Yeah, that would be great. Fascinated to know the extent to which orally ingested collagen can avoid breakdown like most proteins and the factors that influence.
Supplemental collagen yes. Let body naturally incorporate it into tissues needing collagen. mRNA with LNP delivery to potentially brain, eyes, heart etc & deposition where not needed - no way. Another money spinner with severe adverse effects from BigPharma it would seem. Bill Gates praises mRNA technology for dramatically reducing costs. Therefore expands profit margin. He ignores safety.
Sure, society practically demands proactive vanity, but I can't help but think that younger looking skin will probably also be younger acting skin--and it would shock me if there weren't lots of unknown pathways and interactions affecting health. Looking good is probably a path to feeling good.
I would love to see video on collagen peptides and also hyaluronic acid :-) your videos are great, I love how you describe the actual biomechanics of each substance!
Yeah, skin cosmetics and other stuff, but I just can't wait when the discussion would shift to ligaments, tendons and cartillages and how would this technology apply not just to aging but also to people affected by terrible debilitating genetic connective tissue disorders.
Since elasticity is what appears to be lost I'm surprised at all the focus given to collagen rather than elastin, especially given that the face will deform differently even with collagen added ...but then again a restylane injection can absolutely fill in wrinkles for a year or so and definitely makes one look younger...
Great video yet again! It would be great if you could share companies offering products linked to the subjects you’re covering. If a company starts offering mRNA collagen, I’d be very interested in trying it out💪🏻
When I took biology, the professor said elastin was the protein that gave skin its elasticity. If that is true, why is elastin never mentioned when people talk about skin aging and loss of elasticity?
Copper Gluconate plays an important role in Collagen manufacture and is a simple cheap and effective way to help improve your skin quality and hair. Copper also helps to reverse grey hair to some degree..
Great video. I would like to see a discussion on precursors of collagen compared to collagen supplements. As precursors you also have orthosilisic acid (a more bioavailable form of silicon) supplement, named often Biosil that contributes to collagen formation. thanks
Anecdotally, a 90-day course of polypodium leucotomos extract visibly improved my skins' appearance. Supposedly active in the extracellular matrix as an anti-inflammatory/antioxidant. Purported as an oral sunscreen.
It would be interesting to see studies of natural and easily accessible (cheap!) sources of animal gelatin. I tried powdered formulations for over a year with little apparent effect, but after about 3+ months of using natural sources (homemade), my nails are growing stronger (thicker and less splitting/tearing) and faster.
Thanks Eleanor. Would be nice to get a presentation, or interview with an expert, on photobiomodulation. Science around the biological effects of light, especially near infrared effects on skin health and remodeling seems worth exploring.
I've been taking 15g of collagenup marine collagen a day for two weeks and my family is stunned. 5g in the am and 10g pm in coffee. My lines are disappearing. My son said I looked 10 years younger. It works.
Just wanted to express my gratitude for your videos. I'm really enjoying them and feel I'm learning a lot. Also, not sure if I'm the only one, but i can't stand seeing these poor critters tested on. I hope science is able to move beyond animal testing at some point sooner than later in the future.
I’m just ready for actual procedures or pharmacology that Will actually start doing something. As long as I’ve been alive, it’s still just wear sunscreen, stay active, avoid smoking alcohol stress, have good nutrition, and sleep well.
Collagen really help my joint specially my knee, I workout a lot and started taking Collagen a year ago, mixed it in my Coffee and put some in my tea 2 hour before bed at night and it does help my recovery and I can squat in full range of motion with pain, its amazing as 50yrs old exercise addict.
Thanks! Would be good to know what kinds of dietary components might inhibit breakdown of collagen and loss of hyaluronic acid. Recall that EGCG (in tea) for example might inhibit to some degree MMPs which cause breakdown in collagen, and rosemary might inhibit hyaluronidase which breaks down hyaluronic acid. In what concentrations and which collagen types are affected I have no idea, but I consume both.
There is one thing : It is not a destruction of collagen as we age rather the type of collagen changing from type1 to type III under the influence of TGF beta as a result of SASP of senescent cells. Type III collagen does not hold water as good as type 1 collagen hence the aged and wrinkled skin.
