My oldest son is in his early 20's and he has type 1 diabetes. But thank God for this piece of article ua-cam.com/users/postUgkxVYhghKWmrUgXARZ_ydZTvmmcrw5L0I5i At first he thought he had the flu and was lying down on the bed for three days until his sister took him to the hospital. They took his blood and it was 600. What I do not understand is how he could have gotten it, since no one in the family has it. But he is winning the battle now. This is good stuff.
Lots of people have been asking what the various inflammatory mediators are that are referred to in this production: It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...
Simply wonderful, but I'd really appreciate if the commentary used the actual names of the proteins instead of just referring to them just as proteins or "another hormon-like substance"... Not very informative
It's Amylin- or islet amyloid polypeptide, is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Here's the paper www.ncbi.nlm.nih.gov/pmc/articles/PMC4109527/
This was great, thanks, I been tryin to find out about "current treatment of type 2 diabetes" for a while now, and I think this has helped. Ever heard of - Laniley Kansabella Magic - (Have a quick look on google cant remember the place now ) ? Ive heard some super things about it and my mate got cool success with it.
Cheers for the Video clip! Apologies for butting in, I would love your initial thoughts. Have you ever tried - Patlarny Sugar Outcome Principle (search on google)? It is a smashing exclusive product for reversing diabetes without the headache. Ive heard some interesting things about it and my best friend Jordan after a lifetime of fighting got amazing results with it.
Excellent overview of the interaction between insulin production, inflammation, and type II diabetes. Could you provide additional resources to identify the other hormone-like substance released by the beta cells mentioned as well as the other molecules mentioned but not named? Thank you!
1) How does excessive glucose in the blood stream damage you if the proper amount of insulin would have told cells to take the glucose into them anyway? 2) What cells take up glucose? All cells? Just certain cells? 3) In this case it was radicals, but how to normal inflammatory proteins get released? 4) What reaction in the body is inflammation supposed to do? Why is it good?
I can probably answer these questions, but I'm not a trained biologists. I mainly speak as someone who's had an interest in biology, and knows some of the basics. 1). The reason why high glucose levels are so damaging, is because glucose is very high in energy content. Although basic in its simplicity, it generally creates a lot of stimulation and is broken down to create energy for the body. Too much of this energy can cause parts of the body to "burn out;" muscle aches, hot flashes and fainting are associated with glucose toxicity, among other symptoms. 2). A lot of cells take up glucose, but the most important cells in this case are: muscle cells and fat cells. Muscle cells can convert the glucose into the energy it needs to move; conversely, fat cells store up glucose to prevent it from being unnecessarily part of the bloodstream. Insulin is what is used to drive glucose into cells, but for those with diabetes, their own cells are less receptive of glucose; sometimes outright denying intake despite the presence of insulin (usually referred to as Insulin Resistance.) 3). I don't really know much about how inflammation works, aside from its purpose and that it's caused by a set of conditions, which warrant an inflammatory response. 4). The reason why inflammation exists, is because it aids the immune system. At the site of infection, white blood cells release a hormone that makes the surrounding blood vessels leak their contents; specifically, the goal is to introduce water into the site. This helps white blood cells with mobility, and allows for the transport of more protiens and hormones, and it generally fades away as the immune response dials down.
I think the public needs to eat more fiber, like pumpkin seeds, and sunflower seeds, with every bite of soft food, that we take. It may sound crazy, but more seed in the bloodstream, will reduce the Inflammasomes from forming in the pancreas, and also prevent malaria from spreading in the bloodstream from pregnant mosquitoes biting through the skin with their deadly proboscis!
Great video and I really enjoyed it, but sorry I found one big mistake in the early part of the video: obesity is actually not the cause of the diabetes. The answer should be insulin resistance due to over-eating of refined carbs is the main culprit. Here's the why: refined carbs causes constant insulin spike, leads to insulin-resistance, leads to fat cell formation, causes leptin-resistance, hence constant hunger. Thus the eating cycle starts again. Yes we should treat obesity, but it is not their fault. Refined carbs are the hidden culprit.
