How to extract capsaicinoids from chili peppers
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- Опубліковано 13 кві 2014
- Capsaicinoids are interesting compounds with multiple, very different uses.
In this video I use a Soxhlet extractor to extract the capsaicinoids from Ghost Chili peppers.
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Nile talks about lab safety: • Chemistry is dangerous.
I once rubbed a Hot chili pepper on my Poison Oak rash, and It helped the healing by replacing the annoying itching with a pleasant burning sensation.
+ZZP Zing Pheonix I hope you didn't get poison oak from going in the woods, and having the leaves touch your 'nether region'... lol...
wow like put out a fire with lava
I once rubbed Thai birds eye chili on the tip of my dingledonger on a dare once. It wasn't anywhere near as bad as I was expecting
I'm guessing it was a relatively mild pepper and felt like heat rub?
Gary If you consider 50,000-100,000 SHU to be mild…
"extremely unpleasant" is one way to say "it's the stuff they *dilute* before putting it in mace spray"
I wouldn't call it unpleasant. It's more euphoric (when talking about a piece the size of a toothpick end)
@@BodywiseMustard the fuckyou talkinh about
Euphoric as in Amazing to think how potent such a tiny piece of the solution on the end of a toothpick would be so hot, that it would feel like a flame being placed upon you’re tongue 🔥🔥🇬🇧🔥🔥
@@CallMeMimi27 the shear amount of pain triggers an intense rush of endorphins after about 1 min that in some people can be on level with oxycotin
him: extremely unpleasant
me after rubbing it on me: holy mother of satan's left nipple, all I feel is pain and what I crave for is the sweet release of death
"It's not lethal, but you wish it was"
-- quote from some ancient website about capsaicin extraction
I wish you remembered the name of said website, that’s an interesting quote
No joke when i ate a ghost chilli i remember wishing i died cos it hurt so bad (i was 15) was also throwing up constantly
@@___meph___4547 lol for me it felt like molten lava in my throat and lasted for an hour had a full on fever after
I once tried 'sauce' from a competition near the finals. I won't really, but i got a drop on my finger when a trial was passed to the audience.
It was past the 1m mark and kept me entertained for 30min. 😂
Also gro nagas on my balcony. Well fruiting. They where insane and i shared it. One of our mad lads eat it like like a candy. Other copied without testing. Got a good sick in special after exing 1l of milk after.🤣
always say how hot they are when not know people. It can get very nasty pretty fast otherwise.
Btw, he was warned. Chillis past 200k outright stank the danger. Capsaicin tastes and smells slightly bitter to me.
Naga bhut jolokia. They have around 1m.
As a kid (~14-15) I tried making a pepper extract.
1. I basically just boiled a bunch of dried chilis.
2. In a tiny, thin walled pot.
3. In the kitchen.
4. I then left the long enough for the water to boil off completely.
Cue burnt chilis, and noxious smoke cloud in family kitchen!
But hey, 22 years later, and now I know how it's actually done! Thanks! 😁
I was about to do the same thing with oil and I remembered this video existed, what a coincidence
I hope you got spanked for that
Bro that bong is crazy
😂😂😂😂
@@-mega--volt-15 r/iamverysmart
Electric Meme nobody will ever get it right. R/woooosh
@@-mega--volt-15
You need a toke
ew
I can't think of anything more evil than grinding ghost peppers in someones coffee grinder
Leaving a tiny bit of dust left over
Adding capsaicin to their bottle of KY Jelly. I know, I'm an evil bastard.
I've done it to myself by accident. It wasn't that bad because I'm used to peppers. It would have ruined a normie's day.
Edit: coffee, not beating off. I ain't that dumb.
Hehe I should try it
Jesus! Too evil. No, please don't do it.
I was FREAKIN ROBBED!!!
Nile didn’t taste test it at the end! 🥵
According to him it's a bit strong.
