Treatment with Tocilizumab for COVID-19
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- Опубліковано 10 чер 2024
- In this lesson I take a look at a new promising medication being trialed in the US right now to potentially treat COVID-19. This medication is called Tocilizumab, which is an immunosuppressant interleukin-6 receptors inhibitor. I talk a little bit about this drug and its past, including past FDA approvals for other diseases, before going in to how exactly it is that this drug works.
From there I talk about how these mechanisms of action might be beneficial in COVID-19. I reference a couple studies, one small, early on study from China, as well as a more recent much larger study from Italy, that one which showed a significant reduction in mortality.
I finally finish out covering the dosing as well as the common side effects to be seen with this medication.
0:00 Intro
0:49 Basics
4:56 For COVID-19
6:05 Studies
11:01 Dose & Effects
12:00 Conclusion
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You probably have no idea how much you are helping doctors like me.. thank you from the bottom of my heart.
This is so awesome to hear! Thats the goal is to be able to provide good quality info to people and I really appreciate hearing that it is doing just that!
The irony of this comment 3 years later
My husband was in trouble with Covid pneumonia( the doctor said it could go either way) he started getting better after this treatment. It was very helpful.
Eddy, I am a certified professional coder. My job involves auditing and coding diagnoses for ED and Hospital in-patient encounters. I have just binge-watched all your covid related video and just want to say thank you. I know your videos are designed for critical care nurses but in my role validating documentation and assigning diagnosis codes to provider notes, I read HPIs, hospital course summaries, and progress notes. I review lab reports and imaging reports. It is incredibly useful to really understand the notes and not just depend on ICD 10 and CMS definitions of criteria for various diagnoses. It is not my job to question the medical decision making, just record it, but at a personal level, I want to understand the rational for various treatments. The Covid pandemic has delivered a kind of hospital course unlike any other acute disease I have followed. You have helped me to understand the evolution of the treatments applied to Covid as well as enlighten me in other areas that have caused me to wonder. I don't want to be a provider, but I think I would love medical school, just for the opportunity to consume the knowledge.
Never anything wrong with learning and growing more for whatever purpose. Hope you enjoyed the video!
as an ER nurse, this is super helpful
Awesome! Glad to see people from all areas are getting good info from these videos. Stay safe out there!
To Lecture or tocilizumb ?
You are simply gem. Your teaching is simply amazing. I am glued to your videos
Thank you so much for the kind words! Glad you are enjoying them. 😊
This saved my moms life!
Great to hear this was used and your mom had a great outcome!
Does this medicine made any side effects......
Was ur mom in the icu?
@@ICUAdvantage how is she now? Any affects after 5 months -
ICU nurse here. I administered this for the first time the other night and it seemed to have an almost immediate benefit! My patient was maxed out on Levophed and we were considering a second pressor when I started the shift but by the end of the night, I'd titrated it down to 4 mcg/min. Core temp also came down from 104.1 to 98.4! This is very anecdotal, I know, but I'm still very excited to have seen such a sudden, positive change in just one shift.
Thanks for sharing Bruce. While anecdotes may not have a place in research, they absolutely can plan a role in our perceptions and expectations. Happy to hear you saw such a great response with your patient!
I have survived covid 19 because of this medication. Nurses said that I have improved after this injection. Now out of hospital to give a testimony 🙂
@@Hareesh09 Is this injection made any side effects on you ?
My Brother is in a serious condition due to Covid infection. He is also a kidney Dialysis patient......
Pls reply
this video also very helpfull for me and my family members now we satisfied that we gave this to our patient thank you sir
Great information! Thanks for helping us keep up to date with all the information!
My pleasure Dana! Glad you enjoyed it.
Thanks for posting these, very helpful.
Glad it was helpful!
Appreciate you !! Keep them coming !
You got it! Thank you!
My father is fighting currently. Hes on a bipap. Hes on his 5th day of remdesivir. Next step is this option. I'm praying it helps him. He is strong.
I'm so sorry to hear about your father. You father and you and your family are in my thoughts and prayers!
Thank you. He was given this treatment 5 days ago. I'm praying for his recovery. He is stable. It's a very slow progression. I appreciate all the information I learned on this video. Thank you for your prayers
Hi Justin1311, I trust your father is well. My father is at same stage and he has been given Tocilizumab after Remedesvir. Would you mind telling me your father’s progress?
How is your father now? Prayers
My father passed away on Aug.28th. He didnt have covid any longer. He tested negative 5 days before he left us. He passed away due to a 2nd sepsis that his body contracted due to long term ventilator use. He was 21 days on a ventilator and 14 days on a bipap. He was such a strong fighter. I will miss and love him for all eternity.
