ChIP-seq Data Analysis (part-1) Identification of Enriched TFBS

ChIP-seq data analysis was done from the publicly available dataset GSE127183. Samples are treated to induce the expression of SNAIL-1 transcription factor. The aim of this analysis is to identify enriched TFBS in the peaks using the classical match approach. Peaks from the sample GSM3629871 are subjected to a pre-existing workflow (pipeline) in the geneXplain platform. In this part, we can see that SNAIL-1 motifs are clearly over-represented in the peak regions. Also, binding motifs for several other families of transcription factors are significantly over-represented. This may give us an idea that SNAIL-1 factors cooperate with several other factors to regulate gene expression in the investigated colorectal cancer cells.