Cohesin is only present in the kinetochore because polo- like and Arora B enzymes breaks off the Scc1 units of cohesins elsewhere. These enzymes won't be able to attack the cohesin at kinetochore because of the presence of phosphatase. and APC ubiquitinates securin letting the separase break the Scc1 of Cohesin
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metaphase to anaphase transition -> APC degrades inhbitor of separinf and therefore activating dperain. allows chromosome to be segregtaed to the 2 poles - in the anapjhse stage. what happens went the tension is uneven - or MT is unevenly placed. MAD2 is one sensor thatat inhibit the APC thereby the anaphase promoting complex can not activate seperain. so cohesin cant be brokenand the cell cannot segregate chromosomes into anaphse. so M to A is blocked. when MT not properly engaged the cell needs to pause it.
I have taken all the details from original research articles.... in text books it’s not depicted in a proper fashion... in harvey Lodish’s book it’s somewhat better
Excellent class dear sir. Dear sir I have one question.which is more correct, Question is How many check point in cell cycle. 3 or 4 I learnt earlier that only 3 check point.that is G1,G2 and metaphase to anaphase check point.kindly reply
As the name suggests it helps in chromosome condensation and higher order folding after prophase during metaphase,in fact out of many factors ,condensins and cohesins make the metaphase chromosome so nicely packed.
Hello..thank you for the video..I am preparing for the CSIR net n looking for my doctorate in neurobiology. Can you guide me for the same as a neurobiologist pls.
I am a master student in the UK and this video answered my exam question at Excellent level... Thanks
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Nicely presented!! Helped a lot! Thank You
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Your explaining more better than MIT which I saw before your video and for about 1 hr
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.A very excellent explanation sir..thank a lot
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Your cell biology lecture is very much lucid
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Very very Knowledgeable 👍
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well explained Sir, Thank you
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Great lecture sir ☺️ thank you so much ☺️
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ur amazing tysm!!
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Cohesin is only present in the kinetochore because polo- like and Arora B enzymes breaks off the Scc1 units of cohesins elsewhere. These enzymes won't be able to attack the cohesin at kinetochore because of the presence of phosphatase. and APC ubiquitinates securin letting the separase break the Scc1 of Cohesin
Reference: Karp, G. (2016). Cell and Molecular Biology (8th ed.). Wiley.
Nice as always
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This video is very well described..👍
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Recomended by prof. crisafulli University of Messina, italy
incredible
This was the older one . I request you to watch the new one ua-cam.com/video/0BqJ58ZiWwA/v-deo.html
Also here is the link for cell biology playlist. Here you will get videos on diverse cell bio topics explained by me. ua-cam.com/video/5XUazORwjmQ/v-deo.html
At any point you need explanation on a topic let us know. We are there to listen to your request
Really great 🎊
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
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Just simply awesome
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@@animatedbiologywitharpan sure
metaphase to anaphase transition -> APC degrades inhbitor of separinf and therefore activating dperain. allows chromosome to be segregtaed to the 2 poles - in the anapjhse stage.
what happens went the tension is uneven - or MT is unevenly placed. MAD2 is one sensor thatat inhibit the APC thereby the anaphase promoting complex can not activate seperain. so cohesin cant be brokenand the cell cannot segregate chromosomes into anaphse. so M to A is blocked. when MT not properly engaged the cell needs to pause it.
Nicely summarized again. You are really good at summarizing. Keep it up.
Good day sir. I wanted to ask what would happen if cohesin was lost before metaphase?
Cohesins are not lost before chromosome separation because there is no mechanism for doing that.
Thanks.. of u don't mine, can i get the reference this video. Because in Albert blok doesn't detail MPF.
I have taken all the details from original research articles.... in text books it’s not depicted in a proper fashion... in harvey Lodish’s book it’s somewhat better
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@@animatedbiologywitharpan dude that has to have been SO much work
respect!
good video!
Excellent class dear sir.
Dear sir I have one question.which is more correct,
Question is
How many check point in cell cycle.
3 or 4
I learnt earlier that only 3 check point.that is G1,G2 and metaphase to anaphase check point.kindly reply
I too have the exact same question.
So, what is the function of condensins?
As the name suggests it helps in chromosome condensation and higher order folding after prophase during metaphase,in fact out of many factors ,condensins and cohesins make the metaphase chromosome so nicely packed.
Have my semester end exams today. Hope this helps.
All the best
Hello..thank you for the video..I am preparing for the CSIR net n looking for my doctorate in neurobiology. Can you guide me for the same as a neurobiologist pls.
9987997041 is my whatsapp
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What is molecular basis of cell cycle. Plz give answer
Please check out my cell bio playlists where you would find many videos regarding cell cycle control by cycling and cdk ,maturation promoting factor
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you are explaining one point and the arrows are toward other points