Lung Function (FEV1) Is Associated With Alzheimer's Disease Incident Risk
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- Опубліковано 2 бер 2024
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Papers referenced in the video:
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank jnnp.bmj.com/content/early/20...
An Integrated, Multimodal, Digital Health Solution for Chronic Obstructive Pulmonary Disease: Prospective Observational Pilot Study pubmed.ncbi.nlm.nih.gov/35142...
Spirometry Reference Equations for Central European Populations from School Age to Old Age
journals.plos.org/plosone/art... - Наука та технологія
Great video as usual, thanks! I wish you could do a "how to for dummies" video that explains how you use Excel etc. to log data and calculate correlations.
Thanks @mannmstorm , that video is on the to-do list, likely sooner vs later
@@conqueragingordietrying1797looking forward to this!
Genuis 🎉 Thank you excellent information video. I would have assumed high serum glucose and a1c were both associated with a proclivity for AD. Wow. I even had to go to the transcript to make sure I heard right!
I've often wondered if the FEV1 associations are partly mediated through some neurological recruitment component. It's a shame grip strength or other measures weren't included in the Mak et al 2023 study.
grip strenght is easily trainable though. Why do you think fev1 is mediated by some neurological component?
yes. it is a shame that in 2024 there is still so much narrow-minded and bad quality research out there. They spend so much money, and in the end the results are not really applicable.
@@nuovoaccount998 There's some evidence of a partial mediation of fev1 by grip strength, see Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults 2014.
Its only a 1 sec long measurement, and those situations usually involve recruiting as many fibres as possible all at once. That's going to depend on many things, but one of them will be the ability to send a coordinated signal from the brain through the nerves, to primarily the diaphragm here.
@@monnoo8221 I think the UK biobank has more variables. They seem to have restricted to 18 clinical biomarkers for ideological reasons related to biological age calculators. But with such a strong signal on FEV1, they should go back and repeat the study on any remaining markers they can access, and conduct a mediation analysis and sort out the how any mediation works.
@@jamesgilmore8192 agree, to that i was implicitly referring to-
love ur continuous dedication and passion 😊
Thanks @sooooooooDark!
Amazing how crucial the training dose is? Great video!
I bought the spirometer on your previous recommendation. I found it useful in evaluating whether a change in exercise routine helped or hurt my FEV (it helped).
Breathless work
This is David P. Great content, Mike. I was reading that grip strength, and also disparities of grip strength between left and right arms, are predictive of Alzheimer's.
By the way, do you have a hypothesis on what is the mechanistic relationship between lung capacity and Alzheimer's?
Hey David, and thanks. It could be an age-related decrease for physical activity, thereby resulting in lower expiratory muscle mass and/or strength. Or perhaps, an age-related increase for oxidative stress limits expiratory muscle function?
Thanks. Good Results. I assume you don't have APOE4 version of APOE which most people don't check.
Thanks @peterz53, nope, e3e3
Where do you post a general diet compostion? Is your general diet composition available for free or it is paywalled?
The most recent list is in this video:
ua-cam.com/video/1-XyniGEvCs/v-deo.html
An update based on Monday 1/15/24's blood test is coming with the next ~week and a half
Daily diet info is on Patreon, which is paywalled
Thank you so much! @@conqueragingordietrying1797
I have the asthmamd peak tester. Maybe I have an odd shaped mouth, but unless I pinch the edges of my mouth tight to the unit with my other hand, I get leakage out the side and a greatly reduced volume measurement. I never figured out how to calculate the FEV1 from the device reading , but I can usually max out the unit (about 800 l/min), so I am not concerned about it.
Michael from years of recreational snorkeling I can guess that the best way to improve your lungs in all respects is to follow training and advice from free divers. If you have access to the sea a few free dives (always safely) will assure you that diving is a secret (in my opinion) on the road to longevity! Alternatively, workouts can be done at home (dry training) or in the pool. The combination has good results.
