Total Iron Binding Capacity (TIBC) Explained

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  • Опубліковано 21 гру 2024

КОМЕНТАРІ • 68

  • @tomasponte1427
    @tomasponte1427 6 років тому +9

    Loved your tutorial! I totally understood the concept! I had a hard time getting it right in my head, but now it makes sense! Thank you!!

  • @jacquescalixte9211
    @jacquescalixte9211 4 роки тому +4

    WOW!!!!! Thank you so much. I have done so much research on my own. I wish I would have watched this video six months ago. Now I have it save and can share the information. Thank again.
    \

    • @Legomed
      @Legomed  4 роки тому

      Thanks for the kind comments Jacques! I am very glad that you found this helpful. Best wishes Vernon

  • @sokinahnasser6065
    @sokinahnasser6065 5 років тому +1

    I watched many videos and read many books,, you are the one who made it clear for me
    big thanks ,, god bless you.

    • @Legomed
      @Legomed  5 років тому

      Thanks very much!

  • @levinpyzera5266
    @levinpyzera5266 2 роки тому +1

    thank you so much, I finally understood what is meant by "serum-iron" it was so confusing before I found your video

  • @wildfire7268
    @wildfire7268 4 роки тому +3

    Transferrin carries iron molecules around the body
    body so let's say
    Each transferrin molecule has two seats or two spots where iron
    can be carried
    total iron binding capacity would be the
    maximum amount of iron that can bind
    to the transferrin molecules in
    this is then usually expressed as a
    value in micrograms micrograms per
    deciliter or can be
    all right so in a normaltotaliron
    binding capacity would be somewhere
    binding capacity would be somewhere
    between 250 to 450 micrograms
    so this is the maximum amount of iron
    that can be bound
    then serum iron is simply the total
    amount of iron that
    is then somewhere between 50 to 150
    mlcrograms
    Serum iron is total iron that is actually bound to
    transferrin
    Total iron binding capacity is that let's say the potential
    for iron binding
    for iron binding so the total amount of
    iron that can be bound if all
    the seats were taken up on all the transferrin
    molecules of
    as I've drawn in this picture as well
    that about one-third of the seats
    that about one-third of the seats are
    taken under normal circumstances and
    we
    Serum iron that is divided by the totaliron binding
    capacity capacity will tell us what number of
    seats are taken
    and if we turn this into a percentage so
    we have to multiply this with 100 then
    unsaturated iron binding capacity or so
    called you I
    *total iron binding capacity equals the
    serum iron plus the unsaturated iron binding capacity

  • @محمدعليمهدلي-ح6ق
    @محمدعليمهدلي-ح6ق 2 місяці тому +1

    So, why low TIBC levels usually indicate high levels of iron in the blood? You said TIBC depends on the number of transferrin molecules that exist in the blood

  • @abdulghaffarsafwat7448
    @abdulghaffarsafwat7448 3 місяці тому

    Interesting
    🎉
    Many thanks 🙏 for you great explanation

  • @horschiday9449
    @horschiday9449 2 роки тому +1

    Thank you very much!! Finally someone who explains this clearly :D

  • @shinola228
    @shinola228 3 місяці тому

    I feel like l finally understand this but what l don't understand is what is the relevance of the tibc and its degree of saturation. It seems to me if you know the serum iron value - which is already in a transferrin molecule and free to go anywhere in the body- why does it matter how many available transferrin molecules there are ? ( assuming they're not 100% saturated}

  • @snowgurl21
    @snowgurl21 5 років тому +4

    THANK YOU!! YOu MADE IT SO MUCH MORE SENSE

  • @courtneyappolloni2817
    @courtneyappolloni2817 3 роки тому +4

    What would it mean then if your transferrin and TIBC are both low, but your iron, iron saturation and your ferritin are in normal range? It’s hard to find anything on the web regarding that particular scenario. Anyone else see this before?

    • @drewsss49
      @drewsss49 2 роки тому

      You ever find an answer?

    • @jetwaveboard6729
      @jetwaveboard6729 2 роки тому

      Im trying to find the same answer. I starting to think that it means you have a lack of protein in your diet based on my research.

  • @jetwaveboard6729
    @jetwaveboard6729 2 роки тому

    How can I increase my transferrin? I see that no where online.

  • @octoberisloveryley
    @octoberisloveryley 4 роки тому

    I keep thinking of the TIBC and iron sat like a see saw, where the high TIBC has to offset the iron sat at exactly the opposite of the tibc. Am I wrong in this?

  • @hamidehhamzehpoor514
    @hamidehhamzehpoor514 11 місяців тому

    Thank you your explanation was excellent 😊

  • @ruchipujara793
    @ruchipujara793 7 років тому +2

    It was a very helpful video.
    Thank you

  • @ilkaysanl8907
    @ilkaysanl8907 2 роки тому +1

    Finally got it, thank you so much

  • @chamodichathurika4032
    @chamodichathurika4032 2 роки тому +1

    Thank you soo much 😍u made it easier to understand

  • @kellieashton3697
    @kellieashton3697 5 років тому +2

    Amazing! This helped me so much. Thank you

    • @Legomed
      @Legomed  5 років тому

      Dear Kellie, thanks for the kind feedback. Glad that is helped!

