Great video. You somehow seem to frequently post exactly what I've been reading about myself. On another note your psychopharm vids have made teaching medical students a hell of a lot easier, so thanks!
They looked forward to that moment with joy, but without haste, not pining for it, but seeming to have a foretaste of it in their hearts, of which they talked to one another. But when they looked at me with their sweet eyes full of love, when I felt that in their presence my heart, too, became as innocent and just as theirs, the feeling of the fullness of life took my breath away, and I worshipped them in silence. Their children were the children of all, for they all made up one family.
What about Deliriant hallucination, such as those produced by Scopolamine and Diphenhydramine? How come they resemble real life to such a great extend?
Some of the most interesting things I've read are "experience reports" from inhalant use/abuse. A lot of them describe the most supernatural and profound sounding experiences of a complete apprehension of the entire universe, or like such as. But those substances are relatively well documented as, to be very gentle, not having high therapeutic potential. And comments on those reports also frequently exhort the writers to stop or they'll ruin their lives. That to me creates an interesting abstraction, because 5-HT2A agonists likewise induce or encourage profound experiences, so given the dichotomy between 5-HT2A agonists and inhalants in terms of apparent safety and therapeutic potential, it's clear that profundity of experience itself isn't the sole driver of the antidepressant potential and low abuse potential of psychedelics. It's not surprising-the pharmacological profile of inhalants is basically "make all neurons work more badly and less goodly than before"-but it's interesting.
Interesting video! I just wanna add something to the Louis Wain discussion. It's quite possible that he had autism and made fractal art for stimming, as theyre full of repetitive patterns. He showed interest in cubist art way before hospitalization and might not have been able to draw it because he drew to earn money, so maybe he didnt have the time for experimentation. Also, he didnt date his art and i've seen a drawing he did of a normal cat on the hospital's garden, so it could be made days or years after hospitalization and we wouldn't know. Plus, people with schizophrenia often have smaller attention spans while autistic people can spend *a lot* of time working with their special interest, and Louis' art is hyper-detailed.
Cool observation and it might be! back in the day autism was commonly misdiagnosed with mental illnesses. Autistic artist could have long periods of time sticking to just one style/object but it doesn't mean they would stick with it forever.
Please can you make more videos on the MoA of psychedelics when you get the chance? I'm incredibly interested after seeing your video on delayed effects of SSRIs. I'm curious to know if the reason people tend to report withdrawals from coming off SSRIs but not psychedelics is because of the difference in the MoA.
Thank you for the video. Great insights. But something doesnt add up. Arent some hallucinogens such as Ketamine and PCP, NMDA antagonists? According to the information presented I would expect them to inhibit the top down system and thus inhibit and not produce hallucinations
The next video will talk about exactly this. You are correct ketamine and PCP block NMDA (and upregulate AMPA), leaving the individual with disturbed feed-forward mechanisms. This is a situation prone to delusions more so than overt hallucinations (see 7m:17s of the video), which is what we see with the dissociatives.
Eeehhh, there's very little evidence that Louis Wane actually had schizophrenia. At a certain period of his life he came out with these psychedelic cats, but it hasn't influenced his style permanently. He still drew a regular humanised cats later on.
I don't think I follow your analogy to delusions and hallucinations. Wouldn't a delusion ("seeing patterns in the noise") be a top-down process? You're taking some preconceived high-level idea and misapplying it to the sensory data you get. By contrast, a "hallucination" seems to imply something completely alien and novel manifesting itself to me spontaneously via sensory channels, which is what I would have expected a bottom-up misfire to result in.
It’s the most common antipsychotic but if it’s the drug induced psychosis I wouldn’t even reccomend weed due to the nature of that illness, unfortunately there are some people that experience psychosis symptoms after smoking but if that hasn’t happened before then you will be alright
Great video. You somehow seem to frequently post exactly what I've been reading about myself.
On another note your psychopharm vids have made teaching medical students a hell of a lot easier, so thanks!
They looked forward to that moment with joy, but without haste, not pining for it, but seeming to have a foretaste of it in their hearts, of which they talked to one another. But when they looked at me with their sweet eyes full of love, when I felt that in their presence my heart, too, became as innocent and just as theirs, the feeling of the fullness of life took my breath away, and I worshipped them in silence. Their children were the children of all, for they all made up one family.
What about Deliriant hallucination, such as those produced by Scopolamine and Diphenhydramine? How come they resemble real life to such a great extend?