Yep, thanks @hristosstrihas4010. Anything that offers additional airway resistance (beyond exercise) should improve lung function, whether it's a specific device, or free diving...
hi , the adjusted for sickness plot may not be so accurate , for the biomarker could cause the sickness which cause brain loss
I think it would be worth investigating how correlated FEV and bioage are. Wouldn't that be a neat tool to determine bioage?
I can look at correlations within my own biological age data, but right now the sample size is small (~10 blood tests that align with FEV1)
I remember vaguely hearing that lung capacity is also a strong marker for longevity.
Asking myself if vo2max is the way to go about this? Maybe bariatric chamber?
VO2max will optimize FEV1 only so much, and there is an age-related FEV1 decline even for the top 5%, which would be expected to have the highest VO2max.
There are lung-specific trainers that offer more resistance than regular exercise training, that's my best bet.
Maximum voluntary ventilation has the highest correlation with age as I remember. But its also the most challenging of the lung function markers to measure and is usually only done in a clinic.
Interval training or max all out efforts seem to be useful
Have you explored correlations of FEV1 with other markers?
I haven't, but could!
@@conqueragingordietrying1797 I do wonder if there is a correlation with HRV or REM. I would also try detrending FEV1 and maybe HRV & sleep measurements. If you can figure out what keeps FEV1 at the top of its range while trying to improve the overall values with training, that's helpful information. Excel has detrending functions as I recall but if you need help just reach out.
Interesting on the triglycerides being more beneficial(good type), human body is super complex. My mcv/mchc is always low normal and I thought that was a bad thing due to o2 transport capacity. I’m now wondering if something like a weekly nasal cannula 02 would be beneficial for longevity? Also, do you believe the “overtraining” spirometer on your lungs was the cause of this better data? If so, we all should be training with this spirometer?
Nope-overtraining the lungs led to worse FEV1, and when I removed it, FEV1 went back to my original level.
The goal is to resist the age-related FEV1 decline, so if that means more HIIT and/or a lung-specific trainer, that's the plan...
@@conqueragingordietrying1797 Hi Mike, when I looked at your previous protocol for lung training it was not targeting FEV1, more long steady breathing. Suggest to focus on much shorter sessions and maybe try overspeed training, in addition to underspeed training.
What effect does high intensity aerobic exercise have on FEV1 and FVC? Effects of high intensity aerobic exercise on treadmill on maximum-expiratory lung capacity of elderly women- "The effects of high intensity aerobic exercise for maximum-expiratory lung capacity are shown in Table 1. FVC was 2.1 l before exercise and improved significantly to 2.3 l after exercise (p
Yes, exercise will improve FEV1, but as shown in the video, it declines even for the top 5%, who likely have the best fitness.
Thank you! Keep up the great work! @@conqueragingordietrying1797
thoughts on Zinc Chloride for oral microbiome?
I've though about ZnCl, it's a possible experiment that I'll try...
One problem with these health comparisons is the metrics come from a population that is often unhealthy and there’s no real way to know. Some estimates suggest that more than 40% of American adults show evidence of insulin resistance meaning they’re metabolically unhealthy. Some pundits have that number greater than 75%.. So it really doesn’t make sense to use these values as a yardstick they’re inherently skewed unhealthy. Iow, when compared with a healthy population your values may be much better than these comparisons suggest.
absolutely. Yet, the age related decline is independent from that. That being said, every single study that proposes age related decline is also based on a largely sub-optimal aging process. Those curves may look very different in 200 years (if there are any curves at all).
As of today, we don't have any data. One possibility though would be to compare a selection of people that never had major changes in their weight throughout their adult life, ...as kind of a proxy for a superior aging process. But even then, data are missing.
Do you think the associations would change ( a larger number would be positively associated) if vascular dementia was the focus? Is there an association between parasites and Alzheimer’s?
