I wonder if you “act out” your dreams in one decade, but stop in the following decades, if it is still a predictor? In my 20’s I was insanely acting out in my dreams, but in my 30’s and 40’s, it never happened again.
You should have Dr. Joseph Signorile as a guest. One of the leading researchers in resistance training interventions in Parkinson’s disease. Awesome work out of the University of Miami.
There is no test Parkinson’s Disease. The clinical diagnosis she speaks of requires 3 of 4 but there also many many non motor symptoms that can appear even before the motor symptoms. There’s a saying, “if you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s” because everyone’s presents and looks different.
This is interesting, but in the end, the information about acting out dreams "a lot" isn't very useful. What is a lot? Once we have that information, what can be done about it? It certainly is not equivalent to catching cancer early as we can usually do something about that. My father died of Parkinson's. My wife sometimes acts out her dreams. A lot? Well, what exactly is a lot? 3-4 times a month? A week? What?
I have a strong feeling that Dextromethorphan (a cough suppressant, one of the primary ingredients in cough and cold meds) certainly does. Even at recommended dosages.
Also, incidence is highest in the south east central part of the nation (not the midwest). Additionally, farmland is not associated with PD in the midwest (or nationwide), likely because its a poor proxy for pesticide exposure. That said, there are certain geographies where that association can be detected (which might hint at which pesticides are of interest). Stay tuned for new papers out of the Racette Lab at Barrow.
I have RSBD and so you are describing me. This is the reason I started the Carnivore diet. While my RSBD isn't totally gone in 4 months it has lessened by over 75%. And there are Parkinson's patients that have basically lost all their symptoms. It would be great if you spoke on this.
I was surprised you didn't mention the lady in England, Joy Milne, who is able to smell Parkinsons. Supposedly there is a test coming out based on the compounds that she is able to smell.
It has to be during REM sleep. There is a part of the brain that paralyzes the body during this part of your sleep cycle. If it is damaged and not working properly you may move and even speak during REM sleep as you are dreaming. That is RBD, a precursor to neurodegenerative disease.
@@martinlutherkingjr.5582 Not definitively no. You should try to have a sleep study done where they hook up electrodes to your muscles and can determine whether or not you have muscle activity coinciding with REM sleep. Good luck!
@@martinlutherkingjr.5582 There's various wearables that claim to measure sleep cycles, like the Oura ring. I'm not sure how accurate they are. Then just record your sleep, compare time: you have at least an indication.
The guest lacks fundamental understanding of Parkinson’s disease. Because you don’t have a basic understanding of the disease, you weren’t able to ask her the right questions. Parkinson's Disease is a neurological condition resulting from the pathology of alpha-synuclein. Understanding the role and effects of α-synuclein in PD is important to diagnosing it and mitigating the disease's progression. There are multiple predictive tests that have nothing to do with sleep tests. There’s the AlphaSyn-SAA salivary test, an early test for prediction. There is the Syn-One skin biopsy detects the presence of phosphorylated alpha-synuclein in the skin. And there are genetic tests that can help predict the likelihood and type of PD. The one technical aspect she touched upon, interference with lysosomal degradation, is not a primary etiological pathway and was not correctly explained. Mutant α-synuclein oligomers interfere with normal cellular processes, including mitochondrial function and lysosomal degradation. These disruptions lead to cellular stress, inflammation, and further exacerbate progressive neurodegeneration. Your lack of understanding of Parkinson’s disease prevented you from recognizing your guest’s shortcomings. Overall, this video was not informative and somewhat misleading.
Google scholar shows Dr. Niotis as having over a dozen papers with over 400 sites. She's affiliated with the very first Alzheimer's prevention clinic in the United States, and is one of the highest sided researchers in the US. So she seems to be fairly cognizant of the pathology and in fact trusted enough to be cited routinely by other specialists in the field. Could you provide for us your CV so we could have some kind of comparative understanding of your background?
Need a sibilance / pop filter for female voices on electrostatic microphones. It is likely exaggerated because of the choice of mic. A good choice for a dark voice like Peter but not for some guests.
I have insomnia, RBD, dementia, tremor, trouble swallowing, nocturia, high bilirubin counts, ED, tripping, loss of smell, sluring speech...The list goes on. Yet, neurogists can't figure it out. How can doctors be so bad at their jobs?
@@MarionMM I’ll take that as “I don’t care care enough to actually educate myself, let alone actually substantiate any actual argument about it” Cool, think whatever you like.
She almost admitted the obvious. Nicotine is a preventative. The amount of cognition diseases have increased as the use of nicotine has decreased. The percentages in the population almost mirror one another.
