Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and The 3 Most Important Levers to Pull
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- Опубліковано 16 лип 2024
- Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and The 3 Most Important Levers to Pull | Brought to you by Athletic Greens all-in-one supplement athleticgreens.com/tim , Oura smart ring wearable ouraring.com/, and Eight Sleep’s Pod Pro Cover sleeping solution for dynamic cooling and heating www.eightsleep.com/tim.
Dr. Peter Attia (PeterAttiaMD.com) is a former ultra-endurance athlete (e.g., swimming races of 25 miles), a compulsive self-experimenter, and one of the most fascinating human beings I know. He is one of my go-to doctors for anything performance or longevity-related.
But here is his official bio to do him justice:
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (how long you live), while simultaneously improving healthspan (how well you live).
Peter trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including Resident of the Year, and the author of a comprehensive review of general surgery. He also spent two years at NIH as a surgical oncology fellow at the National Cancer Institute where his research focused on immune-based therapies for melanoma. He has since been mentored by some of the most experienced and innovative lipidologists, endocrinologists, gynecologists, sleep physiologists, and longevity scientists in the United States and Canada.
Peter also hosts The Drive, a weekly, deep-dive podcast focusing on maximizing longevity and all that goes into that, from physical to cognitive to emotional health. It features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Subscribe on Apple Podcasts, Spotify, Overcast, or wherever you listen to podcasts.
Please enjoy!
00:00 Start
03:29 Liquid Biopsy
15:50 Four pillars of exercise
19:22 Posture
27:40 Zone Two training
29:55 Diets, fasting, nutrition
40:10 “3 levers” framework
44:36 Muscle loss when fasting
46:38 Psilocybin and MDMA
01:11:01 Cholesterol and ApoB
01:28:42 Rapamycin and lifespan
01:56:30 Sauna benefits
02:01:00 Preferred Zone Two method
02:04:30 Effectiveness of Semaglutide
02:11:32 Resources and recommendations
02:14:06 Texas-the good, the painful
02:18:39 Zone Two deep dive
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16:44 "a table with one leg is obviously not a table" *immediately cuts to a table with one leg*
The Zone 2 content was the best part! I’ve been doing Zone 2 training for the last month on the advice of a friend. I was skeptical at first, but holy smokes has it been a game changer. I am about 80 pounds overweight, but a month ago I was 90lbs overweight and killing myself going to the max on the rowing machine. Started doing Zone 2 instead and the weight started to shed. Beyond that, my resting heart rate has gone from the mid 80s to the low 70s and my endurance for hikes and bike rides has skyrocketed. Awesome to hear the deep dive on the science behind this! For those curious, I’m doing four 60 minute sessions per week on the rower and wearing a heart rate monitor to stay in Zone 2. Quite frankly, it’s a much slower rate than I’d like to go-especially when other people are on the rower next to mine and blowing me away-but I have seen the benefits firsthand.
J
Justin Shively, give us an update!🙋🙏
I saw Peter on Joe Rogan for the first time around one year ago. Since then I have committed to intermittent fasting 5-6 days a week and have managed to lose 60 pounds - Thank you, Peter!
then I am sure you will love dr #RobertMorsend even more, just check his YT channel and let me know after...
How much muscle did you lose you think?
@@jvm-tv I don’t think I did. I am more lean than ever, but I have been doing 5-10 minute intense muscle training daily
@eblman Nice. It is good that you’ve managed to integrate it into your life. I mainly do 16:8 say 95% of the time for 5-6 days a week and then I’ll just do a short 12 hour fast the other two days to give myself some time back to enjoy a late night snack now and then. I haven’t fasted for more than 20 hours and I don’t think I have the determination to get to those levels
@@jvm-tv one doesn't lose muscle doing intermittent fasting (aka time restricted eating). One loses muscle when undergoing starvation.
Hey there, fellow listeners. I copied and recalculated the timestamps from Tim's website to fit this video.