Send it to hot ones
@@___meph___4547 2 british journalists tried a burger w alot of this extract and one of them lost feeling in his hands and his eyes rolled back. people have gone to the hospital w a ruptured liver and contracted blood vessels that lead oxygen to the brain. dont lie on the internet
@@___meph___4547 feel free to drink a whole flask of it so we can be rid of yet another waste of space. Bye.
@@h.f6364 i can't believe how reckless some people are with blatantly lying on the internet. Imagine if someone read that and thought it sounded like a fun idea.
Just to add to the initial warning: I got a surprisingly tiny amount of capsaicinoids on the corner of eye. If you do this, do not, DO NOT give in to the urge to rub your eye even lightly. I swear I was literally sure I was going blind. That's how bad it hurt.
He is not making this up. IT IS PAINFUL.
I never plan on making this but I gotta ask.... If you cannot rub your eye then what can you do to get the capsasin away from your eye?
@@jond3929 wash it
@@jond3929 lick a pinch of salt, you will get relieve immediately.
As an additional warning
DO NOT GO TO PEE WHATEVER YOU DO
I paid the price lads n lasses, do not make my mistakes, wash your hands before you pee
The next time someone asks you what you think is the most amazing breakthrough humanity has accomplished so far try and remember the internet. The amount of knowledge people share and learn from is staggering. Almost all knowledge is just one click away aided by people like NileRed here taking the time to put well made videos online for others to enjoy and learn. That thought always runs through my head when watching the content of the more technical channels like this one. Thanks for the video even if it's a few years late....
unfortunately, the amount of bullshit shared overwhelms the knowledge by orders of magnitude.
Finally I have a good answer for all those pesky people that keep asking me "What the most amazing breakthrough humanity has accomplished so far?" as I go about my day to day life.
@@thomasneal9291 thats not actually true your just saying that to sound deep
@@BossOfAllTrades You're awfully presumptuous.
@@BossOfAllTrades bruhh almost all the kids my generation are more into keeping up with internet drama, shitty instagram "celebrities" with fake body parts, bullshit vlogs and the list goes on. So yeah there's a fair amoumt of garbage that almost 70% people are more attentive towards.
Peter Piper Packed the Pipe with Powdered Peppers
This deserves to be the top comment lol
This is a spicy thread!
420th upvote pog
Breaking Bad with weeds...
Peter Piper packed the pipe with purple pot.
God help the person who makes this stuff without gloves, and then goes to the bathroom
And it's not NNN
I had a bottle of pepper spray that my dog chewed through and it exploded all over my bathroom and of course I didn't clean it up as well as I thought I had. You can guess what happened next. Dog was fine btw she took it like a champ.
Aaahhhyaaaayaaaiiii! Agony !
The next step for complete purification should be running a silica gel column, since one of the stated impurities is beta carotine. Carotine is completely nonpolar, so starting with hexanes should flush it out. Then you can gradually increase the polarity of the solvent to grab the capsaicin, which has several polar functional groups.
I recently did this to spinach to remove carotene and pheophytin from the chlorophyll, which was my target.
Cool, thanks! I will definitely try this out when I get the chance.
So is this next step necessary for consumption? or just to purify the capsaicin even more to get it as close to 100% pure as possible? I guess what I really like to know is if it's possible to take a totally harmless consumable product like a pepper, coffee, or even a flower like a dandelion, use an extraction process like this and come up with something that can kill u?? Obviously there are things out there that have some pretty harmful chemicals within.
Abida Babida No it is not necessary. It is merely to try and obtain pure crystalline capsaicin. However, you actually should NOT eat pure capsaicin because your body might respond to it dangerously. Assuming that you completed the extraction at home and with food grade materials, then this extract is perfectly safe to use in food.
Using this extraction on many safe foods can be dangerous. Some foods have chemicals that are safe in small doses, but toxic in higher doses. The amount of this chemical in comparison to the volume of food keeps the dose low. By concentrating it, you can get to a level where it is unsafe. It really depends on the food that you choose and the solvent that you choose to extract it with. In general though, you should always be careful and fully research everything. Especially if you are planning to eat your product.
