The Clot Thickens in Atherosclerosis but How?
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- Опубліковано 6 сер 2023
- This episode is based on a request by a listener to address Dr. Malcolm Kendrick's hypothesis on the clot as the underlying initiator of atherosclerosis which he proposed in his book, The Clot Thickens. Based on his observations, Dr. Kendrick talks about atherosclerosis as a blood disorder from increased clotting due to damage to the blood vessel lining. My points in this episode clarify the immune science of atherosclerosis and blood clotting, and delve into the significance and role of platelets in the disease process.
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#theclotthickens #atherosclerosis #ldl #cholesterol #platelets #metabolichealth #inflammation #reversedisease - Розваги
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My working theory is that atherosclerosis is a one-two punch, or like a binary explosive (but lots of little firecrackers).
There are many compounds that can wash out the glycocalyx. The glycocalyx acts as our shields, and It takes many hours for it to be restored.
Focusing on high blood glucose as a wash-out mechanism, in the Standard American Diet (SAD) we get glucose spikes from multiple meals a day (including snacks) sugary drinks (including 100% fruit juice). The glycocalyx just doesn't have a chance to properly rebuild - sleeping hours isn't enough time. That all cascades much worse with insulin resistance / diabetes. Glucose itself can glycate any cell, but is it enough to cause an inflammatory reaction? Sugar by itself has been declared to be 'safe' in the 'science'.
With the glycocalyx washed out, Nitrous Oxide is not released, so blood pressure may increase. Hypertension is now seen as part of the greater metabolic disorder.
Oxidized products are inflammatory, and damaged LDL is a problem - identified as small, dense LDL. As you say, damaged enough as to be not recognized by the usual receptors to be removed from circulation (so they build up) , and to be identified as a foreign body by our immune system. But the vascular walls are well protected by the glycocalyx from most of the many toxins we are exposed to except for specific high-flow sites, like branches and sharp turns. Damage is minimal. Industrially processed seed oils are highly oxidative, but are Generally Recognized As Safe (GRAS).
But in the continuous presence of all of the glucose in our diet, our shields are down, and the sdLDL and other oxidized products cause injury to and overwhelm the epithelium, and make their way into the vessel wall, where the auto-immune response ensues.
sorry for mangling the terminology.
I see the problem as the *combination* of sugar and oxidized seed oils in our ultra-processed food diet. Separately, not so bad. Our body can handle a little sugar from fruit, milk, or honey. The seed oils, it just tries to sequester that stuff.
And something I haven't seen talked about - why would there be a mechanism to wash out our vascular endothelial glycocalyx on a temporary basis?
That would be the flight-or-fight mechanism, in my estimation. Cortisol + Adrenaline dump glucose, washing out the glycocalyx keeping the blood vessels restricted and increasing blood pressure with the increased blood flow to push energy to every nook and cranny of the capillaries. This runs the risk of damage for a time, during an emergency. _Desperate Times Call for Desperate Measures._
It doesn't seem like running marathons continuously are good for longevity.
As for me, the best strategy to eliminate sdLDL and other factors is whole blood donation. Maybe there was something to the practice of blood-letting. Today it is a win-win situation, good for society as well.
As part of the immune cascade forming the clots, it would be interesting if science would address the more recent phenomenon of the fibrous rubbery clots forming in artery walls of both the living and cadavers - not the typical jelly clots. Is this because of prolonged inflammatory irritation from spike proteins? This is really the elephant in the room, especially in the young. Myocarditis was common. As part of a study conducted here in Texas, I am aware that mrna generated spike tended to last quite a long time in the bloodstream. Naturally occuring spike went away within a few months. Nucleocapsids from natural viral infection remained for a long time.
I am totally baffled. She put forward a thesis statement in the intorduction; a dissemination of Malcolm Kendrick's blood clot-artheriosclerosis theory.........and then never referred to him, his theory or his work again.
Doctor. I liked your talk. I liked especially that you took the Book by Kendrick and shared your perspective. A request. Can you please add a slide or two (handwritten ok) with key bullets and key pieces of logic or your idea of the sequential flow of events.
@RamaVetury Thank you for your comments. I didn't do slides because this is actually a podcast but you are not the 1st to ask for them. I will work on a format whereby people can have more graphics of what I am discussing.
