WOW!!!!! Thank you so much. I have done so much research on my own. I wish I would have watched this video six months ago. Now I have it save and can share the information. Thank again. \
Transferrin carries iron molecules around the body body so let's say Each transferrin molecule has two seats or two spots where iron can be carried total iron binding capacity would be the maximum amount of iron that can bind to the transferrin molecules in this is then usually expressed as a value in micrograms micrograms per deciliter or can be all right so in a normaltotaliron binding capacity would be somewhere binding capacity would be somewhere between 250 to 450 micrograms so this is the maximum amount of iron that can be bound then serum iron is simply the total amount of iron that is then somewhere between 50 to 150 mlcrograms Serum iron is total iron that is actually bound to transferrin Total iron binding capacity is that let's say the potential for iron binding for iron binding so the total amount of iron that can be bound if all the seats were taken up on all the transferrin molecules of as I've drawn in this picture as well that about one-third of the seats that about one-third of the seats are taken under normal circumstances and we Serum iron that is divided by the totaliron binding capacity capacity will tell us what number of seats are taken and if we turn this into a percentage so we have to multiply this with 100 then unsaturated iron binding capacity or so called you I *total iron binding capacity equals the serum iron plus the unsaturated iron binding capacity
So, why low TIBC levels usually indicate high levels of iron in the blood? You said TIBC depends on the number of transferrin molecules that exist in the blood
I feel like l finally understand this but what l don't understand is what is the relevance of the tibc and its degree of saturation. It seems to me if you know the serum iron value - which is already in a transferrin molecule and free to go anywhere in the body- why does it matter how many available transferrin molecules there are ? ( assuming they're not 100% saturated}
What would it mean then if your transferrin and TIBC are both low, but your iron, iron saturation and your ferritin are in normal range? It’s hard to find anything on the web regarding that particular scenario. Anyone else see this before?
I keep thinking of the TIBC and iron sat like a see saw, where the high TIBC has to offset the iron sat at exactly the opposite of the tibc. Am I wrong in this?
Dear Janice, I cannot comment on your results specifically, as I cannot give medical advice on UA-cam, but in general it could be because the tests were not done fasting, or perhaps after a dose of iron was taken. It could also mean that there is iron overload, which has many causes. I suggest that you discuss with your doctor. Kind regards Vernon
Then I don't understand why TIBC is high in iron def anemic. It seems based on this explanation, TIBC should be more or less constant while UIBC will be high in Fe def anemia. Unless there is a stimulation of increased production of Transferrin in Fe def anemia.
If Ferrintin decrease TIBC also decrease, for someone with iron overload if treated ferrintin goes down, and TIBC also goes down then he will not reach a normal TIBC value I'm confused...
I am in the health care field and have always had a problem understanding this concept. And I think I do not understand because of not knowing the mechanism of the test. In the blood there is apotransferrin and transferrin, transferrin being the one that is loaded with Fe, two Fe each transferrin. So maybe I assume wrong the TIBC would be the sum of apotransferrin and transferrin. Apotransferrin is without the iron, is it not? So would apotransferrin + transferrin not be the TIBC. We already know the serum transferrin or iron level right? So when you draw the 100 cc and draw the theoretical twelve yellow transferrins, what does the lab do to strip all the iron off the transferrin that was originally in this 100 ml of blood. There must be some as it is not zero. And then how do they "put it back" to measure this serum transferrin. Why don't they just measure the apotransferrin and the transferrin levels separately and add them. When they give the number of serum transferrin as 1.8 mmol/dl then since there are two Fe on each transferrin, wouldn't the actual serum iron be doubled?
Loved your tutorial! I totally understood the concept! I had a hard time getting it right in my head, but now it makes sense! Thank you!!
WOW!!!!! Thank you so much. I have done so much research on my own. I wish I would have watched this video six months ago. Now I have it save and can share the information. Thank again.
\
Thanks for the kind comments Jacques! I am very glad that you found this helpful. Best wishes Vernon
I watched many videos and read many books,, you are the one who made it clear for me
big thanks ,, god bless you.
Thanks very much!
thank you so much, I finally understood what is meant by "serum-iron" it was so confusing before I found your video
No problem!
