My husband is 64 and has O-M disease. He received radiation to the prostate and affected lymph nodes, and has been on Lupron/Zytiga therapy for the past nine months. His PSA continues to be negligible, there's no evidence of cancer on scans and his Mayo doctors consider him to be in remission. We were devastated by his stage 4 diagnosis, but now we do have hope! Thank you for your videos and insightful information!
@@foodislifesouthafricacapet3716 I'm glad I could be of some encouragement at a time that I know is terrifying and overwhelming. Lord knows we need all we can get! Best wishes!🥰
Thank you Dr Scholz and Alex for this video. I just had a PSMA pet scan which detected 1 possible bone met on my 6th left rib. This video makes me optimistic of a complete remission of my PCa.
Fantastic video! Always a pleasure to watch and listen to your very informative clips. Thanks for keeping us up to date on everything prostate cancer related!
For stage 4 PSA to get to undetectable levels with hormone therapy do the patients have their prostates removed? If not, I'm confused how one could have undetectable PSA while still having a prostate. Wouldn't the presence of any prostate tissue have some PSA? Asking because I often hear that with stage 4 they don't do surgery.
Great and informative video. Question: In cases, with Mets would you treat the primary (prostate) also? Or just focus on the individual of Oligo- Mets? Is there an advantage on treating both?
If my doctor is really not doing any more than lupron shots should I see another doctor or at 75 am just going to die soon? Cancer is in most lymph nodes.
That depends on the extent of the metastases and other factors, but it is definitely possible to survive many years after bone metastases are discovered. Hormone therapy, for example, can oftentimes keep the disease in check for years and sometimes patients can even achieve a 'durable remission' meaning that the disease remains in check even if the treatment is stopped. There is a lot to consider, and we have patient advocates on our free helpline that can discuss some of the nuances with you. You can find our contact information at pcri.org/helpline. You may find this video of Eugene Kwon, MD, from our 2021 conference helpful (the link should take you directly to when his lecture begins): ua-cam.com/video/DhxSwN3-5jw/v-deo.html We also have this playlist of 23 shorter videos for men with 'advanced disease,' meaning disease that has spread to the bones, distant lymph nodes, or organs and/or disease that has become resistant to hormone therapy : ua-cam.com/play/PLHj3V3RB2V-iRh_hnLqajcFpTXyVzW_Oi.html We also have this interview with a patient who has been living with metastatic prostate cancer to the bones that you may find interesting: ua-cam.com/video/wlDPjZzFfvE/v-deo.html
Greetings I am Amir from India. My father is a diagnosed of prostate cancer. He is currently on harmone and radiation therapy. Initially he was taking casodex alongwith lueprolide. After four months doctors stopped the casodex. Now only harmone and radiation therapy being given. Patient is complaining of frequent urination despite in treatment. Kindly suggest some remedy to relieve the symptoms. Regards
I have Oligo-Metastases Disease in my right internal iliac lymph node, and the posterior urinary bladder wall near the apex. PSA rising now at 2. I had radiation a year after my Radical prostatectomy 5 years ago. My Doc wants ADT I want a cure not just palliative care will chemo work on the bladder? as I am no longer a candidate for radiation...
Hello, The patient advocates on our free helpline may be able to help you with your question. You can find our contact information at pcri.org/helpline.
I am past this, I have extensive nodal mets. They range from my neck to my lower abdomen, and everything in between. I am on ADT and Xtandi with a very low PSA. Am I basically waiting for my PCa to mutate once again, and then get on the chemo train? I was told by my Oncologist that he wants to do simple scans once a year to see if I get any other mets, and or the nodes further increase in size.
Fire your onco if they haven't yet suggested 4-6 cycles of Taxotere (Docetaxel). Research is showing adding Taxotere to what you're already on ("triplet" therapy) helps extend life in us meta patients by YEARS I'm on the combo now and it's not so bad. The first few days after your shot you feel pretty gross, but after that you start to feel somewhat normal. If you can put up with being a bit tired for 12-18 weeks in return for a much longer lifespan...
At about 3:20 in the video, Dr. Scholz indicates that only about 15% of men with PCa, after targeted radiation therapy for a lesion, will experience an abscopal effect where another non-targeted lesion shrinks because of the activation of the immune system... Would Provenge help in activating the immune system in these situations? Has there been a trial to look at that? What about the use of checkpoint inhibitors such as Keytruda in this situation?
That's a great question, and I have wondered the same thing. Unfortunately, I don't believe it has been studied, but I will add it to our list of questions for upcoming videos in case Dr. Scholz knows of something.
"May still be curable" with metastatic prostate cancer is a stretch. There will always be outliers in any cancers but curable stage 4 prostate cancer is rare.
Yeah, he cites about 10-15% of his patients having a long durable remission after the discovery of oligometastasis, and that was using old scans. There are not much data on outcomes nowadays, considering the recent approval of PSMA PET scans, but everyone is optimistic that earlier detection of oligometastses will improve those rates.
My husband is 64 and has O-M disease. He received radiation to the prostate and affected lymph nodes, and has been on Lupron/Zytiga therapy for the past nine months. His PSA continues to be negligible, there's no evidence of cancer on scans and his Mayo doctors consider him to be in remission. We were devastated by his stage 4 diagnosis, but now we do have hope! Thank you for your videos and insightful information!