Actually, its probably caused more so by constant eating and your body being in a constant state of glucose intoxication. Carbs, sugars, it matters not what the source is or if its been passed through a horrific processing machine. It all gets broken down into the same molecule. Why I say this is because fasting for multi day periods, which is what we experienced evolutionarly, can reverse diabetes entirely.
Fascinating... quality animations! Does anyone know what the other "hormone like substance" secreted by the beta cells is? I assume it might be some sort of cytokine? and what what would be the evolutionary purpose of secreting it? why should excess glucose cause an immune response?
I think it might be amylin, which is secreted alongside insulin in a ratio of 100:1, so there's lots of it. I read somewhere that in such overwhelming quantities it can begin to aggregate in the islets and be proinflammatory
I haven't looked too far into this yet, but a quick pubmed search turned up a 2013 article by Taylor-Fishwick, et al. in Diabetologia: doi: 10.1007/s00125-012-2732-9. Their study suggests that that IL-12 plays a direct role in the beta cell inflammatory process. This cytokine is upregulated by TNF-alpha, IL--1beta, and IFN-gamma, and this cocktail was required in their study to induce IL-12 from both human donor and rodent beta cells in vitro. It sure would have been nice if the video included relevant citations!
It's Amylin- or islet amyloid polypeptide, is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Here's the paper www.ncbi.nlm.nih.gov/pmc/articles/PMC4109527/
It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...
Can anyone tell me how I can find a source for this information? Its the exact information that I need but I cant reference a UA-cam video. Thanks in advance
Very insightful video and very logically presented, but what is the name of the small signalling protein (the key protein involved in inflammation in the body), converted by the newly active proteins made by the inflammasome? And why can't you include the actual names of these proteins?
Could this mechanism be actually the result of an evolutionary balancing process, preventing Beta-Cells to overpopulate and/or oversupplying the system with insulin, and is now our doom, because clycose levels never had been that high before it has become this way due to our modern diet? My Question is, if that could be some kind of a secondary function for the immunesystem to react on certain eventualities. Does something like a hyperactive Insulin-System exists, which would be prevented by population-control-mechanism? Just wondering here.
I don't get it Is type 2 diabetes the lack of insulin production caused by high mortality of beta cells which in turn causes high blood glucose levels? Or is type 2 diabetes the high insulin resistance of cells in the muscle and liver not taking up glucose and causing high blood glucose?
+Xostrich12X both. It seems that in type 2, the resistance comes first, and then beta cells secrete even more insulin, and eventually leads to their death by the action of white cells described in the video! So it's not always 1 cause and 1 consequence, its biology and its always as complex as it is so you should keep an open mind when study it, to accept the way it works.
Especially simple carbs, like sucrose (table sugar) fructose (fruits) and high fructose corn syrup(placed in almost all processed foods! "We have seen the enemy..and he is ..us".stuffing our faces daily with these slow killing poisons..and more sadly still allowing our kids and grand-kids to do the same...SHAME!!
I watched all the videos in amazement. looks like machines inside a perfectly functioning factory. but these machines do not choose their behavior themselves. there can only be one GOD who orders them to work this way.
This was great, been searching for "in type 2 diabetes the main problem is the body" for a while now, and I think this has helped. Have you heard people talk about - Laniley Kansabella Magic - (search on google ) ? Ive heard some amazing things about it and my cousin got amazing results with it.
This same machanism of inflamasomes caused the death of alveoli and blood vessels cells during COVID...We have to learn how to have better control of this ancient mechanism..
Hey! Thanks for sharing! On a separate note; have you thought about " Vidadsmedia What is Type 2 Diabetes " (Have a quick look on google...cant remember the exact words)? My hangout buddies had some dealings with them and was impressed by their great testimonials and reviews and tried their recommendation!