HOWEVER, only the first few timestamps line up. Read the end for more information.
02:39 What is a liquid biopsy, and why is Peter excited about this recent innovation? How does it work, what is it good at detecting, and why does Peter consider the bureaucratic red tape snagging its rollout a “tragedy?”
15:50 The four pillars of exercise someone seeking to improve their metabolic health should understand.
18:28 A few of the major causes for modern posture problems, and methods for remedying them.
24:54 If Peter were Czar for a day, here’s how he’d train children to grow up into a more habitually active adulthood.
27:39 What is zone two training, and what is it designed to do?
29:55 Why a ketogenic diet won’t necessarily make you lose weight (nor will an all-Doritos or all-Twizzlers diet, for that matter).
32:18 What Peter has learned about fasting since the last time we talked.
36:25 The pros and cons of front-loading one’s meals when observing time-restricted feeding (aka intermittent fasting).
40:33 The three levers of Peter’s nutritional framework: caloric restriction, dietary restriction, time restriction. “Always pull one, sometimes pull two, occasionally pull three, never pull none.”
45:09 Does Peter recommend using branched-chain amino acids to mitigate muscle loss during a fast?
47:04 Thoughts on a recent New England Journal paper comparing the effects of Lexapro to psilocybin in patients with depression, and how you can (and why you should) increase your scientific literacy to best understand the results of such papers.
1:07:47 Why the research around MDMA as a treatment for patients with PTSD comes to clearer conclusions than the study comparing Lexapro and psilocybin.
1:09:41 How is Peter’s thinking evolving around apoB and its relationship to cholesterol control in the body?
1:21:44 Are there any benefits to low apoB outside of lowering cardiovascular risk?
1:23:22 What is Mendelian randomization, how does it allow us to infer cause when an experiment is not done, and how was it used recently to understand the correlation between lower apoB and improved all-cause mortality?
1:26:20 Is Peter more bearish or bullish on rapamycin since the last time we discussed it? As someone who’s not receiving an organ transplant, why has he been taking it for the past three years?
1:37:36 Beyond potentially increasing lifespan, do we know if rapamycin can reverse aging-related impairments to our healthspan, such as hearing loss?
1:42:04 What are some of the other pharmacological candidates for extending lifespan or healthspan that Peter currently finds interesting? How does someone bring potential candidates to the attention of the ITP?
1:54:15 How the Age of COVID may have finally driven Peter (and his poor family with whom he’s been locked down) bananas.
1:56:26 Why Peter has become bullish on the efficacy of saunas no matter how vigorously the Finns try to sway him otherwise.
2:00:59 Peter’s preferred method of zone two training.
2:01:41 Peter’s thoughts on semaglutide, the new drug treatment for chronic weight management that was just approved by the FDA.
2:10:29 Peter’s resources and recommendations for people who want to further step up their scientific literacy, improve their ability to separate fact from fiction, and discern hype from reality.
2:12:50 On the botanical origins of certain Central American spirits, and the only thing about Texas that Peter doesn’t like (so far).
2:15:32 Decaffeinated brands, Tommy Want Wingy, and other parting thoughts.
2:18:40 As promised, here’s the segment detailing everything you ever wanted to know about zone two training: aerobic efficiency, what happens on a chemical level, current research, minimum effective dose, and long-term adaptations and benefits.
Okay, so it seems like Tim cut a few things away for the audio-only-version. That's why after the third timestamp, the timing is off.
If you listen to this podcast and feel like correcting the timestamp, please sub-comment your corrections in an intelligible way. I will change them here.
Or just post a complete comment seperately :D
Also, here's the link to his website: tim.blog/2021/06/08/peter-attia-2/
And here's a link to a timestamp conversion tool on my website: vilz.gg/timestamps :)
You did great thank you!
The first edit is at 29:40. After that, add 50secsto each time stamp (to get the corrected time), UNTIL the next edit (which I don’t know what time it is).