Nile Red Well your answer just made me think n realize that however much this interests me, the fact that I'm not a chemist n don't know much about chemicals tells me I can wind up doing something stupid & dangerous if i don't educate myself on this more. Thanks!
Abida Babida You definitely need to research everything before you carry out a reaction, but that is how you learn. You can watch videos online and read background about various reactions. Just from this you will learn quite a bit.
What type of chemistry are you more interested in, organic or inorganic?
Add this oil to a homemade smoke bomb and you can clear a city block.
sell it to both sides and watch them duke it out.
@TheMoreSubsYouHaveTheGayerYouAre Their stickers are enough for me to hate 'em.
TheMoreSubsYouHaveTheGayerYouAre what about the ones who hit random people with bike locks? Or just attack random bystanders? Are they fighting for freedom ones or are they made up by Fox?
@@jb76489 He's too busy watching CNN to understand that such a thing as nuance exists, don't mind him.
@@jb76489 What about the leader of Antifa bringing a gun to his kids school and getting shot by police at point blank? That the antifa we're talking about here? lmao
"make most people extremely uncomfortable"
Thats an understatement. I once tried pure 9 million scoville extract. Was hanging over the sink for almost half an hour. At least my nose was clear afterwards.
Alaskan guides say that it's better than heavy firearms where Grizzlies are concerned. Although right now I'm feeling sorry for the poor bears hanging over their sinks
@@nmarbletoe8210 With a steady supply of cold water its actually bearable.
@@nmarbletoe8210 not necessarily,sometimes it makes bears wild and attack you even more. A neighbour of mine sprayed pepper spray at bear and it went wild and mauled him
@@definitelynotyuribezmenov7611 oh no! thanks for the info!
@@nmarbletoe8210 sure
I enjoy all the alliteration that you did "Powdered pepper particulates"
ha, thanks. I didn't even realize that I had done that!
Capsaicin and ethanol sounds like one hell of a drink
There are videos of people drinking pure capcaicin mixed with vodka. Search some up, if you enjoy schadenfreude
Eija
Really?
I saw only one video of pure caspinse and that's unbelievable 13 million cp
Hello respected gentlemen.
Please, esteemed, I have not seen this article and the method of extraction and distillation.
I want to know about this subject.
I will be thankful to you.
Please.
HELLFIRE!!!
i callee a batch between me and a friend "Satans Piss Pot"
~80% Irish putcheen
~10 Thai chillies
safe to say it lives up to the name😂
We did this at university as an undergrad prep. We were all giving the warning of the guy who regretted not washing his hands before going to the toilet. Teaches you how chemicals get everywhere so easily
So the soxhelt extractor is basically a glorified Pythagoras cup?
I was thinking that when I saw the nerdrage video on the extractor
Spooky Wizard pretty much.
no the pythagoras cup is a glorified soxhelt extractor
Yea but it's prettier too so there
WOW! It's pretty rare to find someone else who knows what a Pythagoras cup actually is! :D
Hmm Coffee made with a Soxhlet extractor would be fun :)
Ethanol covfefe
that's pretty close to how a percolator coffee maker works
I've done this before. Started with 50% fine ground espresso and 50% breakfast blend. Added it to a 500 mL soxhlet with about 300 mL distilled water in a flat bottom flask. In this instance, each extraction takes roughly 1-1.5 hours. I've found that 2 or 3 extractions yields a very delicious product with a nice "wake me up NOW" potency. 4 or more extractions, however, begins to bring a lot of undesirable flavors over. By the 5th extraction, it's almost too bitter to drink. One thing worth noting is that after the first extraction, when the water/ coffee returns to boiling it will froth up quite a bit. To combat this, I use an oversized boiling flask and strong magnetic stirring to keep the froth from going up into the soxhlet. Expect to spend several hours to make 1 cup of coffee. It will be very good coffee though as long as you don't overdo it.
