Do you have links to any academic papers you used in the making of this video? This video taught me everything I need to know for a term paper I'm writing on the metabolism of psilocybin, but I'd like to learn more.
This is one of my favourite videos ever, I didn’t even know this type of academia existed let’s alone was accessible by the public. I think I found what I want to do with my life
I wish you were my biochem teacher... Excellent presentation: Your voice and direction was engaging and easy to follow. I come from a science background, but it's been many years since university, so I had basic understanding of certain molecules, actions, and processes. It was refreshing to have an approachable description on an interesting topic.
Based on this biosynthetic pathway, you would expect to find at least some DMT in psilocybin-containing mushrooms but that is not the case. The reason is that the methylation occurs after the oxidation at position 4. There is an article that explains this published in 2018. Have you considered other biosynthetic pathways than what's presented?
I'm reminded of something Alexander Shulgin wrote in TihkaL about a study were DET had been added to the culture medium of a Psilocybe species, and had been metabolised to 4-OH-DET and the phosphorylation analogue. This should suggest that the 4-hydroxylase has a rather high affinity for binding to various tryptamine derivatives. The fact that norbaeocystin, baecystin and even the muscle-relaxant quaternary aminium analogue aerogenocin, seems to support the idea that the 4-hydroxylase is a very active enzyme and somewhat 'promiscuous'. But, it's affinity to the indole side of the tryptamines, should've been studied further. I don't think it's so strange that DMT, isn't detected in significant quantities in (most) varieties of psilocybin producing mycelium and mushrooms.. But, I have mainly been reading Stamets book about Psilocybin mushrooms and free sources on the web. Sorry if this wasn't the best explanation. BTW, I remember reading about tryptamine in some type of common food mushroom. But, it's rather long ago. I will edit this comment if I find more information on tryptamine metabolism in fungi...
Hi, catalyst university, since psilocin is the active reagent, can we take psilocin directly instead of taking Psilocybin firstly and asking the enzyme to convert it into psilocin in our body.
@@metalbrute4795 I mean I did take 20g dry so probably overdid it. But, I've been wanting to quit for a minute, so its probably time. I had some good memories with the substance but also scary ones.
Didn't know Psilocybin was actually a pro-drug! Still lovin' your channel since I discovered it a year ago! PS: good to see research revisited on drugs like these in recent years, as they might actually benefit in certain mental disorders! In your face, Nixon!
I appreciate it, Biomed Master! And yes, the War on Drugs has done us a huge amount of damage as a society. While there are drugs I would say to never use, and I don't condone their use, people will still use them, and so rehabilitation programs are a far better solution to an impossible problem. Prohibition of alcohol in the 20s is evidence enough of that.
@@Sevisstillalive drug rehab/treatment doesn’t work for 90% of substance users. Why? allowing people to freely educate themselves on the substances they want to investigate without fear of interference, fear of investigation, harassment, arrest, incarceration & even murder by police or the DEA is vastly better than maintaining the War on Drugs-People. One ends Cartels & horrors of disease & incarceration by legalizing ALL drugs and regulating them accordingly. People will always consume whatever they want. They should have access to pure known dosage amounts of whatever they desire. True freedom in any market requires freedom to experiment & research…cant do that now…
Do you have links to any academic papers you used in the making of this video? This video taught me everything I need to know for a term paper I'm writing on the metabolism of psilocybin, but I'd like to learn more.
This is one of my favourite videos ever, I didn’t even know this type of academia existed let’s alone was accessible by the public. I think I found what I want to do with my life
Excellent presentation, thank you!
You're welcome!
I wish you were my biochem teacher...
Excellent presentation: Your voice and direction was engaging and easy to follow.
I come from a science background, but it's been many years since university, so I had basic understanding of certain molecules, actions, and processes. It was refreshing to have an approachable description on an interesting topic.
