer telomere good ?
@emmas8.Could you explain how prolonged fasting more than 1 day would shorten your telomeres?
These are great. Really appreciate these videos.
Conflating rumination with stress and shorter telomeres? IMO both positive and some negative rumination is a good thing that can take time to build bridges and unite neurons that might not ever have made the necessary problem-solving connections, and often runs parallel with positive medium stress conditioning and long distance exercise.
There is a dichotomy in that high BP and malnutrition can go undetected if related to poor dietary habits. When we can burn off huge amounts of calories we have a tendency to believe we can eat and sustain ourselves on whatever, whenever, and supplements will always be there later to provide us with quick fixes. We also can develop the idea there are no boundaries to how much we can overstress our physiological systems and psychological limitations; that's the mythology too often reinforced in sports media and military propaganda which ignores the greater likelihood of permanent traumatic injury, as well as PTSD and its aftereffects.
Thanks for posting a great discussion, doctors. It was a privilege to listen to both of you here together.
Exactly! Most people in America are deficient in some vitamin or mineral because they do not eat the foods that have those nutrients in them. There really are no quick fixes, no magic pill and no supplement that is going to cure diseases made because of a poor diet. Thank you for such a well written and wise comment.
Great people and great interview. Thanks. But as a friend asked me, "Hasn't the Horvath clock replaced telomere length for gauging biological age?" Was this taped 5 years ago?
Another fabulous interview by Dr Rhonda Patrick. Dr Epel states that sugary drinks and red meat are inflammatory and likely to accelerate Telomere depletion. I get the sugar link, but didn't Rhonda Patrick (citing others) challenge the 'red meat bad' claim? If I recall correctly, it was based on one flawed study where the red meat consuming group was completely uncontrolled for other lifestyle factors and was compared to vegetarians who are more likely to be at least a little conscious of what they consume.
Hello Dr Ronda Patrick, would it be possible to make a video on your supplementation/diet routine during your pregnancy/right after? I also learned about visbiome recently and would have loved to use your affiliate link :)
all your video's are awesome even if not fully understood. I am requesting David Sinclair if he is relevant in your knowledge he is about the aging process...
I assume, from personal experience, that ones creative pursuits plants oneself (assuming you capability to make time for it, or go discover it) into a deeply relaxed, creative, and curious state. From a love for mathematics and coding to a love for creating art, writing, playing/ making music, reading, or whatever your preference is. Getting in that deep parasympathetic state, raising vagal tone, stabilizing your heart rate, getting you into a deeply focused creative zone. Ide assume creative pursuit is a great proxy for meditation, considering you are sober. Especially if you do some deep breathing while you do your craft. You enter a reparative state that anyone should be attracted to, not only so you are perusing, bettering your craft, but addittionally you are activating/birthing new creative nuerons, and potentially reversing oxidative stress on your body. Nutrition for the brain coming from your own hacking/ understanding of homeostasis.
Rhonda I have not heard you speak about Thyroid health and increasing the metabolic rate. have you got any content or thoughts on this?
Sascha Ehrentraut or on iodine? I must go look now.
Regarding the 15m mark, I've heard Peter Attia mention that telomeres may be more of a marker of aging (like hair color), so extending them (or coloring), isn't likely to help.
However, after listening to this, it sounds like there is some causal relationship.. especially considering how people with lower amounts of telomerase (via genetics (progeria) or environmental), leads to a greater probability of CVD/dementia... or how women, in addition to longer telomeres at birth, estrogen up-regulates telomerase.. and therefore might partly explain the longer lifespan compared to men. And since women have a higher risk for autoimmune diseases (but less cancer) suggests the force driving longevity must be pretty strong! Perhaps the pre-menopause blood/iron donation is also a factor.
Finally, would have loved to have heard their take on cloning as it relates to telomeres . For example, while Dolly the sheep's early death might have been viral related, weren't her telomeres much shorter than her chronological age would have predicted? Has 20-years of cloning since provided any additional insights between the connection of telomeres and life-span?
The book mentioned at the end 'The Telomere Effect' is available as an eBook for Kindle, at just 2.40 US $. Can not be a bad buy.