That is similar to how percolating works. Ever had percolated coffee? It sucks. It's burnt bitter almost chewy coffee. In order to do this with coffee you would have to adjust pressure so it boils lower so the temperature doesn't burn the coffee or release tannins in the coffee.
@Kali Southpaw This is the most Breaking Bad shit I've ever read. A+ use of lab equipment
I’ve been watching you videos for just over 3 years I think. Your production was still good back in the day. But gosh you’ve transformed and grown! Way to go keep it up!
I repeated this procedure with methanol, and used a pressure-equalizing addition funnel instead of a Soxhlet extractor. I just had to open the stopcock each time it filled up. Also, instead of evaporating the methanol in open air, I distilled it off in order to save it.
Great videos, keep up the good work!
Food grade solvent?!! Methanol?? 7 yrs later are u still ok??, Good if yes🖤
@@nileblack No, doesn't have to be. I used HEET fuel line antifreeze that I distilled to get rid of any oils.
@@MrItsthething wow u replied even after 7 yrs ... Lol it's just weird to think ... And thanks..😊
Truly most excellent, your communication skills are superlative, and beautifully explained for such a young person as yourself. I am most impressed! I am truly looking forward to your next demonstration! Cheers and wonderful job!!
I love visiting your old videos. You've come so far!
crazy how far you can go in 7 years. cheers NR loved your videos since the start
3:30
Stoner1: Bro, we don't have a soxhlet extractor.
Stoner2:Get me an avocado, a snorkel and some foil.
Stoner1:What?
Stoner2:Trust me bro, I've made science equipment with less.
I made a bong from a hollowed out banana, a Bic pen and some chewing gum once. I can totally see this work.
Most stoners are just improvisational engineers, even if they dont realize it (:
I'm with Stoner2. In 5 minutes or less I can make something with whatever I can find just laying around.
Hi there, I think the ivory solid you were left with in the 500 ml rbf was actually capsaicin whereas the dark orange syrup that you have obtained was a mixture of mainly beta carotene and "syrup-trapped" capsaicin. It might well be possible that during concentration under reduced pressure the solubility of capsaicin in ethanol has dropped and capsaicin has partly crushed out. I like your videos!
I was literally thinking about requesting you do this but you already done it! You're a beast my guy
When you enjoy NileRed vids so much plus love peppers, so you like the video before it starts because you know you’re going to anyway.
Dear Mr. Red sir, thank you for this very good demonstration, I enjoyed it very much. pierre from New Mexico
u r welcome child. this is now my new account. I have shifted into musical scientific extractions.
I did something similar to this when I was a paranoid little s*** to make pepper spray, and I tested it on myself.
I took a two hour shower about an hour later.
I was not expecting classic NileRed when I clicked on this. You've come a long way in the past decade.
The end product looks evil as hell that stuff would never be anywhere near my mouth
🐔
Or my anus. I guess some would love it though.
also if you use a coffee grinder... don't use it for coffee or you'll have a real hot one ;)
almost impossible to get all the pepper residue cleaned out.
Very cool. Wish we could've watched you rotovap it too lol. Idk why I love watchin time lapse vids of solvent recovery, it's weirdly satisfying for me.
I love soxhlet extractors they’re beautifully designed and work perfectly ❤️
Was watching this to extract some peppers and was amazed to hear about his plans to make capsaicin with vanillin, which is featured in his famous hot sauce from gloves video
I did this with 190 proof grain alcohol when I was younger and instead of evaporating it, I dipped a bunch of blotter paper in the solution and let them dry. Then I cut them into ten-strips and wrapped them in tin foil and then when I’d have friends over; left them out on the table to test if they were actually my friends. Anyone that stole them from me were dealt instant karma. I called them “ten-strip-friendships”.
This is a great video; very well explained, clear, concise. Thank you! However, you did not mention the use of MgSO4 for drying. Also, for the impurities, could you have done a aqueous workup?
