Epistasis types - dominant, recessive, double dominant, dominant recessive epistasis

This lecture explains about the mechanism and principle of gene gene interaction with the help of epistasis. This lecture also explains different types of Epistasis including dominant, recessive, double dominant, dominant recessive epistasis.
Epistasis is the phenomenon of the effect of one gene being dependent on the presence of one or more 'modifier genes', the genetic background. Thus, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them, leading to non-additive[clarification needed] effects. Epistasis has a large influence on the shape of evolutionary landscapes, which leads to profound consequences for evolution and evolvability of phenotype traits.
This can be the case when multiple genes act in parallel to achieve the same effect. For example, when an organism is in need of phosphorus, multiple enzymes that break down different phosphorylated components from the environment may act additively to increase the amount of phosphorus available to the organism. However, there inevitably comes a point where phosphorus is no longer the limiting factor for growth and reproduction and so further improvements in phosphorus metabolism have smaller or no effect (negative epistasis). Some sets of mutations within genes have also been specifically found to be additive.[21] It is now considered that strict additivity is the exception, rather than the rule, since most genes interact with hundreds or thousands of other genes. Epistasis within the genomes of organisms occurs due to interactions between the genes within the genome. This interaction may be direct if the genes encode proteins that, for example, are separate components of a multi-component protein (such as the ribosome), inhibit each other's activity, or if the protein encoded by one gene modifies the other (such as by phosphorylation). Alternatively the interaction may be indirect, where the genes encode components of a metabolic pathway or network, developmental pathway, signalling pathway or transcription factor network. For example, the gene encoding the enzyme that synthesizes penicillin is of no use to a fungus without the enzymes that synthesize the necessary precursors in the metabolic pathway. Just as mutations in two separate genes can be non-additive if those genes interact, mutations in two codons within a gene can be non-additive. In genetics this is sometimes called intragenic complementation when one deleterious mutation can be compensated for by a second mutation within that gene. This occurs when the amino acids within a protein interact. Due to the complexity of protein folding and activity, additive mutations are rare.
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Thank you for watching

[@bauhiniafolia9673]

Time Stamp :
Recessive = 3:13
Domminant = 7:29
Duplicate Domminant = 11:53
Duplicate Recessive = 15:20
Domminant Recessive = 19:31
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[@radhakrishnatella104]

can u pls explain about duplicate dominance with cumulative effect(ratio is9:6:1)

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Thank you for making this tutorial. It really helped me figure epistasis out

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[@yen19adver]

HELP! Why is C_P_ = Anthocyanin if it is Duplicate Recessive? Should it be only ccpp?

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[@ashcariba]

At 11:25, you mentioned that wwgg squash will be green in colour. Why is this? Why is it not white? How do you decide which recessive to choose?

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Thank you so much sir

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Thank you

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[@pakistanagriculture4759]

The concept of Epistasis is very important in genetics, how different types of epistasis impact the methods of crop improvements in plants?

[@Nicky.Mvlogs]

Thanku

[@RayMond-nd5er]

thanks

[@MrLuwangcha]

I am missing a class today and I overheard the teacher teaching EPISTATIS so I sit in an empty class and watch this video.

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Did you like it?

[@rasharush]

Sir..in 5th type.. The dominant gene which prevent expression of othergene.. (That is D gene at dominant condition prevent others expression and at resessive form it alow.. Other genes expression...) Am I correct.. It is urgent.. Pls give reply as soon as possible😢

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superb!

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Thank you

[@vakkalagaddalakshmi4376]

Hi I am totally confused with epistasis,incomplete dominance and incomplete penetrance.plz explain the difference of 3

[@shomusbiologyofficial]

Rewatch it couple of times

[@vivianmamboleo7538]

I'm confused about the duplicate recessive. 18:00. isn't it supposed to be cp? not CP...since its a recessive dominant

[@dharmdesai1822]

vivian mamboleo he is wrong in last dominant recessive example also and the question you are talking about duplicate recessive you are not seeing that the example it says that C and P are the enzymes which are require for the production of anthocyanin and you are wrong about dominant recessive thing because in epistasis we can't see which is greater instead of this we see which hypostates or hides which so... Listen carefully and firstly read something about epistasis so that you would have idea what I was talking about.

[@poojasawale3784]

thanks sir

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legend

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God Bless you..

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[@miamiperpinan444]

You told us in 9:15 that G is for Green and g is for yellow how come that (wwG) turned out to be Yellow and (wwgg) turned out to be Green? I somehow got confuseddddd

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did you find out?

[@keanuvernon6114]

Question should all lectures be recorded at 10g/year university or is that asking too much in 2020.

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[@paulinak4624]

So if allele a is epistatic to allele b then is a masking b or is b masking a?

[@shomusbiologyofficial]

Epistatic gene suppress the effect of hypostatic gene

[@studyaccount3034]

Sir..i don't understand what happened in Duplicate dominant epistasis...kisne kisko mask kia?

[@AjithaKR-sx2sl]

Why there is multiple gene for a single function like why there are two genes for giving colour to kernel of wheat.

[@deepakr.k4071]

Tq

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[@ArvindSharma-rc6wt]

How to helfull epistasis new species

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Mashallah what an explanation.... What's your qualification. If u don't mind

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[@sarahhello27]

I cant figure out the difference between dominant epistasis and dominant recessive epistasis.

[@shomusbiologyofficial]

Re-watch it

[@shantasubedi2636]

👌👌

[@drujjawalrathore]

I can't get why some people say 'homozygous' recessive - Just tell me one case of heterozygous recessive.

[@shomusbiologyofficial]

+Ujjawal Rathore it's not possible.

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Sir samajh main atche sa nahi aa raha hain

[@oliviaderose5782]

omg thx

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[@simonasaldanha6007]

THE LAST ONE IS WRONG. ITS 13:3 ..U GOT TO ADD THE LAST ONE IN NO MALVIDIN COLUMN SO IT BECOMES 13 AND 3

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Microbiology

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15:30

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