Actually the coating and fillers play a small role in the dosing. The FDA allows a 20% difference from the standard dose. That can be 20% lower or 20% higher . So a total of 40% difference is allowed between different batches of the drug.. within its own generic company or its competitors or the brand name. So yes, pay close attention. The patient is the one who may easily notice a difference, not the doctor , or pharmacist or the pharmacy that is more concerned with profit than for your well being.
I found the same info. The FDA allows a 20% deviation in active ingredients. I get my Levodopa from the VA as I am an a 100% disabled Agent Orange victim of the Vietnam war. I have no control over where they get their meds from and often wonder how good they are because I've never been able to try any other brands. I currently take 15 25/100 tabs a day. This is such a terrible disruptive disease. I wonder how Sinemet brand is?
@@invoxicated i was introduce to agent orange in 1969 in a vietnam jungle also. i went on to college after my year in country and graduated as a pharmacist. i owned a large pharmacy for 40 years when finally as my symptoms started to rule my life i sold the store and filed a claim wih VA in 2013. of course was denied back then so i continued as is.. in 2020 i filed another claim that included my updated condition and of course was given 100% P&T... so i got a lawyer and refiled my 2013 claim. was paid back pay from 2013 , not so easily , but successfully.. thats good advice you offer on generic drugs and the importance of not changing brands of levodopa. though often it may not be so important for other drugs and conditions. my motor symptoms are controlled well at current dose and i pick up on the slightest deviation of dose. im not at 15 000 mg a day of levodopa yet, but its coming, you speak and present yourself well, maybe consider a sight to advocate for your VA claims. sincerely j myers
Larry - thanks for this information. I’ve been taking the same generic form of carbi/levodopa for 5 years. Due to travel I had to fill my prescription at an unknown to me (but still CVS pharmacy). The pills were a slightly different shape and not scored. I was a little surprised they hadn’t informed me of the switch but I thought (besides the inconvenience of the nonscored pills) that they would be the same. I’ve been having trouble with my “off times” occurring more frequently and their onset is quite abrupt. I go from feeling ok to being in a severe off time zone immediately. I thought it was me. Now I am going to look into this more. Again thank you
💫Thank you for sharing your experience. Something that changed my life overnight and I tell everyone: 😊 I personally switched from generic cd/ld to the brand name, Rytary, last March and I have to say my side effects from severe fatigue, dizziness upon standing, dry mouth, tearfulness, and terrible dyskinesia (for me included terrible racing thoughts and anxiety!) subsided. My life improved 100%. That's just my story. 😊 Also, I must add: I also realized with the generic, I felt as if it was only getting to 70% of my body. Meaning after trying the Rytary, I could feel my shoulders and feet and hands. Sounds strange but again Parkinson's is so weird, is it not!? Thanks for all PD avengers does Larry!! ❤
I used Teva than Sun and while Sun was noticeably weaker. It's probably been 5+ years since I've allowed any other brand but I 've run into rumors of shortages anyd the quality of my last two 90day supplies has been noticable decreased. I don't have the name with me but it's round with no score but luckily it cuts ok and I think it is stronger. Almost all my meds haVE changed brands recently and I seem to get dyskenesia, headaches or body aches with many of the changes.
Actually the coating and fillers play a small role in the dosing. The FDA allows a 20% difference from the standard dose. That can be 20% lower or 20% higher . So a total of 40% difference is allowed between different batches of the drug.. within its own generic company or its competitors or the brand name. So yes, pay close attention. The patient is the one who may easily notice a difference, not the doctor , or pharmacist or the pharmacy that is more concerned with profit than for your well being.
I found the same info. The FDA allows a 20% deviation in active ingredients. I get my Levodopa from the VA as I am an a 100% disabled Agent Orange victim of the Vietnam war. I have no control over where they get their meds from and often wonder how good they are because I've never been able to try any other brands. I currently take 15 25/100 tabs a day. This is such a terrible disruptive disease. I wonder how Sinemet brand is?
@@invoxicated i was introduce to agent orange in 1969 in a vietnam jungle also. i went on to college after my year in country and graduated as a pharmacist. i owned a large pharmacy for 40 years when finally as my symptoms started to rule my life i sold the store and filed a claim wih VA in 2013. of course was denied back then so i continued as is.. in 2020 i filed another claim that included my updated condition and of course was given 100% P&T... so i got a lawyer and refiled my 2013 claim. was paid back pay from 2013 , not so easily , but successfully..
thats good advice you offer on generic drugs and the importance of not changing brands of levodopa. though often it may not be so important for other drugs and conditions. my motor symptoms are controlled well at current dose and i pick up on the slightest deviation of dose. im not at 15 000 mg a day of levodopa yet, but its coming,
you speak and present yourself well, maybe consider a sight to advocate for your VA claims. sincerely j myers
Thank you Larry
Larry - thanks for this information. I’ve been taking the same generic form of carbi/levodopa for 5 years. Due to travel I had to fill my prescription at an unknown to me (but still CVS pharmacy). The pills were a slightly different shape and not scored. I was a little surprised they hadn’t informed me of the switch but I thought (besides the inconvenience of the nonscored pills) that they would be the same. I’ve been having trouble with my “off times” occurring more frequently and their onset is quite abrupt. I go from feeling ok to being in a severe off time zone immediately. I thought it was me. Now I am going to look into this more. Again thank you
1pp
💫Thank you for sharing your experience. Something that changed my life overnight and I tell everyone: 😊 I personally switched from generic cd/ld to the brand name, Rytary, last March and I have to say my side effects from severe fatigue, dizziness upon standing, dry mouth, tearfulness, and terrible dyskinesia (for me included terrible racing thoughts and anxiety!) subsided. My life improved 100%. That's just my story. 😊 Also, I must add: I also realized with the generic, I felt as if it was only getting to 70% of my body. Meaning after trying the Rytary, I could feel my shoulders and feet and hands. Sounds strange but again Parkinson's is so weird, is it not!? Thanks for all PD avengers does Larry!! ❤
I used Teva than Sun and while Sun was noticeably weaker. It's probably been 5+ years since I've allowed any other brand but I 've run into rumors of shortages anyd the quality of my last two 90day supplies has been noticable decreased. I don't have the name with me but it's round with no score but luckily it cuts ok and I think it is stronger. Almost all my meds haVE changed brands recently and I seem to get dyskenesia, headaches or body aches with many of the changes.
truth