1:49:38 → 1:54:15
@@jmesy Nice, thank you
The real MVP
Tim Ferris is doing us all a favour by unpacking Dr Peter Attias vast knowledge in language that most of us can understand
That is a good thing.
One of the best, most underrated interviews on the net. Thanks. 🔥
I love how this level of information quality is available freely online. Truly amazing.
Thank you for this!
It's been a rough week and seeing this on my notification feed was beautiful. Thank you gentlemen.
You are such a bright light! Thank you for all you give and the vulnerable way you do it!
👍
Great episode! I love how open or latitudinally he thinks about so many topics and is so important!!! Amazing man
What a treasure trove of information. Peter and Tim are doing yeoman's work with this podcast.
Wow. This is like a blast from the past for me. I really found Tim and Peter from one of their first podcast ages ago. I love to see them back together again, face to face. This is heartwarming. I really appreciate and thank both of you for all the work you've put out into the world.
i also like their unintentional matching outfits and baldness
About 10 days...there are several things you say that decrease your credibility substantially in my opinion.
DUDES PERFECT TIMING!!! This podcast LITERALLY just explored/answered everything I am going through right now in life😀💜🙏
then maybe it is time for you to check dr #RobertMorsend YT channel and let me know if you like him too...
Emily Barry - EVERYTHING??🤯
whoa!!! That's ALOT!
We are so lucky that content exists in the world like this. I enjoy this particular format and like consuming podcasts like this on youtube .So if TF could repeat this format, it would be enjoyed. Grateful for all of it regardless though. Thanks Tim,,
It's nice when someone this intelligent can find people to talk to.
Just a funny takeaway, when he's talking about exercise and the table analogy it immediately after pans out to the table they're sitting at which has a single leg/pillar in the middle😂
Paul Dipetro...🤣 (wanna bet you are probably the ONE person who noticed this?)
So, Yah... 'gotcha' Attia! A one legged table IS a table (and you're seated AT it🤣
Omg hilarious - great pick up
Lol, I was going to comment this same thing..
As soon as I saw that I laughed and scrolled to the comments to find this. 😂🤣
Seeing my two greatest mentors in a room together warms my heart 🙏
THANK YOU SO MUCH for the journal club resource. I cannot accurately assert how beneficial this is to me in my endeavor to perform scientific analysis in lieu of traditional education routes. I enjoy neuropharmacology/ biology very much and this gives me hope to bridge the generational plague of a division between working class contemplative and actionable idea- integrator.
Cheers and thank you again.
Any Peter Attia interview is top shelf !! Good work Tim Ferris !
EXCITED TO WATCH THIS TONIGHT!
Big fan of Dr. Attia, he's very eloquent.
I love both of them. And the fact they can see themselves reflected off of each other.
First thing I noticed. Why are they not standing (or squatting) for the interview?
Peter is an incredible intellect but you are an amazing moderator ! Great video. Thanks you
Helll yeah I’ve been waiting for Peter Attia on your channel
Love when these 2 get together!
Please make chapters. They are very much necessary in a long podcast like this.
He does have show notes on his website if that helps
Great stuff: unpacking some serious knowledge to the public from all perspectives... Great narrative style of the doctor..
So excited to watch this!
Very cool podcast, such good content when you have Attia on your show.
Movement is medicine.
This is a great episode. Very interesting and a lot of great information.
This video is going on my blog, Thanks Tim :)
“The most potent drugs we have are food and exercise” ~ Dr.Peter Attia
Unless you have cancer then you need exercise diet and really powerful drugs.
And cheese and wine for fuck sake. Live a little.😂
@@theodenednew8874 I don't think one size fits all. There are a lot of people alive because of chemo.
What about sleep?!