Such an awesome video. i dig the animations. happy anniversary to this video
your videos improved so much
Capsaicinoids flavored 190+ proof alcohol shots would be the hottest drink imaginable.
Add Wasabi, Piperine and Cinnamon oil to make it even better.
Did it once, diluted with tequila not to get alcohol poisonning after the first shot...
Very nasty side effects, but otherwise I was fine.
I think my piss still burned me three weeks later...
100% pure alcohol is poisonous to tissue. But if you add one drop of water, it isn't.
I know a place that sells tequila shots with finely chopped habaneros inside. That shit hurts.
Officer Meow Meow Fuzzyface
That's not true. Well, the second half isn't true.
All ethanol is poisonous to tissue, but it's a matter of degree. Lower concentrations need to contact the tissue for much longer to display toxic effects.
I think the effect you're referring to is based on osmotic pressure. The less water in the ethanol, the stronger its "pickling" effect is on tissue. Basically, water flows from high concentration to low concentration. The larger the concentration gradient, the stronger the effect. Because of this, 100% ethanol "sucks" the water out of your cells, killing them very quickly. But the same can be said about 99% ethanol.
The reason you always see 99% ethanol and never 100% ethanol is because ethanol dissolves water very easily. Even in dry climates, unless you have 0% humidity, the ethanol will promptly dissolve water from the air, and dilute itself from 100% to 99%. The near impossibility of keeping ethanol completely anhydrous is the reason you can never find it.
I followed your process exactly and at my family gathering we had a few days ago I put about 1mL into the entire pot of chili. Everybody voiced their discomfort. 10/10 would prank Gramma again
You have an evil soul lol
@@johnlemon5904 imagine all the people, crying all the day, ooh ooh
And then everyone stood up and clapped
God, that is so wicked. Yuck
My top tip for reducing chilli burn on skin is to use neat washing up liquid and a nail brush on wet skin. Works a treat.
Thanks for the video.
For a long time I have dreamt of what it would be like to extract the spicy chemical from peppers. This video is so cool.
Thanks bro, I need it for an April Fools prank.
hi nigel how long have i been subscribed
quite a while
Hey Kevin
At least 7 years
Nigel I wanna know how long I’ve been subscribed too
Pretty cool seeing these old videos
This was a good one. At our pharmacy we often make hair growth liquid with capsicum tincture.
Capsaicin on skin: pain reliever
Capsaicin in eyes: infernos of hell
Capsaicin in mouth: little bitta both
I already watched it cz I'm his subscriber from so long and came here again after Ann's video.
Me too
Me too
This is an excellent method for making *potent* pepper-spray. Using a good delivery system is key as you don't want "spray" -rather a direct stream.
Thanks so much! That will be extremely potent
The jar I was soaking the peppers in somehow got a thin layer of capsaicin/oil on the outside. I went to shake it and my hands started burning, 10 hours later and it was still hurting. Only after I soaked my hands in a baking soda solution did it finally stop
Very good explanation :) Maybe, showing the rotary evaporator could've been interesting for people, who didn't have had the chance to work in a lab.
I was thinking of doing that, but decided against it because my rotovap is too ugly to be on video. It has to be decades old by now
@@NileRed it doesn't matter that how it looks, but as an chemist the knowledge matters. Thanks for sharing ths
If you accidentally spill something very spicy on your hands or any part of your body and it burns a lot, thick dairy products like yoghurt, butter or ghee can help relieve the pain of capsaicin.
Excellent video! Fascinating and well-made. I love the diagram and all of your methods!
Hello respected gentlemen.
Please, esteemed, I have not seen this article and the method of extraction and distillation.
I want to know about this subject.
I will be thankful to you.
Please.
I wonder how anhydrous the ethanol is while being exposed to the atmosphere. Anhydrous ethanol is pretty hydrophilic.
i got this nasty stuff sprayed over my face for military training, only 0.3% ratio.
1h40 of pure pain, never again !
