Alpha Lipoic Acid (Cell Biology and Randomized Trials)
Вставка
- Опубліковано 6 лют 2025
- 00:18 Cell Biology
2:33 Dietary Sources
3:45 Obesity
4:36 Diabetes
5:36 Neuropathy
7:15 Hypertension
8:14 Multiple Sclerosis
10:00 Covid-19
10:53 Side Effects
Lipoic acid is a very popular nutritional supplement. In this video, I’ll explain what it is, the biological effect in the cell, and the results of numerous randomized controlled trials in obesity, diabetes, hypertension, multiple sclerosis, neuropathy, and even covid-19
Sources:
Oregon State University article on lipoic acid: lpi.oregonstat...
Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis: pubmed.ncbi.nl...
Lipoic acid in secondary progressive MS A randomized controlled pilot trial: www.neurology....
Determination of free α-lipoic acid in foodstuffs by HPLC coupled with CEAD and ESI-MS: www.sciencedir...
Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis: pubmed.ncbi.nl...
Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials: www.ncbi.nlm.n...
A Randomized, Single-Blind, Group Sequential, Active-Controlled Study to Evaluate the Clinical Efficacy and Safety of α-Lipoic Acid for Critically Ill Patients With Coronavirus Disease 2019 (COVID-19): www.ncbi.nlm.n...
The effects of alpha lipoic acid (ALA) supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials: www.ncbi.nlm.n...
R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens: www.ncbi.nlm.n...
Article on “lipoic acid supplement” without the product: www.consumerla...
α-Lipoic Acid and Insulin Autoimmune Syndrome: diabetesjourna...
Comment or ask questions below! I would be happy to answer!
Subscribe on UA-cam for more videos every Wednesday!
Make video requests in the comments section!
Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: amazon.com/dp/... It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty.
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
![Top 7 Alpha Lipoic Acid Foods & Vitamin SCAM [Neuropathy & Diabetes]](http://i.ytimg.com/vi/9SROQJl-a6I/mqdefault.jpg)
I will say that my Dad took it to help his painful diabetic neuropathy, but he took a higher dose. He took 1200 to 1400 mg a day. Initially he didn't think it worked until he wound up in the hospital for his heart and they wanted him to walk, but the pain was so bad he couldn't walk. We brought his alpha lipoic acid into hospital, and within a day he was able to do the walking they wanted him to do because of the pain had decreased so much. Then with in 3 to 4 days, he was almost back to where he was before he went into the hospital. I saw it first hand. So I know that for him it actually worked. Being prediabetic, I tried to take it for numbness in my limbs, but it caused indigestion, and with already having GERDS, I could not take it. 20 yrs later after a debilitating vertigo attack, I found that my issue is MS. Given my MRI results, my neurologist believes I have had it for 20+ years.
Great video!! :) Love that you made one on ALA :D It's a fascinating compound - would be incredible if this very cheap supplement could help a little with MS brain atrophy. I think if the ALA MS study is correct the benefits would only be seen over 20 years. It is a long term impact that compounds over time most likely. 20-30 years of slowed brain volume loss will be huge compared with just using it for a year or two. Time will tell I suppose, I wish more MS research was looking at this - stopping brain atrophy is HUGE in my opinion (if this is the case). It is half the problem... 50% lesions 50% brain loss. Might be beneficial for the general population also if it is good for the brain :)
Thank you for this very informative video. Your video answered all of my questions regarding this supplement. Kudos to you Dr. Beaber for this timely information!
Thanks
@@DrBrandonBeaberthanks for doing these videos! I have watched as many as I can since my recent relapse! I have my PhD and have been going through as much literature as I can. Are you familiar with myelin peptide transdermal patches? Small but solid study from 2013 in JAMA Neuro and no further studies? pubmed.ncbi.nlm.nih.gov/23817921/
Are you recently diagnosed? He has a great video for that too.
What about the lead and cadmium ?
Been taking since February, I dont notice any help with pain but if it is stopping atrophy i will definetly keep taking! To me that alone is worth it.
I was just contrmplating getting off it too.
Thanks Dr B! I was really happy to hear you didnt take a work call with a situation going on- family first! ❤
I came here to say the same thing.
Could you do a video on N-acetyl glucosamine? It is another nutritional supplement that has been reported to be beneficial for MS patients. Thank you!!
Thanks for the suggestion.
N-acetylglucosamine is indeed very interesting...the one interventional trial in people with MS used 6 to 12 grams per day - a high dose which can be very expensive and many people with MS use N-acetylglucosamine but in much smaller doses which may not be effective...
Love a video on low dose naltrexone
Been taking 600 mg BID ALA for years now for MS pain. I have run out from time to time and the pain definitely increases when stopped. I'm a believer.
I'm glad it's working for you.