My husband got his stage 4 diagnosis last week, you just gave me hope
@@foodislifesouthafricacapet3716
I'm glad I could be of some encouragement at a time that I know is terrifying and overwhelming. Lord knows we need all we can get! Best wishes!🥰
@@ga6589 you are so so right I'm so scared our kids are so young my husband is so positive but I'm struggling
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Thank you Dr Scholz and Alex for this video. I just had a PSMA pet scan which detected 1 possible bone met on my 6th left rib. This video makes me optimistic of a complete remission of my PCa.
That was a great explanation of my treatment. You are giving me great hope of a cure!
Fantastic video!
Always a pleasure to watch and listen to your very informative clips. Thanks for keeping us up to date on everything prostate cancer related!
Great Dr.Shchultz ! Thank you.
Thank you as always! 🙏
Thank you so much . Very helpful
You give me hope.
For stage 4 PSA to get to undetectable levels with hormone therapy do the patients have their prostates removed? If not, I'm confused how one could have undetectable PSA while still having a prostate. Wouldn't the presence of any prostate tissue have some PSA? Asking because I often hear that with stage 4 they don't do surgery.
Can you share with us what some of these scans look like with commentary?
Great and informative video.
Question: In cases, with Mets would you treat the primary (prostate) also? Or just focus on the individual of Oligo- Mets? Is there an advantage on treating both?
Is there a possibility that doubtful metastasis findings during lumber MRI be false positive?
Thank you very helpful Blessings
If my doctor is really not doing any more than lupron shots should I see another doctor or at 75 am just going to die soon? Cancer is in most lymph nodes.
If you have stage 4 prostate cancer of the bone is it curable?
That depends on the extent of the metastases and other factors, but it is definitely possible to survive many years after bone metastases are discovered. Hormone therapy, for example, can oftentimes keep the disease in check for years and sometimes patients can even achieve a 'durable remission' meaning that the disease remains in check even if the treatment is stopped. There is a lot to consider, and we have patient advocates on our free helpline that can discuss some of the nuances with you. You can find our contact information at pcri.org/helpline.
You may find this video of Eugene Kwon, MD, from our 2021 conference helpful (the link should take you directly to when his lecture begins): ua-cam.com/video/DhxSwN3-5jw/v-deo.html
We also have this playlist of 23 shorter videos for men with 'advanced disease,' meaning disease that has spread to the bones, distant lymph nodes, or organs and/or disease that has become resistant to hormone therapy : ua-cam.com/play/PLHj3V3RB2V-iRh_hnLqajcFpTXyVzW_Oi.html
We also have this interview with a patient who has been living with metastatic prostate cancer to the bones that you may find interesting: ua-cam.com/video/wlDPjZzFfvE/v-deo.html
Greetings
I am Amir from India. My father is a diagnosed of prostate cancer. He is currently on harmone and radiation therapy. Initially he was taking casodex alongwith lueprolide. After four months doctors stopped the casodex. Now only harmone and radiation therapy being given. Patient is complaining of frequent urination despite in treatment. Kindly suggest some remedy to relieve the symptoms.
Regards
I have Oligo-Metastases Disease in my right internal iliac lymph node, and the posterior urinary bladder wall near the apex. PSA rising now at 2. I had radiation a year after my Radical prostatectomy 5 years ago. My Doc wants ADT I want a cure not just palliative care will chemo work on the bladder? as I am no longer a candidate for radiation...
Hello,
The patient advocates on our free helpline may be able to help you with your question. You can find our contact information at pcri.org/helpline.
I am past this, I have extensive nodal mets. They range from my neck to my lower abdomen, and everything in between.
I am on ADT and Xtandi with a very low PSA. Am I basically waiting for my PCa to mutate once again, and then get on the chemo train?
I was told by my Oncologist that he wants to do simple scans once a year to see if I get any other mets, and or the nodes further increase in size.
Fire your onco if they haven't yet suggested 4-6 cycles of Taxotere (Docetaxel). Research is showing adding Taxotere to what you're already on ("triplet" therapy) helps extend life in us meta patients by YEARS
I'm on the combo now and it's not so bad. The first few days after your shot you feel pretty gross, but after that you start to feel somewhat normal. If you can put up with being a bit tired for 12-18 weeks in return for a much longer lifespan...
My Husband psa is 28000 it’s very high😢 what does this mean?
At about 3:20 in the video, Dr. Scholz indicates that only about 15% of men with PCa, after targeted radiation therapy for a lesion, will experience an abscopal effect where another non-targeted lesion shrinks because of the activation of the immune system... Would Provenge help in activating the immune system in these situations? Has there been a trial to look at that? What about the use of checkpoint inhibitors such as Keytruda in this situation?
That's a great question, and I have wondered the same thing. Unfortunately, I don't believe it has been studied, but I will add it to our list of questions for upcoming videos in case Dr. Scholz knows of something.
"May still be curable" with metastatic prostate cancer is a stretch. There will always be outliers in any cancers but curable stage 4 prostate cancer is rare.
Yeah, he cites about 10-15% of his patients having a long durable remission after the discovery of oligometastasis, and that was using old scans. There are not much data on outcomes nowadays, considering the recent approval of PSMA PET scans, but everyone is optimistic that earlier detection of oligometastses will improve those rates.