I finally understood Soxhlet extraction thanks to your video.
Love this channel!
Can you do a video on how to extract pipperine from black peppers?
Fer Contreras he posted it
Your wish has been granted
I wonder if there is a way to directly compare the heat your body is perceiving to the actual temperature that would produce that feeling.
Probably quite different since nothing is being damaged
im glad youtube recommended this tio me 8 years later!
Amazing video dude!!!
Ever notice the catechol moiety in capsaicin? I always thought that it might have dopaminergic activity.
Interesting facts... I have to look into this.
Used red hot chilly peppers, now dancing, instructions unclear.
better than me, i got the extract stuck in my bladder.
very nice video man!
I swear I never get stuck watching youtube but you have me watching vid after vid!
I did this a long time ago with everclear. And I intentionally didn't concentrate it all the way. I dipped my whole finger in the alcohol, put it on my tongue and felt like I just ate the sun. I was also dry heaving, coughing, watery nose.... it's very powerful stuff EVEN IF dilute. If you wanna use for self defense (I was attacked by a pitbull once) just put it in a small cologne bottle. You may also be able to add some liquid butane as I think cologne bottles lock pressure unless pressed down. To keep them from diluting on the shelf. I'd just use a small thick bottle if you do this. Butane does create pressure but very low compared to other aerosols.
You don't need to add butane. The spray mechanism will create droplets in the air.
I guess "mace" and such products are aerosol cans and only have a valve so they need butane/propane.
Your alcohol-insoluble precipitate was probably a mixture of waxes and a few salts which are soluble in ethanol at high temperatures but not at low temperatures; if I recall correctly - granted, my organic chemistry and biochemistry days are a decade behind me now - the fruits of plants in the nightshade family are fairly rich in long-chain fatty acid waxes.
Jesse Cohen thank you, i was looking for this answer. The appearance checks out too.
I was looking for this answer aswell! Just posted a comment about it and that I just out the solution in +8°C enviroment to see if I can separate these!
Perhaps I should move on to -20°C aswell afterwards? I Can get down to aprox -80°C!
I cant find a chart of capsaicin solubility in ethanol vs temperature... :/
That was awesome. Always wanted to be a chemist/scientist when I was a kid.
I'm going to have to get some extra glassware to accompany my soxlet extractor. I've not used my soxlet yet, but this one definitely gives me good reason.
This is not your typical brewing process in Minecraft you've get used to...
What common "food grade" solvents are there? im interested in it for home made hot sauce.
+Kid Kirby Technically the "safest" is buying everclear or another high proof vodka/ethanol from the store.
Thanks :) Nile Red
+Nile Red If you havea lot of work to do with it, say, making tons of limoncello etc.... www.alibaba.com/showroom/food-grade-alcohol.html if you want significantly less (and/or can't afford more...) organicalcohol.com/store/
+Nile Red anhydridous vodka?
+Nile Red could u use isoproal acholol and just evap it all
You have come so far over 7 years
Ahh it uses a bell siphon! Thanks excellent video! I always extract jalapeno into oil fresh.. then drive water off the oil for jalapeno oils. From this pain cremes and other stuff like that is made. I don't have a need for anything as pure as that! Still I like the alcohol concept, I may try that some time. That concentrate would literally burn holes in your skin in long exposure! Love your videos! Thanks!
misread the title as:
How to extract cannabinoids from chili peppers
U need to lay off the weed bro lmao
Only works on red hot chili peppers
Anybody else here because this video just happen to show up in Recommended?
My Corona!
Nah
That was great!! Thank you!
Yes, exactly what I was looking for
Use your coffee grinder XD. That will be hot coffee after you do need to grind some coffee beans :D
UA-cam recommendation: since there are protest, here is a video on how to make pepper spray
UA-cam throwing gas on the fire lol
Concentrated capsaicin is a wonderful way to make food spicier without adding any flavour that would change the overall player of the dish You just have to be a very very careful You add because this stuff is ridiculously spicy very little goes a long ways
Wow I have to get one of these extractors!
