Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment
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- Опубліковано 13 жов 2024
- Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment. Aplastic anemia is when your bone marrow scores "F" on the final exam. It's failed.
Aplastic anemia is a Pancytopenia (anemia, leukopenia, thrombocytopenia) causing fatigue (tired all the time), infections, bleeding.
There are many causes of aplastic anemia; can be inherited or acquired.
MCV is usually increased in Aplastic Anemia.
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Phenytoin
Yes!
Phenytoin
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This is a great video my sister has a aplastic anemia and we are getting ready to start the bone marrow transplant treatment for her
How was the treatment? How's your sister? Want to know everything about it
Hi I had a plastic anemia issue. But right now I have cure from it yes I have take allopathy(chemical) medicines. But later on I have shifted to ayurvedic medicine( natural medicine).
After taking ayurvedic I have been healed/cured from it.
completely
Yes it can cured. And healed.
@@pravinjadgeri6980Ayurvedic is great, but no one is going for the scam whatsapp number bs.
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Nice review of aplastic anemia! Just wanted to add that sometimes you can get a hypocellular MDS that looks similar to severe aplastic anemia. Usually cell morphology and cytogenetics will help you differentiate the two (hypocellular MDS you would expect more chromosomal abnormalities, aberrant megakaryocytes + megs will be small in appearance), however clinically they can look very similar. Thanks for the video!
Thanks for your comment!
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This video is extremely concise and complete for a big topic of aplastic anemia. Came back here from reading harrison's. Contents can be confirmed as same. Thank you medicosis ❤
Glad it was helpful!
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Presently diagnosed with Pancytopenia, awaiting further evaluation. Your presentation is the the best I've viewed and highly reccommend it. Thanks for composing this video.
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The answer to the question is D. Phenytoin
Thanks for the tutorial. It really helped
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Phenytoin . Lovely explanation
Thank you AA patient. Recently diagnosed. This explains more than any doctor i have seen. Much love!!!
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Eltrombopag has been added to standard immunosupression for AA.
Thanks, helped out with my presentation on TERT gene mutations causing aplastic anaemia.
I am glad to hear that! Thanks for watching!
I am binging ur videos ...much appreciated ..why don't we consider aplastic anemia as one of the differential for dry tap as mylofibrosis or mylophtisis since it causes hypocellular bone marrow
Great video as always! I should note that Parvo-B19 very rarely causes Aplastic Anemia and is more often with Pure Red Cell Aplasia
True
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The Answer for the Question at 18:53 is Phenytoin, a Sodium channel blocker.
Phenytoin, thanks for your explanation and efforts ❤
My pleasure!
Such an excellent video again. Thank you 🤍☕☕
My pleasure 😇
thank you sm for this ive been in the hospital for a month so hopefuly i can get a bone marrow transplant thank you
You are realy great teacher
Thanks alot my lecturer
Good day Sir, so I have a speculation as well as to why MCV is high is aplastic anemia.I’d love to know your thoughts.
If MCV= Hematocrit(ht)/[RBC]
This would mean that a decrease in [RBC] or increase in Ht should give high values of MCV right?
We also know that in aplastic anemia, while Ht might remain the same (since all the other hématopoïetic cells are also affected), [RBC] is definitely low, hence giving high MCV values.
Just a speculation, please correct me if I’m wrong😊.Thank you.
MCV is also calculated via forward light scatter in flow cytometry. This gives each cell a direct reading of size
thank you for the helpful video but the UA-cam ads make it very difficult with the constant interruption. Any way you can prevent that ?
Phenytoin.... and thanks for ur time Dr.
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And you WILL NEVER FAIL US
Thank you!
great explaination
I hope you add video about Diamond Blackfan anemia
Amazing video thank you so much !!
Phenytoin... Nice one!!
Really awesome video ... excellent !!!
Thanks 🙏
i've applastic anemia. age:20years
my doctor gave me horse atg with cyclosporine on 8thjanuary,2018.I'm also taking tab.eltrombopag 25mg
but my platelet&hemoglobin count is not increasing.Last cbc report is below:
HG-10.5,PL-34000,wbc-5.34
my hla type match is 10/9%.
Now what can i do???
Please reply
Azmeer Hossan Joy I also have it for 3 years now 3 months ago I got a bone marrow transplant and I’m getting better
i have aplastic anemia too. i was given horse and rabbit ATG and i'm now in remission. i hope you the best of luck!
ua-cam.com/video/8DUg9RocIio/v-deo.html
My daughter starts ATG today. Praying it works for her with little side effects.
Got diagnosed last month with aplastic anemia, taking promacta, steroids and cyclosporine for 3 weeks now, waiting on chemo and stem cell transplant. The hardest part for me right now is dizziness and fatigue wish me luck, Im glad you all feel better , God Bless you.
phenytoin...
awesome explanation
Today i have to learn aplastic anemia for my tomorrow hematology class and this video was absolutely amazing and very helpfull.
I got only one question.. I have read that the hypothesis that aplastic anemia is a state before mielodisplasic syndrome is not so strongly approved according to the new findings in the genome. I dont know how true this is but i read some good arguements
Thanks for your comment! You are absolutely welcome! As for that theory, I am not sure, to be honest!
Phenytoin.... Excellent and capsulated class
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Lovely presentation
Answer is phenytoin
Thank you!