Stress hormones are great for surviving emergent scenarios but the delitirious effects in the physiological aftermath destroy/age us. Grace under pressure can be cultivated through yoga and meditation along with other lifestyle changes congruent with living a long and healthy life.
So true! Have you gotten to check out the talk with her and the sleep expert? That one is such a good follow up to this because they talk about weight loss and stress and sleep.
19:08 was so relevant to me and my daily intake of life-nectar....aka coffee. Thanks Dr. Patrick!, you made my day.
Wait, what, the females in M/F twins have male-length telomeres? That's a huge insight briefly mentioned and so surprising - what the heck is the mechanism there? What does "masculinization" mean in utero? This seems like it has to peg telomere length determination after sexual differentiation AND as a function of factors present at the placenta/uterine interface.
Hi Rhonda! I really like your videos and I think I can count on your opinion. Its off topic, but recently i read about spinach extract which contains beta ecdysteron. What do you think about it? Does it work? If it does it would be interesting to make a video about it. Thank you for your answer in advance! Have a nice day! :)
Hello Dr. Rhonda Patrick,
You rock! I, however, am very confused about what good fat and bad fats are considered these days. Would you be willing to talk about this in more detail? I know there is evidence that full-fat dairy is actually good for us and it does not cause heart problems, on the contrary.
However, the government has been promoting low-fat (mostly full of sugar) options for a healthy lifestyle. I am on a keto diet and I struggle to understand which fats and why are good for me and my toddlers - who also need loads of fats. I am not educated on the topic but would really appreciate if you would help shed light on this one. Because if we search for what good fats as, this is more or less clear - omega 3 fatty oils, fish, nuts, avocados, etc. The struggle comes on the bad fat research. Full-fat dairy appears to be in the bad fat group (the saturated ones). Could you please explain what are the kind of fats out there and why they are good/ bad? This would be soo useful for people on a keto diet, I´m sure!
Thanks so much!
Does anyone know the brand of gluclose monitor she mentioned? Thanks
Superb preparation for healthy offspring! May your telomeres lengthen ,
And your doublestrand DNA
Strengthen
If one had a CGM, what range would you stay in?
I am eating broccoli sprouts with mustard seed powder as i watch this.
They are healthy at the moment ur eating them...
I learned this from Dr. Greger
How's it taste
@@jeffpuhlick8405 gross. So I put lemon based dressing organic and healthy kind, made it better.
what is processed meat? and red meat was mentioned, can this be explored more specifically, as in what type of processing... does that include salami made in the traditional way say recipes from 200 years ago, or meat that is butchered on a home farm and eaten within several days, or perhaps bacon made with celery juice and prepared at home, compared to say beef hot dogs, purchased at Walmart or Sprouts
...
Any thoughts on telomeres inhibitors in the fight against cancer??
Great presentation. Thank you. But you did not mention the horror affects of vegetable oils. That is just as bad or maybe more than sugars and also remember Msg it is very bad. also those products have many different names so we will not recognize them. Please consider this. Thank you again.
Anyone else waiting for the sinclair interview?
Can’t wait! Do they have one scheduled?
@@shellabella8625 it was done a while ago but not published yet!
yes!
Yes! It was done in February, and it's almost August now. So, nearly half a year. At this point I just want to know whether it will be released AT ALL, so that I know whether to keep my hopes up.
Dr. Rhonda, you should really start to think about reversing your push of sulforaphane in those smoothies etc.... it really turns out that you could be unknowingly hurting a lot of people because of toxicity issues......... look it up, things change according to the data, follow it.
Hi - I've always had severely excessive saliva, as in "words sound wet and slushy, saliva strings between her teeth and forms at the mouth every time she speaks", it's gotten worse over the past few months. I'm 27 years old and have the most saliva I've had since I was 2. I'm also showing early aging signs (my neck under my chin crinkles a little when I look down, and my weak chin's starting to turn into a full turkey neck). My question is, am I going to be a gurgling mess by age 40 or won't this get worse continually? I can still sort of manage my saliva but I drool a couple times a day now whereas I used to only drool about once a week.