Great information, but one fatal flaw: You presume obesity is a cause, not a symptom. You presume that obese people eat more sugar, rather than exploring an underlying mechanism that causes people to have high levels of blood sugar (hello, adrenal gland), which also causes another hormonal cascade that causes people to store energy for whatever emergency the physiology is predicting. You also don't talk about all the skinny people with diabetes. So, get back to work and figure it out before my daughter suffers a similar fate to me and her Dad. Our people come from nordic regions with short growing seasons, causing us to store energy more efficiently than those who lived in more food-rich areas. In addition, we likely ate more meat and dairy products than our peers further South. This matters. It matters to your research, and until you acknowledge it, your research will never help the people you hoped to help.
My oldest son is in his early 20's and he has type 1 diabetes. But thank God for this piece of article ua-cam.com/users/postUgkxVYhghKWmrUgXARZ_ydZTvmmcrw5L0I5i At first he thought he had the flu and was lying down on the bed for three days until his sister took him to the hospital. They took his blood and it was 600. What I do not understand is how he could have gotten it, since no one in the family has it. But he is winning the battle now. This is good stuff.
Lots of people have been asking what the various inflammatory mediators are that are referred to in this production:
It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...
Can these beta cells be brought back to life
Simply wonderful, but I'd really appreciate if the commentary used the actual names of the proteins instead of just referring to them just as proteins or "another hormon-like substance"... Not very informative
I agree
It's Amylin- or islet amyloid polypeptide, is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1.
Here's the paper www.ncbi.nlm.nih.gov/pmc/articles/PMC4109527/
@@BudgetPaladin Bless you bro!
This was great, thanks, I been tryin to find out about "current treatment of type 2 diabetes" for a while now, and I think this has helped. Ever heard of - Laniley Kansabella Magic - (Have a quick look on google cant remember the place now ) ? Ive heard some super things about it and my mate got cool success with it.
@@MariMari-vt9pj the current treatment is to avoid sugar like the plague so like that you dont get it in the first place
The representation of molecules in your videos always amazes me.
ua-cam.com/video/YGo6xybwj2k/v-deo.html Daniel Fernandes
Cheers for the Video clip! Apologies for butting in, I would love your initial thoughts. Have you ever tried - Patlarny Sugar Outcome Principle (search on google)? It is a smashing exclusive product for reversing diabetes without the headache. Ive heard some interesting things about it and my best friend Jordan after a lifetime of fighting got amazing results with it.
AMAZING job by the team of incredibly hardworking computer modelers & programmers to create these accurate animations!!
Excellent overview of the interaction between insulin production, inflammation, and type II diabetes. Could you provide additional resources to identify the other hormone-like substance released by the beta cells mentioned as well as the other molecules mentioned but not named? Thank you!
Did you find anything?
1) How does excessive glucose in the blood stream damage you if the proper amount of insulin would have told cells to take the glucose into them anyway?
2) What cells take up glucose? All cells? Just certain cells?
3) In this case it was radicals, but how to normal inflammatory proteins get released?
4) What reaction in the body is inflammation supposed to do? Why is it good?
I can probably answer these questions, but I'm not a trained biologists. I mainly speak as someone who's had an interest in biology, and knows some of the basics.
1). The reason why high glucose levels are so damaging, is because glucose is very high in energy content. Although basic in its simplicity, it generally creates a lot of stimulation and is broken down to create energy for the body. Too much of this energy can cause parts of the body to "burn out;" muscle aches, hot flashes and fainting are associated with glucose toxicity, among other symptoms.
2). A lot of cells take up glucose, but the most important cells in this case are: muscle cells and fat cells. Muscle cells can convert the glucose into the energy it needs to move; conversely, fat cells store up glucose to prevent it from being unnecessarily part of the bloodstream. Insulin is what is used to drive glucose into cells, but for those with diabetes, their own cells are less receptive of glucose; sometimes outright denying intake despite the presence of insulin (usually referred to as Insulin Resistance.)
3). I don't really know much about how inflammation works, aside from its purpose and that it's caused by a set of conditions, which warrant an inflammatory response.