@@NicholasDunbar kinda think you missed the spirt of the point there. Oh look there is a commercial on TV w that Captin Obvious guy, those are funny
This is the best podcast. Great guests and conversation
So true. Both incredibly hard workers at the top of their field. Both been giving me directions and point of interest for a long time.
Heyyyyy.
Many gems dropped as per usual. Thank you!
16:38 looks down and is currently sitting next to a table with one leg.
lmao
Hahaha
Ah, yes, but the one legged table has a cylinder base that supports it.
Very informative, thank you both.
Several of these scientific and statistical terms like power and primary objective are easier to understand when presented in a fashion like this than in class.
Thank you for this great info!!!!!!
Oh buddy, love that this is in video form
Tim is a great interviewer. Although he has a robust understanding of most (all?) of the conversation’s subject matter, he knows when to have his guests elaborate because dummies like me need things broken down into bite size pieces.
Between the interrupting, the quality of the questions, and the tangents, I find him weak.
Tim is a master compared to Rogan. Makes me cringe when people still listen to Rogan as their main pod.
@@tylerodell3368 I don't listen to either but I have to say Tim sounds the same now as he did 8 years ago. Exactly. Sounds a bit fake to me and seems like there has been no growth at all.
I was a big early listener of Tim's podcast but found it too repetitive after a couple of years.
I'm taking notes and hitting rewind throughout, lol.
But the don’t finish their thought..then shift
This was super valuable.
This is basically a jack of all trades Tim interviewing a different version of himself that decided to focus more on health and become a Doctor. You guys could basically be clones down to the style and even the Speedmasters lol
Excited to see video!
Good video!Thank you for your job!!!
Life is short. I had Melanoma as has my mother. I'm probably good because they got it very early when it was thin. I have averaged 10 hours of exercise and ate well my whole life. The problem is I had too much sun and possibly a melanoma marker. Point being is live every day with a gratefulness...
I've found rebounding on my beloved Bellicon rebounder has increased my proprioception. Thanks my fellow Texans for introducing me to Topo Chico twist of lime on a past podcast. It's also one of my loves.
wish all of Tim's podcasts were video recorded
they're already awesome but if they were recorded and had show notes they would be even better
two of my favourite bald intellectuals nerding out, cheers fellas.
Thank you Tim and Peter, I listen to the whole thing. Love the conversation you're both brilliant and studious.
Full of amazingly new information, so many topics looked at in depth!
16:41 "A table with one leg is not a table" ... [camera pans out to show Dr. Attia using a one legged table]
Me: proceeds to piss myself laughing
Best duo!
Awesome guy's!
At 2:08:30 for a 200 lbs person a 20% weight loss will result in a 160lbs final weight not a 180lbs.
Love your insight, Dr Attia 👍
Great interview
We need Peter's book. Not getting any younger lol.
I must confess I zoned out for a while during some very technical speak ... But really enjoy the intelligent conversation and comraderie between you. Especially interested in the latest developments re: MDMA and mushroom treatments for PTSD and depression. Thank you!!!
@@user-rc7vm2sk8x Guessing this is a hack. ☹️
I like how, as a true scientist, Dr. Attia doesn't shy away from continuosly validating and eventually contradicting assumptions he made in the past based on new discoveries: I remember him talking to Rogan of being a strong supporter and practicioner of the OMAD with a big dinner being the only meal, while here he discusses about the potential detrimental effect of strict time-restricted feeding regimes on muscle mass and visceral fat. It all makes a lot of sense.
RE: better metabolic health exercise. Exercise is so important it cannot be over overstated it's one of the most potent drugs we have.
The four pillars of fitness is it is like a table with four legs. you have to have all four legs. They are ●strength ●stability ●aerobic efficiency and ●anaerobic performance.. Peter explains stability -" stability is the ability of the body to transfer load from the body to the outside world and vice versa." He explains the hamstrings are critical in this and how to ask them with a position lying on your back.
This is informative and clarifying for me.
