ASCP | MLS | MLT | hemoglobin C & other variants

👉ASCP Short Notes in Hematology: www.amazon.com/dp/B0CYK4QV9P
ASCP, INTERNATIONAL MEDICAL LABORATORY SCIENTIST, MLS, ASCPi, MLT
Join us in this video as we explore the fascinating world of hemoglobin variants, with a focus on Hemoglobin C (Hb C) and other related disorders. Discover the genetic mutations, their effects on the hemoglobin molecule, inheritance patterns, pathophysiology, symptoms, clinical findings, peripheral blood findings, laboratory diagnosis, and considerations for genetic counseling and treatment.
In the first part, we delve into the genetic mutations, clinical findings, and laboratory diagnosis of disorders involving Hb C-Harlem, Hb E, Hb O-Arab, Hb D, and Hb G. Gain insights into the unique characteristics and diagnostic approaches for each variant.
Next, we discuss compound heterozygous disorders involving Hb S with Hb C, b-thalassemia, Hb D, Hb O-Arab, Hb Korle Bu, and Hb C-Harlem. Understand the clinical and laboratory findings associated with these combinations of hemoglobin variants.
We then explore the electrophoretic mobility of Hb A, Hb F, Hb S, and Hb C at an alkaline pH. Additionally, we explain how other methods such as the Hb S solubility test, citrate agar electrophoresis at acid pH, and high-performance liquid chromatography can effectively distinguish Hb S and Hb C from other hemoglobins with similar mobility.
Moving on, we uncover the genetic mutations, inheritance patterns, pathophysiology, and clinical and laboratory findings in hemoglobin variants that result in methemoglobinemia. Gain a comprehensive understanding of this condition and its diagnostic implications.
We also delve into the inheritance patterns, causes, and clinical and laboratory findings of unstable hemoglobin variants. Discover the unique characteristics and challenges associated with these variants.
Finally, we discuss the pathophysiology of hemoglobin variants with increased and decreased oxygen affinities, highlighting the key differences from unstable hemoglobins. Understand how these variants affect oxygen transport and their clinical implications.
If you're interested in learning how to interpret test results to identify the specific hemoglobin variants present in a patient based on their case history and clinical and laboratory findings, we provide valuable insights in this video.
Expand your knowledge of hemoglobin variants and deepen your understanding of these complex genetic conditions. Subscribe now and join us on this enlightening journey through the world of hematology.