This is rather suprising study, given that I've thought that protein cross-linking is one of the key drivers driving skin aging, which is why treatments like laser skin resurfacing work, as the crosslinks are wiped out and new, functional collagen is formed to replace them as the skin heals.
I would like to see a review of the effectiveness of collagen supplementation. Also, you are correct. It's pronounced "veh-sicles." I will fight anyone over this.
Yes. Review collagen powders. Given the fact that proteins are large molecules that can not be absorbed by the gut without first being broken down (digested) into their constituent amino acids, taking collagen directly seems stupid to me, or at least inefficient. Taking an essential amino acid supplement should be just as good or better, since they can be absorbed directly and synthesized to collagen (or any other needed protein) as long as they are present in sufficient abundances. Theoretically, collagen supplements should only help in EAA deficient subjects.
Since collagen is a protein (amino chain ) it would be equal to any other protein supplement, the body would separate the aminos and use them to whatever it thinks is the best use for each amino
Disappointed to find out they had removed the thymus. Fibrosis & autoimmunity could be side effects. IIRC bleomycin injection into skin can cause lung fibrosis & scleroderma. Also, were these male mice only? ~ Collagen hydrosylates are interesting & not just for skin aging. There's an orally bioavailable octapeptide from chicken collagen hydrolysate that can improve endothelial function, prolyl hydroxyproline can improve mood, etc.
Presbyopia is a common age related condition, collagen maybe consider as culprit due to over disposition on ciliary muscles causing loss elasticity and visual accommodation, wouldn't be reasonable to design a gene therapy to express collagenase enzyme to target that excess collagen without harming other eye components
The lost of connective tissue integrity as a whole makes everything sag. It also forces muscles to work harder to complete the job. I have ehlers danlos syndrome and i live with this every day as a 39 yo.
Hello! Could you, please, investigate regarding of collagen intake? Personnaly, I take Multi-Collagen Protein Powder (5 Types 1, 2, 3, 5 and 10 Collagen Peptides) Hydrolyzed Grass-Fed Bovine, Wild Sea Fish & Free-Range Chicken, the product is unflavored. Thank you! 😊
If you took DNA from a person when they were 25 years old, stored it and then injected it back into that person when they were 35 would it turn back the biological age of the person. I know that injecting young blood into older people has some benefits but it would be better if it had your own dna
Also, waiting for tenascin stimulation which is yet another important subtance that get s your tissues back and place before they stretch like hell. Who knows, maybe there's hope for Ehlers Danlos and Marfan.
Yes, I saw the case report, think it was in the Netherlands or Belgium. Thnx for pointing out. In any case, let's hope someone who can throw $ millions will stimulate this resesrch.
Now i like collagen, but i also like p53... but which is better. There's only one way to find out....!
Hah! There can only be one... Worlds Coolest Protein!
Given your thoroughness and breakdown of biomechanics I would definitely love to see a Sheeky Collagen poweder/pill breakdown.
Agreed!
Yes, as well as if it is possible to produce collagen peptides at home from cheaper stuff!
Yeah, that would be great. Fascinated to know the extent to which orally ingested collagen can avoid breakdown like most proteins and the factors that influence.
I would like to know your view on collagen powders
Yes please!
I would love to hear more about collagen, supplements, and their effectiveness. Thank you for such a great video.
Supplemental collagen yes. Let body naturally incorporate it into tissues needing collagen. mRNA with LNP delivery to potentially brain, eyes, heart etc & deposition where not needed - no way. Another money spinner with severe adverse effects from BigPharma it would seem.
Bill Gates praises mRNA technology for dramatically reducing costs. Therefore expands profit margin. He ignores safety.
Sure, society practically demands proactive vanity, but I can't help but think that younger looking skin will probably also be younger acting skin--and it would shock me if there weren't lots of unknown pathways and interactions affecting health. Looking good is probably a path to feeling good.
Yes, I would like to see what your research says about ingesting collagen.
I would love to see video on collagen peptides and also hyaluronic acid :-) your videos are great, I love how you describe the actual biomechanics of each substance!
Yeah, skin cosmetics and other stuff, but I just can't wait when the discussion would shift to ligaments, tendons and cartillages and how would this technology apply not just to aging but also to people affected by terrible debilitating genetic connective tissue disorders.