Now will my friends drink a full vial for 5 dollars
stonegolem2001 no, offer them a large bottle of milk. That's all they need.
same basic extraction setup can be used for many alkaloids, including those of more psychoactive categories just sayin' :D
Dmt :)
@@pyrorc Can it?
Hello respected gentlemen.
Please, esteemed, I have not seen this article and the method of extraction and distillation.
I want to know about this subject.
I will be thankful to you.
Please.
That is very amazing! Always love to see this knowledge and can't live without it.
Yet I have to ask if anyone knows how long it will preserve? Thanks
That’s a dope bong bro
soxhlet extractor works kind of like Pythagoras cup right?
Yes.
Yep, fluid dynamics my dude
Thanks for the very informing video. I understand that extracting pure capsaicin would be troublesome given that there are other capsaicinoids present in peppers, but I was wondering if it would at least be feasible to separate the beta-carotene from the capsaicinoid mixture. For instance, wouldn't using sodium hydroxide solution (pH>11) work in an extraction procedure, since the -OH group bonded to the benzene ring in the capsacinoids would become deprotonated, thereby making capsacinoid salt that would be soluble in aqueous solution? The aqueous layer can then be isolated and acid can be added to restore the protons on the capsacinoids. I would think that the precipitated capsaicinoids can then be filtered from solution.
If it isn't too much trouble, can you try it out and see how it goes?
I am going to do lab work about extracting pure capsaicin. Thanks for the idea, I am going to check it and tell if it actually works and overall yield.
Did you give it a try would really like to know the results
@@garynunn7395 if you read this before tomorrow can you explain it short therm again i think i will try it tomorrow and look if it works i got a project on right now and im kina helpless on how to clean it
@@akkerbeztleubekova2484 i already did a HPLC analysis and found out i only got 18.5% clean capsaicin in my ,,oil‘‘ or rather i would say in my liquid quewinggum substance
A trick to speed things up a tad. I pour the solvent in through the top of the soxhlet. That way I get an initial siphoning quickly. That's more efficient than filling the flask and then adding the soxhlet.
That's a crazy bong ya got there.
Just FYI: got capsaicin burns - rinse with milk. The fatter - the better. Not a perfect absorbent, but one can find it quickly.
Exactly, that's why they say to drink milk instead of water if you're eating spicy food. What is a capsaicin burn but a hyper-concentrated failed attempt at eating a ghost chili, after all?
Could you just boil/distill off the ethanol instead? Not everyone has a 5k rotovap in their lab lol. Assuming thermal decomposition isn't an issue.?
yep
Great job! Btw, do u have any idea of the concentration used in pepper srays?
Wait, how do the capsaicinoids work as a pain reliever? Do they make something else painful so you don't feel the original pain?
They constantly stimulate pain in the nerve cells thus depleting their neurotransmitter reserves of substance p, without such the sensation of pain cannot be transmitted to the brain.
The way I learnt is that it has to do with pain gating. The body has a mechanism for figuring out which nerve signal is correct when several nerves signal from the same area signal, a mechanism called gating. One triggered nerve will inhibit the signals from another one. By triggering the burning heat receptors, these signals are seen as more acute than pain, and the deep pain receptors are blocked. The ointment also contains menthol, which trigger cold receptors. The brain never gets the pain signal, since the pain is blocked in a peripheral gate coupling. It gets both extreme heat (capsaicin) and cold (mentol) signals at the same time, which it interprets as an ok feeling.
Mary Udomah Basically, Yeah. Your body gets so much pain that your nerves simply stop reacting to pain for a while
I read this as "How to extract caprisun from chili peppers"
Another great video!
Thanks!
I used your method to make tincture from my weed. Works exactly the same.
"Capsasanoids are not particularly toxic" . . . :D unless you got a Chili Allergy like me
Hey! Here I thought I was alone in the world! Capsaicin allergy ruins my life XD