@@DrBrandonBeaber Thanks Doc, Love your vids!
Great video! These are my favorite type of videos you put out. Would love to see more similar videos taking a look at other popular supplements and symptom managing medications for MS pts.
I will do more videos along these lines
@@DrBrandonBeaber well I watch every video you put out, so I'll look forward to it :)
Hi from Israel interesting video I will send it to my daughter
I eat mostly plant-based food but use beef tallow (grass-fed) to make soups (fry onions) and roast potatoes etc. as my oil. Grass-fed beef tallow is super healthy and has conjugated linoleic acid (CLA), arachidonic acid (AA), oleic acid, palmitic acid, alpha-linolenic acid (ALA), and stearic acid. Spinach, broccoli, yeast, peas, and brussel sprouts, have ALA too. It is aided by vitamin C for absorption. I have taken so many supplements in my life I am over them. I am committed to using food to help my brain and body now. (also, coming off a fast I took a big handful of vitamins and maybe had some bad rice and gave myself food poisoning in a big way, so that might be why I just can not take supplements right now - probs an easy way to get the support of ALA) Still, the grass-fed beef tallow feels just right and makes roasted potatoes insanely good. Thanks for your Video, your content is always excellent.
I've been taking it for likely over a year but didn't know not to take it with a meal so thanks for that. I transitioned to SPMS about 10 years ago at age 50. My last MRI last year did show brain volume loss. I haven't had a new lesion or other MRI changes for about this same time and changed to Ocrevus at that time just changing to Augagio this January. Too early to know if any of this is having any impact. That is probably impossible to know based on one person's experience with all the changes and actions within a year
I have been taking 1200mg for years with no noticeable side effects. After 2 mRNA vaccinations I developed erythromelalgia in my hands and feet. I didn’t know how much ALA was helping until I missed a few, it helps the burning pain so much. I’ll have to ask my neurologist how my brain volume is looking
Thank you for this video. Have you done anything on glutathione, NAC, NAd, or glycine? Thank you
Great video. I have a burning sensation on the right side of my neck which comes back if I stop taking ALA. So I keep taking it for that, pluss the brain atrophy study you mentioned. Results from another larger trial will be presented at ECTRIMS 2024 (I think). Hopefully it will confirm the previous study. If so, I would say it is pretty revolutionary when it comes to neuroprotection in MS.
Please consider a video on N-A-G (n-acetyl glucosamine).
Thanks for the suggestion.
N-acetylglucosamine is indeed very interesting..lhte one interventional trial in people iwth MS used 6 to 12 grams per day - a high dose which can be very expensive and many people with MS use N-acetylglucosamine but in much smaller doses which mauy not be effective...
Good day to you Dr. B. I wanted to ask you if your know Dr. Saray Stancic because her youtube video about lifestyle medicine gives me great hope. And she has MS too. A video with the both of you would be awesome to watch. Thank you and have a good day.
Thank you so much Dr Beaber for this excellent review about Liopic acid as I believe it needs more research attention for I feel like it is underrated. I am an MS patient myself and I started noticing it helped me with my fatigue the days I take it and boost my energy level ...not sure whether it is fancy or true though but this is how I felt.
Thank you for another great l video Dr Brandon, I can't say I've tried it myself but I just might try it as a supplement in the morning but I was wondering more about magnesium glycinate for nerve pain instead.
I take it everyday. Works great for me. I have normal brain mass with MS and works great for pain.
Awesome
Started taking it a week ago for the neuropathic pain in my feet and legs. Hopefully I will notice a change.
I hope it works for you.
Dr. Brandon i would like to ask you as a neurologist who treats MS for patients like me who have chronic vertigo of unknown origin or as a Covid long hauler and dont want SSRIS..whats the harm of low dose benzos for relief if the patient finds them beneficial? Both are addictive but benzos have less side effects..so why wont drs prescribe them..all meds have side effects..i dont personaly believe low dose benzos have worse side effects from steroids dmts or ssris. And they are used for vertigo so why is it hard for a neuro to presribe them to relieve severe ongoing dizziness
it is exciting to hear about stuff that can't be patented
no brain atrophy on this spring's MRI for this 60 yr. old PPMS guy!
i also had hsct in mexico sept 2023.
I started alpha lipoic acid in the last few months, I'm on my 2nd bottle. The brain atrophy stats mentioned seem possibly worthwhile for 30 can$ bucks a month. At 60 the last MRI HAD NO NEW LESIONS SO AS A PROGRESSIVE MSER crumbling damage MS combatted by being happy and lightly actiive, well rested and happy are the best strategy.