Correlation, causation, etc etc. But let's assume that what you're saying is the absolute fact. Co-committently there has been a gigantic drop off in mortality related to smoking.
@@Jay-ho9io that would beg the question that the deaths were truly smoking related to begin with. If every smoker who dies of a heart attack, complications from a stroke, or arterial sclerosis is deemed to be smoking related then one would expect that smoking related deaths would fall as the smoking rate decreased even though the death rates of the above mentioned causes have remained relatively constant.
@@Friardavidosss If you're going to tilt at the windmill that smoking is not related to pulmonary, oncological and cardiovascular mortality, the research on that is settled to the level that it is completely upon you to provide overwhelming evidence. In the vernacular,, "cool story bro"
We all need improved sleep. For decades it was a badge of honor to work or study excessively and not get enough sleep.
I wonder if you “act out” your dreams in one decade, but stop in the following decades, if it is still a predictor? In my 20’s I was insanely acting out in my dreams, but in my 30’s and 40’s, it never happened again.
My sister had Parkinson's . She had a lot of anxiety and dealing with stress years before diagnosis with physical symptoms.
Gotta say, the best outtro music on a podcast!
She needed to be way more specific on those symptoms than even what Peter was trying to coax out of her.
You should have Dr. Joseph Signorile as a guest. One of the leading researchers in resistance training interventions in Parkinson’s disease. Awesome work out of the University of Miami.
There is no test Parkinson’s Disease. The clinical diagnosis she speaks of requires 3 of 4 but there also many many non motor symptoms that can appear even before the motor symptoms. There’s a saying, “if you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s” because everyone’s presents and looks different.
Description currently links to the wrong video
Wow! I had no idea about the acting out your dreams sign.
This is interesting, but in the end, the information about acting out dreams "a lot" isn't very useful. What is a lot? Once we have that information, what can be done about it? It certainly is not equivalent to catching cancer early as we can usually do something about that. My father died of Parkinson's. My wife sometimes acts out her dreams. A lot? Well, what exactly is a lot? 3-4 times a month? A week? What?
Yeah, this is far too vague.
One time is enough for concern if its done during the REM stage and can't be attributed to being drug-induced.
Does anyone speaks about abuse of alcohol is one of the causes of?
Not every smoker will get lung cancer but smoking contributes to it!
I have a strong feeling that Dextromethorphan (a cough suppressant, one of the primary ingredients in cough and cold meds) certainly does. Even at recommended dosages.
Maybe not directly, but alcohol does negatively influence deep sleep, and hence the brain's ability to "clean" itself.
Would childhood PTSD contribute to the long term atrophy of the dopamine producing region and possibly be a causal factor?
Also, incidence is highest in the south east central part of the nation (not the midwest). Additionally, farmland is not associated with PD in the midwest (or nationwide), likely because its a poor proxy for pesticide exposure. That said, there are certain geographies where that association can be detected (which might hint at which pesticides are of interest). Stay tuned for new papers out of the Racette Lab at Barrow.
I have RSBD and so you are describing me. This is the reason I started the Carnivore diet. While my RSBD isn't totally gone in 4 months it has lessened by over 75%. And there are Parkinson's patients that have basically lost all their symptoms. It would be great if you spoke on this.
"acting out your dreams"...oh man my poor dog.
Best comment ever
I was surprised you didn't mention the lady in England, Joy Milne, who is able to smell Parkinsons. Supposedly there is a test coming out based on the compounds that she is able to smell.
What about talking in your sleep? Is that considered acting it out?
It has to be during REM sleep. There is a part of the brain that paralyzes the body during this part of your sleep cycle. If it is damaged and not working properly you may move and even speak during REM sleep as you are dreaming. That is RBD, a precursor to neurodegenerative disease.
@@sandman1347 Is there a way to figure out if it’s during REM sleep outside a lab setting?
@@martinlutherkingjr.5582 Not definitively no. You should try to have a sleep study done where they hook up electrodes to your muscles and can determine whether or not you have muscle activity coinciding with REM sleep. Good luck!
@@martinlutherkingjr.5582 There's various wearables that claim to measure sleep cycles, like the Oura ring. I'm not sure how accurate they are. Then just record your sleep, compare time: you have at least an indication.
@@martinlutherkingjr.5582 Probably no. You should pursue a sleep study.
I never acted out dreams ... but my one arm stopped swinging .... then tremor etc
Isn't it the nicotine that is neuro protective rather than the smoking...? Easy to supplement in nicotine with lozenges or gum 👌🏻.