Dear Doctor, my name is Marco and I write from Rome, Italy. I have read dr kendrick's book and find it very interesting and more "realistic" about atherothrombotic genesis. I will watch all his videos and try to get an idea of his hypothesis as well. Kind regards from Rome
Thank you, Marco. I am doing a whole series on the pathogenesis of atherosclerosis (Episodes 45 through 52) and in each episode I look at different aspects of the puzzle and how they fit together. I hope you'll enjoy them. If you have any questions, come to one of my livestream events and I'd be happy to answer them, or you can just ask here on UA-cam too. Best regards.
Also, your summary of what a person should do to help their situation would be great.
Do you agree with Dr Sean O mara
I'll be doing an episode to look at practical implications of my thoughts on atherosclerosis. I am unfamiliar with Dr. O'Mara's point of view? What is his take?
First time I have listened to your pod cast and was attracted by the fact that you were discussing Dr Kendricks hypothesis discussed in the clot thickens however after a brief introduction then I was disappointed that your pod cast seemed to carry on to the topic that you wanted to discuss rather than anything to do with Dr Kendricks hypothesis so I am none the wiser as to whether you believe Dr Kendrick has some valid points or whether you think he is talking rubbish.
I don't think he is "talking rubbish" though some of his explanations are perhaps more guesses and seemingly based on his intuition. The thrombotic issue he stresses on (which his book is named after) is what I tried to address in the podcast episode although I mostly focused on platelets and not the coagulation pathway per se. However, clotting is an immune phenomenon and is part of the heart attack pathway. I didn't have time to do a deep dissection into his theory but I will say he has some good intuition as to the events involved and perhaps needs a bit more of the basic science to illustrate some of the events. If there is interest I could do a deeper dive...thanks for commenting!
@@vlmdrounds Yes, thank you for your perspective. We know that you do not shy away from correcting straight-up errors; from watching previous episodes.
The way I see it, you made it clear that you were responding to a _hypothesis_ and I get, overall, that "it fits".
That it wasn't intended to be a proof, but in my N=1 experiment, It is far better than the clogged plumbing bogosity; and I am better informed from your podcast. Thank you!
@@jamesalles139You are so welcome. You made some good points. My problem is trying to explain everything in a succinct way. It's really hard to do in 30 minutes. BUT, the most recent episode (53) on reviewing Dayspring and Attia, allowed me to talk about some basic foundational concepts that set the stage for some of Kendrick's proposals. The sections on the RBC membranes and how RBCs carry a lot of cholesterol and contribute to the plaque are the ones to focus on. I will probably do an episode on RBCs and macrophages to further expand on the idea. I wish I had more time and support to do these episodes. I do love teaching but as a 1 person team it's really hard to get everything out the way I want to. I have basically been leaving a trail of crumbs with episodes to lay the foundation for later linking them all. The Dayspring and Attia episode allowed some of that tying-together-of-loose ends...but 2 hours! I was hoarse halfway through!
So how does one maintain the balance?
@dry509 I am assuming you mean how we maintain a balance between inflammatory and anti-inflammatory states. Our bodies tolerate a wide range of swings in acute situations. I think the danger is in a chronic of prolonged state of inflammation or tolerance. Attention to the basics of nutrition, exercise, sleep and alleviation of stress are always fundamental to keeping a state of 'balance' in the body.
I am totally baffled. You put forward a thesis statement in the intorduction; a dissemination of Malcolm Kendrick's blood clot-artheriosclerosis theory.........and then never referred to him, his theory or his work again. So do you agree with him or not?
@harryturnbull4781 Sorry I wasn't clearer, Harry. I was saying that clotting is part of the immune response and therefore a part of the atherosclerotic process which is, in essence, an immune process with auto-inflammatory and autoimmune components. Kendrick's hypothesis is on the right track--the details may be a bit lacking and off but he is far closer than many others.
@@vlmdrounds Ok thanks. Does this also tie in with some thinking that insulin resistence pre-empts inflammation and other issues such as clotting?
@@harryturnbull4781 Insulin resistance is one factor in inducing a pro-inflammatory state. ROS formation through different mechanisms results in inflammation, as does circadian disruption.