Peter recommends working standing or squatting. Breathing from the diaphragm. Sitting you don't use these muscle groups.
My experience - Asians squat regularly and can do deep squats for an extended time with no problem therefore they are fit in that way from their daily lives.
Triceps are looking on point, Tim! -Soren
Great great conversation
Just started PS K9 inhibitor. Rapatha apo b dropped from 230 to 80 in 2 months. Waiting for my LP(a) results. Sadly Kaiser doesn't even test for these particles. Had to go to an outside lab but it's worth it to know.
Speaking of the “nubbin,” growing up my older cousin told me that end part of the banana was lethal b/c snakes injected poison into it. I’m glad me and Dr. Attia share the same thinking on this.
Does anyone know the guidelines to use the 4 pillars of exercise? I mean the exact workout. because I'm searching for it on internet and there's no a concrete guidelines to do it..(not yet)
Yes !!! Peter attia the best
"All dorito Diet" lol haha. I love how Peter can say really funny things while being super serious about it
For those interested in metabolic health in a conversational podcast form: can't recommend his "The Drive" podcast enough. He talks to phenomenal researchers in cardio-metabolic health including Rick Johnson (fructose metabolism), Robert Lustig (from Sugar the bittersweet truth fame), Matthew Walker (author of best selling Why we sleep), Gerald Shulman (Banting Awardee) , Tom Dayspring (great cardio educator), Jason Fung (Diabetes code) and many others to name.
"A table with one leg is not a table."
*Editor cuts to view of a table with one leg*
Very interesting - I HIIT and HIRT 3 times per week. I'm on strict keto. I Intermittent Fast eating lunch and dinner within a 6 hr window 1pm to 7pm. A supplement stack of 12. My chronological age is 69, my biological age is 32 according to a GlycanAge Test.
Thanks for sharing your health secrets. What are the supplements for 60 yes non diabetic pure vegetarian
@@gogreen5984 Magnesium with Potassium, Electrolyte mix, Multi B , Calcium AKG, DHA and EPA separately, Vitamin E (only Tocotrienol) K (Combined MK 1,2,4 and 7) Resveratrol and CoQ10, Mixed mushroom extract (Reishi, Lions Mane, Cordyceps) D3 (twice a week 40000IU including K2 , Boron and small amount of zinc) Adaptogens (Ashwaganda and Rhodiola) Sea Kelp, TUDCA, Collagen with Hyaluronic Acid, Phospholipid Complex. Keto Diet including fish, organic eggs, grass fed, pasture raised beef - cruciferous veg, (I'm Allergic to nuts!) Organic High Fat Yoghurt, Avacado. Organic Avacado oil and coconut oil. (no processed seed oils etc)
44:26 the first time I have ever heard Peter Attia laugh and I've been listening to him for years. He's found the last ingredient for longevity ;-)
Same Will! I've watched several of Peter's videos over the years and never seen/heard him laugh. Definitely a different side of him.
I have trouble sleep with a full stomach. I often fast from six pm to late morning or early afternoon.
Very smart guy
Love it 🔥
No way!! Finally!!!
fantastic
Holy $h!t !!! How interesting! I've missed this channel. Very distracting in terms of trying to get work done for the man, however the man can suffer for today! Now, what's my VA doing?! Ha ha 🤣🤣 Go Tim!!! 👍👍👍
16:40 "a table with one leg is not a table"
immediately cuts to the wide shot, showing that the table between them has one leg
Are you doing shorts? If not, it would be good to have this time categorized. Thanks
The straight dope on cholesterol and 4 hour work week. Both life changing
Same jersey, biceps, and hairline? What are the odds. Love you both.
He really be ahead of the curve cuz this was in 2022 and Ozempic is the rage right now
37:40: IDEAL REGIME, best 16-hour IF: exercise, BIG BREAKFAST, modest lunch, fast after that.