Would Love you to look into oral consumption of collagen powder
Since elasticity is what appears to be lost I'm surprised at all the focus given to collagen rather than elastin, especially given that the face will deform differently even with collagen added
...but then again a restylane injection can absolutely fill in wrinkles for a year or so and definitely makes one look younger...
restylane is toxic chemical
Great video yet again! It would be great if you could share companies offering products linked to the subjects you’re covering. If a company starts offering mRNA collagen, I’d be very interested in trying it out💪🏻
When I took biology, the professor said elastin was the protein that gave skin its elasticity. If that is true, why is elastin never mentioned when people talk about skin aging and loss of elasticity?
Yes please do an episode on Hydrolyzed collagen and other collagen and elastin protective supplements.
You don't know how grateful I am.Thank you Miss Sheeky. And yes to the collagen powder I've been interested in it lately
Copper Gluconate plays an important role in Collagen manufacture and is a simple cheap and effective way to help improve your skin quality and hair. Copper also helps to reverse grey hair to some degree..
I needed my weekly sheekey. Thanks
Great video. I would like to see a discussion on precursors of collagen compared to collagen supplements. As precursors you also have orthosilisic acid (a more bioavailable form of silicon) supplement, named often Biosil that contributes to collagen formation. thanks
Anecdotally, a 90-day course of polypodium leucotomos extract visibly improved my skins' appearance. Supposedly active in the extracellular matrix as an anti-inflammatory/antioxidant. Purported as an oral sunscreen.
What brand do you use for polypodium leicotomos? Pill form?
Since 1968, in Spain is used for Psoriasis, the name of medicine is Anapsos.
I really do hope you do a video on collagen replacement therapy. (Edit: I meant collagen powder and the science behind it)
It would be interesting to see studies of natural and easily accessible (cheap!) sources of animal gelatin. I tried powdered formulations for over a year with little apparent effect, but after about 3+ months of using natural sources (homemade), my nails are growing stronger (thicker and less splitting/tearing) and faster.
What do you define by "natural homade sources"?
@Connie H If the ingredients show colagen you may be OK. Just remember that most candies et al. are made with corn starch, ergo, no intended effect.
I also think that supplement doses are too low. I recomend pork rinds or "cortezas de cerdo" in spanish. 70% collagen.
Thanks Eleanor. Would be nice to get a presentation, or interview with an expert, on photobiomodulation. Science around the biological effects of light, especially near infrared effects on skin health and remodeling seems worth exploring.
I've been taking 15g of collagenup marine collagen a day for two weeks and my family is stunned. 5g in the am and 10g pm in coffee. My lines are disappearing. My son said I looked 10 years younger. It works.
Just wanted to express my gratitude for your videos. I'm really enjoying them and feel I'm learning a lot. Also, not sure if I'm the only one, but i can't stand seeing these poor critters tested on. I hope science is able to move beyond animal testing at some point sooner than later in the future.
I’m just ready for actual procedures or pharmacology that Will actually start doing something. As long as I’ve been alive, it’s still just wear sunscreen, stay active, avoid smoking alcohol stress, have good nutrition, and sleep well.
Drinking lots of water also improves the skin. It does seem to be the build up of glucosepane as we age that causes a loss of elasticity in the skin.
Yes I would also love to know more about the effectiveness of collagen supplements and which is best. :)
Collagen really help my joint specially my knee, I workout a lot and started taking Collagen a year ago, mixed it in my Coffee and put some in my tea 2 hour before bed at night and it does help my recovery and I can squat in full range of motion with pain, its amazing as 50yrs old exercise addict.
Thanks! Would be good to know what kinds of dietary components might inhibit breakdown of collagen and loss of hyaluronic acid. Recall that EGCG (in tea) for example might inhibit to some degree MMPs which cause breakdown in collagen, and rosemary might inhibit hyaluronidase which breaks down hyaluronic acid. In what concentrations and which collagen types are affected I have no idea, but I consume both.
You take rosemary every day? How much and in which form
Please do a video about powered collagen
There is one thing : It is not a destruction of collagen as we age rather the type of collagen changing from type1 to type III under the influence of TGF beta as a result of SASP of senescent cells. Type III collagen does not hold water as good as type 1 collagen hence the aged and wrinkled skin.