Transferrin carries iron molecules around the body
body so let's say
Each transferrin molecule has two seats or two spots where iron
can be carried
total iron binding capacity would be the
maximum amount of iron that can bind
to the transferrin molecules in
this is then usually expressed as a
value in micrograms micrograms per
deciliter or can be
all right so in a normaltotaliron
binding capacity would be somewhere
binding capacity would be somewhere
between 250 to 450 micrograms
so this is the maximum amount of iron
that can be bound
then serum iron is simply the total
amount of iron that
is then somewhere between 50 to 150
mlcrograms
Serum iron is total iron that is actually bound to
transferrin
Total iron binding capacity is that let's say the potential
for iron binding
for iron binding so the total amount of
iron that can be bound if all
the seats were taken up on all the transferrin
molecules of
as I've drawn in this picture as well
that about one-third of the seats
that about one-third of the seats are
taken under normal circumstances and
we
Serum iron that is divided by the totaliron binding
capacity capacity will tell us what number of
seats are taken
and if we turn this into a percentage so
we have to multiply this with 100 then
unsaturated iron binding capacity or so
called you I
*total iron binding capacity equals the
serum iron plus the unsaturated iron binding capacity
So, why low TIBC levels usually indicate high levels of iron in the blood? You said TIBC depends on the number of transferrin molecules that exist in the blood
Interesting
🎉
Many thanks 🙏 for you great explanation
Thank you very much!! Finally someone who explains this clearly :D
I feel like l finally understand this but what l don't understand is what is the relevance of the tibc and its degree of saturation. It seems to me if you know the serum iron value - which is already in a transferrin molecule and free to go anywhere in the body- why does it matter how many available transferrin molecules there are ? ( assuming they're not 100% saturated}
THANK YOU!! YOu MADE IT SO MUCH MORE SENSE
What would it mean then if your transferrin and TIBC are both low, but your iron, iron saturation and your ferritin are in normal range? It’s hard to find anything on the web regarding that particular scenario. Anyone else see this before?
You ever find an answer?
Im trying to find the same answer. I starting to think that it means you have a lack of protein in your diet based on my research.
How can I increase my transferrin? I see that no where online.
I keep thinking of the TIBC and iron sat like a see saw, where the high TIBC has to offset the iron sat at exactly the opposite of the tibc. Am I wrong in this?
Thank you your explanation was excellent 😊
It was a very helpful video.
Thank you
Finally got it, thank you so much
Thank you soo much 😍u made it easier to understand
Great to hear it!
Amazing! This helped me so much. Thank you
Dear Kellie, thanks for the kind feedback. Glad that is helped!
How can we staminate (Si)
My total iron is 349 and my saturation is 90 super hight what does its mean
Dear Janice, I cannot comment on your results specifically, as I cannot give medical advice on UA-cam, but in general it could be because the tests were not done fasting, or perhaps after a dose of iron was taken. It could also mean that there is iron overload, which has many causes. I suggest that you discuss with your doctor. Kind regards Vernon
So if serum fe ion increase then ticb decrease??
As a general rule this is true, but remember that the transferrin can also go up and down.
It was very helpul thanks soooo much
Superb explanation
Thank you for a good explanation
Thank you u are great and that was so helpful
whats the purpose of saturating the sample prior to the test?
It's already saturated when it enters.
Great explanation!!!!
Thanks for the video!!! It was clear!!!!!! :)
thanku so mach sir
you clear the concept very easily
Excellent explanation.
Then I don't understand why TIBC is high in iron def anemic. It seems based on this explanation, TIBC should be more or less constant while UIBC will be high in Fe def anemia. Unless there is a stimulation of increased production of Transferrin in Fe def anemia.
Very helpful.many thanks
If Ferrintin decrease TIBC also decrease, for someone with iron overload if treated ferrintin goes down, and TIBC also goes down then he will not reach a normal TIBC value I'm confused...
Thank u..I got it😊
all thanks for you dr
amazing, helped me a lot
So Helpful!
Dear Rommy, thanks for the kind feedback. Glad you found it useful. Best regards Vernon
Thank you very much
I am in the health care field and have always had a problem understanding this concept. And I think I do not understand because of not knowing the mechanism of the test. In the blood there is apotransferrin and transferrin, transferrin being the one that is loaded with Fe, two Fe each transferrin. So maybe I assume wrong the TIBC would be the sum of apotransferrin and transferrin. Apotransferrin is without the iron, is it not? So would apotransferrin + transferrin not be the TIBC. We already know the serum transferrin or iron level right? So when you draw the 100 cc and draw the theoretical twelve yellow transferrins, what does the lab do to strip all the iron off the transferrin that was originally in this 100 ml of blood. There must be some as it is not zero. And then how do they "put it back" to measure this serum transferrin. Why don't they just measure the apotransferrin and the transferrin levels separately and add them. When they give the number of serum transferrin as 1.8 mmol/dl then since there are two Fe on each transferrin, wouldn't the actual serum iron be doubled?
Much appreciated ❤doc
thank you,sir.
thank you so much!
You're welcome
Thank u soo much🙏
Most welcome
Thank you
thank you verry much , thanks thanks 10000 times
thanks so much :)
Thank you!
excellent
Best!
Thanks a lot
OK so I didn't find this helpful in the least bit. Thanks anyway?
Thank you!
Thank you
Thank you so much