100% correct! It’s odd how in 2024 some people still don’t understand that tobacco and nicotine are two separate things.
So again, fasting > autophagy are foundations for healthy living and aging.
So intermittent fasting will be good denser against Parkinson’s as it stimulates autophagy
The guest lacks fundamental understanding of Parkinson’s disease. Because you don’t have a basic understanding of the disease, you weren’t able to ask her the right questions.
Parkinson's Disease is a neurological condition resulting from the pathology of alpha-synuclein.
Understanding the role and effects of α-synuclein in PD is important to diagnosing it and mitigating the disease's progression.
There are multiple predictive tests that have nothing to do with sleep tests.
There’s the AlphaSyn-SAA salivary test, an early test for prediction.
There is the Syn-One skin biopsy detects the presence of phosphorylated alpha-synuclein in the skin.
And there are genetic tests that can help predict the likelihood and type of PD.
The one technical aspect she touched upon, interference with lysosomal degradation, is not a primary etiological pathway and was not correctly explained.
Mutant α-synuclein oligomers interfere with normal cellular processes, including mitochondrial function and lysosomal degradation. These disruptions lead to cellular stress, inflammation, and further exacerbate progressive neurodegeneration.
Your lack of understanding of Parkinson’s disease prevented you from recognizing your guest’s shortcomings. Overall, this video was not informative and somewhat misleading.
Thank you. I needed that. I have multiple risk factors and a great Uncle who had it. I'll look into that testing. Have a great day my friend.
Google scholar shows Dr. Niotis as having over a dozen papers with over 400 sites. She's affiliated with the very first Alzheimer's prevention clinic in the United States, and is one of the highest sided researchers in the US.
So she seems to be fairly cognizant of the pathology and in fact trusted enough to be cited routinely by other specialists in the field.
Could you provide for us your CV so we could have some kind of comparative understanding of your background?
Need a sibilance / pop filter for female voices on electrostatic microphones. It is likely exaggerated because of the choice of mic. A good choice for a dark voice like Peter but not for some guests.
What about restless leg syndrome? Does this fall under the 90%?
No. RLS significantly different from disturbed REM sleep
Sounds like epigenetics and psychology plays a part in families with trends
Paraquat is a herbicide not a pesticide.
I have insomnia, RBD, dementia, tremor, trouble swallowing, nocturia, high bilirubin counts, ED, tripping, loss of smell, sluring speech...The list goes on. Yet, neurogists can't figure it out. How can doctors be so bad at their jobs?
With that diagnosis, I've had Parkinson for the past 40 years.
❤❤❤
90% seems extraordinarily high
Agreed, hard to believe
The vocal fry is hard to listen to 😢
Yeah it just isn't professional.
It's a normal voice
I'm an airline pilot, and when I hear it on the radio from female pilots I am so tempted to transmit "vocal fry".
It's annoying to hear her whistle after the Sss words. Is that preventable, ugh
@@kiranmkota Not anywhere in the world except a few regions in the USA.
WHAT!! To much going on with ones health/Information when it comes to disease
Gonna call BS on that 90% likely-hood.
I sincerely doubt you have any background to back that up, but yeah it would be good to know what backs up her claim.
@@JustMe-ne5dw I sincerely doubt you have any background to be doubting anyone.
@@MarionMM I’ll take that as “I don’t care care enough to actually educate myself, let alone actually substantiate any actual argument about it”
Cool, think whatever you like.
@@JustMe-ne5dw Cool ,think whatever you like.
She almost admitted the obvious. Nicotine is a preventative. The amount of cognition diseases have increased as the use of nicotine has decreased. The percentages in the population almost mirror one another.
Correlation, causation, etc etc. But let's assume that what you're saying is the absolute fact. Co-committently there has been a gigantic drop off in mortality related to smoking.
@@Jay-ho9io that would beg the question that the deaths were truly smoking related to begin with. If every smoker who dies of a heart attack, complications from a stroke, or arterial sclerosis is deemed to be smoking related then one would expect that smoking related deaths would fall as the smoking rate decreased even though the death rates of the above mentioned causes have remained relatively constant.
@@Friardavidosss If you're going to tilt at the windmill that smoking is not related to pulmonary, oncological and cardiovascular mortality, the research on that is settled to the level that it is completely upon you to provide overwhelming evidence.
In the vernacular,, "cool story bro"
It’s no fun
Interesting conversation, but I think she also has a PhD in vocal fry - my goodness.
Hmm, all those symptoms sure sound like our current president.
???? speaking about nothing disappointing
some anti-aging members find pd relief, among other things, with dep-pro/deprenyl/selegiline