Fantastic explanation
Thank you so much 😊
slow but very clear thank you
Fetal anomaly caused by phenytoin is Fetal Hydantoin Syndrome
And Lithium causes Ebstein's anomaly (atrialisation of ventricles)
11 years a go when I was 10,I was diagnosed with aplastic anemia, Now,no sign of it,but it has brought PNH
Answer- Phenytoin
Thank you so much, you are the best!
Such a great explanation WoooW❤️
Informative + fun, thanks man!
My pleasure 😇
Are any curing of A Plastic Anemia other than bone merro transplant
Plz reply
@Rocio Ch. A. Rocio Ch. A. My Younger Brother Face with this from when he was of about 10 year old ,
And Doctor's was suggested for Bronemerro but we was not gone for bonemerrow.
Now he is of 16 year old •
And Blood transfusion has been happening every single day since last one week.
And the doctor is speaking for the bonemerro😢😢😢
@Rocio Ch. A. Now My Younger Brother is no more 😢😢😢😢
Another great Video, Thanks!
Phenytoin
I like you're special and simple way
please keep going ❤
perfect presentation very helpfuland easily comprehensive/thanks deeply
My pleasure! Please share with your friends! Thanks a million! 😃
I have a question.
If there is anemia why there is no hepatosplenomegaly (for compensating anemia)
Why there is no lymphadenopathy(as there will be increased infection)
Can you please answer these.
I can't find any satisfactory answer.
When I see the disease in the book, I feel disturbed by the many details. Then I search on UA-cam and find a video for you. I am very happy, thank you very much from the heart💙💙💙💙💙💙💙💙✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨✨💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙💙🙏🙏🙏🙏🙏🙏🙏🙏
Beautiful explanation...well done
Thank you so much! Excellent explanation!
My pleasure 😇
I go to the same school Eric Connor went to, he is one of the eight people in the world who has had aplastic anemea.
Aplastic anemia patients are more than eight.
@@MedicosisPerfectionalis sorry, that is my mistake, my gym teacher told me that there are eight, but apparently that is incorrect.
No worries...There are way more than that.
Thanks for being honest and open-minded...I really appreciate that :)
thank you for the explanation
My pleasure 😇
I am trying to understand. It's so much fun. Thank you so so so much.
Thank you so much 😊
please clear one of my queries not related to this video ....i.e why are neutrophils high in pregnancy state
Pregnancy is a physiological “stress” state.
you are a life saver!
Thank you 🙏
@Medicosis Perfectionalis I had VSAA but was too old for transplant. Am in remission but still lacking stamina after 3 years. Is there a reason my oncologist didn't want me to take a vitamin B supplement after hATG, while taking Cyclosporine (Sandimmune) and Promacta? Every time I asked he would tell me to wait on that.
How is your condition now?
@@mishalahsan161 numbers are in the good range, but bruising very easily, and still lacking stamina. Grateful to be alive, try to live life as close to "normal " as I can.
🩸 Hematology Playlist: ua-cam.com/play/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU.html&si=tomFsUjAgOKhOJVq
Wow my Dr told me yesterday I was low in iron and need to take iron with orange juice she never went into this could be the cause of my headache which I think is nerve pain .thanks for the info
My pleasure...I wish you speedy recovery...Keep me updated...Good luck 👍
Aplastic anemia with high MCV but normocytic?? I don’t understand or you made a mistake at the intro
Great
what do you mean about pregnency and its associateion with acquired aplastic anemia and PNH and pregnency ...please explain how this causes occur.Thank you
Thank you sir
Thank you doctor. Is there any foods to supply indirect medicine for the pancytopania??
It depends on the cause. Unless you treat the underlying cause, it’s not going away.
I was diagnosed with aplastic anemia with low rbc, low hgb, low hct, high MCV, but high reticulocytes, if bone marrow is not producing enough cells, why is reticulocyte count higher than normal? (Bone marrow cellularity is at 5-10%)
may b u had MDS[myelodysplastic syndrome has all you listed including hypercellular bone marrow]
Could be relative reticulocyte count cuz its a percentage of whole blood. If it decreaces less than hct decreases then it’ll appear to increase. Theres a formula to get the adjusted retiuclocyte count in his earlier videos
So it is low WBC and when blood is diagnosed they should show low in number. But again person can show leukemia. In other words, what will the WBC count be in acute myeloid leukemia and pancytopenia?
thank you for your a nice explanation
It gives me great pleasure! You’re always welcome!
What abour a megaloblastic anemia does has pancytopenia?!
How can we differentiate between the clinical presentation of megaloblastic anaemia and aplastic anaemia when both have pancytopenianin common????????
Clinical presentation will be the same.
If there’s vitamin B12 deficiency, you might find neurological problems.
The difference is on the bone marrow biopsy.
@@MedicosisPerfectionalis I still watch your epic series since my 2nd yearMBBS 🥺 so grateful to learn from a great doc like you 🤗
what about using Eltrombopag to stimulate platelet precursors and bone marrow stem cells to grow?
Very nice video, great 🤩
Thank you 😊
OMG what a video, many thanks 😭🌹❤️
Glad you enjoyed it!
The boss ❤
Thank you!
impressive!!
Thank you 😊
phenytoin. thank you for your great explanation
Correct! Thanks for your nice comment:)
Much appreciated!
Thank you so much 😊