A thought I often have is that small studies are not to be ignord and bigger studies are only somewhat bigger enough to get rsults, patents and money. Re. the money thing- unpatentable stuff seems in certain respects less liikely to have trumped up clams.,,, Again - follow the money when weighng opinions).
dr Brandon Beaber siempre sin muy interesantes sus videos. Gracias por compartir investigaciones sobre suplementos para mejorar la Esclerosis múltiple. Hay alguna información sobre adaptógenos por ejemplo Melena de León?
What’s the best time to take it ?
@@Nikiii229 Empty stomach morning and afternoon. Na-RALA is most bioavailable. 480-600mg are good dosages. Any form of ALA deplete biotin reserves so low dose biotin(300-600mcg) is reccomended to take also. 48hours before lab tests discontinue taking biotin as it can present false results especially for thyroid.
Dr. Beaver, have you done a video on ABA-101 and progressive MS? That is a trial I would like to learn more about and know your clinical opinion on it.
I do not but thanks for the suggestion
You dont have videos on the leaky gut syndrome..microbiome i would be very interested in the studies concerning that
I mention it in the middle of this video: ua-cam.com/video/2SKKc_ccegQ/v-deo.html
Ty for reminding me of this- I did take this as a supplement from Dr Aaron Bosters clinic- his “ Refresh” brand of supplements-I absolutely forgot- I did feel a bit better on it.
I’ll be tossing some in my cart soon- as we can all stand to feel the best we can.
#SharingisCaring
Would you consider making a video about trigeminal neuralgia and how it differs if the cause is MS vs a vascular issue? Thanks
I have a video about trigeminal neuralgia and I do mention this briefly: ua-cam.com/video/et_RV1Xud0c/v-deo.html
@@DrBrandonBeaber oh sorry I must’ve missed it. Thanks
Thank you so much for your videos, Dr Beaber!! I take 600mg of ALA daily. Does it work? I have no idea, but ANYTHING that has the potential to slow accelerated brain atrophy is well worth it, in my opinion. No noticeable side effects to speak of.
gonna try some.. also phosphatidal choline (sp?)
Dear Dr. Beaber ,
Would you be able to design cliniical trials for such supplements?
Me personally? I don't have any experience with clinical trial design, but I have a general idea about how one would go about it. Some of my colleagues have worked with pharmaceutical companies and have designed trial before.
Can Alpha Lipoic acid actually cause QTc Prolongation as some medicines can, or is it just an for anyone who already has QTc Prolongation Syndrome? I wasn't sure how to interpret the comment here. There is not a lot of research I could find. There is also evidence it can reduce the QTc Prolongation interval. I have been taking 1200 mg a day for 4 years and this is the first I have heard that it can have this side effect. Thank you.
I did find one study suggesting a statistically significant increase in QTc with ALA, but the mean difference was only 14 (from 408.8 to 422.8, the later of which is still in the normal range). Certainly this is a concern for someone with QTc prolongation or a marginal QTc www.sciencedirect.com/science/article/pii/S2590257122000360#:~:text=ALA%20produced%20a%20statistically%20significant,as%20adjunctive%20components%20in%20schizophrenia.
@@DrBrandonBeaber Thank you for the response, Dr. Beaber. This attached article is one that I also read. It shows a reduction in QTc interval from 422.80 to 408.80 and not an increase. "An unexpected and interesting finding was the significant reduction in QTc interval in patients after ALA administration. No studies explored the relationship between the role of ALA and ECG parameters. Psychiatric drugs such as antipsychotics, seem to result in QT prolongation, and that is why it is considered a significant limiting factor when prescribing medications. (Beach et al., 2018). Our results suggest ALA to be a risk-reducing intervention on QTc interval control." This is still modest, but reassuring.
@@DrBrandonBeaber Thanks for the response, Dr. Beaber. The article attached is one of the articles that I read. It shows a reduction in QTc interval of 422.8 to 408.8 and not an increase. "An unexpected and interesting finding was the significant reduction in QTc interval in patients after ALA administration. No studies explored the relationship between the role of ALA and ECG parameters. Psychiatric drugs such as antipsychotics, seem to result in QT prolongation, and that is why it is considered a significant limiting factor when prescribing medications. (Beach et al., 2018). Our results suggest ALA to be a risk-reducing intervention on QTc interval control. " It modest reduction, but reassuring.
Me: I should look into maybe taking this since it's pretty safe. I'll ask my doctor 😊
You: rare insulin autoimmune syndrome, maybe more common in Japanese people?
Me, half Japanese half white: 😦 but does that include me? I can never tell lmao
I took it for a few days and i felt so amazing... But that 'amazing' wasn't sustained, unfortunately
Hm. Unfortunate
Started 600 mg. daily, Altman company, no sign of right or left. ➡ 👈 No results yet either, except that my urine smells like sewage. 😝 If you tell me that I have to take 2 a day, and that as a result I will remain Ms. Superbrain forever, I will consider it. 🤔