Blastocyst Culture in IVF Is Not for Everyone
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- Опубліковано 15 чер 2015
- Blastocyst stage transfer, an alternative to day 3 transfer in IVF, does not always benefit the patients, according to the Center for Human Reproduction's Dr. Norbert Gleicher. Learn more about blastocyst culture at: goo.gl/VzQm3Y
I feel so lucky I watched this video before starting my IVF. I found a doctor who is recommending day-3 no PGT-A testing for me. I had several consults with other doctors who only perform day 5 with PGT-A testing FET. I agree with Dr. Gleicher 100%. Thank you for this invaluable information!
This is always the best explanation, with consideration of multiple perspectives.
Same in France in my centre... well here in France though, we have social security so it's not a matter of money not to have transfer because all embryos failed to reached day 5 but still, feels bad... Thanks for this video
This is so extremely helpful. And I am just so thankful for you sharing. I have felt very stressed about what to do. We have four donated day 3 embryos. They're proven, our donors had their 2 daughters and no failed transfers. I feel confident in the embryos however I don't have so many embryos we can grow to blast and feel confident we will end up with a healthy pregnancy. Now I have the right information moving forward. Thank you.
Did you push through with day 3 transfer?
Thank you for this very informative video doctor.
I was not informed of this option when I did my IVF when I was 35. The clinic only mentioned about doing transfer on Day 5. The embryologist updated us that embryos were doing great up until day 4, then on Day 5, he coldly called to inform us that none of the embryos all disintegrated and did not make it to DAY 5. It was so devastating.
I’ve figured that everything is about money, I am so overwhelmed with this IVF procedure
So pity. Such a waste to discard all the embryos, should have transferred on day 3 and give it a try
@@niurcajimenez6252 i just did IVF a few days ago and im also seeing everything is about money and they dont care too they want to do their ivf in one patient and move on to the next.
@@laurenvillegas6103 that’s true, that’s why we have to do our own researches because they see us as a number sadly.
Yes! Well, explained VLOG! My doctors also advised me to restrain from it. I guess. We really need awareness with everyone! Anyway! Thanks for sharing the video! Really helpful regarding the transfer related points.
Thanks for sharing your experience, Sarah. It's heartening to hear that the message to stay away from blastocyst culture might be getting out there!
was your pregnancy successful?
This video doesn’t mention blastocyst transfers due to PGD testing (to prevent transfer of embryos with the affected genetic mutation). More cells can be biopsied from a blastocyst compared to day 3 embryo. In addition, cells biopsied from a blastocyst are taken from the trophectoderm, which gives rise to the placenta whereas the lineage of the cell(s) biopsied from day 3 embryo is unknown.
Bravo! This is the best explanation I ever heard!
We're glad you found it helpful!
Slobodan Aleksic Dr Norbert is great, isn’t he!
Day 3 transfer benefits refer also to one or two not first quality ovocite for older patients?
Thanks a lot for Your precious attention
Thanks for the clarification. Wish we saw the video earlier and saved the money. We had a day 5 transfer - embryo reached early blastocyst was good quality says the consultant but it we lost it 3 days before we reach the 2 week wait :-(
How did you know you lost it before day 12?
Why is headache after egg retrieval for many days?
What age though statistically you think that relevant to use 3 day embryos? Or how many eggs retrieved or fertilized is considered a good number for blastocyst instead of 3 day?
Hello Dr
Done my frozen eggs embryos on 5/11/20 which r blastocyst 6day Type A&B I’m 48 age taking estradiol 2mg QID plus injection . Dr check my outline of uterus is good . Had 2 pt came out negative done today blood wk came out negative on 2 wks didn’t do my hcg level . Dr recommend to wait 4 days to do my hcg level then we go from there. My question what went wrong if it’s frozen donor embryos which I understand it’s high rate 4 pregnancy . Can u give me advice thank u .
Hi, is this information still relevant or have there been any other studies that contradict this?
Can you share the studies referred to in the latter half of this video?
I love your channel. Wish i am in nyc
Doctor, what is your opinion on the method called: Intentional Endometrial injury?? Do you have a video on that? Do you aplay this method to your patients? Thank you!
Hi V. Angel, that's a great question! We are actually using endometrial scratching in select cases, and that would be a great video topic. Thanks for the suggestion!
No rule for endomtrial scratching in improving implantation rate
Hello doctor... I recently had Ivf with donor eggs but it failed. Embryos transferred were on day 5 grade 1. I have high nk cells does this effects??? I took intralipid with barglob for 6 months. Do I need to go for donor embryo???
Hello Anju, our physicians believe that it's more important to look at
inflammation and autoimmunity in general, rather than focus specifically
on NK cells. If you need medical advice from our physicians, please
contact us here: goo.gl/dLAEA3
I had my eggs retrieved on 28th Feb 2023, and is scheduled for FET on 5th May 2023. Is this a normal procedure/protocol?
I have come across this video a little too late unfortunately.
