CAGRISEMA: Breaking Down NEW Weight-Loss Solution | Obesity Medicine | Dr. Dan Obesity Expert
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- Опубліковано 17 бер 2024
- Introducing CAGRISEMA: The Latest Breakthrough in Weight-Loss Medication That You Need to Learn About
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Watch my previous videos about how to fight obesity and about the best medicine for weight loss:
▪️ Watch This Before Taking Mounjaro: • Watch This Before Taki...
▪️ From Ozempic to Mounjaro: • How to Switch from Oze...
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: • Muscle Loss with Ozemp...
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: • Managing Nausea from O...
▪️ Ozempic: Stomach Paralysis Update: • Ozempic: Stomach Paral...
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: • How to Switch from Oze...
▪️ Ozempic Paralyzed My Stomach: • Ozempic Paralyzed My S...
▪️ How to Inject Mounjaro: step-by-step tutorial: • How to Inject Mounjaro...
In this informative video, I delve into the realm of new weight-loss medications, specifically focusing on the intriguing CagriSema. With a growing number of agents hitting the market like Wegovy, Saxenda, Zepbound, Contrave, and Qsymia, the question arises: why the influx of new options? Obesity is not a one-size-fits-all issue; it's complex, with diverse phenotypes and pathologies driving individual experiences.
Join me as I explore CagriSema, a blend of two molecules - semaglutide (also known as Wegovy or Ozempic) and the novel cagrilintide, an amylin analogue. Amylin, a naturally occurring hormone, plays a crucial role in regulating blood sugars alongside insulin. Cagrilintide's unique properties, combined with semaglutide, aim to tackle weight loss and glycemic control synergistically.
I discuss a fascinating phase 2 trial that sheds light on CagriSema's potential benefits. The trial, involving participants with type 2 diabetes and obesity, demonstrated promising reductions in A1C levels and significant weight loss without specific dietary or exercise interventions.
While CagriSema shows early promise, it's essential to note that further research, including phase 3 trials with larger sample sizes, is needed to ascertain its efficacy and safety profile. Stay tuned for more updates on CagriSema's journey toward potential FDA approval, expected no earlier than late 2025, possibly initially for diabetes management. Don't miss out on this groundbreaking exploration into the future of weight-loss medications!
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I’m in the clinical trial for this.
Do you like it? Thinking to try.
Tell us more, if you’re allowed to. 🤔
I am doing my own research with CangriSema. The appetite suppression is stronger than Tirzepatide. The gastric emptying is slower than Tirzepatide. I am very impressed. Before my research, I was on 15mg of Tirzepatide per week. 15 mg of Tirzepatide per week was no joke. However, CangriSema is on a whole different level.
Should be emphasized that those weight-loss results were for T2D ppl, and T2D ppl in general tend to lose about 1/3 less weight on these meds than non-T2D folks.
So, that 15.6 percent over 32 weeks is probably more like 23-ish percent WL in non-T2D ppl. AND, 32 weeks is a pretty short trial.
A full-length trial, say 68+ weeks, would then probably yield WL in the range of 25 to 30 percent of body weight (likely closer to 30).
IOW, at least equal to Reta. Impressive. ✅
Man thank you for this video.
Thank you 🙏🙏🙏
thank you!!
Another good one…
It’s Cagrilintide (you’re pronouncing an extra syllable in the middle)
Interesting. I wonder if the weight loss involved only fat loss or also lean mass, including muscle mass. If participants weren't working out or dieting, that might have skewed the results for semaglutide. The reason is that GLP-1 / GIP drugs are supposed to be taken as an "adjunct" to diet and exercise. However, aside from weight loss issues, Cagrisema seems to be pretty good for A1c.
When you lose weight you always lose both fat and lean mass. Unless you purposefully increase muscle building exercise by a good measure. Even so you most likely still lose lean mass but could end up with more percentage of lean mass in the end if you have a lot a weight to lose to begin with.
Cagrisema works! using less than dose was on with semaglutide and still very powerful.... note: using a research peptide, nonetheless its +99% pure, good enough for me.
What’s the dosing mixture?
Are you doing two shots? I have not found the cagrisema just the two separate.
Will this be better for type 2 diabetics? Thank you
Potentially. It looks good in the phase 2 trial. We will have to see what the phase 3 trials show us!
I'm confused. So Zepbound is not a combination of the two weight loss ingredients? Thanks for all your help.
Zepbound is one molecule: tirzepatide - that targets two receptors: GLP-1 and GIP. Amylin is really the third hormone in the group that controls satiety.
No worries! No zepbound isn't two separate entities. It is one molecule that has the ability to bind to the GIP and GLP-1 receptors. It binds more tightly and consistently to the former. Cagri-sema is two separate molecules in the same vial!
i wish you were uploading with higher volume. i can barely hear you
You are the first to state that. Perhaps increase your volume?
@@theofficialdrdanyou sound fine mate
👌🏽
♥️❤️💗
Is Cagrisema cheaper
Not on the market yet.
Cutting-edge medication, with best in class weight loss? It won’t be cheaper.
All I’m hoping for is that it won’t be more expensive. 🙏
Would it be a bad idea to mix low dose Tirzepatide 2.5mg, with Contrave so that possibly can keep Tirz dose lower for longer? does that even make sense:)?