Double Marker test करवाना क्यों जरूरी है?|| Double Marker high risk आया है, अब क्या करें?

Double marker or dual marker test is very important test during the pregnancy in order to screen the possibility of chromosomal abnormalities particularly Down syndrome or trisomy 21. It is done along with NT scan at 11- 14 weeks of pregnancy when baby's length (CRL) between 45 - 84 mm. Blood sample of the mother taken for the test on the same day when NT scan is done. 2 markers free beta hcg and PAPP-A level seen in the serum and combined with NT scan markers and give the probability of Trisomy 21, 13, 18 and abnormality of X and Y chromosome. If it comes high risk for any Chromosomal abnormality then it should be confirmed by invasive tests, either by Chorionic Villus Sampling (CVS) or Amniocentesis.
If it is done correctly it can pick up to 93-95% of Down syndromes.
Care should be taken-
NT scan should be done by Fetal Medicine specialist or Doctor who is Trained for doing first trimester scan and certified by the Fetal Medicine Foudation, UK.
Sample should be taken on the same day when NT scan is done
Sample should be sent to the certified Genetic
labs only
Benefits of Doing Double marker or Combined test -
Helps to make an early diagnosis
Non invasive
High sensitivity
Cost effective
Serum markers Combined with NT scan marker
Limitation
It is screening test not Confirmatory one
Every women who is pregnant is at risk of Down syndrome or other Chromosomal abnormalities. This screening should be done to the every single pregnant women.
Dr. Alkesh Soni
MD Obst & Gyn, Fellowship in High risk pregnancy and Fetal Medicine
Fetal and Maternal Medicine consultant
Aarambh Fetal Medicine and Genetic Center
203-204 Phalashri Plaza, Phadnis colony, near Industry house A. B. Road Indore
Madhya Pradesh 452008
For appointment- 6263711034
www.aarambh.ind.in
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