This is rather suprising study, given that I've thought that protein cross-linking is one of the key drivers driving skin aging, which is why treatments like laser skin resurfacing work, as the crosslinks are wiped out and new, functional collagen is formed to replace them as the skin heals.
If VCs decide to fund a company based on this technology, they should give the author's shares. It's good for them to have skin in the game. 😉
I would like to see a review of the effectiveness of collagen supplementation.
Also, you are correct. It's pronounced "veh-sicles." I will fight anyone over this.
Yes. Review collagen powders. Given the fact that proteins are large molecules that can not be absorbed by the gut without first being broken down (digested) into their constituent amino acids, taking collagen directly seems stupid to me, or at least inefficient. Taking an essential amino acid supplement should be just as good or better, since they can be absorbed directly and synthesized to collagen (or any other needed protein) as long as they are present in sufficient abundances. Theoretically, collagen supplements should only help in EAA deficient subjects.
5:33
cutest noise i heard today
Micro needling is already used with out medication to promote firmer skin
Since collagen is a protein (amino chain ) it would be equal to any other protein supplement, the body would separate the aminos and use them to whatever it thinks is the best use for each amino
Please do a video on oral (pill) collagen consumption!
Disappointed to find out they had removed the thymus. Fibrosis & autoimmunity could be side effects. IIRC bleomycin injection into skin can cause lung fibrosis & scleroderma. Also, were these male mice only?
~
Collagen hydrosylates are interesting & not just for skin aging. There's an orally bioavailable octapeptide from chicken collagen hydrolysate that can improve endothelial function, prolyl hydroxyproline can improve mood, etc.
Maybe a portion of aging but not wholly. Keep up your amazing work ma’am
I request a future sheekey science show on zebrafish and TREEs.
Please do a vidoe on supplementation of collagen!
This is actually a huge breakthrough if it continues to be developed. Could rewind the exterior clock by decades for humans 😎
Presbyopia is a common age related condition, collagen maybe consider as culprit due to over disposition on ciliary muscles causing loss elasticity and visual accommodation, wouldn't be reasonable to design a gene therapy to express collagenase enzyme to target that excess collagen without harming other eye components
The lost of connective tissue integrity as a whole makes everything sag. It also forces muscles to work harder to complete the job. I have ehlers danlos syndrome and i live with this every day as a 39 yo.
You also need hyaluronic acid as well to make skin look as it should.
Could you please post a review on readly available powder pills cologen, as it is far more easily available to most people.
Hello!
Could you, please, investigate regarding of collagen intake?
Personnaly, I take Multi-Collagen Protein Powder (5 Types 1, 2, 3, 5 and 10 Collagen Peptides) Hydrolyzed Grass-Fed Bovine, Wild Sea Fish & Free-Range Chicken, the product is unflavored.
Thank you! 😊
Interesting, occurred to me that melanin could prevent photoaging
Black don't crack!
Too much collagen can lead to fibrosis too
5:43 I thought you were English, but you wrote "standardize" not "standardise"
Aha, I am a strong 's' vs. 'z' user, but do much American writing, sometimes is just a habit
mRNA injections you say? What a splendid idea. 🤣🤣🤣
If you took DNA from a person when they were 25 years old, stored it and then injected it back into that person when they were 35 would it turn back the biological age of the person. I know that injecting young blood into older people has some benefits but it would be better if it had your own dna
Oh no mRNA and lipid Nanoparticles.. RUNN!!!
What about a run-away collagen production mimicking Scleroderma or worse systemic slcerosis? Yikes!
eat beef bone broth everyday and youll look fresh
Prolin glycin lysin is same working i put valin sometimes in ✅🎁
Also, waiting for tenascin stimulation which is yet another important subtance that get s your tissues back and place before they stretch like hell. Who knows, maybe there's hope for Ehlers Danlos and Marfan.
Only one family with hEDS has tenascin X issues thus far. But the CTD community is definitely watching..
Yes, I saw the case report, think it was in the Netherlands or Belgium. Thnx for pointing out. In any case, let's hope someone who can throw $ millions will stimulate this resesrch.
I can just imagine all those covidiots right now going off right now because you called mrna in lnp gene therapy 😄
😮😮😮💯🔥👍
collagen is important, but it will not reverse aging. It may reverse the appearance of aging, but aging is far more than an appearance.