Aminoglycosides | Bacterial Targets, Mechanism of Action, Side Effects
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- Опубліковано 24 лип 2024
- Lesson on Aminoglycoside Antibiotics. Aminoglycoside antibiotics all have the suffix of -mycin, -micin or -cin and may be confused with the macrolides, which have the suffix -thromycin. Aminoglycosides are almost always used in conjunction with another antibiotic and are administered parenterally. Bacterial targets for aminoglycosides include gram negative coverage. There are specific side effects with use of aminoglycosides as well, which we also discuss in this lesson.
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Great video!! Simplified and clear.
Kindly note that Aminoglycosides may be used for Aerobic Gram-positive bacteria such as most Staph aureus, Viridans group Streptococci and Enterococcus BUT they must be used in COMBINATION with another antibiotic.
informative, simple and straight to the point, not rushed, easy to retain. thank you humbly
He teaches everything clearly 🙏🏼🙏🏼
It was amazing ! perfectly stuctured and the most important in it ! Helped me alot :)
Thank you so much for donating your time & knowledge!
Great video, but the tricks are not accurate and can be confusing. You left out Vancomycin, which is not an aminoglycoside, but technically ends in "-mycin". Also, a lot of the Lincosamides end in "-mycin" and are clearly not aminoglycosides either. The other thing is Neomycin is technically an aminoglycoside and it is NOT parenteral. Otherwise, I love your simplification of a topic that can be very confusing.
U kean
Thanks Sir for simple explanation....
thank you it was very obvious, much appreciation.
As a side note Aminoglycosides are not exclusively administered via IV. Especially, Cystic Fibrosis patients regularly inhale Aminoglycosides.
Very good thank you bro !
Great explanation❤️❤️
I was injected the gentamicin directly into my vain back in 2004 and never forget about the side effect I felt right away. I never felt such a pain from an injection in my life. My arm was on fire, it felt like I was injected with peri peri or something like that. The pain was so intense that why I never forgot about the name of this injection.
P.S. I was hospitalized 10 days for severe malaria and typhoid and was getting IV treatments.
😢
very Nice. Thank you
thank you, the best again and again!!!!!
Nice presentation
2:11
Why?
Why they are ineffective against gram positive aerobs?
Awesome video!
Brilliant task
Amazing video 🤲❤️
Sir how imipenem and gentamicin combination is used for pseudomonas infection .
Both causes nephrotoxicity
Very helpful
very helpful!
Nice lecture Sir, upload more lectures on pharmacology
Thank you for your kind words! I will continue to make more pharmacology lessons - any lessons you would like to see? :)
Thank you ❤
Great videos
Ilove this
Tysm
What about tobramycin eye drop?
為什麼胺醣類?跟胺糖有甚麼關係?why does it call 胺醣類? what is the relationship between them?
Wait,, according to this video aminoglycosides kills only gram negative bacteria ,,,but is is used in tuberculosis which is caused by gram positive bacteria,,can you explain this?
According to some other sources aminoglycosides bind to 50s domain. Aminoglycosides bind to magnesium in rRNA on the 50s domain. What can you say about that? Have you heard about it? It’s strange that different sources give different info.
Aminoglycoside and tetracyclines binds to 30 s
Only streptomycin.binds to.30S. others bind to.either 30S/50S interface of 50S
why aminoglycoside work a best in slightly alkaline condition ??
Aminoglycosides, being weak bases, have optimal potency in alkaline media. The lower the pH the weaker the effect. If you want to exploit this, use a urinary alkaliner when using AMG's to treat UTI's.
Why are aminoglycosides rapidly bacteriocidal but tetracyclines only bacteriostatic even though they both bind and Inhibit the 30s subunit?
Aminoglycosides causes incorporation of incorrect aminoacids in the growing peptide chain..this will alter protein synthesis and alter cell wall permeability. Causing cell.wall.lysis and hence cidal
@@OneTouchPharmacology Great! Is there a paper or video I can go look at for more detail?
Visit one touch Pharmacology 😀
Refer KD tripathi
a playlist on microautophagy, please !
Nice!!! but why are aminoglycosides not used against gram-positive organisms
Aminoglycoside are transported well in gram negative bacteria, they are given with pencillins to cover gram positive bacteria
Gram positive have thicker cell.wall.. difficult for.amnioglycosides to cross
One Touch Pharmacology great 👍 can you refer me to a good book where I can learn this
Moreover gram posive only few have porins .. just go through some micro text
here in 2022
我比較需要比菲多而不是抗生素i need 比菲多more not antibiotics
Very Bad Effect inner ear
Why?any experience