SALT FORM OF THE DRUG

Most of the drugs are either weak acids or weak bases.
One of the easiest approaches to enhance the solubility and dissolution rate of such drugs is to convert them into their salt forms.
In general for a weakly acid drug such as barbiturates and sulphonamides a strong base salt is prepared such as sodium or potassium salts.
For a weakly basic drugs such as several alkaloidal drugs a strong acid salt is prepared such as hydrochloride or sulphate salts.