Some of the most interesting things I've read are "experience reports" from inhalant use/abuse. A lot of them describe the most supernatural and profound sounding experiences of a complete apprehension of the entire universe, or like such as. But those substances are relatively well documented as, to be very gentle, not having high therapeutic potential. And comments on those reports also frequently exhort the writers to stop or they'll ruin their lives. That to me creates an interesting abstraction, because 5-HT2A agonists likewise induce or encourage profound experiences, so given the dichotomy between 5-HT2A agonists and inhalants in terms of apparent safety and therapeutic potential, it's clear that profundity of experience itself isn't the sole driver of the antidepressant potential and low abuse potential of psychedelics. It's not surprising-the pharmacological profile of inhalants is basically "make all neurons work more badly and less goodly than before"-but it's interesting.
Please continue this series
One day I will return!
😯👍🏻”FASCINATING”!!
crazy how intriguing…. & you Are Amazing!
Wow👌🍄🌞
This series is fantastic. Is there still plans to continue it? I would love to hear more!
Interesting video! I just wanna add something to the Louis Wain discussion. It's quite possible that he had autism and made fractal art for stimming, as theyre full of repetitive patterns. He showed interest in cubist art way before hospitalization and might not have been able to draw it because he drew to earn money, so maybe he didnt have the time for experimentation. Also, he didnt date his art and i've seen a drawing he did of a normal cat on the hospital's garden, so it could be made days or years after hospitalization and we wouldn't know. Plus, people with schizophrenia often have smaller attention spans while autistic people can spend *a lot* of time working with their special interest, and Louis' art is hyper-detailed.
Cool observation and it might be! back in the day autism was commonly misdiagnosed with mental illnesses. Autistic artist could have long periods of time sticking to just one style/object but it doesn't mean they would stick with it forever.
i absolutely love everything about this
Fantastic video, great information, keep them coming! Peace & love.
Please can you make more videos on the MoA of psychedelics when you get the chance? I'm incredibly interested after seeing your video on delayed effects of SSRIs. I'm curious to know if the reason people tend to report withdrawals from coming off SSRIs but not psychedelics is because of the difference in the MoA.
i'm not even a medical student mate and i'm learning tons
Thank you for the video. Great insights. But something doesnt add up. Arent some hallucinogens such as Ketamine and PCP, NMDA antagonists? According to the information presented I would expect them to inhibit the top down system and thus inhibit and not produce hallucinations
The next video will talk about exactly this. You are correct ketamine and PCP block NMDA (and upregulate AMPA), leaving the individual with disturbed feed-forward mechanisms. This is a situation prone to delusions more so than overt hallucinations (see 7m:17s of the video), which is what we see with the dissociatives.
check out mycodext on Instagram. he got some dope stuff. he sells psychedelics products.. shrooms, lsd, dmts. he's a reliable plug.
@@PsychoFarm Maybe you could do a video on N,N-Dmt. Would be interesting.
So how would you explain closed eye visuals or visuals experienced in total darkness? There's nothing to look at and misinterpret.
Eeehhh, there's very little evidence that Louis Wane actually had schizophrenia. At a certain period of his life he came out with these psychedelic cats, but it hasn't influenced his style permanently. He still drew a regular humanised cats later on.
If delusions and hallucinations are brought about by opposite changes… why do schizophrenics get both?
"MDD or schizoaffective disorder, thats just a technicality".
Is love disappointment a bottom-up or top-down preponderance?
I don't think I follow your analogy to delusions and hallucinations. Wouldn't a delusion ("seeing patterns in the noise") be a top-down process? You're taking some preconceived high-level idea and misapplying it to the sensory data you get.
By contrast, a "hallucination" seems to imply something completely alien and novel manifesting itself to me spontaneously via sensory channels, which is what I would have expected a bottom-up misfire to result in.
Check out his previous video on dopamine and psychosis. It explains it way better than I could.
Will there be an antipsychotic medicine in the future that allows you to smoke weed again? Like is this possible?
You can...at least seroquel..it will not cause harm
@@Yocole5 what is seroquel?
It’s the most common antipsychotic but if it’s the drug induced psychosis I wouldn’t even reccomend weed due to the nature of that illness, unfortunately there are some people that experience psychosis symptoms after smoking but if that hasn’t happened before then you will be alright
Metaphorically of course I’m not giving any medical related advice