  • @mohammaddeymi4983
    @mohammaddeymi4983 3 роки тому

    How can we staminate (Si)

  • @Michiv1
    @Michiv1 4 роки тому +1

    My total iron is 349 and my saturation is 90 super hight what does its mean

    • @Legomed
      @Legomed  4 роки тому

      Dear Janice, I cannot comment on your results specifically, as I cannot give medical advice on UA-cam, but in general it could be because the tests were not done fasting, or perhaps after a dose of iron was taken. It could also mean that there is iron overload, which has many causes. I suggest that you discuss with your doctor. Kind regards Vernon

  • @blueinguana7345
    @blueinguana7345 5 років тому +1

    So if serum fe ion increase then ticb decrease??

    • @Legomed
      @Legomed  5 років тому +1

      As a general rule this is true, but remember that the transferrin can also go up and down.

  • @naghmeazadi8294
    @naghmeazadi8294 8 років тому +4

    It was very helpul thanks soooo much

  • @brijeshdr7091
    @brijeshdr7091 10 місяців тому

    Superb explanation

  • @LinhTruong-jk8zq
    @LinhTruong-jk8zq 3 роки тому +1

    Thank you for a good explanation

  • @roabakhriba4076
    @roabakhriba4076 3 роки тому +1

    Thank you u are great and that was so helpful

  • @justforlaughs12310
    @justforlaughs12310 8 років тому

    whats the purpose of saturating the sample prior to the test?

    • @jonmedler4902
      @jonmedler4902 8 років тому +1

      It's already saturated when it enters.

  • @natalietran2598
    @natalietran2598 8 місяців тому

    Great explanation!!!!

  • @ItsNicoleVeuthey
    @ItsNicoleVeuthey 10 років тому +3

    Thanks for the video!!! It was clear!!!!!! :)

  • @vishalthakur-kv4kx
    @vishalthakur-kv4kx 4 роки тому

    thanku so mach sir
    you clear the concept very easily

  • @camerondavis1914
    @camerondavis1914 4 роки тому

    Excellent explanation.

  • @nusaibahibraheem8183
    @nusaibahibraheem8183 Рік тому

    Then I don't understand why TIBC is high in iron def anemic. It seems based on this explanation, TIBC should be more or less constant while UIBC will be high in Fe def anemia. Unless there is a stimulation of increased production of Transferrin in Fe def anemia.

  • @engyyehia7732
    @engyyehia7732 6 років тому +1

    Very helpful.many thanks

  • @mia4464
    @mia4464 2 роки тому

    If Ferrintin decrease TIBC also decrease, for someone with iron overload if treated ferrintin goes down, and TIBC also goes down then he will not reach a normal TIBC value I'm confused...

  • @aparnam6127
    @aparnam6127 6 років тому +3

    Thank u..I got it😊

  • @rahmaellahony5206
    @rahmaellahony5206 6 років тому +1

    all thanks for you dr

  • @jurcanraluca3705
    @jurcanraluca3705 5 років тому +1

    amazing, helped me a lot

  • @rommysramblings8566
    @rommysramblings8566 5 років тому +1

    So Helpful!

    • @Legomed
      @Legomed  5 років тому

      Dear Rommy, thanks for the kind feedback. Glad you found it useful. Best regards Vernon

  • @theflyingfish_void
    @theflyingfish_void Рік тому

    Thank you very much

  • @Kittyququmber
    @Kittyququmber 10 років тому

    I am in the health care field and have always had a problem understanding this concept. And I think I do not understand because of not knowing the mechanism of the test. In the blood there is apotransferrin and transferrin, transferrin being the one that is loaded with Fe, two Fe each transferrin. So maybe I assume wrong the TIBC would be the sum of apotransferrin and transferrin. Apotransferrin is without the iron, is it not? So would apotransferrin + transferrin not be the TIBC. We already know the serum transferrin or iron level right? So when you draw the 100 cc and draw the theoretical twelve yellow transferrins, what does the lab do to strip all the iron off the transferrin that was originally in this 100 ml of blood. There must be some as it is not zero. And then how do they "put it back" to measure this serum transferrin. Why don't they just measure the apotransferrin and the transferrin levels separately and add them. When they give the number of serum transferrin as 1.8 mmol/dl then since there are two Fe on each transferrin, wouldn't the actual serum iron be doubled?

  • @zahir7103
    @zahir7103 Рік тому

    Much appreciated ❤doc

  • @mindfulness559
    @mindfulness559 6 місяців тому

    thank you,sir.

  • @povolone312
    @povolone312 2 роки тому

    thank you so much!

  • @brittophone6219
    @brittophone6219 2 роки тому

    Thank u soo much🙏

  • @nyawirawaithaka4993
    @nyawirawaithaka4993 3 роки тому +1

    Thank you

  • @cherchetutrouve6056
    @cherchetutrouve6056 9 років тому

    thank you verry much , thanks thanks 10000 times

  • @biochemistry3821
    @biochemistry3821 8 років тому +2

    thanks so much :)

  • @scottmaughan1284
    @scottmaughan1284 9 років тому

    Thank you!

  • @stargazor4753
    @stargazor4753 9 років тому

    excellent

  • @camillococcia2706
    @camillococcia2706 10 років тому +2

    Best!

  • @reemali4447
    @reemali4447 6 років тому

    Thanks a lot

  • @rockycycle2682
    @rockycycle2682 6 років тому +2

    OK so I didn't find this helpful in the least bit. Thanks anyway?

  • @KaiKai-td9gp
    @KaiKai-td9gp 8 років тому +2

    Thank you!

  • @aimz_med
    @aimz_med 3 роки тому +1

    Thank you

  • @mariocesarbenitez5552
    @mariocesarbenitez5552 11 місяців тому

    Thank you so much