Where can I get your Lung Volume monitor 🤔
I got mine on Amazon, it's the MirSmart One
RU taking NAC, and if not do you think it would improve lung function? (E.G. COVID studies)
I'm not currently taking it, and likely the greatest impact on lung function would be regular exercise training (i.e. fitness), in addition to lung-specific training
It might have been more helpful to look at dementia generally than just Alzheimer’s specifically
That's a fair point. Here are a couple of studies that address that with similar results to AD:
Association of Lung Function With Cognitive Decline and Incident Dementia in the Atherosclerosis Risk in Communities Study 2023
Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals 2023
What is your specific lung workout plan?
I'm not using the lung-specific trainer (yet), but in the past, I worked up to the highest resistance setting for 8 minutes/d, 6d/week. That was too much, based on the FEV1 decline
If/when I go back to it, I'll start small, like 1minute/d, 6d/week
Hi Michael. How do you know it is not reverse causation? It could be that people with Alzheimer exercise less so end up having worse lung function.
Hi @Battery-kf4vu, study participants were free of AD at the baseline assessment, which argues against reverse causation in this case...
@@conqueragingordietrying1797 You mean they already had poor lung function at the start of the study?
What lung-specific training do you do to improve FEV? Sorry if you've answered this elsewhere.
No worries, I used the BreatherFit, but overtrained on it. If there's a FEV1 dip, I'll go back to it, but will need to sort out the frequency and daily duration so that I don't repeat the same mistake 2x
@@conqueragingordietrying1797 BreatherFit is supposed to improve VO2max also, so this could be a great way to improve two life-extension biomarkers with one stone. Thanks for the tip.
very nice, as always.
What do you think are the main factors driving that decline? My guess would be flexibility of the rib cage, strength of the muscles supportive for breathing (serratus, abd. transversus etc) and strength of the diaphragm.
The results of the hazard ratio study clearly points to 2 related areas. (1) the overall oxygenative capacity, not only in the brain, but also in the body, (2) the capacity to handle glucose (accessible carbs). Both may be linked to mitochondrial health, of course. Yet MCV and RBCc clearly point also to a depletion of stem cell capacity and RBC production. Would be interesting to know the folate status of affected people relative to healthy ones.
Unfortunately, the study does not provide a normalization to basic body measures like height, and width of rib cage, or even grip strength for overall muscle status. The separation into naive quantiles does not allow a prediction.
For me the consequence is pretty clear: I will buy a respirometer immediately,... Thanks so much!
"What do you think are the main factors driving that decline?"
Sugar intake.
@@btudrus that would be correct answer if my question would have been about glycosylation, or collagen damage. You are overgeneralizing. Yes sugar can cause those, yet there are quite some more possible causes for the systemic failure. FEV1 s on the level of the organism, hence there is a multitude of other possible reasons.
@@monnoo8221 " You are overgeneralizing."
Not really. The sugar does 90% of the damage at least through several mechanisms!
@@btudrus I know that it is dangerous. Yet, lack of vit C, lack of folate, lack of exercise and its effect on cytokines, lack of stretching causing low stem cell recruitment, lack of hydration, lack of O3, inflammation due to other causes,. PM2.5,... all can also lead or aggravate the issue, and caring about those may easily overrule the effect f certain amounts of sugar
@@monnoo8221 "easily overrule the effect f certain amounts of sugar"
not true, as sugar per se causes most of what you mentioned...
Any content on reducing arteries blockage? I feel like, in order to live forever that is the number 1 issue to fix
not necessarily. It depends on the individual.
you have to avoid it in the first place. Measure your Lp(a), this gives you a clear hint whether there are any injuries of the arteries. To clear it out, Nattokinase and turmeric has been suggested to be very helpful.
In order to prevent calcification of plaques, vit K2 is essential. But overall calcification of arteries is likely to be not reversible.
so, injuries of arteries has to be avoided. Which is nothing Michal is suffering from.
Stiffness of arteries due to calcification and damaged collagen, and stiffness of RBC due to malformed collagen attribute to injuries. Oxidative stress from glucose, homocysteine and systemic inflammation are further very important contributors. Cure: Vit C, vit A, Omega 3, vit K2, folate in high doses.