How long does civilization have if babies are progressively born with shorter telomeres? How long until genetic birth defects become common to the point of becoming a serious issue that needs to be addressed as an existential threat to our species?
I was wondering this too... and what happened to the humans that lived through WW1 and WW2 and were born between to parents who were in the thick of it
what length would my Telomeres be at brith when father was aged 47 ??
44:53 Omega 3 EPA and DHA and then Vitamin D
Any comments about GDF-11?
Excellent information. Although I would have liked to hear about the effects of EMFs on telomeres. I can only imagine...
I have been suffering with severe chronic fatigue for over 6 months. I am 40 years old am athletically fit, well aside from being so tired I look fit. A lifetime of bodybuilding and kickboxing I ate fairly healthy then suddenly my body just tuned off. Gradually the loss of energy came on over 2018 then by December i was not able to get out of bed anymore. I am still off work to this day. I have been through every test known to man and there where some odd things that came up like ZERO vitamin D I have now fixed that. Had a bad fatty liver I am guessing from to much sugar. I have now balanced the enzymes and have reduced the fattiness a lot but there is probably another year to go till all the fat is gone. This cured form from chronic headaches and getting colds and chest infections almost every month. I am still so tired.. I can never get enough sleep and when I am out I am in deep deep sleep. If I go for a walk while I am walking I feel ok about average not full or energy just average. After the short walk when I sit down I am so tired I fall asleep when I wake up i continue to be exhausted. My wife has been researching Mitochondria issues. The problems I have seem to line up with this, all the blood work shows I have an issue with this. There are therapies to help like Oxygen breathing therapy combined with high dosses of vitamins and a strict palio style diet but nothing is covered under medical because its still considered voodoo science. I feel like I am starting to die. I have always been a fighter and now my body is giving up. Kidny's are also starting to fail and I have a huge loss in IQ and Cognitive ability. I do not drink do not smoke, I eat healthy, rest try to exorcise nothing works and no doctors are helping. they just say well this is how it is you cant work... I cant accept this its not normal. Being 40 and not able to work anymore is really scary. I have always worked with my hands and have to get back to work for my sanity and financial reasons.. Not sure how posting here will help.. I really dont know what to do. Just wanted to share my situation hopefully one day we find out whats causing this.
Maybe asking and answering these questions can be of some help to you:
Thyroid?
Testosterone?
IGF-1?
Nutritional deficiencies?
Adult-onset food allergies?
Choline to treat fatty liver?
Recent/current Life stressors?
Sexual dysfunction?
How much sleep do you get?
What is “healthy eating” to you?
Contact a doctor who can diagnose mitochondrial diseases?
Contact a mental health professional?
Wishing you all the best. Good luck.
Do a diet shift. Change things up. Try different sups for mitochondria support. Too much activity puts stress on the body. There are people out there who can't do anymore than 2 days of exercise. Etc.
@@tylerbradshaw9596
Thyroid?
- Healthy
Testosterone?
- 465 ng/dL
IGF-1?
Lower range but considered normal
Nutritional deficiencies?
Not anymore
Adult-onset food allergies?
No
Choline to treat fatty liver?
Yes
Recent/current Life stressors?
Moved overseas where I do not speak the language
Sexual dysfunction?
No and no signs of slowing down
How much sleep do you get?
7-9 hours is optimal for me but since the fatigue i cant get enough.. i can sleep 20 hours a day and still can barely operate properly.
What is “healthy eating” to you?
A keto or palio based diet
Contact a doctor who can diagnose mitochondrial diseases?
No such thing where I live. This is still considered voodoo science. This is what my wife and I feel is going on. We are 99% sure.
Contact a mental health professional? Yes and they see some frustrations and stresses but no signs of depression or mental struggles causing this severe of fatigue.
@@SkedgySky Yep this is what I am currently doing. A palio based diet was suggested to help treat mitochondria issues. My normal workout routine is 5 days a week. 3 days kickboxing 2 days weights. with work 5 days a week 10 hours a day as a welder. I use to work outside as a welder 7 days a week 12 -14 hours a day for 36 days in a row then go to the gym after for 2 hours .. so to be where I am all of a sudden is a nightmare.
