MRCP UK Part -2 | Sample Lecture | CAH (Congenital Adrenal Hyperplasia) + Cholesterol + Amenorrhoea

MRCP UK Part -2 | Sample Lecture | CAH (Congenital Adrenal Hyperplasia) + Cholesterol + Amenorrhoea - Video Descriptions are given below:
CAH (Congenital Adrenal Hyperplasia) + Causes of Amenorrhoea + H & V
Congenital Adrenal Hyperplasia
Overview
• group of autosomal recessive disorders
• affect adrenal steroid biosynthesis
• in response to resultant low cortisol levels the anterior pituitary secretes high levels of ACTH
• ACTH stimulates the production of adrenal androgens that may virilize a female infant
Cause
• 21 hydroxylase deficiency (90%)
• 11 beta hydroxylase deficiency (5%)
• 17 - hydroxylase deficiency (very rare)
Congenital adrenal hyperplasia: features
21 - hydroxylase deficiency features
• virilisation of female genitalia
• precocious puberty in males
• 60 - 70% of patients have a salt - losing crisis at 1 - 3 wks of age
11 - beta hydroxylase deficiency features
• virilisation of female genitalia
• precocious puberty in males
• hypertension
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