Thank you for the very in-depth analysis of psilocybin! Very informative, especially the metabolism of it
Phenomenal video thank you
Based on this biosynthetic pathway, you would expect to find at least some DMT in psilocybin-containing mushrooms but that is not the case. The reason is that the methylation occurs after the oxidation at position 4. There is an article that explains this published in 2018. Have you considered other biosynthetic pathways than what's presented?
I'm reminded of something Alexander Shulgin wrote in TihkaL about a study were DET had been added to the culture medium of a Psilocybe species, and had been metabolised to 4-OH-DET and the phosphorylation analogue.
This should suggest that the 4-hydroxylase has a rather high affinity for binding to various tryptamine derivatives. The fact that norbaeocystin, baecystin and even the muscle-relaxant quaternary aminium analogue aerogenocin, seems to support the idea that the 4-hydroxylase is a very active enzyme and somewhat 'promiscuous'. But, it's affinity to the indole side of the tryptamines, should've been studied further. I don't think it's so strange that DMT, isn't detected in significant quantities in (most) varieties of psilocybin producing mycelium and mushrooms.. But, I have mainly been reading Stamets book about Psilocybin mushrooms and free sources on the web. Sorry if this wasn't the best explanation.
BTW, I remember reading about tryptamine in some type of common food mushroom. But, it's rather long ago. I will edit this comment if I find more information on tryptamine metabolism in fungi...
Cool! Thanks
very informative
Amazing 👏 video.
Oakland and Santa Cruz the fungi are decriminalized as well as Denver.
Yes, definitely.
Also have experienced lack of desire to drink after both those 2 tested psychedelics.
Thanks for the input. It's always nice when people personally can corroborate a scientific finding like this.
Would love to see a video about THC
I've got one in the works.
Do you have the references for this video? Thank you!
Hi, catalyst university, since psilocin is the active reagent, can we take psilocin directly instead of taking Psilocybin firstly and asking the enzyme to convert it into psilocin in our body.
Psilocin is not as stable as psilocybin, which may be the reason why the fungus phosphorylates psilocin (storage).
Do you have the references?
So what happens if you bypass the liver and intravenously take psilocin? Does it not get as much lost?
Huh? Goes directly from blood to liver. Read up on your anatomy.
it will be uncomfortable my friend, rather just soak in lemon or any acid for 20mins and hit them later
@@metalbrute4795 why am I having seizures when I trip?
I would stop immediately if i were you. Some of us are more seizure prone and shouldn't touch this stuff at all!
@@metalbrute4795 I mean I did take 20g dry so probably overdid it. But, I've been wanting to quit for a minute, so its probably time. I had some good memories with the substance but also scary ones.
Didn't know Psilocybin was actually a pro-drug!
Still lovin' your channel since I discovered it a year ago!
PS: good to see research revisited on drugs like these in recent years, as they might actually benefit in certain mental disorders!
In your face, Nixon!
I appreciate it, Biomed Master! And yes, the War on Drugs has done us a huge amount of damage as a society. While there are drugs I would say to never use, and I don't condone their use, people will still use them, and so rehabilitation programs are a far better solution to an impossible problem. Prohibition of alcohol in the 20s is evidence enough of that.
@@CatalystUniversity What do you say to the people that think rehabs are just cash grabs, fancy $$$$$$ long stay hotels?
@@Sevisstillalive drug rehab/treatment doesn’t work for 90% of substance users. Why? allowing people to freely educate themselves on the substances they want to investigate without fear of interference, fear of investigation, harassment, arrest, incarceration & even murder by police or the DEA is vastly better than maintaining the War on Drugs-People. One ends Cartels & horrors of disease & incarceration by legalizing ALL drugs and regulating them accordingly. People will always consume whatever they want. They should have access to pure known dosage amounts of whatever they desire. True freedom in any market requires freedom to experiment & research…cant do that now…
Toke off🤣
When LSD video?
You can get all psychedelic products from the above name👆💊
Confusing. Interesting, but not great explanation of certain details of the compounds or how triptamine is generated in the body.
All thanks to Henryshroom on IG for his perfect recommendations and nice products I think you need him