@@monnoo8221 didn't quite understand everything on what you said but, I think blood flow is very important. For instance exercises promote blood circulation and creation of new blood vessels and help your body use the oxygen in your blood more optimally.
And I think hair loss and erectile dysfunction is due to poor blood flow or circulation.
And hardening of the arteries is a death sentence. So having no sense of what caused your arteries to be clogged is very very bad.
But I'm worried I'm already past the point of no return. And I can't find any guide anywhere that talks about removal just that it's not possible which I don't like that at all.
I been trying to find what is the bodies natural mechanic that get rid of plaque in the arteries
All I see is that plaque in the arteries form and then that it, but why do they form and what is the body natural plan with plaque formation in the first place?
For instance fat forms in the body, but if you fast or exercise your body starts to use it as fuel.
And another thing about natural mechanics in the body.
Is autophagy where the body consume it self, well recycle dead or deform cells in the body. And that seems like a very important natural mechanic in the body that we should give the body some time to do for awhile for a healthy long life.
So like discovering hardening of the arteries it's like I'm fucked already and can't do anything about it. For example I just ate like super buttery popcorn and the other day I used a lot of oil to stir fry etc
And I didn't really realize how damaging that is.
You are what you eat.
The other natural mechanic I discovered is the liver basically filters and cleans your blood.
So like yellow pee is actually a bad unhealthy sign, so is dark poo etc
Like I'm really frustrated how health was taught in schools. It wasnt done serious enough.
My heart health and body could of been way better if I understood the importance of exercise and eating healthy.
Btw are you aware of Bryan Johnson? I appreciate what he is doing in regards to his diet.
And promoting "Biological age" which makes a lot of sense. That rate of aging aka deterioration can be different from others.
Also last thing I want to say, is immortality is actually simply an engineering problem not really a spiritual one.
And I think, conquering/slowing aging is like the ultimate healthy thing you can do.
Also last last thing I know that telemere length in cells, is one of the main issues of aging.
Hmm I need to look into stress because it's to vague but it's one of the causes to shorting of telemeres.
Much like how your body uses "energy," which is saying like that is still vague to me. But your body burns calories from what it consumes as a energy source for many functions in the body I guess
And stress is... Idk
"Any content on reducing arteries blockage?"
Lowering the insulin and resolving chronic inflammation. Then the body will heal itself.
For example prolonged fasting may be a way how to achieve this...
@@btudrus that's what Dr Berg was saying. But i couldn't find additional information on that anywhere else tho
think FEV1 is related to lung size which give u a measure of (RAM in computer meomory terms) access to oxygen . which link it to red blood cells count. which is link to limit of speed of brain function.
lung function and the RBCs data could definitely be linked to AD, I can see them together being more predictive than either alone
How to deal with mild anemia? Non iron related.
Find the cause.
Did you ever catch Covid? If so, did it influence your FEV1?
Fortunately not...
I wonder if training fev1 affects causation of AD
Yep-there are no RCTs that have explored that, unfortunately. As a worst case scenario, I think it makes sense to avoid the age-related FEV1 deline...
Would general exercise increase FEV1?
Yes, but the question is, what exercise dose (if any) is able to resist the age-related FEV1 decline?
A lung-specific trainer offers more resistance than exercise training.
@@conqueragingordietrying1797 If diaphragm recruitment is a major component of FEV1 then the training needs to be power based, which is in short stop when the power output first goes down. As you've measured 9 trials you can likely figure out when that is for you.
@@conqueragingordietrying1797 the graph shows the decline of the general population which likely doesn't do any exercise so I wouldn't be too worried about the what
What about people with sleep apnea?
The age-related FEV1 decline is robust, so I'd assume it applies to people with sleep apnea, too
I use CPAP but it's not optimal. I'd like to just resolve whatever the root cause of sleep apnea for me is so I don't have to rely on CPAP. @@conqueragingordietrying1797
Vax
ASSOCIATION IS NOT A CAUSATION!
Nobody claimed that it is.