My knowledge become extended from your lecture. Awesome lecture💖
Awesome to hear Lydia! Thank you!
ICU Advantage when do you think covi vaccine could come out?
The million dollar question... from what I hear, if all goes perfectly, maybe late fall early winter? But even then at this point, I don't think it would be in enough quantity to be available for the general public at large. A LOT of factors and thinks we just don't know yet, so really this is just a best guess.
ICU Advantage thanks much
I do agree that it will not come out soon, maybe later next year?
@@yongcho9683 We can only hope!
Hello! Sorry, this might seem an out of the topic question, but could you tell me what app you use in your iPad Pro for this great presentation? Thanks!
I screen cast my Mac with Adobe Photoshop open.
UK is using this on all High dependency unit patients currently and for those who have severe covid... There has been positive results so far
That's awesome to hear!
Everyone has a covid story, friend positive within 3 days on full face mask 2 callopsed lungs, 40s fit non smoker close to ventilator coma then used this with double steroids lungs cleared up ,3 days later moved to normal ward oxygen levels normal.
Now the slow recovery starts
@@crasherkev1 it saved my mum's life 🙏🙏🙏🙏
It seems lower pf ratios, lengthier symptoms is very concerning. I guess it depends on what phase of the covid cascade the patients in when receiving a dose. Lowering inflammation vs lowering autoimmune system. If patient is already in ARDS, would it still be worth it? Or perhaps it could be more effective in those only needing nasal canula O2 with stronger immune system at the that time? Too many questions, but thats what research is for. I still think iv dexamethasone has played a major role in the treatment of covid19, possibly larger than remdesivir.
Yeah a lot of great questions that I think we just don't know the answers to yet. I completely agree about dex, but even that, a drug we have used for so long, we don't know the perfect timing for it on when to give. So much of the treatment here is based on the timing I think and until we have more data to know for sure, its often going to be a judgement call based on experience and best guess based on condition.
Very good information
Thank you Mohan!
How do we detox it once we done with it. Worries about Side effects after.. My liver enzymes went up to 313. - but I’m now home after 21 days
We've been using it for a bit and have gotten solid results so far.
This is awesome to hear. I can't wait to see what comes of it being used here. Thanks for sharing this.
Thanks for sharing
My husband got bilateral pneomonia, getting this injection today, kindly pray for him
@@kuukiakhter9092 how's your husband?
But This medication is to treat RA right?
@@paug86 yeah, it helps calm inflammatory processes that cause RA damage. The hope was it could interrupt the runaway inflammatory processes of severe COVID. However, it just didn't show us improved patient outcomes and has been discontinued as a consideration for experimental treatment.
Thank you so much...
You're most welcome
Moderna’s phase 1 vaccine trial results have been published in the New England journal of Medicine. Can you interpret the results for us lay people. What do the assay numbers mean? Particularly the PRNT assay data
Honestly I'm not very versed in this info. I don't know if I'll cover this info as I try to make videos that directly address issues and topics related to critical care.
It worked for me, November, 2021 in hospital.
Very informative and well explained video👍👍👍 love from Pakistan 🇵🇰 😀
We want this injection. It is not find anywhere. Anyone know about this, where it found pls tell address.
A Very dear friend of mine was just put on this for covid pneumonia that came on very quickly. We are praying very very hard that this will help him recover. He doesn't deserve this horrible disease.
So did he recover😭? My uncle will also be going through this... Your feedback will give me relief
How did your friend do?
@@aishwaryamohanty618 how is your uncle?
@@NubQub he's now all good fine and healthy
TOP! Thanx man.
Awesome! You're welcome!
Remdesivir in combination with Tocilizumab would be a great combo.
I would agree! Also think there are others. I think this is going to be a multi-pronged approach to treating these patients.
Why use all those heavy drugs when Ivermectin does the work perfectly on stage 1, 2 and sometimes 3 of the disease?
My father recieved dosage of both
@@SwapnilSoni how is he doing now? Swapnil
@@rohit.k7920 he passed away on 11/11
. Be on the lookout for fungal pneumonia if your patient takes us also potentially consider prophylactic treatment. Unfortunately I had to patients that took this medication and both followed the exact same clinical course developing fungal pneumonia.
India just approved itolizumab which is a psoriasis drug and cd6 blocker. Even though the clinical trials had only 30 patients, the results were still very good that they approved this drug for moderate to late stage disease. Can you do a video on this but also on another drug that seems to be promising which is leronlimab. Thank you
Any of the "mab" drugs are going to be IL-6R blockers. The basic premise is going to be the same as here with Tocilizumab. That said, as I mentioned in there, some only impact the soluble IL-6R while others only impact the membrane bound IL-6R. One of the nice things with Tocilizumab is that it blocks both.