4). The reason why inflammation exists, is because it aids the immune system. At the site of infection, white blood cells release a hormone that makes the surrounding blood vessels leak their contents; specifically, the goal is to introduce water into the site. This helps white blood cells with mobility, and allows for the transport of more protiens and hormones, and it generally fades away as the immune response dials down.
I think the public needs to eat more fiber, like pumpkin seeds, and sunflower seeds, with every bite of soft food, that we take. It may sound crazy, but more seed in the bloodstream, will reduce the Inflammasomes from forming in the pancreas, and also prevent malaria from spreading in the bloodstream from pregnant mosquitoes biting through the skin with their deadly proboscis!
we need to stop eating sugar aswell
Great video and I really enjoyed it, but sorry I found one big mistake in the early part of the video: obesity is actually not the cause of the diabetes.
The answer should be insulin resistance due to over-eating of refined carbs is the main culprit.
Here's the why: refined carbs causes constant insulin spike, leads to insulin-resistance, leads to fat cell formation, causes leptin-resistance, hence constant hunger. Thus the eating cycle starts again.
Yes we should treat obesity, but it is not their fault. Refined carbs are the hidden culprit.
Actually, its probably caused more so by constant eating and your body being in a constant state of glucose intoxication. Carbs, sugars, it matters not what the source is or if its been passed through a horrific processing machine. It all gets broken down into the same molecule. Why I say this is because fasting for multi day periods, which is what we experienced evolutionarly, can reverse diabetes entirely.
@@Chaos------ Sugar / Fructose / Carbs / Refined Carbs --> Insulin --> Insulin Resistance --> Obesity + T2DM
Fascinating... quality animations!
Does anyone know what the other "hormone like substance" secreted by the beta cells is? I assume it might be some sort of cytokine? and what what would be the evolutionary purpose of secreting it? why should excess glucose cause an immune response?
uli87 exactly wondering the same thing. I want to know what that hormone is.
Jesus! Thanks God for people like you! Now I want to know all of that!
I think it might be amylin, which is secreted alongside insulin in a ratio of 100:1, so there's lots of it. I read somewhere that in such overwhelming quantities it can begin to aggregate in the islets and be proinflammatory
I haven't looked too far into this yet, but a quick pubmed search turned up a 2013 article by Taylor-Fishwick, et al. in Diabetologia: doi: 10.1007/s00125-012-2732-9. Their study suggests that that IL-12 plays a direct role in the beta cell inflammatory process. This cytokine is upregulated by TNF-alpha, IL--1beta, and IFN-gamma, and this cocktail was required in their study to induce IL-12 from both human donor and rodent beta cells in vitro. It sure would have been nice if the video included relevant citations!
It's Amylin- or islet amyloid polypeptide, is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1.
Here's the paper www.ncbi.nlm.nih.gov/pmc/articles/PMC4109527/
Wow! Dramatic and so informative.
Is the inflammation originating from overfed fat cells in the gut?
It is islet amyloid polypeptide that is produced by the beta cells in response to prolonged insulin production in the islet, triggering assembly of the inflammasome by resident white blood cells. The inflammasome serves to activate caspase (I believe caspase 1), which then activates the inflammatory protein interleukin-1, which is secreted from the white blood cells into the islet, causing death of the islet beta cells. Hope this helps...
Amazing..Informative...keep doing more and more topics.
Mesmerizing video with complex structures made so simple to understand!
BETTER THAN ANY ASMR VIDEO
Im confused HELP , is that type 2 or type 1 diabetes, i thought when pancreas can't produce insulin that that is type 1 diabetes?
A special thanks to Dr udoka for curing me from type 1 diabetes,keep saving lives sir
Can anyone tell me how I can find a source for this information? Its the exact information that I need but I cant reference a UA-cam video. Thanks in advance
Me too! Did you find anything?
Wonderful work!
*@Growndweller* If you want the best method for curing diabetes go here now:: www.HootCure. club
Very insightful video and very logically presented, but what is the name of the small signalling protein (the key protein involved in inflammation in the body), converted by the newly active proteins made by the inflammasome? And why can't you include the actual names of these proteins?
one of the best videos on diabetes ive seen. loved the microscopic imagery.
