Amanda and Kelly’s Story - Talking About Crysvita® (burosumab-twza)

Visit bit.ly/40EmQiU to See Full Prescribing Info & Medication Guide. Watch to learn more about the Uses and Important Safety Information for CRYSVITA (burosumab-twza).
Amanda and Kelly have been compensated by Kyowa Kirin for her participation in this video.
Meet Amanda and Kelly, who share the importance of having conversations with their families about X-linked hypophosphatemia (XLH) and CRYSVITA. Kelly says, "I've counted 32 members of my family who have it, so it makes sense for me to talk about my experience with CRYSVITA". Amanda talked to her cousin about their journey with XLH and experience with Crysvita. They reinforce the importance of talking to your doctor to learn more about your disease and how to manage it. This is Amanda and Kelly’s experience and yours may be different. If you experience side effects, please talk to your doctor.
Individual results may vary. Please see Important Safety Information about CRYSVITA below and at the end of the video.
What is CRYSVITA?
CRYSVITA is a prescription medicine used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH).
Important Safety Information You should not take CRYSVITA if:
• You take an oral phosphate supplement and/or a specific form of vitamin D supplement (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
• Your phosphorus levels from a blood sample are within or above the normal range for age.
• You have kidney problems.
What is the most important information you should know about CRYSVITA?
• Some patients developed allergic reactions (e.g., rash and hives) while taking CRYSVITA. Your doctor will monitor you for symptoms of an allergic reaction while you are taking CRYSVITA. Your treatment may need to be discontinued for serious allergic reactions.
• High levels of phosphorus in the blood have been reported in some patients taking CRYSVITA. This may be related to a risk of high calcium levels in the kidneys. Your doctor will collect blood samples to monitor your levels. If you are already taking CRYSVITA, dose interruption and/or dose reduction may be required based on your serum phosphorus levels.
• Administration of CRYSVITA may result in reactions at the injection site, such as hives, reddening of the skin, rash, swelling, bruising, pain, severe itching of the skin, and collection of blood outside of a blood vessel (i.e., hematoma). Call your doctor if you develop an injection site reaction. CRYSVITA may be discontinued if severe injection site reactions occur.
What are the possible side effects of CRYSVITA?
• Adverse reactions that were seen in children with XLH are:
• Fever
• Injection site reaction
• Cough
• Vomiting
• Pain in arms and legs
• Headache
• Tooth abscess
• Dental cavities
• Diarrhea
• Decreased vitamin D levels
• Toothache
• Constipation
• Muscle pain
• Rash
• Dizziness
• Nausea
• Adverse reactions that were seen in adults with XLH are:
• Back pain
• Tooth infection
• Restless legs syndrome
• Decreased vitamin D levels
• Dizziness
• Constipation
• Muscle spasms
• Phosphorus levels increased in the blood
• Narrowing of the spaces within the spine is common in adults with XLH, and pressure on the spinal cord has been reported in adults taking CRYSVITA. It is not known if taking CRYSVITA worsens the narrowing of the spaces within the spine or the pressure on the spinal cord.
Before taking CRYSVITA, tell your doctor about all of your medications (including supplements) and medical conditions, including if you:
• Are taking oral phosphate and/or active vitamin D (such as calcitriol, paricalcitol, doxercalciferol, calcifediol).
• Are pregnant, think you may be pregnant, or plan to become pregnant. There is not enough experience to know if CRYSVITA may harm your unborn baby. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
• Are breastfeeding or plan to breastfeed. There is not enough experience to know if CRYSVITA passes into your breast milk. Talk with your doctor about the best way to feed your baby while you receive CRYSVITA.
While taking CRYSVITA, tell your doctor if you experience:
• An allergic reaction such as rash or hives
• A rash, swelling, bruising, or other reaction at the injection site
• New or worsening restless legs syndrome
These are not all the possible side effects of CRYSVITA. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.
For important risk and use information, please see the full Prescribing Information here bit.ly/40EmQiU.
This video is intended for US audiences only.
Crysvita® is a registered trademark of Kyowa Kirin Co., Ltd.
©2024 Kyowa Kirin, Inc. All rights reserved.
COMM-US-CRY-0716 September 2024