I had 5 embryos fertilise and all were progressing well on day 3. Day 5 only one was a poor quality blastocyst that was transferred, the rest were morulas. Unfortunately the clinic said they would freeze morulas and if they didn’t turn to blastocyst on day 6 they were no good and wouldn’t make a baby. Day 6 one was a very early blastocyst and not good enough for freezing. My cycle failed and I had none to freeze. I wish I had a 3 day transfer.
I don't mean to be invasive, but how old are you? Have you ever heard of Raidant wonder? If not check them out.
I’m so sorry! This is actually malpractice.
@@harvemedharvemed7796 I'm only 30
@@jessienicola609 Please look up radiant wonder. Maybe it will help you. My prayers are with you as I am still trying at 44. I have faith we will have out babies.
And a question : what are the odds of a slow embryo (like only 4 cells on day 3) to reach day 5 ? Or to give a successful pregnancy if transferred anyway (no matter the cell number)?
Hey...what happened with your IVF?
your video is very informative. i really thank you for sharing such a amazing video i just have few more questions. i will be very pleased if you answer my questions How can you tell if the embryo transferred on D3 would or wouldn't make it to D5 in culture? Once transferred we have no control on what's happening to the embryo. You just cannot tell.. i hope you will not mind my questions. waiting for reply. thanks in advance...
I have the same curiosity about what's happening to the embryos if transfered on d3. However, after seeing this video I'm set on going ahead the d3 transfer. I don't want to put any extra stress on the embryos with refreezing and thawing. It's worth the try, this is how they used to do it!
@@RitaGreen did you do fresh transfer?
@@mariaante5708 yes and it failed. My next transfer we grew it to day 5 and I'm 35 weeks pregnant now with that embryo
@@RitaGreen Hi Rita, thank you for answering. Congratulations on your successful ttc journey! Im currently starting my 1st IVF. May I ask if you did fresh transfer also on this one? And how many eggs retrieve and how many fertilized, and made it to embryo and to d5?
@@mariaante5708 I did embryo adoption. I have videos on my journey. So they were frozen.
Does this still apply if im freezing the embryos first and then doing the transfer later?
Hi Tara, that's a great question. We would say yes, since culturing embryos to blastocyst stage end up reducing the number of embryos available for freezing as well!
@@CenterforHumanReproduction
Hello I am going through it right now. I am 40yrs I was told my egg were not mature on day o so they did on day one and they were fertilized today is gay 4 I am told they did not reach blastocyst. What can I do? Do I ask them to freeze it and get me ready for transfer anyways or it is too late?
Can anyone link to these studies? I would like to read them and discuss with my specialist.
Google Gleicher et al. He’s done many studies himself.
I have 16 frozen day three embryos....we did not PSG test them.... should we unfreeze them all to see who makes it to day 5? Im 40 years old and can NOT afford $3500 every transfer
Hi Beth & Erik, thank you for your question! Our physicians don't recommend blastocyst culture or PGS in most cases--here's why: bit.ly/2Itn46d That said, treatment recommendations are obviously individual to each patient's situation, so if you are interested in getting our physician's advice on your specific situation, please contact us here: goo.gl/q3ggjA to set up your consultation.
I did not know that embroyos stay alive longer in the uterus versus the lab dish? Why would that effect it?
I was told fresh transfer success a 42 year old is 6 percent? I held out any better hope on FET. So I guess I can disregard better chances with FET? :(
Wow I am stunned
My amh is .745
10 follicles on day 3
62 estradiol
7.8 FHS
What do you think is my percent success rate?
You can freeze earlier. Day 1 frozen have the highest survival change after thawing cause they’re the most stable. There’s not necessarily a better chance with FET. Btw your number look good for your age! Remember to not PGTA test them (check out his other videos).
I wish my doctor would have listened to me!!! I asked for a 3 day and he said that it was old school and that he only did 5 day transfers these days....just so frustrating
Do you think they do it, so patients can keep on paying???
Muvaa Mayraa yes I do or because they honestly don’t know what they doing...I also think that doctors learn one way of doing things and when a person like me comes in and tries to give them a new way it’s like well I’m the doctor and what I know is the only right way....
Elisa Marie I am feeling the same way - after two ivf stim cycles, I responded well to the hormones, creating at least 12 and 13 embryos that fertilized. By Day 5, only 3 and then 1 had made it. They tested them each time and they all cane back abnormal. Not once did my Dr mention DHEA, Acai Berry, antioxidants, etc. I am so frustrated! I’m only 33! Seems like egg quality is an issue and on the first cycle failure my drill already coldly mentioned donor eggs...are you kidding me!? 🙄 This Dr has been so helpful just reading about their research in NY. I’ve bought supplements and just started taking them! I want my androgen levels tested ASAP. 🙏🏼
Hi,
Iam a poor responseder in my first ivf cycle which my doctor chancellor it and started again with another protocol but again only 2 eggs I got , but both fertize and one embryo stop growing after 4 days and other reaches on day 5 blasting stage and freeze,
Now my doctor wants to do hystoscopy because they find polyp in uterus and and after that they want me to use other ivf cycle start and do embryos day3 transfer instead of using frozen embryos.
