That's a very good question. If we look at pre-hepatic Jaundice, it usually occurs due to excessive haemolysis, leading to significantly increased unconjugated bilirubin in the blood. This means the liver produces far more conjugated bilirubin. Now remember conjugated bilirubin is broken down into urobilinogen in the gut where around 10% is reabsorbed by the body. Thus if we have more unconjugated bilirubin being produced we will also have more conjugated bilirubin being produced. And if we have more conjugated bilirubin being produced we will also get high levels of urobilinogen being produced. Since we have more urobilinogen being produced more of it will be reabsorbed into the blood and thus we see increased urobilinogen. Hope that makes sense, if not, let me know!
This is VERY helpful and informative, thank you very much!
Thank you! Glad you're finding it useful!
Awesome video
Why is urobilinogen increased in pre hepatic jaundice
That's a very good question. If we look at pre-hepatic Jaundice, it usually occurs due to excessive haemolysis, leading to significantly increased unconjugated bilirubin in the blood. This means the liver produces far more conjugated bilirubin. Now remember conjugated bilirubin is broken down into urobilinogen in the gut where around 10% is reabsorbed by the body.
Thus if we have more unconjugated bilirubin being produced we will also have more conjugated bilirubin being produced. And if we have more conjugated bilirubin being produced we will also get high levels of urobilinogen being produced. Since we have more urobilinogen being produced more of it will be reabsorbed into the blood and thus we see increased urobilinogen.
Hope that makes sense, if not, let me know!