@Trinitrophenylnitramine The latest science has proven its caused from sugar and not fat. It was even talked about on this channel. It was covered in countless science articles showing how we where lied to about the dangers of sugar. Hense the rise in popularity of the Keto diet. As soon as I cut sugar and still ate the same things my fatty liver was improved in only 6 months. All I changed was sugar intake.
I wonder how grandparents telomere length impacts grandchild?
The UCSF initiative for no sugary drinks isn't as great as she makes it sound. They still push large coolers of coke and soda beverages, including diet coke, coke zero, etc. Just not straight high fructose corn syrup. As well as a cooler of ice cream and cookies at the cash register. In my mind it stops extremely short of what it could've been, maybe even harming the consumer in different ways that otherwise wouldn't otherwise drink diet soda's.
Did I hear that right? the older the father the longer the telomeres in spermatozoa? Mechanism???
Did you see the new results on the vitamin D supplementation?
What is up with that?
? Elaborate?
But does longer telomere mean the chromosome can be replicate more times? Does longer telomere just mean you lose more with each replication?
The recording of the David Sinclair podcast must have burst into flames or something.
💕💕💕
will VI-E lengthen Telomeres ??
Can't believe she's 55 😲
I wonder if progesterone is as, or more, important than oestrogen.
bendtrucker good question.
Studies of hormone replacement therapy have found more benefit with estrogen alone than with estrogen plus progesterone:
www.nature.com/articles/nrendo.2016.164
For hair it is.
Rhonda,failed to ask her ,what she does to keep her telomeres healthy and long?
10 minutes walk everyday. Less stress (so hard ). More fiber, leafy greens.
Etc micronutrients magnesium. Vit d . Zinc. Copper (careful with dosage ,rely on food ) vitamin c
Vit b12 .
Music . Meditation. Quality relationships
Oooohhhh yaaaaayyy!!!!!!
Coffee wooohoooo
Look at me Juan Valdez, love that coffee
250K subs & 51K views... for a wonky technical interview.
There IS hope...
Do something small and ez every day and that how you program your sub conses
50:00
Why do women live longer? Grandmothers are needed more than grandfathers, might have something to do with it. 💚 But I like the physiological answer better. 🖤🧙♂️🇧🇦 In utero development, or lack thereof, marks for life. If the mainframe is missing parts or connections, the results will be deficient. Epigenetics is worthy of further study. My father was 30 when I was conceived, a latent benefit of WWII. Rushing into parenthood is, for some, pure folly. 💚
Lost 21 kilos recently. Was bordering BMI 30.
How have you stayed seemingly healthy to the age of 70? I'm 28 and want to be healthy for as long as possible.
How old is Dr. Elissa Epel?
And is she Susan Lucci's sister?
Stress can be neurological. When you hold it just simply shake like a dog
Here are two very intelligent professionals discussing very critical, environmental or epigenetic factors in longevity. It would have been even more interesting had you discussed HeLa cells. Is this research not applicable to your discussion?
It's my believe that our life is Planned from start to finish , Our time of birth and our time of passing set in stone !!! we are born with a set amount of energy to complete this lifetime ,If you spend most of your life stressing,or just seeing the negative side of everything your energy will be weakened ,to the point where the last year's of your life will be a struggle. If you try to see the positive side of everything, your energy will allow you a far easier passing and a more fulfilling life 😊😊 Think positive +
Do you agree with dr Joe dispenza and what he is doing?
Is everybody's telomere's the same length from birth?
Wow, great question
No they are not, the interview goes into detail several times about the effects of both parent's contributing genes, the mother's stress level and diet during pregnancy, etc, that would account for differences at birth.
Reg. there discussion on the long telomeres in mice.
Labmice are according to Bret Weinstein bred and sold by one company alone and have a mutation. Wild mice don't have long telomeres. Unexpectedly long telomeres in labmice expained here. ua-cam.com/video/JLb5hZLw44s/v-deo.html