Currently not available anywhere in Mumbai ...we crucially need this injection for serve covid patent have admitted in ICU... please, anyone know about this availablity in mumbai let me know ..🙏🙏
My father was on bipap for 12 days and from last 2 days they have intubated him and he on mechanical ventilation.. doctors are suggesting not to use actemra/tocilizumab.. please suggest something for his speedy recovery
I am so sorry to hear about your father. I would trust in the providers who know what is going on to make the best decisions they can. Unfortunately I would not be able to comment on the care of someone I am not involved in. Praying for a quick recovery!
how is your dad doing?
Great. 👍
Thank you!
Thank you now i understand how it works! my father is on his 5th day in the ICU doctors recommend this but warned us its not yet FDA approve in our country but after watching this gives us hope that we still have a chance to help him recover 🙏🙏🙏
So sorry to hear your father is battling this right now. I hope for a quick turn around for him! 🙏🏼
While it is CI in case of acute infection?
Isn't covid19 an acute infection already?
My son age 33 years old three inj remdesivir 100 mg /20ml. His spo2 on monitor is 70.please advise for best results
I'm so sorry to hear your son is battling this right now. Trust in your providers and medical team. They will be able to give you the answers and information you need. Praying for your son!
thankyouuuu
You're welcome! 😊
Tq
You're welcome!
Tocilizumab 400mg injection pune me kaha melega pls reply
In collectors office
Where can we buy this medicine?
Only available in hospital as far as I know
Sir why most of the Covid 19 patients die with cardiac arrest on ventilator ?
My father was given tocilizumab on friday. Today Monday. He showed litle improvement yesterday but today his oxygen requirement has gone up. Has tocilizumab worked or failed?
How’s your father? My brother was given this last week, similar response with your father. It didn’t seem to help and his Oxygen levels even went down. 😢
@@ancientchords how's your brother? My mum had this therapy yesterday she's in ICU please pray for her.
@@ashmatharu159 We refused the 2nd dose, it didn’t really help. The cough came back, liver enzymes got worst. I talked to other doctors. Ivermectin is better. The tocilizumab is better given earlier stage. My brother continued on with ivermectin per the flccc protocol and is doing better. He is now out of ICU. There is no single medicine that will do the trick, it has to be multimodal approach. Please check the flccc website and their protocols. Most of all, spiritual & mental health is important.The whole family did video calls and sang songs of encouragement for him, prayed with him. We applied James 5:13-15. The first time we did this, his camera was off because he was intermittently confused and always short of breath. Yesterday, he was already talking in full sentences and not confused. Praising God for this miracle.
Yes, I will pray for your mom. 🙏🏼
@@ancientchords I'm happy to hear about your brother doing well now and yes I talk to her on the phone and text her . But I dont know what to do if they ask me if she needs another dose ? I'm really worried
Just greaaaaat!
Awesome!!
Currently not available anywhere in Mumbai ...we crucially need this injection for serve covid patent have admitted in ICU... please, if anyone know about this availablity in mumbai let me know ..🙏🙏
😢 I'm seeing on the news what you all are going through. Stay strong and keep up the good fight. It may not seem like it now, but it will eventually pass. Praying for everyone over there right now.
@@ICUAdvantage
www.ketto.org/fundraiser/offer-a-helping-hand-to-support-modho-mandals-treatment?
Have a look on this above link ..🙏🙏
Any small contribution would be of great help to make our patient possible.🙏
May brother nid this medicine....can u help up sir...
can a patient on a ventilator with covid be given this medication?
Yes
Today my sister in-law take tocilizumab hope she can improve her health
how is ur sister
MyGod bless you and keep you save and away from harm
Thank you and you as well!
Today we r going to use for my mom... Plsss pray guy
Prayers. Hoping for a speedy recovery for your mom!
How's your mom?
corona sardi khasi acchi ho gayi hai sab kuch accha hai per oxygen leval 70 75 68 bata raha hai 5 6 din se to ye injection lena jaruri hai
A last stage me daalte hain i c u patients ko plz mat dalo
Saving life is important. But the after-effect of this is makes you more prone to fungal infections like black fungus.
In India this is shortage 🔥🔥🔥🔥🔥🔥
😢
I want this injection. Buy. Plesz. Help me. i will pay
It's very expensive
This drug is effective to treat pockets
🙄
Thanks for the great video! Lots of great free open access medical education youtube channels out there pumping out COVID content. Would love to hear what you all think about our channel! We have a handful of Tocilizumab videos out there in the video-verse!