Reeeeverseee Diabeteees with a “Pancreaas Jumpstart” twitter.com/5a085d502fa946eb6/status/804558352671973376 Inflammation aaand Type 2 Diabetes
great animation..
Excellent explanation and animation !Thanks a lot !
Could this mechanism be actually the result of an evolutionary balancing process, preventing Beta-Cells to overpopulate and/or oversupplying the system with insulin, and is now our doom, because clycose levels never had been that high before it has become this way due to our modern diet?
My Question is, if that could be some kind of a secondary function for the immunesystem to react on certain eventualities. Does something like a hyperactive Insulin-System exists, which would be prevented by population-control-mechanism? Just wondering here.
What is population control mechanism?
Are there specific paper references for this video? It's so great!
I don't get it
Is type 2 diabetes the lack of insulin production caused by high mortality of beta cells which in turn causes high blood glucose levels?
Or is type 2 diabetes the high insulin resistance of cells in the muscle and liver not taking up glucose and causing high blood glucose?
+Xostrich12X both. It seems that in type 2, the resistance comes first, and then beta cells secrete even more insulin, and eventually leads to their death by the action of white cells described in the video! So it's not always 1 cause and 1 consequence, its biology and its always as complex as it is so you should keep an open mind when study it, to accept the way it works.
Great graphics, great commentary why the crappy sound-effects? Completely destroyed the content for me.
Thank you so much 🙏🙏🙏
That’s crazy I just really been diagnosed with diabetes type two And I was in a coma for like three weeks how do even know I had diabetes
Are u doing alright now? Listen to the talks by surgeon Robert Cywes M.D. on his channel.
Where does inflamotry appears ?on the surface of the skine or inthe body?
Excellent !!!
Please make more of these videos!
awesome animation, but the sound effects are super distracting and really corny.
Nice pictures, but not a lot of information. And completely missing the fact that carbohydrate intake drives t2d.
Especially simple carbs, like sucrose (table sugar) fructose (fruits) and high fructose corn syrup(placed in almost all processed foods! "We have seen the enemy..and he is ..us".stuffing our faces daily with these slow killing poisons..and more sadly still allowing our kids and grand-kids to do the same...SHAME!!
Very informative.
I watched all the videos in amazement. looks like machines inside a perfectly functioning factory. but these machines do not choose their behavior themselves. there can only be one GOD who orders them to work this way.
incredible
This was great, been searching for "in type 2 diabetes the main problem is the body" for a while now, and I think this has helped. Have you heard people talk about - Laniley Kansabella Magic - (search on google ) ? Ive heard some amazing things about it and my cousin got amazing results with it.
Love this
We are not actually Human , we are something..............
This same machanism of inflamasomes caused the death of alveoli and blood vessels cells during COVID...We have to learn how to have better control of this ancient mechanism..
so that's what it sounds like in there
Hey! Thanks for sharing! On a separate note; have you thought about " Vidadsmedia What is Type 2 Diabetes " (Have a quick look on google...cant remember the exact words)? My hangout buddies had some dealings with them and was impressed by their great testimonials and reviews and tried their recommendation!
Isn't it type 1 diabetes?
Great information, but one fatal flaw: You presume obesity is a cause, not a symptom. You presume that obese people eat more sugar, rather than exploring an underlying mechanism that causes people to have high levels of blood sugar (hello, adrenal gland), which also causes another hormonal cascade that causes people to store energy for whatever emergency the physiology is predicting. You also don't talk about all the skinny people with diabetes. So, get back to work and figure it out before my daughter suffers a similar fate to me and her Dad. Our people come from nordic regions with short growing seasons, causing us to store energy more efficiently than those who lived in more food-rich areas. In addition, we likely ate more meat and dairy products than our peers further South. This matters. It matters to your research, and until you acknowledge it, your research will never help the people you hoped to help.
💝💙💚🌺❤️
👍💗😎
Don't eat the carbs. Problem solved.