I don’t know what I do
Hi Sana, thanks for your comment! We'd love to help you figure out what your next step should be, if you are open to becoming a patient at our center. (If you are not in NYC, no worries, we do offer phone and Skype consultations). If you are interested, please contact us here: goo.gl/q3ggjA
Do you have a Center in SFO?
How many days after implantation happen in day 3 transfer
Typically embryos take about 2 days to implant. This article about how implantation works
(www.centerforhumanreprod.com/fertility/implantation-still-the-big-black-box-in-ivf/?UA-cam&Description&UA-cam-comment-answered-by-CHR)
explains many aspects of that process.
What does 3AA blastocyst means ?? What are its chances of it being successful..
Makes sense. 5 of my friends had ET at Day 3 and all had beautiful healthy babies. Two of them tried again and had zero embryos when asked to wait till Day 5.
I just had my first IVF done. Two embryos retrieved that were grade 2 in day 3 (9 cells or more), pretty good, but the lab had them until day 7 and then we got news that blastocysts were developmentally arrested. So I had none! Now my dc gives me an option to freeze on day 3 instead (I need to finish up 3 IVF cycles as a package). And I asked her about it before IVF too... now I lost two embryos:( and costed me $20k for this cycle! gosh this video is 3 years ago...the best method is to design a protocol for individual patients. In my case I need a protocol for me who are DOR instead of same protocol as “normal” ones
Hello, how did your IVG go?
@@mariaante5708 we gave up already. Mine Didnt work :(
@@BeccaL2016 Im sorry to hear that. May I ask what happened to the other 3 IVF cycle you did? Did they retrieve any eggs and did they make it to fertilization? I feel a bid disheartened to hear this as I am currently ongoing in my 1st IVF because of low AMH and advanced age. Hoping to learn from others experience.
@@mariaante5708 I actually did total of 4 cycles. The very first cycle I mentioned above was the best one. I didnt have any mature ones from the other 3 cycles. So my chance was really 0%. The doctor said my situation was below average of the same age. So everyone can have different results. Don’t get discouraged! Good luck!
@@mariaante5708 how are you doing? Did you go through with your planned IVF? Are you open to sharing your results/age?
I feel a bit cheated after watching this. My day 5 transfer was cancelled due to the cells not developing fast enough and a day 3 transfer was not even considered.
Sorry to hear that! This is sadly a very common story we hear from our patients a lot--that's why we are putting out videos and articles to educate the public, as well as the medical community on the issue.
Sorry to hear that!!
How can you tell if the embryo transferred on D3 would or wouldn't make it to D5 in culture? Once transferred we have no control on what's happening to the embryo. You just cannot tell.
Because you can compare the outcome - meaning the life birth rate. Compare how many day 3 make it to life birth to how many day 5 make it and the add the ones that didn’t make to day 5 to the day 5 overall outcome. It’s called statistic. Course you can measure it.
What about day 2 embriyos. Is it good for transfer
Did u ever get an answer on this? On 2 day embryo transfer?
I have A/B quality six embryo of day three. Doctor said I have good endometrioum. How many chances of success?
Hello Priti, thanks for your comment! We can't tell you what the chance of your IVF working would be (as there are so many factors involved), but we wish you best of luck!
May I ask what may be the cause of poor development from day 3 embryo to day 5 blastocyst?
I was reading one paper according to which the majority (about 80%) of late day 5 embryos have aneuploidy which is the cause of poor development from day 3 to day 5. Eventually these aneuploid embryos will arrest and die. But still, out of these slow day 5 embryos there are still about 15-20% (depending on age) that are good and will lead to pregnancy. That's why some will let the slow ones grow until day 6 or 7 to see if they reach blastocyst stage and then do biopsy and PGS.
@@yangjianhunt sorry this is very misleading. An embryo in general isn’t meant to grow in a Petri dish in a lab. That’s why some of them won’t survive. Life birth rate is higher overall when you transfer on day 3. Doesn’t mean that the embryo is chromosomally abnormal. It’s too early a stage to know because embryos can fix themselves.
What is the success rate of 5th day 2BC blastocyst transfer?
Success rate depends on a lot of factors beyond the grade of the embryos. For example, how is the female patient's endometrium? Does she have autoimmune conditions? If so, are they treated proactively? The grading method itself is also different from center to center. There's no easy answer.
Thanks for reply.
I woke up to this
I'm falling under poor responder category. What is the best method for me? 2 days transfer, 3 days, 5 days? Fresh or Frozen? Thank you very much in advance.
P.S Best explanation ever!
I wish you had got a reply as I wanted an answer to that question too
Dr. Gleicher has another video about it. He usually recommends fresh day-3 transfer if you have limited number of embryos. PGT-A testing is never performed on day 3 embryos, embryo needs to be 5 days to do the testing.
Interested in this but his voice is awful