Funny, but I came to that conclusion ~20 years ago, based on literature extant at that time. Hard to actually DO it, however.
PS: added: come to think of it, this idea went back as far as Adelle Davis, circa 1970! "Eat breakfast like a king, lunch like a prince, and dinner like a pauper".
Anyone else think it was funny that immediately after his comment about a table with one leg not being a table it switched cameras to an actual table with one leg??
anyone find the newsletter he mentions? Metabolomics and energetics ?
More videos like this Tim please. Thanks for some brain food..👍🎉
Dope interview. Btw with Tim's last name if you switch the "e" and the "i" with an "a" and a "t" his name is Tim Farrtss 🤣🤣🤣
My two favorite people! Only missing Jocko. Thanks, boys
Where are you from bro?
I’m a late runner. 50s. So I study these things Peter talks about with posture. He’s correct about young kids. Watch them close when they run. It’s perfect form.
Infrequently publicly traded companies will use relative performance in headlines, ie '2nd quarter revenues were up 200%' without commenting on the absolute revenue gain.
Interesting topic the Acarbose. How does it compare (as it seems to have the same mechanism of action) as Berberine? How do the two compare?
The problem, for me, with all these compounds like rapamycin or metformin is how do I, just an average joe, get access to them?
Need tips / hack on hair growth
I need to links to purchase those chairs
Does anyone know what kind of wristwatch Tim is wearing?
What I find really sad is that Peter had a life changing experience with insulin resistance that made him question if we were treating diabetes all wrong, and made him regret how he treated his patients, but now he seems to be doing the same, first with LDL-c and now with ApoB (number of artherogenic particles). There are so many parallels between diabetes and cardiovascular disease (CVD). E.g. diabetes used to be considered the disease of high blood glucose, he's saying that CVD is a disease of high blood ApoB. High glucose is known to cause damage and diabetes complications, high ApoB is suspected to cause damage and artherosclerosis. There are many drugs that lower blood glucose, there are many drugs that lower ApoB. Many of the glucose lowering drugs make diabetes worse. It took decades for the medical establishment to accept this (it's still not fully accepted). We do not fully understand the long term effects of ApoB lowering drugs. Also, high glucose is the consequence of the underlying disease (insulin resistance) and it is possible to reverse the disease if it's tackled directly (e.g. switch to low carb/keto/carnivore diet and make sure insulin is under control). Obviously, for most people, except maybe people with familial hypercholesterolimea, high ApoB is a downstream consequence of some other imbalance. Even if high ApoB was causal in artherosclerosis (in reality it seems to be only one component though), we should focus our efforts on figuring our what is the true cause of this imbalance, instead of trying to fix it at a later stage...
37:55 that is the worst eating schedule one can do if they do intermitting fasting, because you don't want to break a fast with a huge load of food, you want to break the fast with something light. The last meal you do before you start your fasting period, should be the kings meal and I prefer doing that at night because when I wake up, I can go long without eating.
I'm still a bit confused on what zone 2 is and when you enter it relative to using blood glucose vs fat, etc. Can anyone recommend some resources?
I’ve done a lot of research on this myself lately and discovered that it’s different for everyone. It’s training below your aerobic threshold and if you really want to make sure you are doing that you’re going to need a good chest strap heart rate monitor like the Polar H10 and an app that can measure DFA-alpha1. HRV Logger is currently the only option for iOS. Android users can also use Fatmaxxer which is a better app. But you basically want to make sure that while you are doing your cardio that DFA-alpha1 never drops below threshold .75 because then you’ve crossed over your aerobic threshold. If you just go by aerobic zone charts you can’t be sure that you are doing this, but it should get you pretty close most of the time. There’s also the talk test and breathing test. If you can maintain breathing with your mouth completely closed and only breathing through your nose then you are likely below your aerobic threshold. This should be sufficient for most people, but I love using tech and wearables to give me more info about what’s going on inside my body and for that extra advantage it gives me.